Life Sciences Graduate Programs

Research Output

2003
2 Scopus citations

BACE1 (β-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

Luo, Y., Bolon, B., Damore, M. A., Fitzpatrick, D., Liu, H., Zhang, J., Yan, Q., Vassar, R. & Citron, M., Jan 1 2003, In : Neurobiology of Disease. 14, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

142 Scopus citations

Computer software to find genes in plant genomic DNA.

Davuluri, R. V. & Zhang, M. Q., 2003, In : Methods in molecular biology (Clifton, N.J.). 236, p. 87-108 22 p.

Research output: Contribution to journalArticle

10 Scopus citations

Effects of nuclear-presenting-macrophage colony-stimulating factor on the process of malignancy

Cao, Z. Y., Zhang, B., Rao, Q., Li, G., Zheng, G. G. & Wu, K. F., Jul 2003, In : International journal of hematology. 78, 1, p. 87-89 3 p.

Research output: Contribution to journalLetter

3 Scopus citations

Enhancement of NIH3T3 cell proliferation by expressing macrophage colony stimulating factor in nuclei

Cao, Z. Y., Wu, K. F., Li, G., Lin, Y. M., Zhang, B. & Zheng, G. G., Mar 2003, In : Chinese Journal of Cancer Research. 15, 1, p. 43-47 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Expression and functional reconstitution of IL-18 receptor in K562 leukemia cells

Zhang, B., Cao, Z. Y., Wu, K. F. & Lin, Y. M., Oct 1 2003, In : Leukemia Research. 27, 10, p. 971-972 2 p.

Research output: Contribution to journalLetter

3 Scopus citations

Expression and production of bioactive human interleukin-18 in transgenic tobacco plants

Zhang, B., Yang, Y. H., Lin, Y. M., Rao, Q., Zheng, G. G. & Wu, K. F., Oct 1 2003, In : Biotechnology Letters. 25, 19, p. 1629-1635 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Expression and significance of IL-18 in the bone marrow of patients with hematological diseases

Zhang, B., Rao, Q., Zheng, G., Cao, Z., Ma, X., Li, G., Lin, Y., Geng, Y. & Wu, K., Feb 1 2003, In : Chinese Medical Journal. 116, 2, p. 218-221 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Expression of IL-18 and its receptor in human leukemia cells

Zhang, B., Ma, X. T., Zheng, G. G., Li, G., Rao, Q. & Wu, K. F., Sep 1 2003, In : Leukemia Research. 27, 9, p. 813-822 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Expression of LL-37/hCAP-18 gene in human leukemia cells

Yang, Y. H., Zheng, G. G., Li, G., Zhang, B., Song, Y. H. & Wu, K. F., Oct 1 2003, In : Leukemia Research. 27, 10, p. 947-950 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

'Hitting you over the head': Oncologists' disclosure of prognosis to advanced cancer patients

Gordon, E. J. & Daugherty, C. K., Jan 1 2003, In : Bioethics. 17, 2, p. 142-168 27 p.

Research output: Contribution to journalArticle

176 Scopus citations
1 Scopus citations

Thin client performance for remote 3-D image display.

Lai, A., Nieh, J., Laine, A. & Starren, J., 2003, In : AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium. 1 p.

Research output: Contribution to journalArticle

20 Scopus citations

Usability in the real world: Assessing medical information technologies in patients' homes

Kaufman, D. R., Patel, V. L., Hilliman, C., Morin, P. C., Pevzner, J., Weinstock, R. S., Goland, R., Shea, S. & Starren, J., Jan 1 2003, In : Journal of Biomedical Informatics. 36, 1-2, p. 45-60 16 p.

Research output: Contribution to journalArticle

150 Scopus citations

Validation of a decision regret scale

Brehaut, J. C., O'Connor, A. M., Wood, T. J., Hack, T. F., Siminoff, L., Gordon, E. & Feldman-Stewart, D., Jul 1 2003, In : Medical Decision Making. 23, 4, p. 281-292 12 p.

Research output: Contribution to journalReview article

483 Scopus citations
12 Scopus citations
2002

An AscI boundary library for the studies of genetic and epigenetic alterations in CpG islands

Dai, Z., Weichenhan, D., Wu, Y. Z., Hall, J. L., Rush, L. J., Smith, L. T., Raval, A., Yu, L., Kroll, D., Muehlisch, J., Frühwald, M. C., De Jong, P., Catanese, J., Davuluri, R. V., Smiraglia, D. J. & Plass, C., Oct 1 2002, In : Genome research. 12, 10, p. 1591-1598 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Aβ deposition is essential to AD neuropathology

Estus, S., Borchelt, D., Kindy, M. S. & Vassar, R., Jun 2002, In : Journal of Alzheimer's Disease. 4, 3, p. 133-138 6 p.

Research output: Contribution to journalReview article

8 Scopus citations

Clinical significance of IL-18 gene over-expression in AML

Zhang, B., Wang, Y., Zheng, G. G., Ma, X. T., Li, G., Zhang, F. K. & Wu, K. F., Aug 23 2002, In : Leukemia Research. 26, 10, p. 887-892 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Columbia University's informatics for diabetes education and telemedicine (IDEATel) project: Technical implementation

Starren, J., Hripcsak, G., Sengupta, S., Abbruscato, C. R., Knudson, P. E., Weinstock, R. S. & Shea, S., Jan 1 2002, In : Journal of the American Medical Informatics Association. 9, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

97 Scopus citations

Columbia University's Informatics for Diabetes Education and Telemedicine (IDEATel) Project: Rationale and design

Shea, S., Starren, J., Weinstock, R. S., Knudson, P. E., Teresi, J., Holmes, D., Palmas, W., Field, L., Goland, R., Tuck, C., Hripcsak, G., Capps, L. & Liss, D., Jan 1 2002, In : Journal of the American Medical Informatics Association. 9, 1, p. 49-62 14 p.

Research output: Contribution to journalArticle

123 Scopus citations

Competing clinical trials in the same institution: Ethical issues in subject selection and informed consent

Gordon, E. J. & Micetich, K. C., Mar 1 2002, In : IRB Ethics and Human Research. 24, 2, p. 1-7 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Desiderata for personal electronic communication in clinical systems

Sarkar, I. N. & Starren, J., May 1 2002, In : Journal of the American Medical Informatics Association. 9, 3, p. 209-216 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Direct coupling of the cell cycle and cell death machinery by E2F

Nahle, Z., Polakoff, J., Davuluri, R. V., McCurrach, M. E., Jacobson, M. D., Narita, M., Zhang, M. Q., Lazebnik, Y., Bar-Sagi, D. & Lowe, S. W., Jan 1 2002, In : Nature Cell Biology. 4, 11, p. 28-34 7 p.

Research output: Contribution to journalArticle

349 Scopus citations

Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53

Yoon, H., Liyanarachchi, S., Wright, F. A., Davuluri, R., Lockman, J. C., De la Chapelle, A. & Pellegata, N. S., Nov 26 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 24, p. 15632-15637 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

It’s alive! giving birth to research ethics education

Gordon, E. J. & Parsi, K. P., Jan 1 2002, In : American Journal of Bioethics. 2, 4, p. 65-66 2 p.

Research output: Contribution to journalComment/debate

9 Scopus citations
7 Scopus citations

ß-Secretase (BACE) as a drug target for Alzheimer’s disease.

Vassar, R., 2002, Current treatments and therapeutic targets in Alzheimer’s disease. Zlokovic B., V. (ed.). New York: John Wiley & Sons Ltd., p. 15-40

Research output: Chapter in Book/Report/Conference proceedingChapter

What “race” cannot tell us about access to kidney transplantation

Gordon, E. J., Jan 1 2002, In : Cambridge Quarterly of Healthcare Ethics. 11, 2, p. 134-141 8 p.

Research output: Contribution to journalReview article

10 Scopus citations

β-secretase (BACE) as a drug target for Alzheimer's disease

Vassar, R., Dec 7 2002, In : Advanced Drug Delivery Reviews. 54, 12, p. 1589-1602 14 p.

Research output: Contribution to journalArticle

183 Scopus citations
2001

Attitudes and practices in postmortem organ procurement [1] (multiple letters)

Ramalingam, N. D., Gordon, E. J., Ross, L., Gunderson, S., Wendler, D., Dickert, N. & Capron, A. M., Apr 18 2001, In : Journal of the American Medical Association. 285, 15, p. 1958-1960 3 p.

Research output: Contribution to journalLetter

2 Scopus citations

Characterization of Alzheimer's ß-secretase protein BACE1: Processing and other posttranslational modifications

Haniu, M., Bennett, B. D., Denis, P., Young, Y., Mendiaz, E. A., Fuller, J., Hui, J. O., Kahn, S., Babu-Khan, S., Ross, S., Burgess, T., Katta, V., Nicolson, M., Lull, J., Wang, S., Rogers, G., Vassar, R. & Citron, M., 2001, Progress in Alzheimer's Disease research. Iqbal, K. (ed.). New York: John Wiley & Sons Ltd., p. 50-75

Research output: Chapter in Book/Report/Conference proceedingChapter

Computational identification of promoters and first exons in the human genome

Davuluri, R. V., Grosse, I. & Zhang, M. Q., Jan 1 2001, In : Nature Genetics. 29, 4, p. 412-417 6 p.

Research output: Contribution to journalArticle

322 Scopus citations

Erratum: A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's β-secretase (The Journal of Biological Chemistry (2002) 275 (37712-37717))

Bennett, B. D., Denis, P., Haniu, M., Teplow, D. B., Kahn, S., Louis, J. C., Citron, M. & Vassar, R., May 4 2001, In : Journal of Biological Chemistry. 276, 18, 1 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

Identifying the 3′-terminal exon in human DNA

Tabaska, J. E., Davuluri, R. V. & Zhang, M. Q., Jan 1 2001, In : Bioinformatics. 17, 7, p. 602-607 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Making grandma's data secure: a security architecture for home telemedicine.

Starren, J., Sengupta, S., Hripcsak, G., Ring, G., Klerer, R. & Shea, S., 2001, In : Proceedings / AMIA ... Annual Symposium. AMIA Symposium. p. 657-661 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

Luo, Y., Bolon, B., Kahn, S., Bennett, B. D., Babu-Khan, S., Denis, P., Fan, W., Kha, H., Zhang, J., Gong, Y., Martin, L., Louis, J. C., Yan, Q., Richards, W. G., Citron, M. & Vassar, R., 2001, In : Nature neuroscience. 4, 3, p. 231-232 2 p.

Research output: Contribution to journalArticle

884 Scopus citations

Patient participation in electronic medical records

Tsai, C. C. & Starren, J., Apr 4 2001, In : Journal of the American Medical Association. 285, 13, 1 p.

Research output: Contribution to journalShort survey

18 Scopus citations
84 Scopus citations

Referral and decision making among advanced cancer patients participating in phase I trials at a single institution

Gordon, E. J. & Daugherty, C. K., Dec 1 2001, In : Journal of Clinical Ethics. 12, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Stability of end-stage renal disease patients' treatment decisions

Gordon, E. J., Sep 6 2001, In : Transplantation proceedings. 33, 6, p. 3006-3009 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

The role and responsibility of the media in relation to organ donation and transplantation

Gordon, E. J., Jan 1 2001, The Ethics of Organ Transplantation. JAI Press, p. 293-315 23 p. (Advances in Bioethics; vol. 7).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

"They don't have to suffer for me": Why dialysis patients refuse offers of living donor kidneys

Gordon, E. J., Jan 1 2001, In : Medical Anthropology Quarterly. 15, 2, p. 245-267 23 p.

Research output: Contribution to journalArticle

74 Scopus citations

The β-secretase, BACE: A prime drug target for Alzheimer's disease

Vassar, R., Nov 26 2001, In : Journal of Molecular Neuroscience. 17, 2, p. 157-170 14 p.

Research output: Contribution to journalArticle

155 Scopus citations
2000

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's β-secretase

Bennett, B. D., Denis, P., Haniu, M., Teplow, D. B., Kahn, S., Louis, J. C., Citron, M. & Vassar, R., Dec 1 2000, In : Journal of Biological Chemistry. 275, 48, p. 37712-37717 6 p.

Research output: Contribution to journalArticle

223 Scopus citations

An object-oriented taxonomy of medical data presentations

Starren, J. & Johnson, S. B., Jan 1 2000, In : Journal of the American Medical Informatics Association. 7, 1, p. 1-20 20 p.

Research output: Contribution to journalReview article

30 Scopus citations
4 Scopus citations

Aβ-generating enzymes: Recent advances in β- and γ-secretase research

Vassar, R. & Citron, M., Jan 1 2000, In : Neuron. 27, 3, p. 419-422 4 p.

Research output: Contribution to journalReview article

250 Scopus citations

CART classification of human 5' UTR sequences

Davuluri, R. V., Suzuki, Y., Sugano, S. & Zhang, M. Q., Dec 21 2000, In : Genome research. 10, 11, p. 1807-1816 10 p.

Research output: Contribution to journalArticle

125 Scopus citations