Research Output

2016

A simple, low-cost staining method for rapid-throughput analysis of tumor spheroids

Eckerdt, F., Alvarez, A., Bell, J., Arvanitis, C., Iqbal, A., Arslan, A. D., Hu, B., Cheng, S. Y., Goldman, S. & Platanias, L. C., Jan 2016, In : BioTechniques. 60, 1, p. 43-46 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Differential regulation of ZEB1 and EMT by MAPK-interacting protein kinases (MNK) and eIF4E in pancreatic cancer

Kumar, K., Chow, C. R., Ebine, K., Arslan, A. D., Kwok, B., Bentrem, D. J., Eckerdt, F. D., Platanias, L. C. & Munshi, H. G., Feb 2016, In : Molecular Cancer Research. 14, 2, p. 216-227 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Microparticle levels after arterial injury and NO therapy in diabetes

Wang, Z., Emond, Z. M., Flynn, M. E., Swaminathan, S. & Kibbe, M. R., Feb 2016, In : Journal of Surgical Research. 200, 2, p. 722-731 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Nodal expression in triple-negative breast cancer: Cellular effects of its inhibition following doxorubicin treatment

Bodenstine, T. M., Chandler, G. S., Reed, D. W., Margaryan, N. V., Gilgur, A., Atkinson, J., Ahmed, N., Hyser, M., Seftor, E. A., Strizzi, L. & Hendrix, M. J. C., May 2 2016, In : Cell Cycle. 15, 9, p. 1295-1302 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Plasticity underlies tumor progression: role of Nodal signaling

Bodenstine, T. M., Chandler, G. S., Seftor, R. E. B., Seftor, E. A. & Hendrix, M. J. C., Mar 1 2016, In : Cancer and Metastasis Reviews. 35, 1, p. 21-39 19 p.

Research output: Contribution to journalArticle

10 Scopus citations
7 Scopus citations

Translational significance of Nodal, Cripto-1 and Notch4 in adult nevi

Strizzi, L., Margaryan, N. V., Gerami, P., Haghighat, Z., Harms, P. W., Madonna, G., Botti, G., Ascierto, P. A. & Hendrix, M. J. C., Aug 2016, In : Oncology Letters. 12, 2, p. 1349-1354 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Tumor cell vascular mimicry: Novel targeting opportunity in melanoma

Hendrix, M. J. C., Seftor, E. A., Seftor, R. E. B., Chao, J. T., Chien, D. S. & Chu, Y. W., Mar 1 2016, In : Pharmacology and Therapeutics. 159, p. 83-92 10 p.

Research output: Contribution to journalReview article

55 Scopus citations
2015

A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells

Malchenko, S., Sredni, S. T., Hashimoto, H., Kasai, A., Nagayasu, K., Xie, J., Margaryan, N. V., Seiriki, K., Lulla, R. R., Seftor, R. E. B., Pachman, L. M., Meltzer, H. Y., Hendrix, M. J. C. & Soares, M. B., Mar 31 2015, In : PloS one. 10, 3, e0121707.

Research output: Contribution to journalArticle

4 Scopus citations

Cancer: An extravascular route for tumour cells

Hendrix, M. J. C., Apr 15 2015, In : Nature. 520, 7547, p. 300-302 3 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Cripto-1: An extracellular protein - Connecting the sequestered biological dots

Klauzinska, M., Bertolette, D., Tippireddy, S., Strizzi, L., Gray, P. C., Gonzales, M., Duroux, M., Ruvo, M., Wechselberger, C., Castro, N. P., Rangel, M. C., Focà, A., Sandomenico, A., Hendrix, M. J. C., Salomon, D. & Cuttitta, F., Sep 3 2015, In : Connective tissue research. 56, 5, p. 364-380 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Divergence(s) in nodal signaling between aggressive melanoma and embryonic stem cells

Khalkhali-Ellis, Z., Kirschmann, D. A., Seftor, E. A., Gilgur, A., Bodenstine, T. M., Hinck, A. P. & Hendrix, M. J. C., Mar 1 2015, In : International Journal of Cancer. 136, 5, p. E242-E251

Research output: Contribution to journalArticle

12 Scopus citations

Effects of a novel Nodal-targeting monoclonal antibody in melanoma

Strizzi, L., Sandomenico, A., Margaryan, N. V., Focà, A., Sanguigno, L., Bodenstine, T. M., Chandler, G. S., Reed, D. W., Gilgur, A., Seftor, E. A., Seftor, R. E. B., Khalkhali-Ellis, Z., Leonardi, A., Ruvo, M. & Hendrix, M. J. C., Jan 1 2015, In : Oncotarget. 6, 33, p. 34071-34086 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

Flow cytometric detection of altered signaling in myelodysplastic syndrome and cytopenia

Gao, J., Swaminathan, S., Pai, N., Johnson, Z., Chen, Y-H., Peterson, L. C. & Goolsby, C. L., Jan 31 2015, In : Leukemia Research. 39, 12, p. 1396-1404 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Genetic analysis of the 'uveal melanoma' C918 cell line reveals atypical BRAF and common KRAS mutations and single tandem repeat profile identical to the cutaneous melanoma C8161 cell line

Yu, X., Ambrosini, G., Roszik, J., Eterovic, A. K., Stempke-Hale, K., Seftor, E. A., Chattopadhyay, C., Grimm, E., Carvajal, R. D., Hendrix, M. J. C., Hodi, F. S., Schwartz, G. K. & Woodman, S. E., May 1 2015, In : Pigment Cell and Melanoma Research. 28, 3, p. 357-359 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

New anti-nodal monoclonal antibodies targeting the nodal pre-helix loop involved in cripto-1 binding

Focà, A., Sanguigno, L., Focà, G., Strizzi, L., Iannitti, R., Palumbo, R., Hendrix, M. J. C., Leonardi, A., Ruvo, M. & Sandomenico, A., Sep 7 2015, In : International journal of molecular sciences. 16, 9, p. 21342-21362 21 p.

Research output: Contribution to journalArticle

8 Scopus citations

Targeting nodal in conjunction with dacarbazine induces synergistic anticancer effects in metastatic melanoma

Hardy, K. M., Strizzi, L., Margaryan, N. V., Gupta, K., Murphy, G. F., Scolyer, R. A. & Hendrix, M. J. C., Apr 1 2015, In : Molecular Cancer Research. 13, 4, p. 670-680 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
2014

Characterization of cancer stem-like cells derived from mouse induced pluripotent stem cells transformed by tumor-derived extracellular vesicles

Yan, T., Mizutani, A., Chen, L., Takaki, M., Hiramoto, Y., Matsuda, S., Shigehiro, T., Kasai, T., Kudoh, T., Murakami, H., Masuda, J., Hendrix, M. J. C., Strizzi, L., Salomon, D. S., Fu, L. & Seno, M., Jan 1 2014, In : Journal of Cancer. 5, 7, p. 572-584 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Cleavage of histone 3 by cathepsin D in the involuting mammary gland

Khalkhali-Ellis, Z., Goossens, W., Margaryan, N. V. & Hendrix, M. J. C., Jul 23 2014, In : PloS one. 9, 7, e103230.

Research output: Contribution to journalArticle

16 Scopus citations

FLT3 and NPM-1 mutations in a cohort of acute promyelocytic leukemia patients from India

Swaminathan, S., Garg, S., Madkaikar, M., Gupta, M., Jijina, F. & Ghosh, K., Apr 1 2014, In : Indian Journal of Human Genetics. 20, 2, p. 160-165 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Internalization by multiple endocytic pathways and lysosomal processing impact maspin-based therapeutics

Bodenstine, T. M., Seftor, R. E. B., Seftor, E. A., Khalkhali-Ellis, Z., Samii, N. A., Monarrez, J. C., Chandler, G. S., Pemberton, P. A. & Hendrix, M. J. C., Oct 1 2014, In : Molecular Cancer Research. 12, 10, p. 1480-1491 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

LIN-9 phosphorylation on Threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression

Eckerdt, F., Perez-Neut, M. & Colamonici, O. R., Jan 27 2014, In : PloS one. 9, 1, e87620.

Research output: Contribution to journalArticle

2 Scopus citations

Melanoma tumor cell heterogeneity: A molecular approach to study subpopulations expressing the embryonic morphogen nodal

Seftor, E. A., Seftor, R. E. B., Weldon, D. S., Kirsammer, G., Margaryan, N. V., Gilgur, A. & Hendrix, M. J. C., Jan 1 2014, In : Seminars in Oncology. 41, 2, p. 259-266 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Oncofetal signaling as a target for cancer therapy

Ährlund-Richter, L. & Hendrix, M. J. C., Jan 1 2014, In : Seminars in Cancer Biology. 29, C, p. 1-2 2 p.

Research output: Contribution to journalEditorial

6 Scopus citations

Onset of rosette formation during spontaneous neural differentiation of hESC and hiPSC colonies

Malchenko, S., Xie, J., de Fatima Bonaldo, M., Vanin, E. F., Bhattacharyya, B. J., Belmadani, A., Xi, G., Galat, V., Goossens, W., Seftor, R. E. B., Tomita, T., Crispino, J., Miller, R. J., Bohn, M. C., Hendrix, M. J. C. & Soares, M. B., Jan 25 2014, In : Gene. 534, 2, p. 400-407 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Regulation of greatwall kinase by protein stabilization and nuclear localization

Yamamoto, T. M., Wang, L., Fisher, L. A., Eckerdt, F. D. & Peng, A., Nov 15 2014, In : Cell Cycle. 13, 22, p. 3565-3575 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells

Eckerdt, F., Beauchamp, E., Bell, J., Iqbal, A., Su, B., Fukunaga, R., Lulla, R. R., Goldman, S. & Platanias, L. C., Jan 1 2014, In : Oncotarget. 5, 18, p. 8442-8451 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Two faces of Cathepsin D: Physiological guardian angel and pathological demon

Khalkhali-Ellis, Z. & Hendrix, M. J. C., Jan 1 2014, In : European Journal of Physical and Health Education. 6, 2, 206.

Research output: Contribution to journalReview article

20 Scopus citations
2013

Age-dependent association between protein expression of the embryonic stem cell marker cripto-1 and survival of glioblastoma patients

Tysnes, B. B., Sætran, H. A., Mørk, S. J., Margaryan, N. V., Eide, G. E., Petersen, K., Strizzi, L. & Hendrix, M. J. C., Dec 2013, In : Translational Oncology. 6, 6, p. 732-741 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

ATP11B mediates platinum resistance in ovarian cancer

Moreno-Smith, M., Halder, J. B., Meltzer, P. S., Gonda, T. A., Mangala, L. S., Rupaimoole, R., Lu, C., Nagaraja, A. S., Gharpure, K. M., Kang, Y., Rodriguez-Aguayo, C., Vivas-Mejia, P. E., Zand, B., Schmandt, R., Wang, H., Langley, R. R., Jennings, N. B., Ivan, C., Coffin, J. E., Armaiz, G. N. & 10 others, Bottsford-Miller, J., Kim, S. B., Halleck, M. S., Hendrix, M. J. C., Bornman, W., Bar-Eli, M., Lee, J. S., Siddik, Z. H., Lopez-Berestein, G. & Sood, A. K., May 1 2013, In : Journal of Clinical Investigation. 123, 5, p. 2119-2130 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Erratum: ATP11B mediates platinum resistance in ovarian cancer (Journal of Clinical Investigation (2013) 123:5 (2119-2130) DOI: 10.1172/JCI65425)

Moreno-Smith, M., Halder, J. B., Meltzer, P. S., Gonda, T. A., Mangala, L. S., Rupaimoole, R., Lu, C., Nagaraja, A. S., Gharpure, K. M., Kang, Y., Rodriguez-Aguayo, C., Vivas-Mejia, P. E., Zand, B., Schmandt, R., Wang, H., Langley, R. R., Jennings, N. B., Ivan, C., Coffin, J. E., Armaiz, G. N. & 10 others, Bottsford-Miller, J., Kim, S. B., Halleck, M. S., Hendrix, M. J. C., Bornman, W., Bar-Eli, M., Lee, J. S., Siddik, Z. H., Lopez-Berestein, G. & Sood, A. K., Dec 2 2013, In : Journal of Clinical Investigation. 123, 12, 1 p.

Research output: Contribution to journalComment/debate

Neuroblastoma cells injected into experimental mature teratoma reveal a tropism for embryonic loose mesenchyme

Jamil, S., Cedervall, J., Hultman, I., Ali, R., Margaryan, N. V., Rasmuson, A., Johnsen, J. I., Sveinbjörnsson, B., Dalianis, T., Kanter, L., Orrego, A., Strizzi, L., Hendrix, M. J. C., Sandstedt, B., Kogner, P. & Ährlund-Richter, L., Sep 1 2013, In : International journal of oncology. 43, 3, p. 831-838 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Reprogramming breast cancer cells with embryonic microenvironments: Insights from Nodal signaling

Kirsammer, G. & Hendrix, M. J. C., Jun 1 2013, Cell and Molecular Biology of Breast Cancer. Humana Press Inc, p. 175-189 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The significance of a Cripto-1 positive subpopulation of human melanoma cells exhibiting stem cell-like characteristics

Strizzi, L., Margaryan, N. V., Gilgur, A., Hardy, K. M., Normanno, N., Salomon, D. S. & Hendrix, M. J. C., May 1 2013, In : Cell Cycle. 12, 9, p. 1450-1456 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012

A model of cancer stem cells derived from mouse induced pluripotent stem cells

Chen, L., Kasai, T., Li, Y., Sugii, Y., Jin, G., Okada, M., Vaidyanath, A., Mizutani, A., Satoh, A., Kudoh, T., Hendrix, M. J. C., Salomon, D. S., Fu, L. & Seno, M., Apr 2012, In : PloS one. 7, 4, e33544.

Research output: Contribution to journalArticle

55 Scopus citations

A model of early human embryonic stem cell differentiation reveals inter- and intracellular changes on transition to squamous epithelium

Galat, V., Malchenko, S., Galat, Y., Ishkin, A., Nikolsky, Y., Kosak, S. T., Soares, B. M., Iannaccone, P. M., Crispino, J. D. & Hendrix, M. J. C., May 20 2012, In : Stem Cells and Development. 21, 8, p. 1250-1263 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

FLT3 and NPM1 mutations in a cohort of AML patients and detection of a novel mutation in tyrosine kinase domain of FLT3 gene from Western India

Ghosh, K., Swaminathan, S., Madkaikar, M., Gupta, M., Kerketta, L. & Vundinti, B., Nov 1 2012, In : Annals of Hematology. 91, 11, p. 1703-1712 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Maspin: Molecular mechanisms and therapeutic implications

Bodenstine, T. M., Seftor, R. E. B., Khalkhali-Ellis, Z., Seftor, E. A., Pemberton, P. A. & Hendrix, M. J. C., Dec 1 2012, In : Cancer and Metastasis Reviews. 31, 3-4, p. 529-551 23 p.

Research output: Contribution to journalArticle

66 Scopus citations

Molecular pathways: Vasculogenic mimicry in tumor cells: Diagnostic and therapeutic implications

Kirschmann, D. A., Seftor, E. A., Hardy, K. M., Seftor, R. E. B. & Hendrix, M. J. C., May 15 2012, In : Clinical Cancer Research. 18, 10, p. 2726-2732 7 p.

Research output: Contribution to journalReview article

175 Scopus citations

Nodal expression and detection in cancer: Experience and challenges

Strizzi, L., Hardy, K. M., Kirschmann, D. A., Ahrlund-Richter, L. & Hendrix, M. J. C., Apr 15 2012, In : Cancer Research. 72, 8, p. 1915-1920 6 p.

Research output: Contribution to journalReview article

25 Scopus citations

Potential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer

Strizzi, L., Hardy, K. M., Margaryan, N. V., Hillman, D. W., Seftor, E. A., Chen, B., Geiger, X. J., Thompson, E. A., Lingle, W. L., Andorfer, C. A., Perez, E. A. & Hendrix, M. J. C., May 11 2012, In : Breast Cancer Research. 14, 3, R75.

Research output: Contribution to journalArticle

46 Scopus citations

Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma

Malchenko, S., Seftor, E. A., Nikolsky, Y., Hasegawa, S. L., Kuo, S., Stevens, J. W., Poyarkov, S., Nikolskaya, T., Kucaba, T., Wang, M., Abdulkawy, H., Casavant, T., Morcuende, J., Buckwalter, J., Hohl, R., Deyoung, B., Kernstine, K., Bonaldo, M. D. F., Hendrix, M. J. C., Soares, M. B. & 1 others, Soares, V. M. F. C., Mar 16 2012, In : Sarcoma. 2012, 820254.

Research output: Contribution to journalArticle

8 Scopus citations

Tumor cell vasculogenic mimicry: From controversy to therapeutic promise

Seftor, R. E. B., Hess, A. R., Seftor, E. A., Kirschmann, D. A., Hardy, K. M., Margaryan, N. V. & Hendrix, M. J. C., Oct 2012, In : American Journal of Pathology. 181, 4, p. 1115-1125 11 p.

Research output: Contribution to journalArticle

190 Scopus citations
2011

Embryonic signaling in melanoma: Potential for diagnosis and therapy

Strizzi, L., Hardy, K. M., Kirsammer, G. T., Gerami, P. & Hendrix, M. J. C., Jun 1 2011, In : Laboratory Investigation. 91, 6, p. 819-824 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Expression and functional role of CRIPTO-1 in cutaneous melanoma

De Luca, A., Lamura, L., Strizzi, L., Roma, C., D'Antonio, A., Margaryan, N., Pirozzi, G., Hsu, M. Y., Botti, G., Mari, E., Hendrix, M. J. C., Salomon, D. S. & Normanno, N., Sep 27 2011, In : British Journal of Cancer. 105, 7, p. 1030-1038 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Future perspectives in melanoma research. Meeting report from the "Melanoma Research: A bridge Naples-USA. Naples, December 6th-7 th2010"

Ascierto, P. A., De Maio, E., Bertuzzi, S., Palmieri, G., Halaban, R., Hendrix, M., Kashani-sabet, M., Ferrone, S., Wang, E., Cochran, A., Rivoltini, L., Lee, P. P., Fox, B. A., Kirkwood, J. M., Ullmann, C. D., Lehmann, F. F., Sznol, M., Schwartzentruber, D. J., Maio, M., Flaherty, K. & 6 others, Galon, J., Ribas, A., Yang, J., Stroncek, D. F., Mozzillo, N. & Marincola, F. M., Mar 26 2011, In : Journal of Translational Medicine. 9, 32.

Research output: Contribution to journalReview article

16 Scopus citations

Identification of a polo-like kinase 4-dependent pathway for de novo centriole formation

Eckerdt, F., Yamamoto, T. M., Lewellyn, A. L. & Maller, J. L., Mar 8 2011, In : Current Biology. 21, 5, p. 428-432 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Lessons from Embryogenesis

L, S., KM, H., EA, S., NV, M., DA, K., GT, K., CB, B., JC, K-K., PM, K., REB, S., MJC, H. & Hendrix, M. J. C., 2011, Melanoma Development. A, B. (ed.). Springer-Verlag/Wien, p. 281-296

Research output: Chapter in Book/Report/Conference proceedingChapter

Maspin and cathepsin d partnership in regulating mammary gland development and breast cancer

Khalkhali-Ellis, Z., Zhang, M. & Hendrix, M. J. C., Dec 1 2011, Breast Cancer: Causes, Diagnosis and Treatment. Romero, MR. (ed.). Nova Science Publishers, Inc., p. 161-176 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Normal bone marrow signal-transduction profiles: A requisite for enhanced detection of signaling dysregulations in AML

Marvin, J., Swaminathan, S., Kraker, G., Chadburn, A., Jacobberger, J. & Goolsby, C., Apr 14 2011, In : Blood. 117, 15, p. e120-e130

Research output: Contribution to journalArticle

22 Scopus citations