Medicine, Pulmonary Division

Research Output 1949 2019

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2010
147 Citations (Scopus)

Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity

Mutlu, G. M., Budinger, GR. S., Green, A. A., Urich, D., Soberanes, S., Chiarella, S. E., Alheid, G. F., McCrimmon, D. R., Szleifer, I. G. & Hersam, M., May 12 2010, In : Nano Letters. 10, 5, p. 1664-1670 7 p.

Research output: Contribution to journalArticle

Single-walled carbon nanotubes (SWCN)
toxicity
Toxicity
carbon nanotubes
mice
97 Citations (Scopus)

Categorization and impact of pulmonary hypertension in patients with advanced COPD

Cuttica, M. J., Kalhan, R., Shlobin, O. A., Ahmad, S., Gladwin, M., MacHado, R. F., Barnett, S. D. & Nathan, S. D., Dec 1 2010, In : Respiratory Medicine. 104, 12, p. 1877-1882 6 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Chronic Obstructive Pulmonary Disease
Hemodynamics
Cardiac Catheterization
Lung
27 Citations (Scopus)

Cellular inflammatory infiltrate in pneumonitis induced by a single moderate dose of thoracic X radiation in rats

Szabo, S., Ghosh, S. N., Fish, B. L., Bodiga, S., Tomic, R., Kumar, G., Morrow, N. V., Moulder, J. E., Jacobs, E. R. & Medhora, M., Apr 1 2010, In : Radiation Research. 173, 4, p. 545-556 12 p.

Research output: Contribution to journalArticle

Mast Cells
rats
Pneumonia
Thorax
X-Rays
19 Citations (Scopus)
Lipopolysaccharides
Blood Cells
Gene Expression
In Vitro Techniques
Cell Separation
56 Citations (Scopus)

Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome

Bhorade, S. M., Chen, H., Molinero, L., Liao, C., Garrity, E. R., Vigneswaran, W. T., Shilling, R., Sperling, A., Chong, A. & Alegre, M. L., Sep 15 2010, In : Transplantation. 90, 5, p. 540-546 7 p.

Research output: Contribution to journalArticle

Bronchiolitis Obliterans
Bronchoalveolar Lavage
Lung
Chemokine CCL22
Transplantation Tolerance
16 Citations (Scopus)

Donor transmission of malignant melanoma in a lung transplant recipient 32 years after curative resection

Bajaj, N. S., Watt, C., Hadjiliadis, D., Gillespie, C., Haas, A. R., Pochettino, A., Mendez, J., Sterman, D. H., Schuchter, L. M., Christie, J. D., Lee, J. C. & Ahya, V. N., Jul 1 2010, In : Transplant International. 23, 7

Research output: Contribution to journalArticle

Melanoma
Tissue Donors
Lung
Transplantation
Transplants
28 Citations (Scopus)

E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFα-induced JNK activation

Yang, Y., Do, H. C., Tian, X., Zhang, C., Liu, X., Dada, L., Sznajder, J. I. & Liu, J., Jul 27 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 30, p. 13444-13449 6 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Equidae
Zinc Fingers
Cell Death
TNF Receptor-Associated Factor 2
64 Citations (Scopus)
Hypercapnia
Macrophages
Phagocytosis
Interleukin-6
Tumor Necrosis Factor-alpha
52 Citations (Scopus)

Expanded clinical presentation of community-acquired methicillin-resistant Staphylococcus aureus pneumonia

Lobo, L. J., Reed, K. D. & Wunderink, R. G., Jul 1 2010, In : Chest. 138, 1, p. 130-136 7 p.

Research output: Contribution to journalArticle

Staphylococcal Pneumonia
Methicillin-Resistant Staphylococcus aureus
Exotoxins
Pneumonia
Linezolid
22 Citations (Scopus)

Extracellular signal-regulated kinase (ERK) participates in the hypercapnia-induced Na,K-ATPase downregulation

Welch, L. C., Lecuona, E., Briva, A., Trejo, H. E., Dada, L. & Sznajder, J. I., Sep 1 2010, In : FEBS Letters. 584, 18, p. 3985-3989 5 p.

Research output: Contribution to journalArticle

Hypercapnia
Extracellular Signal-Regulated MAP Kinases
Adenosine Triphosphatases
Down-Regulation
Endocytosis
22 Citations (Scopus)

FLIP: A novel regulator of macrophage differentiation and granulocyte homeostasis

Huang, Q-Q., Perlman, H. R., Huang, Z., Birkett, R., Kan, L., Agrawal, H., Misharin, A., Gurbuxani, S., Crispino, J. D. & Pope, R. M., Dec 2 2010, In : Blood. 116, 23, p. 4968-4977 10 p.

Research output: Contribution to journalArticle

Macrophages
Granulocytes
Homeostasis
Bone
Extramedullary Hematopoiesis
133 Citations (Scopus)

Genetic ancestry in lung-function predictions

Kumar, R., Seibold, M. A., Aldrich, M. C., Williams, L. K., Reiner, A. P., Colangelo, L., Galanter, J., Gignoux, C., Hu, D., Sen, S., Choudhry, S., Peterson, E. L., Rodriguez-Santana, J., Rodriguez-Cintron, W., Nalls, M. A., Leak, T. S., O'Meara, E., Meibohm, B., Kritchevsky, S. B., Li, R. & 8 others, Harris, T. B., Nickerson, D. A., Fornage, M., Enright, P., Ziv, E., Smith, L. J., Liu, K. & Burchard, E. G., Jul 22 2010, In : New England Journal of Medicine. 363, 4, p. 321-330 10 p.

Research output: Contribution to journalArticle

Lung
African Americans
Health
Forced Expiratory Volume
Body Composition
9 Citations (Scopus)

Genetic variation in MYLK and lung injury in children and adults with community-acquired pneumonia

Russell, R., Quasney, M. W., Halligan, N., Li, S. H., Simpson, P., Waterer, G., Wunderink, R. G. & Dahmer, M. K., Jan 1 2010, In : Pediatric Critical Care Medicine. 11, 6, p. 731-736 6 p.

Research output: Contribution to journalArticle

Lung Injury
Myosin-Light-Chain Kinase
Single Nucleotide Polymorphism
Pneumonia
Genes
6 Citations (Scopus)

Hyul-Tong-Ryung suppresses PMA-induced MMP-9 expression by inhibiting AP-1-mediated gene expression via ERK1/2 signaling pathway in MCF-7 human breast cancer cells

Kim, K. S., Yao, L., Lee, Y. C., Chung, E., Kim, K. M., Kwak, Y. J., Kim, S. J., Cui, Z. & Lee, J. H., Dec 1 2010, In : Immunopharmacology and Immunotoxicology. 32, 4, p. 600-606 7 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Transcription Factor AP-1
Gene expression
Acetates
Cells
23 Citations (Scopus)

Insulin regulates alveolar epithelial function by inducing Na +/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt

Comellas, A. P., Kelly, A. M., Trejo, H. E., Briva, A., Lee, J., Sznajder, J. I. & Dada, L., Apr 15 2010, In : Journal of Cell Science. 123, 8, p. 1343-1351 9 p.

Research output: Contribution to journalArticle

Cell Membrane
Insulin
rab GTP-Binding Proteins
Alveolar Epithelial Cells
GTPase-Activating Proteins
45 Citations (Scopus)

Inter-connection between mitochondria and HIFs

Tormos, K. V. & Chandel, N., Apr 1 2010, In : Journal of Cellular and Molecular Medicine. 14, 4, p. 795-804 10 p.

Research output: Contribution to journalArticle

Mitochondria
Respiration
Oxidative Stress
Hypoxia-Inducible Factor 1
Glycolysis
18 Citations (Scopus)

Joubert syndrome associated with severe central sleep apnea

Wolfe, L. F., Lakadamyali, H. & Mutlu, G. M., Aug 15 2010, In : Journal of Clinical Sleep Medicine. 6, 4, p. 384-388 5 p.

Research output: Contribution to journalArticle

Central Sleep Apnea
Wakefulness
Tooth
Respiration
Oxygen
11 Citations (Scopus)

Lenalidomide-induced interstitial lung disease

Chen, Y., Kiatsimkul, P., Nugent, K. & Raj, R., Mar 1 2010, In : Pharmacotherapy. 30, 3

Research output: Contribution to journalArticle

Interstitial Lung Diseases
Lung
Drug-Related Side Effects and Adverse Reactions
Multiple Myeloma
Dinoprostone

Lenalidomide-induced interstitial lung disease.

Chen, Y., Kiatsimkul, P., Nugent, K. & Raj, R., Mar 1 2010, In : Pharmacotherapy. 30, 3, 1 p.

Research output: Contribution to journalArticle

Interstitial Lung Diseases
Lung
Drug-Related Side Effects and Adverse Reactions
Prostaglandins E
Multiple Myeloma
6 Citations (Scopus)

Levels of transferrin in bronchoalveolar lavage fluid in sarcoidosis

Shigemura, M., Nasuhara, Y., Konno, S., Hattori, T., Shimizu, C., Matsuno, K. & Nishimura, M., Apr 1 2010, In : Lung. 188, 2, p. 151-157 7 p.

Research output: Contribution to journalArticle

Bronchoalveolar Lavage Fluid
Transferrin
Sarcoidosis
Serum
Interleukin-2 Receptors
29 Citations (Scopus)

Lung Function in Young Adults Predicts Airflow Obstruction 20 Years Later

Kalhan, R., Arynchyn, A., Colangelo, L. A., Dransfield, M. T., Gerald, L. B. & Smith, L. J., May 1 2010, In : American Journal of Medicine. 123, 5

Research output: Contribution to journalArticle

Forced Expiratory Volume
Young Adult
Vital Capacity
Lung
Smoking
103 Citations (Scopus)

Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis

Loor, G., Kondapalli, J., Schriewer, J. M., Chandel, N., Vanden Hoek, T. L. & Schumacker, P. T., Dec 15 2010, In : Free Radical Biology and Medicine. 49, 12, p. 1925-1936 12 p.

Research output: Contribution to journalArticle

Vitamin K 3
Cell death
Reactive Oxygen Species
Cell Death
Chemical activation
754 Citations (Scopus)

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Weinberg, F., Hamanaka, R., Wheaton, W. W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G. M., Budinger, GR. S. & Chandel, N., May 11 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 19, p. 8788-8793 6 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Growth
Oxidative Phosphorylation
Carcinogenesis
Adenosine Triphosphate
21 Citations (Scopus)

Mitochondrial reactive oxygen species are required for hypoxia-induced degradation of keratin intermediate filaments

Na, N., Chandel, N. S., Litvan, J. & Ridge, K. M., Mar 1 2010, In : FASEB Journal. 24, 3, p. 799-809 11 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Keratins
Alveolar Epithelial Cells
Reactive Oxygen Species
Degradation
70 Citations (Scopus)

Myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells: A three-dimensional FRET study

Khuon, S., Liang, L., Dettman, R., Sporn, P. H., Wysolmerski, R. B. & Chew, T. L., Feb 1 2010, In : Journal of cell science. 123, 3, p. 431-440 10 p.

Research output: Contribution to journalArticle

Myosin-Light-Chain Kinase
Fluorescence Resonance Energy Transfer
Endothelial Cells
Breast Neoplasms
Myosin Type II
43 Citations (Scopus)

Nesprin-2 interacts with α-catenin and regulates Wnt signaling at the nuclear envelope

Neumann, S., Schneider, M., Daugherty, R. L., Gottardi, C., Eming, S. A., Beijer, A., Noegel, A. A. & Karakesisoglou, I., Nov 5 2010, In : Journal of Biological Chemistry. 285, 45, p. 34932-34938 7 p.

Research output: Contribution to journalArticle

Catenins
Nuclear Envelope
Cytoskeleton
Cell signaling
TCF Transcription Factors
32 Citations (Scopus)

Online learning versus simulation for teaching principles of mechanical ventilation to nurse practitioner students

Corbridge, S. J., Robinson, F. P., Tiffen, J. & Corbridge, T. C., Apr 13 2010, In : International Journal of Nursing Education Scholarship. 7, 1, 12.

Research output: Contribution to journalArticle

Nurse Practitioners
Artificial Respiration
Teaching
nurse
Advanced Practice Nursing
344 Citations (Scopus)

Percent emphysema, airflow obstruction, and impaired left ventricular filling

Barr, R. G., Bluemke, D. A., Ahmed, F. S., Carr, J. J., Enright, P. L., Hoffman, E. A., Jiang, R., Kawut, S. M., Kronmal, R. A., Lima, J. A. C., Shahar, E., Smith, L. J. & Watson, K. E., Jan 21 2010, In : New England Journal of Medicine. 362, 3, p. 217-227 11 p.

Research output: Contribution to journalArticle

Emphysema
Stroke Volume
Cardiac Output
Confidence Intervals
Left Ventricular Function
153 Citations (Scopus)

Performance of american thoracic society-recommended spirometry reference values in a multiethnic sample of adults the multi-ethnic study of atherosclerosis (MESA) lung study

Hankinson, J. L., Kawut, S. M., Shahar, E., Smith, L. J., Stukovsky, K. H. & Graham Barr, R., Jan 1 2010, In : CHEST. 137, 1, p. 138-145 8 p.

Research output: Contribution to journalArticle

Asian Americans
Spirometry
Nutrition Surveys
Atherosclerosis
Hispanic Americans
102 Citations (Scopus)

PPAR? Downregulation by TGF in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

Wei, J., Ghosh, A. K., Sargent, J. L., Komura, K., Wu, M., Huang, Q-Q., Jain, M., Whitfield, M. L., Feghali-Bostwick, C. & Varga, J., Nov 22 2010, In : PLoS One. 5, 11, e13778.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Systemic Scleroderma
PPAR gamma
sclerosis
Fibroblasts
48 Citations (Scopus)

Prospective measurements of intra-abdominal volume and pulmonary function after repair of massive ventral hernias with the components separation technique

Agnew, S. P., Small, W., Wang, E., Smith, L. J., Hadad, I. & Dumanian, G. A., May 1 2010, In : Annals of Surgery. 251, 5, p. 981-988 8 p.

Research output: Contribution to journalArticle

Ventral Hernia
Herniorrhaphy
Lung
Diaphragm
Intra-Abdominal Hypertension
66 Citations (Scopus)

Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation

Monzon, M. E., Fregien, N., Schmid, N., Falcon, N. S., Campos, M., Casalino-Matsuda, S. M. & Forteza, R. M., Aug 20 2010, In : Journal of Biological Chemistry. 285, 34, p. 26126-26134 9 p.

Research output: Contribution to journalArticle

Hyaluronoglucosaminidase
Hyaluronic Acid
Reactive Oxygen Species
Glycosylphosphatidylinositols
Epithelial Cells
22 Citations (Scopus)

Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells

Trejo, H. E., Lecuona, E., Grillo, D., Szleifer, I. G., Nekrasova, O., Gelfand, V. I. & Sznajder, J. I., Feb 1 2010, In : FASEB Journal. 24, 2, p. 374-382 9 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Kinesin
Telecommunication traffic
Adenosine Triphosphatases
Microtubules
13 Citations (Scopus)

Sarcoidosis in Ireland: Regional differences in prevalence and mortality from 1996-2005

Nicholson, T., Plant, B. J., Henry, M. T. & Bredin, C. P., Dec 1 2010, In : Sarcoidosis Vasculitis and Diffuse Lung Diseases. 27, 2, p. 111-120 10 p.

Research output: Contribution to journalArticle

Sarcoidosis
Ireland
Northern Ireland
Mortality
Space-Time Clustering
26 Citations (Scopus)

Serum adiponectin is positively associated with lung function in young adults, independent of obesity: The CARDIA study

Thyagarajan, B., Jacobs, D. R., Smith, L. J., Kalhan, R., Gross, M. D. & Sood, A., Dec 9 2010, In : Respiratory Research. 11, 176.

Research output: Contribution to journalArticle

Adiponectin
Young Adult
Coronary Vessels
Obesity
Lung
4 Citations (Scopus)

Spirometry guidelines influence lung function results in a longitudinal study of young adults

Smith, L. J., Arynchyn, A., Kalhan, R., Williams, O. D., Jensen, R., Crapo, R. & Jacobs, D. R., Jun 1 2010, In : Respiratory Medicine. 104, 6, p. 858-864 7 p.

Research output: Contribution to journalArticle

Exhalation
Spirometry
Longitudinal Studies
Young Adult
Guidelines
16 Citations (Scopus)

Surrogate markers and microbiologic end points

Wunderink, R. G., Aug 1 2010, In : Clinical Infectious Diseases. 51, SUPPL. 1

Research output: Contribution to journalArticle

Calcitonin
Pneumonia
Biomarkers
Anti-Bacterial Agents
Communicable Diseases
42 Citations (Scopus)

Systemic inflammation in young adults is associated with abnormal lung function in middle age

Kalhan, R., Tran, B. T., Colangelo, L. A., Rosenberg, S. R., Liu, K., Thyagarajan, B., Jacobs, D. R. & Smith, L. J., Aug 13 2010, In : PLoS One. 5, 7, e11431.

Research output: Contribution to journalArticle

lung function
C-reactive protein
young adults
C-Reactive Protein
Young Adult
68 Citations (Scopus)

The association of pipe and cigar use with cotinine levels, lung function, and airflow obstruction: A cross-sectional study

Rodriguez, J., Jiang, R., Johnson, W. C., MacKenzie, B. A., Smith, L. J. & Barr, R. G., Feb 16 2010, In : Annals of Internal Medicine. 152, 4, p. 201-210 10 p.

Research output: Contribution to journalArticle

Cotinine
Tobacco Products
Cross-Sectional Studies
Smoking
Lung
35 Citations (Scopus)

The nucleoporin Nup153 affects spindle checkpoint activity due to an association with Mad1

Lussi, Y. C., Shumaker, D. K., Shimi, T. & Fahrenkrog, B., Jan 1 2010, In : Nucleus. 1, 1, p. 71-84 14 p.

Research output: Contribution to journalArticle

Nuclear Pore Complex Proteins
M Phase Cell Cycle Checkpoints
Cell Nucleus Active Transport
Interphase
Metaphase
13 Citations (Scopus)

Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells

Kwon, H. Y., Kim, S. J., Kim, C. H., Son, S. W., Kim, K. S., Lee, J. H., Do, S. I. & Lee, Y. C., Dec 1 2010, In : Experimental and Molecular Medicine. 42, 12, p. 849-855 7 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Gene expression
Melanoma
Down-Regulation
Gene Expression
134 Citations (Scopus)

Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitis

Lagishetty, V., Misharin, A. V., Liu, N. Q., Lisse, T. S., Chun, R. F., Ouyang, Y., McLachlan, S. M., Adams, J. S. & Hewison, M., Jun 1 2010, In : Endocrinology. 151, 6, p. 2423-2432 10 p.

Research output: Contribution to journalArticle

Vitamin D Deficiency
Colitis
Vitamin D
Dextran Sulfate
Enterobacteriaceae
9 Citations (Scopus)

Workshop on clinical trials of antibacterial agents for Hospital-acquired pneumonia and ventilator-associated pneumonia

Bartlett, J. G., Barie, P. S., Niederman, M. S. & Wunderink, R. G., Aug 1 2010, In : Clinical Infectious Diseases. 51, SUPPL. 1

Research output: Contribution to journalArticle

Bacterial Pneumonia
Ventilator-Associated Pneumonia
Cross Infection
Pneumonia
Clinical Trials
66 Citations (Scopus)

β-Catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells

Flozak, A. S., Lam, A. P., Russell, S. R., Jain, M., Peled, O. N., Sheppard, K. A., Beri, R., Mutlu, G. M., Budinger, GR. S. & Gottardi, C., Jan 29 2010, In : Journal of Biological Chemistry. 285, 5, p. 3157-3167 11 p.

Research output: Contribution to journalArticle

TCF Transcription Factors
Alveolar Epithelial Cells
Catenins
Lung Injury
Chemical activation
62 Citations (Scopus)

β-catenin phosphorylated at serine 45 is spatially uncoupled from β-catenin phosphorylated in the GSK3 domain: Implications for signaling

Maher, M. T., Mo, R., Flozak, A. S., Peled, O. N. & Gottardi, C., Sep 10 2010, In : PloS one. 5, 4, e10184.

Research output: Contribution to journalArticle

Catenins
Threonine
serine
Serine
threonine
2009
33 Citations (Scopus)

A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe community-acquired pneumonia

Laterre, P. F., Opal, S. M., Abraham, E., LaRosa, S. P., Creasey, A. A., Xie, F., Poole, L. & Wunderink, R. G., Mar 15 2009, In : Critical Care. 13, 2, R36.

Research output: Contribution to journalArticle

Pneumonia
Heparin
Sepsis
Mortality
Placebos
88 Citations (Scopus)

Activity of the β-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion

Maher, M. T., Flozak, A. S., Stocker, A. M., Chenn, A. & Gottardi, C., Jul 27 2009, In : Journal of Cell Biology. 186, 2, p. 219-228 10 p.

Research output: Contribution to journalArticle

Catenins
Cadherins
Cats
Cell Adhesion
TCF Transcription Factors

Advanced locally invasive squamous cell carcinoma

Pankratz, M. M., Chandler, R., Otahbachi, M., Nugent, K. & Raj, R., Jan 1 2009, In : American Journal of the Medical Sciences. 338, 1, 1 p.

Research output: Contribution to journalArticle

Neoplasm Invasiveness
Head and Neck Neoplasms
Squamous Cell Carcinoma
18 Citations (Scopus)

Association of circulating adhesion molecules with lung function: The CARDIA study

Thyagarajan, B., Smith, L. J., Barr, R. G., Gross, M. D., Sood, A., Kalhan, R. & Jacobs, D. R., Jun 1 2009, In : Chest. 135, 6, p. 1481-1487 7 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
Lung
P-Selectin
Spirometry
Young Adult
19 Citations (Scopus)

Attenuation of induced hyperthyroidism in mice by pretreatment with thyrotropin receptor protein: Deviation of thyroid-stimulating to nonfunctional antibodies

Misharin, A. V., Nagayama, Y., Aliesky, H. A., Mizutori, Y., Rapoport, B. & McLachlan, S. M., Aug 1 2009, In : Endocrinology. 150, 8, p. 3944-3952 9 p.

Research output: Contribution to journalArticle

Thyrotropin Receptors
Hyperthyroidism
Thyroid Gland
Antibodies
Protein Subunits