Medicine, Pulmonary Division

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2012
27 Scopus citations

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

Wei, J., Fang, F., Lam, A. P., Sargent, J. L., Hamburg, E., Hinchcliff, M. E., Gottardi, C. J., Atit, R., Whitfield, M. L. & Varga, J., Aug 1 2012, In : Arthritis and rheumatism. 64, 8, p. 2734-2745 12 p.

Research output: Contribution to journalArticle

126 Scopus citations
2011

A dystroglycan/plectin scaffold mediates mechanical pathway bifurcation in lung epithelial cells

Takawira, D., Budinger, G. R. S., Hopkinson, S. B. & Jones, J. C. R., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6301-6310 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Antitumor effect of non-steroid glucocorticoid receptor ligand CpdA on leukemia cell lines CEM and K562

Lesovaya, E. A., Yemelyanov, A. Y., Kirsanov, K. I., Yakubovskaya, M. G. & Budunova, I. V., Nov 1 2011, In : Biochemistry (Moscow). 76, 11, p. 1242-1252 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

A trial of intrapleural adenoviral-mediated interferon-α2b gene transfer for malignant pleural mesothelioma

Sterman, D. H., Haas, A., Moon, E., Recio, A., Schwed, D., Vachani, A., Katz, S. I., Gillespie, C. T., Cheng, G., Sun, J., Papasavvas, E., Montaner, L. J., Heitjan, D. F., Litzky, L., Friedberg, J., Culligan, M., June, C. H., Carrolly, R. G. & Albelda, S. M., Dec 15 2011, In : American journal of respiratory and critical care medicine. 184, 12, p. 1395-1399 5 p.

Research output: Contribution to journalArticle

60 Scopus citations

Barriers to adherence to chronic obstructive pulmonary disease guidelines by primary care physicians

Salinas, G. D., Williamson, J. C., Kalhan, R., Thomashow, B., Scheckermann, J. L., Walsh, J., Abdolrasulnia, M. & Foster, J. A., 2011, In : International Journal of COPD. 6, 1, p. 171-179 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

Biomimetic high density lipoprotein nanoparticles for nucleic acid delivery

McMahon, K. M., Mutharasan, R. K., Tripathy, S., Veliceasa, D., Bobeica, M., Shumaker, D. K., Luthi, A. J., Helfand, B. T., Ardehali, H., Mirkin, C. A., Volpert, O. & Thaxton, C. S., Mar 9 2011, In : Nano letters. 11, 3, p. 1208-1214 7 p.

Research output: Contribution to journalArticle

96 Scopus citations

BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

Shakya, R., Reid, L. J., Reczek, C. R., Cole, F., Egli, D., Lin, C. S., DeRooij, D. G., Hirsch, S., Ravi, K., Hicks, J. B., Szabolcs, M., Jasin, M., Baer, R. & Ludwig, T., Oct 28 2011, In : Science. 334, 6055, p. 525-528 4 p.

Research output: Contribution to journalArticle

156 Scopus citations

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

Wei, J., Melichian, D., Komura, K., Hinchcliff, M. E., Lam, A. P., Lafyatis, R., Gottardi, C., MacDougald, O. A. & Varga, J., Jun 1 2011, In : Arthritis and rheumatism. 63, 6, p. 1707-1717 11 p.

Research output: Contribution to journalArticle

139 Scopus citations

Chronic inflammation and cancer: The role of the mitochondria

Kamp, D. W., Shacter, E. & Weitzman, S. A., Jan 1 2011, In : Oncology (Williston Park, N.Y.). 25, 5

Research output: Contribution to journalArticle

124 Scopus citations

Clinical significance of microbial infection and adaptation in cystic fibrosis

Hauser, A. R., Jain, M., Bar-Meir, M. & McColley, S. A., Jan 2011, In : Clinical microbiology reviews. 24, 1, p. 29-70 42 p.

Research output: Contribution to journalArticle

220 Scopus citations

Comparison of sirolimus with azathioprine in a tacrolimus-based immunosuppressive regimen in lung transplantation

Bhorade, S., Ahya, V. N., Baz, M. A., Valentine, V. G., Arcasoy, S. M., Love, R. B., Seethamraju, H., Alex, C. G., Bag, R., DeOliveira, N. C., Husain, A., Vigneswaran, W. T., Charbeneau, J., Krishnan, J. A., Durazo-Arvizu, R., Norwick, L. & Garrity, E., Feb 1 2011, In : American journal of respiratory and critical care medicine. 183, 3, p. 379-387 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Differentiated transplant derived airway epithelial cell cytokine secretion is not regulated by cyclosporine

Floreth, T., Stern, E., Tu, Y., Stern, R., Garrity, E. R., Bhorade, S. M. & White, S. R., Apr 10 2011, In : Respiratory Research. 12, 1, 44.

Research output: Contribution to journalArticle

3 Scopus citations

Distinct association of the nuclear pore protein Nup153 with A- and B-type lamins

Al-Haboubi, T., Shumaker, D. K., Köser, J., Wehnert, M. & Fahrenkrog, B., Jan 1 2011, In : Nucleus (Austin, Tex.). 2, 5

Research output: Contribution to journalArticle

44 Scopus citations

Effect of obesity on asthma phenotype is dependent upon asthma severity

Raviv, S., Dixon, A. E., Kalhan, R., Shade, D. & Smith, L. J., Feb 2011, In : Journal of Asthma. 48, 1, p. 98-104 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Effect of single vs bilateral lung transplantation on plasma surfactant protein D levels in idiopathic pulmonary fibrosis

Sims, M. W., Beers, M. F., Ahya, V. N., Kawut, S. M., Sims, K. D., Lederer, D. J., Palmer, S. M., Wille, K., Lama, V. N., Shah, P. D., Orens, J. B., Bhorade, S., Crespo, M., Weinacker, A., Demissie, E., Bellamy, S., Christie, J. D. & Ware, L. B., Aug 1 2011, In : CHEST. 140, 2, p. 489-496 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Elevated CO2 levels cause mitochondrial dysfunction and impair cell proliferation

Vohwinkel, C. U., Lecuona, E., Sun, H., Sommer, N., Vadász, I., Chandel, N. S. & Sznajder, J. I., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37067-37076 10 p.

Research output: Contribution to journalArticle

96 Scopus citations

Elevated plasma Clara cell secretory protein concentration is associated with high-grade primary graft dysfunction

Diamond, J. M., Kawut, S. M., Lederer, D. J., Ahya, V. N., Kohl, B., Sonett, J., Palmer, S. M., Crespo, M., Wille, K., Lama, V. N., Shah, P. D., Orens, J., Bhorade, S., Weinacker, A., Demissie, E., Bellamy, S., Christie, J. D. & Ware, L. B., Mar 2011, In : American Journal of Transplantation. 11, 3, p. 561-567 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis

Diamond, J. M., Lederer, D. J., Kawut, S. M., Lee, J., Ahya, V. N., Bellamy, S., Palmer, S. M., Lama, V. N., Bhorade, S., Crespo, M., Demissie, E., Sonett, J., Wille, K., Orens, J., Shah, P. D., Weinacker, A., Weill, D., Kohl, B. A., Deutschman, C. C., Arcasoy, S. & 6 others, Shah, A. S., Belperio, J. A., Wilkes, D., Reynolds, J. M., Ware, L. B. & Christie, J. D., Nov 1 2011, In : American Journal of Transplantation. 11, 11, p. 2517-2522 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Endobronchial valve treatment for prolonged air leaks of the lung: A case series

Gillespie, C. T., Sterman, D. H., Cerfolio, R. J., Nader, D., Mulligan, M. S., Mularski, R. A., Musani, A. I., Kucharczuk, J. C., Gonzalez, H. X. & Springmeyer, S. C., Jan 1 2011, In : Annals of Thoracic Surgery. 91, 1, p. 270-273 4 p.

Research output: Contribution to journalArticle

64 Scopus citations

Epithelial cell death is an important contributor to oxidant-mediated acute lung injury

Budinger, G. R. S., Mutlu, G. M., Urich, D., Soberanes, S., Buccellato, L. J., Hawkins, K., Chiarella, S. E., Radigan, K. A., Eisenbart, J., Agrawal, H., Berkelhamer, S., Hekimi, S., Zhang, J., Perlman, H., Schumacker, P. T., Jain, M. & Chandel, N. S., Apr 15 2011, In : American journal of respiratory and critical care medicine. 183, 8, p. 1043-1054 12 p.

Research output: Contribution to journalArticle

66 Scopus citations

Fermented Viola mandshurica inhibits melanogenesis in B16 melanoma cells

Kwak, Y. J., Kim, K. S., Kim, K. M., Yu, H. Y., Chung, E., Kim, S. J., Cha, J. Y., Lee, Y. C. & Lee, J. H., Jun 6 2011, In : Bioscience, Biotechnology and Biochemistry. 75, 5, p. 841-847 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Hyperthyroidism and pulmonary hypertension: An important association

Vallabhajosula, S., Radhi, S., Cevik, C., Alalawi, R., Raj, R. & Nugent, K., Jan 1 2011, In : American Journal of the Medical Sciences. 342, 6, p. 507-512 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Hypoxia leads to Na,K-ATPase downregulation via Ca 2+ release-activated Ca 2+ channels and AMPK activation

Gusarova, G. A., Trejo, H. E., Dada, L. A., Briva, A., Welch, L. C., Hamanaka, R. B., Mutlu, G. M., Chandel, N. S., Prakriya, M. & Sznajder, J. I., Sep 2011, In : Molecular and cellular biology. 31, 17, p. 3546-3556 11 p.

Research output: Contribution to journalArticle

81 Scopus citations

Ictal central apnea as a predictor for sudden unexpected death in epilepsy

Schuele, S. U., Afshari, M., Afshari, Z. S., Macken, M. P., Asconape, J., Wolfe, L. & Gerard, E. E., Oct 1 2011, In : Epilepsy and Behavior. 22, 2, p. 401-403 3 p.

Research output: Contribution to journalArticle

30 Scopus citations

Increased risk of venous thromboembolism with a sirolimus-based immunosuppression regimen in lung transplantation

Ahya, V. N., McShane, P. J., Baz, M. A., Valentine, V. G., Arcasoy, S. M., Love, R. B., Seethamraju, H., Garrity, E., Alex, C. G., Bag, R., Deoliveira, N. C., Vigneswaran, W. T., Charbeneau, J., Krishnan, J. A., Durazo-Arvizu, R., Norwick, L. & Bhorade, S., Feb 1 2011, In : Journal of Heart and Lung Transplantation. 30, 2, p. 175-181 7 p.

Research output: Contribution to journalArticle

40 Scopus citations

Integrin regulation of β-catenin signaling in ovarian carcinoma

Burkhalter, R. J., Symowicz, J., Hudson, L. G., Gottardi, C. J. & Stack, M. S., Jul 1 2011, In : Journal of Biological Chemistry. 286, 26, p. 23467-23475 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Lean mass predicts asthma better than fat mass among females

Sood, A., Qualls, C., Li, R., Schuyler, M., Beckett, W. S., Smith, L. J., Thyagarajan, B., Lewis, C. E. & Jacobs, D. R., Jan 1 2011, In : European Respiratory Journal. 37, 1, p. 65-71 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ

Jain, M., Budinger, G. R. S., Lo, A., Urich, D., Rivera, S. E., Ghosh, A. K., Gonzalez, A., Chiarella, S. E., Marks, K., Donnelly, H. K., Soberanes, S., Varga, J., Radigan, K. A., Chandel, N. S. & Mutlu, G. M., Jun 1 2011, In : American journal of respiratory and critical care medicine. 183, 11, p. 1490-1498 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Light-induced changes of the circadian clock of humans: Increasing duration is more effective than increasing light intensity

Dewan, K., Benloucif, S., Reid, K., Wolfe, L. F. & Zee, P. C., May 1 2011, In : Sleep. 34, 5, p. 593-599 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Localized cysteine sulfenic acid formation by vascular endothelial growth factor: Role in endothelial cell migration and angiogenesis

Kaplan, N., Urao, N., Furuta, E., Kim, S. J., Razvi, M., Nakamura, Y., McKinney, R. D., Poole, L. B., Fukai, T. & Ushio-Fukai, M., Oct 2011, In : Free Radical Research. 45, 10, p. 1124-1135 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury

Urich, D., Eisenberg, J. L., Hamill, K. J., Takawira, D., Chiarella, S. E., Soberanes, S., Gonzalez, A., Koentgen, F., Manghi, T., Hopkinson, S. B., Misharin, A. V., Perlman, H., Mutlu, G. M., Budinger, G. R. S. & Jones, J. C. R., Sep 1 2011, In : Journal of cell science. 124, 17, p. 2927-2937 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

MCP-1/CCR2B-dependent loop upregulates MUC5AC and MUC5B in human airway epithelium

Monzon, M. E., Forteza, R. M. & Casalino-Matsuda, S. M., Feb 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 300, 2, p. L204-L215

Research output: Contribution to journalArticle

34 Scopus citations

MDCT bolus tracking data as an adjunct for predicting the diagnosis of pulmonary hypertension and concomitant right-heart failure

Davarpanah, A. H., Hodnett, P. A., Farrelly, C. T., Shah, S. J., Cuttica, M. J., Ragin, A. B., Carr, J. & Yaghmai, V., Nov 1 2011, In : American Journal of Roentgenology. 197, 5, p. 1064-1072 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mechanisms for vascular cell adhesion molecule-1 activation of ERK1/2 during leukocyte transendothelial migration

Abdala-Valencia, H., Berdnikovs, S. & Cook-Mills, J. M., Oct 27 2011, In : PloS one. 6, 10, e26706.

Research output: Contribution to journalArticle

16 Scopus citations

Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung

Duch, M. C., Budinger, G. R. S., Liang, Y. T., Soberanes, S., Urich, D., Chiarella, S. E., Campochiaro, L. A., Gonzalez, A., Chandel, N. S., Hersam, M. C. & Mutlu, G. M., Dec 14 2011, In : Nano letters. 11, 12, p. 5201-5207 7 p.

Research output: Contribution to journalArticle

349 Scopus citations

Mitochondrial complex III ROS regulate adipocyte differentiation

Tormos, K. V., Anso, E., Hamanaka, R. B., Eisenbart, J., Joseph, J., Kalyanaraman, B. & Chandel, N. S., Oct 5 2011, In : Cell Metabolism. 14, 4, p. 537-544 8 p.

Research output: Contribution to journalArticle

369 Scopus citations

Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion

Loor, G., Kondapalli, J., Iwase, H., Chandel, N. S., Waypa, G. B., Guzy, R. D., Vanden Hoek, T. L. & Schumacker, P. T., Jul 1 2011, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 7, p. 1382-1394 13 p.

Research output: Contribution to journalArticle

128 Scopus citations

Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin

Mirkovic, I., Gault, W. J., Rahnama, M., Jenny, A., Gaengel, K., Bessette, D., Gottardi, C. J., Verheyen, E. M. & Mlodzik, M., Jun 2011, In : Nature Structural and Molecular Biology. 18, 6, p. 665-672 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

Mauro, C., Leow, S. C., Anso, E., Rocha, S., Thotakura, A. K., Tornatore, L., Moretti, M., De Smaele, E., Beg, A. A., Tergaonkar, V., Chandel, N. S. & Franzoso, G., Oct 2011, In : Nature Cell Biology. 13, 10, p. 1272-1279 8 p.

Research output: Contribution to journalArticle

183 Scopus citations

Nontuberculous mycobacterial hypersensitivity pneumonitis related to a home shower: Treatment and secondary prevention

Hankwitz, P. E., Cervia, J. S., Thomas, C. F., Fink, J. N., Marras, T. & Tomic, R., Jan 1 2011, In : BMJ Case Reports.

Research output: Contribution to journalArticle

4 Scopus citations

Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation

Lam, A. P., Flozak, A. S., Russell, S., Wei, J., Jain, M., Mutlu, G. M., Budinger, G. R. S., Feghali-Bostwick, C. A., Varga, J. & Gottardi, C. J., Nov 1 2011, In : American journal of respiratory cell and molecular biology. 45, 5, p. 915-922 8 p.

Research output: Contribution to journalArticle

99 Scopus citations

Obesity and primary graft dysfunction after lung transplantation: The lung transplant outcomes group obesity study

Lederer, D. J., Kawut, S. M., Wickersham, N., Winterbottom, C., Bhorade, S., Palmer, S. M., Lee, J., Diamond, J. M., Wille, K. M., Weinacker, A., Lama, V. N., Crespo, M., Orens, J. B., Sonett, J. R., Arcasoy, S. M., Ware, L. B. & Christie, J. D., Nov 1 2011, In : American journal of respiratory and critical care medicine. 184, 9, p. 1055-1061 7 p.

Research output: Contribution to journalArticle

81 Scopus citations

P53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis

Dirisina, R., Katzman, R. B., Goretsky, T., Managlia, E., Mittal, N., Williams, D. B., Qiu, W., Yu, J., Chandel, N. S., Zhang, L. & Barrett, T. A., Sep 2011, In : Gastroenterology. 141, 3, p. 1036-1045 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice

Mutlu, E. A., Engen, P. A., Soberanes, S., Urich, D., Forsyth, C. B., Nigdelioglu, R., Chiarella, S. E., Radigan, K. A., Gonzalez, A., Jakate, S., Keshavarzian, A., Budinger, G. R. S. & Mutlu, G. M., Jun 9 2011, In : Particle and Fibre Toxicology. 8, 19.

Research output: Contribution to journalArticle

66 Scopus citations

Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms

Budinger, G. R. S., McKell, J. L., Urich, D., Foiles, N., Weiss, I., Chiarella, S. E., Gonzalez, A., Soberanes, S., Ghio, A. J., Nigdelioglu, R., Mutlu, E. A., Radigan, K. A., Green, D., Kwaan, H. C. & Mutlu, G. M., 2011, In : PloS one. 6, 4, e18525.

Research output: Contribution to journalArticle

69 Scopus citations

Perivascular T-cell infiltration leads to sustained pulmonary artery remodeling after endothelial cell damage

Cuttica, M. J., Langenickel, T., Noguchi, A., Machado, R. F., Gladwin, M. T. & Boehm, M., Jul 1 2011, In : American journal of respiratory cell and molecular biology. 45, 1, p. 62-71 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Pilot randomized study comparing two techniques of airway anaesthesia during curvilinear probe endobronchial ultrasound bronchoscopy (CP-EBUS)

Lee, H. J., Haas, A. R., Sterman, D. H., Solly, R., Vachani, A. & Gillespie, C. T., Jan 1 2011, In : Respirology. 16, 1, p. 102-106 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Prolonged acute care in a 52-year-old man with respiratory failure: Lessons learned from 70-day intensive care unit hospitalization

Mishra, R. K., Alalawi, R., Raj, R. & Nugent, K. M., Oct 2011, In : Journal of Critical Care. 26, 5, p. 532.e9-532.e16

Research output: Contribution to journalArticle

4 Scopus citations

Prompting physicians to address a daily checklist and process of care and clinical outcomes: A single-site study

Weiss, C. H., Moazed, F., McEvoy, C. A., Singer, B. D., Szleifer, I., Amaral, L. A. N., Kwasny, M., Watts, C. M., Persell, S. D., Baker, D. W., Sznajder, J. I. & Wunderink, R. G., Sep 15 2011, In : American journal of respiratory and critical care medicine. 184, 6, p. 680-686 7 p.

Research output: Contribution to journalArticle

133 Scopus citations