Medicine, Pulmonary Division

Research Output 1949 2019

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2014
15 Citations (Scopus)

Mitochondrial one-carbon metabolism maintains redox balance during hypoxia

Martínez-Reyes, I. & Chandel, N., Jan 1 2014, In : Cancer Discovery. 4, 12, p. 1371-1373 3 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Reactive Oxygen Species
Mitochondria
Carbon
Serine
41 Citations (Scopus)

Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells

Kim, S. J., Cheresh, P., Williams, D., Cheng, Y., Ridge, K., Schumacker, P. T., Weitzman, S., Bohr, V. A. & Kamp, D. W., Feb 28 2014, In : Journal of Biological Chemistry. 289, 9, p. 6165-6176 12 p.

Research output: Contribution to journalArticle

Aconitate Hydratase
Alveolar Epithelial Cells
Mitochondria
Mitochondrial DNA
Oxidants
6 Citations (Scopus)

Modeling the relation between obesity and sleep parameters in children referred for dietary weight reduction intervention

Nugent, R., Althouse, A., Yaqub, Y., Nugent, K. & Raj, R., Jan 1 2014, In : Southern Medical Journal. 107, 8, p. 473-480 8 p.

Research output: Contribution to journalArticle

Weight Loss
Sleep
Obesity
Body Mass Index
Pediatrics
14 Citations (Scopus)

Monosialic ganglioside GM3 specifically suppresses the monocyte adhesion to endothelial cells for inflammation

Kim, S. J., Chung, T. W., Choi, H. J., Jin, U. H., Ha, K. T., Lee, Y. C. & Kim, C. H., Jan 1 2014, In : International Journal of Biochemistry and Cell Biology. 46, 1, p. 32-38 7 p.

Research output: Contribution to journalArticle

G(M3) Ganglioside
Endothelial cells
Monocytes
Adhesion
Endothelial Cells
99 Citations (Scopus)

Nonclassical Ly6C- monocytes drive the development of inflammatory arthritis in mice

Misharin, A., Cuda, C. M., Saber, R., Turner, J. D., Gierut, A. K., Kenneth Haines, G. K., Berdnikovs, S., Filer, A., Clark, A. R., Buckley, C. D., Mutlu, G. M., Budinger, GR. S. & Perlman, H. R., Jan 1 2014, In : Cell reports. 9, 2, p. 591-604 14 p.

Research output: Contribution to journalArticle

Macrophages
Arthritis
Monocytes
Joints
Inflammation
10 Citations (Scopus)

Not ALL measures of hyperinflation are created equal: Lung structure and clinical correlates of gas trapping and hyperexpansion in COPD: the Multi-Ethnic Study of Atherosclerosis (MESA) COPD study

Smith, B. M., Hoffman, E. A., Basner, R. C., Kawut, S. M., Kalhan, R. & Graham Barr, R., Jan 1 2014, In : CHEST. 145, 6, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

Total Lung Capacity
Chronic Obstructive Pulmonary Disease
Atherosclerosis
Residual Volume
Gases

Numerical simulations of high-frequency respiratory flows in 2D and 3D lung bifurcation models

Parameswaran, S., Chen, Z., Parameswaran, S., Hu, Y., He, Z. & Raj, R., Jul 4 2014, In : International Journal of Computational Methods in Engineering Science and Mechanics. 15, 4, p. 337-344 8 p.

Research output: Contribution to journalArticle

Lung
Bifurcation
Numerical Simulation
Computer simulation
Ventilation
3 Citations (Scopus)
Ambulatory Care
Palliative Care
Chronic Obstructive Pulmonary Disease
Appointments and Schedules
Outpatients
117 Citations (Scopus)

Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects

Mullen, A. R., Hu, Z., Shi, X., Jiang, L., Boroughs, L. K., Kovacs, Z., Boriack, R., Rakheja, D., Sullivan, L. B., Linehan, W. M., Chandel, N. & DeBerardinis, R. J., Jun 12 2014, In : Cell reports. 7, 5, p. 1679-1690 12 p.

Research output: Contribution to journalArticle

Carboxylation
NADP
Isocitrate Dehydrogenase
Citric Acid Cycle
Cells
62 Citations (Scopus)

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice

Eren, M., Boe, A. E., Murphy, S. B., Place, A. T., Nagpal, V., Morales-Nebreda, L., Urich, D., Quaggin, S. E., Budinger, GR. S., Mutlu, G. M., Miyata, T. & Vaughan, D. E., May 13 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 19, p. 7090-7095 6 p.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Proteolysis
Serine Proteinase Inhibitors
Cell Aging
Suppressor Genes
8 Citations (Scopus)

Patterns of use of prophylaxis for stress-related mucosal disease in patients admitted to the intensive care unit

Frandah, W., Colmer-Hamood, J., Nugent, K. & Raj, R., Jan 1 2014, In : Journal of Intensive Care Medicine. 29, 2, p. 96-103 8 p.

Research output: Contribution to journalArticle

Ulcer
Intensive Care Units
Prescriptions
Pharmacists
Tertiary Care Centers

Patterns of use of prophylaxis for stress-related mucosal disease in patients admitted to the intensive care unit. PMID 22786980

Frandah, W., Colmer-Hamood, J., Nugent, K. & Raj, R., Mar 2014, In : J Intensive Care Med. 29, 2, p. 96-103 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Phase-shifting response to light in older adults

Kim, S. J., Benloucif, S., Reid, K. J., Weintraub, S., Kennedy, N., Wolfe, L. F. & Zee, P. C., Jan 1 2014, In : Journal of Physiology. 592, 1, p. 189-202 14 p.

Research output: Contribution to journalArticle

Light
Melatonin
Acute-Phase Reaction
Circadian Clocks
Circadian Rhythm
9 Citations (Scopus)

Preoperative plasma club (Clara) cell secretory protein levels are associated with primary graft dysfunction after lung transplantation

Shah, R. J., Wickersham, N., Lederer, D. J., Palmer, S. M., Cantu, E., Diamond, J. M., Kawut, S. M., Lama, V. N., Bhorade, S., Crespo, M., Demissie, E., Sonett, J., Wille, K., Orens, J., Weinacker, A., Shah, P., Arcasoy, S., Wilkes, D. S., Christie, J. D. & Ware, L. B., Feb 1 2014, In : American Journal of Transplantation. 14, 2, p. 446-452 7 p.

Research output: Contribution to journalArticle

Primary Graft Dysfunction
Uteroglobin
Lung Transplantation
Pulmonary Fibrosis
Lung
24 Citations (Scopus)

Progress toward improving medical school graduates' skills via a "boot camp" curriculum

Wayne, D. B., Cohen, E. R., Singer, B. D., Moazed, F., Barsuk, J. H., Lyons, E. A., Butter, J. & McGaghie, W. C., Feb 1 2014, In : Simulation in Healthcare. 9, 1, p. 33-39 7 p.

Research output: Contribution to journalArticle

school graduate
Medical Schools
Medical Students
Curriculum
Curricula
13 Citations (Scopus)

Promotion of lung health: NHLBI workshop on the primary prevention of chronic lung diseases

Camargo, C. A., Budinger, GR. S., Escobar, G. J., Hansel, N. N., Hanson, C. K., Huffnagle, G. B. & Buist, A. S., Jan 1 2014, In : Annals of the American Thoracic Society. 11, SUPPL. 3

Research output: Contribution to journalArticle

National Heart, Lung, and Blood Institute (U.S.)
Primary Prevention
Health Promotion
Lung Diseases
Chronic Disease
4 Citations (Scopus)

Recurrent hydrothorax and surgical diaphragmatic repair report of 2 cases and review of the literature

Argento, A. C., Kim, A., Knauert-Brown, M., Boffa, D., Siegel, M. D., Jafari, B. & Puchalski, J. T., Jan 1 2014, In : Journal of Bronchology and Interventional Pulmonology. 21, 2, p. 150-153 4 p.

Research output: Contribution to journalArticle

Hydrothorax
Peritoneal Dialysis
Pleural Effusion
Dyspnea
Fibrosis
36 Citations (Scopus)

Respiratory disease mortality among US coal miners; results after 37 years of follow-up

Graber, J. M., Stayner, L. T., Cohen, R. A., Conroy, L. M. & Attfield, M. D., Jan 1 2014, In : Occupational and environmental medicine. 71, 1, p. 30-39 10 p.

Research output: Contribution to journalArticle

Coal
Dust
Mortality
Pneumoconiosis
Chronic Obstructive Pulmonary Disease
8 Citations (Scopus)

Smoking and mortality in stroke survivors: Can we eliminate the paradox?

Levine, D. A., Walter, J. M., Karve, S. J., Skolarus, L. E., Levine, S. R. & Mulhorn, K. A., Jan 1 2014, In : Journal of Stroke and Cerebrovascular Diseases. 23, 6, p. 1282-1290 9 p.

Research output: Contribution to journalArticle

Survivors
Smoking
Stroke
Mortality
Cardiovascular Diseases
10 Citations (Scopus)

Structure and biomechanics of the endothelial transcellular circumferential invasion array in tumor invasion

Arvanitis, C., Khuon, S., Spann, R., Ridge, K. M. & Chew, T. L., Feb 24 2014, In : PLoS One. 9, 2, e89758.

Research output: Contribution to journalArticle

Biomechanics
Endothelial cells
myosin
Biomechanical Phenomena
endothelial cells
79 Citations (Scopus)

Targeting SOD1 reduces experimental non-small-cell lung cancer

Glasauer, A., Sena, L. A., Diebold, L. P., Mazar, A. P. & Chandel, N. S., Jan 2 2014, In : Journal of Clinical Investigation. 124, 1, p. 117-128 12 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cell Death
Antioxidants
Mutation
Monomeric GTP-Binding Proteins
9 Citations (Scopus)

The acoustic cough monitoring and manometric profile of cough and throat clearing

Xiao, Y., Carson, D., Boris, L., Mabary, J., Lin, Z., Nicodème, F., Cuttica, M. J., Kahrilas, P. J. & Pandolfino, J. E., Jan 1 2014, In : Diseases of the Esophagus. 27, 1, p. 5-12 8 p.

Research output: Contribution to journalArticle

Pharynx
Cough
Acoustics
Pressure
Sensitivity and Specificity
10 Citations (Scopus)

The changing landscape of adult home noninvasive ventilation technology, use, and reimbursement in the united states

Sunwoo, B. Y., Mulholland, M., Rosen, I. M. & Wolfe, L. F., Jan 1 2014, In : Chest. 145, 5, p. 1134-1140 7 p.

Research output: Contribution to journalArticle

Noninvasive Ventilation
Technology
Evidence-Based Practice
Durable Medical Equipment
Current Procedural Terminology
43 Citations (Scopus)

The complex sleep apnea resolution study: A prospective randomized controlled trial of continuous positive airway pressure versus adaptive servoventilation therapy

Morgenthaler, T. I., Kuzniar, T. J., Wolfe, L. F., Willes, L., McLain, W. C. & Goldberg, R., May 1 2014, In : Sleep. 37, 5

Research output: Contribution to journalArticle

Continuous Positive Airway Pressure
Sleep Apnea Syndromes
Randomized Controlled Trials
Prospective Studies
Central Sleep Apnea
16 Citations (Scopus)

The ganglioside GM3 is associated with cisplatin-induced apoptosis in human colon cancer cells

Chung, T. W., Choi, H. J., Kim, S. J., Kwak, C. H., Song, K. H., Jin, U. H., Chang, Y. C., Chang, H. W., Lee, Y. C., Ha, K. T. & Kim, C. H., May 14 2014, In : PLoS One. 9, 5, e92786.

Research output: Contribution to journalArticle

G(M3) Ganglioside
gangliosides
cisplatin
colorectal neoplasms
Colonic Neoplasms
86 Citations (Scopus)

The promise and perils of antioxidants for cancer patients

Chandel, N. & Tuveson, D. A., Jan 1 2014, In : New England Journal of Medicine. 371, 2, p. 177-178 2 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Oxidative Stress
Antioxidants
Diet
Neoplasms
74 Citations (Scopus)

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

Khare, S., Ratsimandresy, R. A., De Almeida, L. M. V., Cuda, C. M., Rellick, S. L., Misharin, A., Wallin, M. C., Gangopadhyay, A., Forte, E., Gottwein, E., Perlman, H. R., Reed, J. C., Greaves, D. R., Dorfleutner, A. & Stehlik, C., Jan 1 2014, In : Nature Immunology. 15, 4, p. 343-353 11 p.

Research output: Contribution to journalArticle

DNA Virus Infections
Inflammasomes
Macrophages
Virus Activation
Caspase 1
3 Citations (Scopus)

The repeatability of gait speed and physiological cost index measurements in working adults

Raj, R., Amiri, H. M., Wang, H. & Nugent, K. M., Jan 1 2014, In : Journal of Primary Care and Community Health. 5, 2, p. 128-133 6 p.

Research output: Contribution to journalArticle

Costs and Cost Analysis
Heart Rate
Walking Speed
Arthritis
Volunteers

The Repeatability of Gait Speed and Physiological Cost Index Measurements in Working Adults. PMID 24327593

Raj, R., Mojazi, A. H., Wang, H. & Nugent, K., Apr 2014, In : J Prim Care Comm Health. 5, 2, p. 128-133 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The Response to High CO2 Levels Requires the Neuropeptide Secretion Component HID-1 to Promote Pumping Inhibition

Sharabi, K., Charar, C., Friedman, N., Mizrahi, I., Zaslaver, A., Sznajder, J. I. & Gruenbaum, Y., Aug 7 2014, In : PLoS Genetics. 10, 8, e1004529.

Research output: Contribution to journalArticle

neuropeptides
Muscle Contraction
Neuropeptides
secretion
Pharyngeal Muscles
16 Citations (Scopus)

The use of convex probe endobronchial ultrasound-guided transbronchial needle aspiration in a pediatric population: A multicenter study

Gilbert, C. R., Chen, A., Akulian, J. A., Lee, H. J., Wahidi, M., Argento, A. C., Tanner, N. T., Pastis, N. J., Harris, K., Sterman, D., Toth, J. W., Chenna, P. R., Feller-Kopman, D. & Yarmus, L., Jan 1 2014, In : Pediatric Pulmonology. 49, 8, p. 807-815 9 p.

Research output: Contribution to journalArticle

Multicenter Studies
Needles
Pediatrics
Population
Mediastinoscopy
37 Citations (Scopus)

TOR signaling couples oxygen sensing to lifespan in C.elegans

Schieber, M. & Chandel, N., Oct 9 2014, In : Cell reports. 9, 1, p. 9-15 7 p.

Research output: Contribution to journalArticle

Sirolimus
Oxygen
Reactive Oxygen Species
GATA Transcription Factors
Glutathione Transferase
24 Citations (Scopus)

Trends in pathogens among patients hospitalized for pneumonia from 1993 to 2011

Smith, S. B., Ruhnke, G. W., Weiss, C., Waterer, G. W. & Wunderink, R. G., Jan 1 2014, In : JAMA Internal Medicine. 174, 11, p. 1837-1839 3 p.

Research output: Contribution to journalArticle

Bacterial Pneumonia
Pneumonia
Hospitalization
Retrospective Studies
12 Citations (Scopus)

Ultrasound-guided pleural access

Shojaee, S. & Argento, A. C., Jan 1 2014, In : Seminars in Respiratory and Critical Care Medicine. 35, 6, p. 693-705 13 p.

Research output: Contribution to journalArticle

Thorax
Ultrasonography
Pleural Diseases
Chest Tubes
Thoracoscopy
13 Citations (Scopus)

Update in cystic fibrosis 2013

Jain, M. & Goss, C. H., May 15 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 10, p. 1181-1186 6 p.

Research output: Contribution to journalArticle

Aminophenols
Cystic Fibrosis Transmembrane Conductance Regulator
Bronchiectasis
Evidence-Based Medicine
Quinolones
4 Citations (Scopus)

Update in sepsis and pulmonary infections 2013

Wunderink, R. G. & Walley, K. R., Jul 1 2014, In : American Journal of Respiratory and Critical Care Medicine. 190, 1, p. 25-31 7 p.

Research output: Contribution to journalArticle

Microbiota
Publications
Sepsis
Pneumonia
Lung
215 Citations (Scopus)

Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication

Bihorac, A., Chawla, L. S., Shaw, A. D., Al-Khafaji, A., Davison, D. L., DeMuth, G. E., Fitzgerald, R., Gong, M. N., Graham, D. D., Gunnerson, K., Heung, M., Jortani, S., Kleerup, E., Koyner, J. L., Krell, K., LeTourneau, J., Lissauer, M., Miner, J., Nguyen, H. B., Ortega, L. M. & 11 others, Self, W. H., Sellman, R., Shi, J., Straseski, J., Szalados, J. E., Wilber, S. T., Walker, M. G., Wilson, J., Wunderink, R. G., Zimmerman, J. & Kellum, J. A., Apr 15 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 8, p. 932-939 8 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-2
Cell Cycle Checkpoints
Acute Kidney Injury
Biomarkers
Critical Illness
3 Citations (Scopus)
Lung
Neoplasms
Adenocarcinoma
Adenocarcinoma of lung
Colon
55 Citations (Scopus)

Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis

Lam, A. P., Herazo-Maya, J. D., Sennello, J. A., Flozak, A. S., Russell, S. R., Mutlu, G. M., Budinger, GR. S., DasGupta, R., Varga, J., Kaminski, N. & Gottardi, C., Jul 15 2014, In : American journal of respiratory and critical care medicine. 190, 2, p. 185-195 11 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Transforming Growth Factors
Fibrosis
Catenins
Lung
65 Citations (Scopus)

α-Catenin cytomechanics - role in cadherin-dependent adhesion and mechanotransduction

Barry, A. K., Tabdili, H., Muhamed, I., Wu, J., Shashikanth, N., Gomez, G. A., Yap, A. S., Gottardi, C., De Rooij, J., Wang, N. & Leckband, D. E., Jan 1 2014, In : Journal of cell science. 127, 8, p. 1779-1791 13 p.

Research output: Contribution to journalArticle

Catenins
Cadherins
Actins
Vinculin
Traction
22 Citations (Scopus)

α-Catenin is an inhibitor of transcription

Daugherty, R. L., Serebryannyy, L., Yemelyanov, A., Flozak, A. S., Yu, H. J., Kosak, S. T., De Lanerolle, P. & Gottardi, C., Jan 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 14, p. 5260-5265 6 p.

Research output: Contribution to journalArticle

Catenins
Cats
Actins
TCF Transcription Factors
Microfilament Proteins
44 Citations (Scopus)

β2-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis

Chiarella, S. E., Soberanes, S., Urich, D., Morales-Nebreda, L., Nigdelioglu, R., Green, D., Young, J. B., Gonzalez, A., Rosario, C., Misharin, A., Ghio, A. J., Wunderink, R. G., Donnelly, H. K., Radigan, K. A., Perlman, H. R., Chandel, N., Budinger, GR. S. & Mutlu, G. M., Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 2935-2946 12 p.

Research output: Contribution to journalArticle

Adrenergic Agonists
Particulate Matter
Air Pollution
Alveolar Macrophages
Interleukin-6
2013
29 Citations (Scopus)

A clinical trial comparing physician prompting with an unprompted automated electronic checklist to reduce empirical antibiotic utilization

Weiss, C., Dibardino, D., Rho, J., Sung, N., Collander, B. & Wunderink, R. G., Nov 1 2013, In : Critical Care Medicine. 41, 11, p. 2563-2569 7 p.

Research output: Contribution to journalArticle

Checklist
Clinical Trials
Anti-Bacterial Agents
Physicians
Electronic Health Records
34 Citations (Scopus)

Adult-onset asthma becomes the dominant phenotype among women by age 40 years: The longitudinal CARDIA study

Sood, A., Qualls, C., Schuyler, M., Arynchyn, A., Alvarado, J. H., Smith, L. J. & Jacobs, D. R., Jun 1 2013, In : Annals of the American Thoracic Society. 10, 3, p. 188-197 10 p.

Research output: Contribution to journalArticle

Young Adult
Coronary Vessels
Asthma
Phenotype
Pediatrics
16 Citations (Scopus)

A novel p38 mitogen-activated protein kinase/Elk-1 transcription factor-dependent molecular mechanism underlying abnormal endothelial cell proliferation in plexogenic pulmonary arterial hypertension

Patel, M., Predescu, D., Tandon, R., Bardita, C., Pogoriler, J., Bhorade, S., Wang, M., Comhair, S., Ryan-Hemnes, A., Chen, J., Machado, R., Husain, A., Erzurum, S. & Predescu, S., Sep 6 2013, In : Journal of Biological Chemistry. 288, 36, p. 25701-25716 16 p.

Research output: Contribution to journalArticle

ets-Domain Protein Elk-1
Endothelial cells
Cell proliferation
p38 Mitogen-Activated Protein Kinases
Pulmonary Hypertension
3 Citations (Scopus)

A reliable and effective method of DNA isolation from old human blood paper cards

Song, Y., Fahs, A., Feldman, C., Shah, S., Gu, Y., Wang, Y., Machado, R. F., Wunderink, R. G. & Chen, J., Dec 1 2013, In : SpringerPlus. 2, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

DNA
Edetic Acid
Tromethamine
Caspase 12
Single Nucleotide Polymorphism
31 Citations (Scopus)

Asbestos-induced alveolar epithelial cell apoptosis: The role of endoplasmic reticulum stress response

Kamp, D. W., Liu, G., Cheresh, P., Kim, S. J., Mueller, A., Lam, A. P., Trejo, H., Williams, D., Tulasiram, S., Baker, M., Ridge, K., Chandel, N. S. & Beri, R., Dec 1 2013, In : American journal of respiratory cell and molecular biology. 49, 6, p. 892-901 10 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Endoplasmic Reticulum Stress
Asbestos
Apoptosis
Endoplasmic Reticulum
16 Citations (Scopus)

Balancing the risks and benefits of oxygen therapy in critically ill adults

Budinger, GR. S. & Mutlu, G. M., Jan 1 2013, In : CHEST. 143, 4, p. 1151-1162 12 p.

Research output: Contribution to journalArticle

Critical Illness
Oxygen
Therapeutics
Guidelines
29 Citations (Scopus)

Body mass index is a stronger predictor than the metabolic syndrome for future asthma in women the longitudinal CARDIA study

Assad, N., Qualls, C., Smith, L. J., Arynchyn, A., Thyagarajan, B., Schuyler, M., Jacobs, D. R. & Sood, A., Aug 1 2013, In : American journal of respiratory and critical care medicine. 188, 3, p. 319-326 8 p.

Research output: Contribution to journalArticle

Young Adult
Coronary Vessels
Body Mass Index
Asthma
Obesity