Research Output

2020

Crystal structures of an unmodified bacterial tRNA reveal intrinsic structural flexibility and plasticity as general properties of unbound tRNAs

Chan, C. W., Badong, D., Rajan, R. & Mondragón, A., Jan 1 2020, In : RNA. 26, 3, p. 278-289 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Development of human ectocervical tissue models with physiologic endocrine and paracrine signaling†

McKinnon, K. E., Sensharma, R., Williams, C., Ravix, J., Getsios, S. & Woodruff, T. K., Aug 21 2020, In : Biology of reproduction. 103, 3, p. 497-507 11 p.

Research output: Contribution to journalArticle

Discovery of the Biosynthetic Machinery for Stravidins, Biotin Antimetabolites

Montaser, R. & Kelleher, N. L., May 15 2020, In : ACS chemical biology. 15, 5, p. 1134-1140 7 p.

Research output: Contribution to journalArticle

Distinct follicular and luteal transcriptional profiles in engineered human ectocervical tissue dependent on menstrual cycle phase

McKinnon, K. E., Getsios, S. & Woodruff, T. K., Aug 21 2020, In : Biology of reproduction. 103, 3, p. 487-496 10 p.

Research output: Contribution to journalArticle

Editorial overview: Taking measure of developing plants and animals

Carthew, R. W. & Shyer, A., Aug 2020, In : Current Opinion in Genetics and Development. 63, p. iii-v

Research output: Contribution to journalEditorial

Effects of telomerase overexpression in the model organism Caenorhabditis elegans

Bayat, M., Tanny, R. E., Wang, Y., Herden, C., Daniel, J., Andersen, E. C., Liebau, E. & Waschk, D. E. J., Mar 30 2020, In : Gene. 732, 144367.

Research output: Contribution to journalArticle

Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype

Doubleday, P. F., Fornelli, L. & Kelleher, N. L., Feb 7 2020, In : Journal of Proteome Research. 19, 2, p. 938-948 11 p.

Research output: Contribution to journalArticle

Embryo integrity regulates maternal proteostasis and stress resilience

Sala, A. J., Bott, L. C., Brielmann, R. M. & Morimoto, R. I., May 1 2020, In : Genes and Development. 34, 9-10, p. 678-687 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Engineered reproductive tissues

Gargus, E. S., Rogers, H. B., McKinnon, K. E., Edmonds, M. E. & Woodruff, T. K., Apr 1 2020, In : Nature Biomedical Engineering. 4, 4, p. 381-393 13 p.

Research output: Contribution to journalReview article

3 Scopus citations

ERdj8 governs the size of autophagosomes during the formation process

Yamamoto, Y. H., Kasai, A., Omori, H., Takino, T., Sugihara, M., Umemoto, T., Hamasaki, M., Hatta, T., Natsume, T., Morimoto, R. I., Arai, R., Waguri, S., Sato, M., Sato, K., Bar-Nun, S., Yoshimori, T., Noda, T. & Nagata, K., Aug 3 2020, In : Journal of Cell Biology. 219, 8, e201903127.

Research output: Contribution to journalArticle

Open Access

Evolution of Transcriptional Repressors Impacts Caenorhabditis Vulval Development

Chamberlin, H. M., Jain, I. M., Corchado-Sonera, M., Kelley, L. H., Sharanya, D., Jama, A., Pabla, R., Dawes, A. T., Gupta, B. P. & Ruvinsky, I., May 1 2020, In : Molecular biology and evolution. 37, 5, p. 1350-1361 12 p.

Research output: Contribution to journalArticle

Exposure of human fallopian tube epithelium to elevated testosterone results in alteration of cilia gene expression and beating

Jackson-Bey, T., Colina, J., Isenberg, B. C., Coppeta, J., Urbanek, M., Kim, J. J., Woodruff, T. K., Burdette, J. E. & Russo, A., Sep 1 2020, In : Human reproduction (Oxford, England). 35, 9, p. 2086-2096 11 p.

Research output: Contribution to journalArticle

Female fertility in the cancer setting: availability and quality of online health information

de Man, A. M., Rashedi, A., Nelen, W., Anazodo, A., Rademaker, A., de Roo, S., Beerendonk, C. & Woodruff, T. K., Jul 2 2020, In : Human Fertility. 23, 3, p. 170-178 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology

Abrisch, R. G., Gumbin, S. C., Wisniewski, B. T., Lackner, L. L. & Voeltz, G. K., Apr 6 2020, In : The Journal of cell biology. 219, 4

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Fly-QMA: Automated analysis of mosaic imaginal discs in Drosophila

Bernasek, S. M., Peláez, N., Carthew, R. W., Bagheri, N. & Amaral, L. A. N., 2020, In : PLoS computational biology. 16, 3, e1007406.

Research output: Contribution to journalArticle

Open Access

Hypercapnia suppresses macrophage antiviral activity and increases mortality of influenza a infection via akt1

Casalino-Matsuda, S. M., Chen, F., Gonzalez-Gonzalez, F. J., Nair, A., Dib, S., Yemelyanov, A., Gates, K. L., Budinger, G. R. S., Beitel, G. J. & Sporn, P. H. S., Jul 15 2020, In : Journal of Immunology. 205, 2, p. 489-501 13 p.

Research output: Contribution to journalArticle

Identification of Plasmodium falciparum proteoforms from liver stage models

Winer, B., Edgel, K. A., Zou, X., Sellau, J., Hadiwidjojo, S., Garver, L. S., McDonough, C. E., Kelleher, N. L., Thomas, P. M., Villasante, E., Ploss, A. & Gerbasi, V. R., Jan 7 2020, In : Malaria journal. 19, 1, 10.

Research output: Contribution to journalArticle

Open Access

Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top-Down Mass Spectrometry

Kafader, J. O., Durbin, K. R., Melani, R. D., Des Soye, B. J., Schachner, L. F., Senko, M. W., Compton, P. D. & Kelleher, N. L., Mar 6 2020, In : Journal of Proteome Research. 19, 3, p. 1346-1350 5 p.

Research output: Contribution to journalArticle

Installing oncofertility programs for common cancers in limited resource settings (Repro-Can-OPEN Study): An extrapolation during the global crisis of Coronavirus (COVID-19) pandemic

Salama, M., Ataman-Millhouse, L., Braham, M., Berjeb, K., Khrouf, M., Rodrigues, J. K., Reis, F. M., Silva, T. C., Sánchez, F., Romero, S., Smitz, J., Vásquez, L., Vega, M., Sobral, F., Terrado, G., Lombardi, M. G., Scarella, A., Bourlon, M. T., Verduzco-Aguirre, H., Sánchez, A. M. & 31 others, Adiga, S. K., Tholeti, P., Udupa, K. S., Mahajan, N., Patil, M., Dalvi, R., Venter, C., Demetriou, G., Geel, J., Quintana, R., Rodriguez, G., Quintana, T., Viale, L., Fraguglia, M., Coirini, M., Remolina-Bonilla, Y. A., Noguera, J. A. R., Velásquez, J. C., Suarez, A., Arango, G. D., Pineda, J. I. D., Aldecoa, M. D. C., Javed, M., Al Sufyan, H., Daniels, N., Oranye, B. C., Ogunmokun, A. A., Onwuzurigbo, K. I., Okereke, C. J., Whesu, T. C. & Woodruff, T. K., Jul 1 2020, In : Journal of Assisted Reproduction and Genetics. 37, 7, p. 1567-1577 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Ligands, Receptors, and Transcription Factors that Mediate Inter-Cellular and Intra-Cellular Communication during Ovarian Follicle Development

Bernabé, B. P., Woodruff, T., Broadbelt, L. J. & Shea, L. D., Feb 1 2020, In : Reproductive Sciences. 27, 2, p. 690-703 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase

Shen, S., Doubleday, P. F., Weerawarna, P. M., Zhu, W., Kelleher, N. L. & Silverman, R. B., Jan 1 2020, (Accepted/In press) In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Micromanipulation of prophase I chromosomes from mouse spermatocytes reveals high stiffness and gel-like chromatin organization

Biggs, R. J., Liu, N., Peng, Y., Marko, J. F. & Qiao, H., Dec 1 2020, In : Communications Biology. 3, 1, 542.

Research output: Contribution to journalArticle

Open Access

MicroRNA miR-7 Regulates Secretion of Insulin-Like Peptides

Agbu, P., Cassidy, J. J., Braverman, J., Jacobson, A. & Carthew, R. W., Feb 1 2020, In : Endocrinology (United States). 161, 2, bqz040.

Research output: Contribution to journalArticle

Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes

Kafader, J. O., Melani, R. D., Durbin, K. R., Ikwuagwu, B., Early, B. P., Fellers, R. T., Beu, S. C., Zabrouskov, V., Makarov, A. A., Maze, J. T., Shinholt, D. L., Yip, P. F., Tullman-Ercek, D., Senko, M. W., Compton, P. D. & Kelleher, N. L., Apr 1 2020, In : Nature Methods. 17, 4, p. 391-394 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response

Béguelin, W., Teater, M., Meydan, C., Hoehn, K. B., Phillip, J. M., Soshnev, A. A., Venturutti, L., Rivas, M. A., Calvo-Fernández, M. T., Gutierrez, J., Camarillo, J. M., Takata, K., Tarte, K., Kelleher, N. L., Steidl, C., Mason, C. E., Elemento, O., Allis, C. D., Kleinstein, S. H. & Melnick, A. M., May 11 2020, In : Cancer Cell. 37, 5, p. 655-673.e11

Research output: Contribution to journalArticle

2 Scopus citations

Native vs Denatured: An in Depth Investigation of Charge State and Isotope Distributions

Kafader, J. O., Melani, R. D., Schachner, L. F., Ives, A. N., Patrie, S. M., Kelleher, N. L. & Compton, P. D., Mar 4 2020, In : Journal of the American Society for Mass Spectrometry. 31, 3, p. 574-581 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Natural variation in a glucuronosyltransferase modulates propionate sensitivity in a C. elegans propionic acidemia model

Na, H., Zdraljevic, S., Tanny, R. E., Walhout, A. J. M. & Andersen, E. C., Aug 28 2020, In : PLoS genetics. 16, 8 August, e1008984.

Research output: Contribution to journalArticle

Open Access

Ndr/Lats Kinases Bind Specific Mob-Family Coactivators through a Conserved and Modular Interface

Parker, B. W., Gogl, G., Bálint, M., Hetényi, C., Reményi, A. & Weiss, E. L., May 5 2020, In : Biochemistry. 59, 17, p. 1688-1700 13 p.

Research output: Contribution to journalArticle

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle

Kosciuk, T., Price, I. R., Zhang, X., Zhu, C., Johnson, K. N., Zhang, S., Halaby, S. L., Komaniecki, G. P., Yang, M., DeHart, C. J., Thomas, P. M., Kelleher, N. L., Christopher Fromme, J. & Lin, H., Dec 1 2020, In : Nature communications. 11, 1, 1067.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry

Park, H. M., Winton, V. J., Drader, J. J., Manalili Wheeler, S., Lazar, G. A., Kelleher, N. L., Liu, Y., Tran, J. C. & Compton, P. D., Jan 21 2020, In : Analytical Chemistry. 92, 2, p. 2186-2193 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Oncofertility as a universal right and a global oncology priority

Bourlon, M. T., Anazodo, A., Woodruff, T. K. & Segelov, E., 2020, In : Journal of Global Oncology. 6, p. 314-316 3 p.

Research output: Contribution to journalEditorial

Open Access
3 Scopus citations

Ordered patterning of the sensory system is susceptible to stochastic features of gene expression

Giri, R., Papadopoulos, D. K., Posadas, D. M., Potluri, H. K., Tomancak, P., Mani, M. & Carthew, R. W., Feb 2020, In : eLife. 9, e53638.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Ovarian tissue cryopreservation as standard of care: what does this mean for pediatric populations?

Nahata, L., Woodruff, T. K., Quinn, G. P., Meacham, L. R., Chen, D., Appiah, L. C., Finlayson, C., Orwig, K. E., Laronda, M. M., Rowell, E. E., Anazodo, A., Frias, O., Rios, J. S., Whiteside, S., Gomez-Lobo, V., Dwiggins, M., Childress, K. J., Hoefgen, H. R., Levine, J. M., Jayasinghe, Y. & 1 others, Moravek, M., Jun 1 2020, In : Journal of Assisted Reproduction and Genetics. 37, 6, p. 1323-1326 4 p.

Research output: Contribution to journalComment/debate

Open Access

Phylogenetics Identifies Two Eumetazoan TRPM Clades and an Eighth TRP Family, TRP Soromelastatin (TRPS)

Himmel, N. J., Gray, T. R., Cox, D. N. & Ruvinsky, I., Jul 1 2020, In : Molecular biology and evolution. 37, 7, p. 2034-2044 11 p.

Research output: Contribution to journalArticle

Open Access

Physics and Biology (of Chromosomes)

Marko, J. F., Jan 17 2020, In : Journal of Molecular Biology. 432, 2, p. 621-631 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Preclinical contraceptive development for men and women

Johnston, D. S. & Goldberg, E., Aug 1 2020, In : Biology of reproduction. 103, 2, p. 147-156 10 p.

Research output: Contribution to journalArticle

Open Access

PRMT1 promotes neuroblastoma cell survival through ATF5

Hua, Z. Y., Hansen, J. N., He, M., Dai, S. K., Choi, Y., Fulton, M. D., Lloyd, S. M., Szemes, M., Sen, J., Ding, H. F., Angelastro, J. M., Fei, X., Li, H. P., Wu, C. R., Yang, S. Y., Malik, K., Bao, X., George Zheng, Y., Liu, C. M., Schor, N. F. & 2 others, Li, Z. J. & Li, X. G., May 1 2020, In : Oncogenesis. 9, 5, 50.

Research output: Contribution to journalArticle

Open Access

Prospects of Rescuing Young Eggs for Oncofertility

Bertoldo, M. J., Smitz, J., Wu, L. E., Lee, H. C., Woodruff, T. K. & Gilchrist, R. B., Oct 2020, In : Trends in Endocrinology and Metabolism. 31, 10, p. 708-711 4 p.

Research output: Contribution to journalShort survey

Proton Radiotherapy to Preserve Fertility and Endocrine Function: A Translational Investigation

Gross, J. P., Kim, S-Y., Gondi, V., Pankuch, M., Wagner, S., Grover, A., Luan, Y. & Woodruff, T. K., 2020, (Accepted/In press) In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journalArticle

Publisher Correction: In vivo structure of the Legionella type II secretion system by electron cryotomography (Nature Microbiology, (2019), 4, 12, (2101-2108), 10.1038/s41564-019-0603-6)

Ghosal, D., Kim, K. W., Zheng, H., Kaplan, M., Truchan, H. K., Lopez, A. E., McIntire, I. E., Vogel, J. P., Cianciotto, N. P. & Jensen, G. J., Apr 1 2020, In : Nature Microbiology. 5, 4, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles

Dilks, C. M., Hahnel, S. R., Sheng, Q., Long, L., McGrath, P. T. & Andersen, E. C., Dec 2020, In : International Journal for Parasitology: Drugs and Drug Resistance. 14, p. 28-36 9 p.

Research output: Contribution to journalArticle

Open Access

Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua

Keenan, S. E., Blythe, S. A., Marmion, R. A., Djabrayan, N. J. V., Wieschaus, E. F. & Shvartsman, S. Y., Mar 23 2020, In : Developmental Cell. 52, 6, p. 794-801.e4

Research output: Contribution to journalArticle

2 Scopus citations

Regulation of the RNA-binding protein Smaug by the GPCR Smoothened via the kinase Fused

Bruzzone, L., Argüelles, C., Sanial, M., Miled, S., Alvisi, G., Gonçalves-Antunes, M., Qasrawi, F., Holmgren, R. A., Smibert, C. A., Lipshitz, H. D., Boccaccio, G. L., Plessis, A. & Bécam, I., Jul 3 2020, In : EMBO Reports. 21, 7, e48425.

Research output: Contribution to journalArticle

Repurposing Papaverine as an Antiviral Agent against Influenza Viruses and Paramyxoviruses

Aggarwal, M., Leser, G. P. & Lamb, R. A., Feb 28 2020, In : Journal of virology. 94, 6

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Simultaneous cross-evaluation of heterogeneous E. coli datasets via mechanistic simulation

Macklin, D. N., Ahn-Horst, T. A., Choi, H., Ruggero, N. A., Carrera, J., Mason, J. C., Sun, G., Agmon, E., DeFelice, M. M., Maayan, I., Lane, K., Spangler, R. K., Gillies, T. E., Paull, M. L., Akhter, S., Bray, S. R., Weaver, D. S., Keseler, I. M., Karp, P. D., Morrison, J. H. & 1 others, Covert, M. W., Jul 24 2020, In : Science. 369, 6502, eaav3751.

Research output: Contribution to journalArticle

3 Scopus citations

STRIPAK Limits Stem Cell Differentiation of a WNT Signaling Center to Control Planarian Axis Scaling

Schad, E. G. & Petersen, C. P., Jan 20 2020, In : Current Biology. 30, 2, p. 254-263.e2

Research output: Contribution to journalArticle

1 Scopus citations

Structural insights into the evolutionarily conserved BAF chromatin remodeling complex

Marcum, R. D., Reyes, A. A. & He, Y., Jul 2020, In : Biology. 9, 7, p. 1-9 9 p., 146.

Research output: Contribution to journalReview article

Open Access

Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation

Abdella, R., Aggarwal, M., Okura, T., Lamb, R. A. & He, Y., Mar 3 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4931-4941 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Tec-1 kinase negatively regulates regenerative neurogenesis in planarians

Karge, A., Bonar, N. A., Wood, S. & Petersen, C. P., Jan 2020, In : eLife. 9, e47293.

Research output: Contribution to journalArticle

Open Access

Tell Me your Superpower!

Woodruff, T. K., Mar 1 2020, In : Endocrinology (United States). 161, 3

Research output: Contribution to journalEditorial

Open Access