Research Output

2020

2019 Pediatric Initiative Network: Progress, Proceedings, and Plans

Nahata, L., Gomez-Lobo, V., Meacham, L., Appiah, L., Childress, K., Hoefgen, H., Dwiggins, M., Whiteside, S., Bjornard, K., Rios, J., Anazodo, A., Finlayson, C., Frias, O., Woodruff, T. & Moravek, M., Aug 2020, In : Journal of adolescent and young adult oncology. 9, 4, p. 457-463 7 p.

Research output: Contribution to journalArticle

Open Access

A computational framework to explore large-scale biosynthetic diversity

Navarro-Muñoz, J. C., Selem-Mojica, N., Mullowney, M. W., Kautsar, S. A., Tryon, J. H., Parkinson, E. I., De Los Santos, E. L. C., Yeong, M., Cruz-Morales, P., Abubucker, S., Roeters, A., Lokhorst, W., Fernandez-Guerra, A., Cappelini, L. T. D., Goering, A. W., Thomson, R. J., Metcalf, W. W., Kelleher, N. L., Barona-Gomez, F. & Medema, M. H., Jan 1 2020, In : Nature Chemical Biology. 16, 1, p. 60-68 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Amplifiers co-translationally enhance CFTR biosynthesis via PCBP1-mediated regulation of CFTR mRNA

Dukovski, D., Villella, A., Bastos, C., King, R., Finley, D., Kelly, J. W., Morimoto, R. I., Hartl, F. U., Munoz, B., Lee, P. S., Zecevic, M. & Miller, J. P., Sep 2020, In : Journal of Cystic Fibrosis. 19, 5, p. 733-741 9 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

A MUC16 IgG binding activity selects for a restricted subset of IgG enriched for certain simian immunodeficiency virus epitope specificities

Schneider, J. R., Shen, X., Orlandi, C., Nyanhete, T., Sawant, S., Carias, A. M., Smith, A. D., Kelleher, N. L., Veazey, R. S., Lewis, G. K., Tomaras, G. D. & Hope, T. J., Mar 1 2020, In : Journal of virology. 94, 5, e01246-19.

Research output: Contribution to journalArticle

A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid

Zhu, W., Doubleday, P. F., Catlin, D. S., Weerawarna, P. M., Butrin, A., Shen, S., Wawrzak, Z., Kelleher, N. L., Liu, D. & Silverman, R. B., Mar 11 2020, In : Journal of the American Chemical Society. 142, 10, p. 4892-4903 12 p.

Research output: Contribution to journalArticle

A spontaneous complex structural variant in rcan-1 increases exploratory behavior and laboratory fitness of Caenorhabditis elegans

Zhao, Y., Long, L., Wan, J., Biliya, S., Brady, S. C., Lee, D., Ojemakinde, A., Andersen, E. C., Vannberg, F. O., Lu, H. & McGrath, P. T., 2020, In : PLoS genetics. 16, 2, e1008606.

Research output: Contribution to journalArticle

Open Access

Celebrating the Silver Anniversary of the North American Testis Workshop

Robaire, B., Eddy, M., Goldberg, E., Griswold, M., Heckert, L., McCarrey, J., Orgebin-Crist, M. C., Papadopoulos, V., Trasler, J., Wright, W., Yan, W. & Zirkin, B., Jul 1 2020, In : Andrology. 8, 4, p. 820-824 5 p.

Research output: Contribution to journalReview article

Open Access

Cell-nonautonomous regulation of proteostasis in aging and disease

Morimoto, R. I., Apr 2020, In : Cold Spring Harbor Perspectives in Biology. 12, 4, a034074.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Challenging Proteostasis: Role of the Chaperone Network to Control Aggregation-Prone Proteins in Human Disease

Sinnige, T., Yu, A. & Morimoto, R. I., 2020, Advances in Experimental Medicine and Biology. Springer, p. 53-68 16 p. (Advances in Experimental Medicine and Biology; vol. 1243).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Chromatin accessibility and histone acetylation in the regulation of competence in early development

Esmaeili, M., Blythe, S. A., Tobias, J. W., Zhang, K., Yang, J. & Klein, P. S., Jun 1 2020, In : Developmental Biology. 462, 1, p. 20-35 16 p.

Research output: Contribution to journalArticle

1 Scopus citations

Chromosome organization by one-sided and two-sided loop extrusion

Banigan, E. J., van den Berg, A. A., Brandão, H. B., Marko, J. F. & Mirny, L. A., Apr 2020, In : eLife. 9, e53558.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Counseling and surveillance of obstetrical risks for female childhood, adolescent, and young adult cancer survivors: recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

van der Kooi, A. L. L. F., Mulder, R. L., Hudson, M. M., Kremer, L. C. M., Skinner, R., Constine, L. S., van Dorp, W., van Dulmen-den Broeder, E., Falck-Winther, J., Wallace, W. H., Waugh, J., Woodruff, T. K., Anderson, R. A., Armenian, S. H., Bloemenkamp, K. W. M., Critchley, H. O. D., Demoor-Goldschmidt, C., Ehrhardt, M. J., Green, D. M., Grobman, W. A. & 13 others, Iwahata, Y., Krishna, I., Laven, J. S. E., Levitt, G., Meacham, L. R., Miller, E. S., Mulders, A., Polanco, A., Ronckers, C. M., Samuel, A., Walwyn, T., Levine, J. M. & van den Heuvel-Eibrink, M. M., 2020, (Accepted/In press) In : American journal of obstetrics and gynecology.

Research output: Contribution to journalReview article

Open Access

Creating a global community of practice for oncofertility

Ataman, L. M., Rodrigues, J. K., Marinho, R. M., Caetano, J. P. J., Chehin, M. B., Alves da Motta, E. L., Serafini, P., Suzuki, N., Furui, T., Takae, S., Sugishita, Y., Morishige, K. I., Almeida-Santos, T., Melo, C., Buzaglo, K., Irwin, K., Hamish Wallace, W., Anderson, R. A., Mitchell, R. T., Telfer, E. E. & 30 others, Adiga, S. K., Anazodo, A., Stern, C., Sullivan, E., Jayasinghe, Y., Orme, L., Cohn, R., McLachlan, R., Deans, R., Agresta, F., Gerstl, B., Ledger, W. L., Robker, R. L., de Meneses e Silva, J. M., Melo e Silva, L. H. F., Lunardi, F. O., Lee, J. R., Suh, C. S., de Vos, M., van Moer, E., Stoop, D., Vloeberghs, V., Smitz, J., Tournaye, H., Wildt, L., Winkler-Crepaz, K., Andersen, C. Y., Smith, B. M., Smith, K. & Woodruff, T. K., 2020, In : Journal of Global Oncology. 6, p. 317-330 14 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Cryo-EM structure of SWI/SNF complex bound to a nucleosome

Han, Y., Reyes, A. A., Malik, S. & He, Y., Mar 19 2020, In : Nature. 579, 7799, p. 452-455 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Crystal structure of an atypical cobalamin riboswitch reveals RNA structural adaptability as basis for promiscuous ligand binding

Chan, C. W. & Mondragón, A., Jul 27 2020, In : Nucleic acids research. 48, 13, p. 7569-7583 15 p.

Research output: Contribution to journalArticle

Open Access

Crystal structures of an unmodified bacterial tRNA reveal intrinsic structural flexibility and plasticity as general properties of unbound tRNAs

Chan, C. W., Badong, D., Rajan, R. & Mondragón, A., Jan 1 2020, In : RNA. 26, 3, p. 278-289 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Development of human ectocervical tissue models with physiologic endocrine and paracrine signaling†

McKinnon, K. E., Sensharma, R., Williams, C., Ravix, J., Getsios, S. & Woodruff, T. K., Aug 21 2020, In : Biology of reproduction. 103, 3, p. 497-507 11 p.

Research output: Contribution to journalArticle

Discovery of the Biosynthetic Machinery for Stravidins, Biotin Antimetabolites

Montaser, R. & Kelleher, N. L., May 15 2020, In : ACS chemical biology. 15, 5, p. 1134-1140 7 p.

Research output: Contribution to journalArticle

Distinct follicular and luteal transcriptional profiles in engineered human ectocervical tissue dependent on menstrual cycle phase

McKinnon, K. E., Getsios, S. & Woodruff, T. K., Aug 21 2020, In : Biology of reproduction. 103, 3, p. 487-496 10 p.

Research output: Contribution to journalArticle

Editorial overview: Taking measure of developing plants and animals

Carthew, R. W. & Shyer, A., Aug 2020, In : Current Opinion in Genetics and Development. 63, p. iii-v

Research output: Contribution to journalEditorial

Effects of telomerase overexpression in the model organism Caenorhabditis elegans

Bayat, M., Tanny, R. E., Wang, Y., Herden, C., Daniel, J., Andersen, E. C., Liebau, E. & Waschk, D. E. J., Mar 30 2020, In : Gene. 732, 144367.

Research output: Contribution to journalArticle

Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype

Doubleday, P. F., Fornelli, L. & Kelleher, N. L., Feb 7 2020, In : Journal of Proteome Research. 19, 2, p. 938-948 11 p.

Research output: Contribution to journalArticle

Embryo integrity regulates maternal proteostasis and stress resilience

Sala, A. J., Bott, L. C., Brielmann, R. M. & Morimoto, R. I., May 1 2020, In : Genes and Development. 34, 9-10, p. 678-687 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Engineered reproductive tissues

Gargus, E. S., Rogers, H. B., McKinnon, K. E., Edmonds, M. E. & Woodruff, T. K., Apr 1 2020, In : Nature Biomedical Engineering. 4, 4, p. 381-393 13 p.

Research output: Contribution to journalReview article

4 Scopus citations

ERdj8 governs the size of autophagosomes during the formation process

Yamamoto, Y. H., Kasai, A., Omori, H., Takino, T., Sugihara, M., Umemoto, T., Hamasaki, M., Hatta, T., Natsume, T., Morimoto, R. I., Arai, R., Waguri, S., Sato, M., Sato, K., Bar-Nun, S., Yoshimori, T., Noda, T. & Nagata, K., Aug 3 2020, In : Journal of Cell Biology. 219, 8, e201903127.

Research output: Contribution to journalArticle

Open Access

Evolution of Transcriptional Repressors Impacts Caenorhabditis Vulval Development

Chamberlin, H. M., Jain, I. M., Corchado-Sonera, M., Kelley, L. H., Sharanya, D., Jama, A., Pabla, R., Dawes, A. T., Gupta, B. P. & Ruvinsky, I., May 1 2020, In : Molecular biology and evolution. 37, 5, p. 1350-1361 12 p.

Research output: Contribution to journalArticle

Exposure of human fallopian tube epithelium to elevated testosterone results in alteration of cilia gene expression and beating

Jackson-Bey, T., Colina, J., Isenberg, B. C., Coppeta, J., Urbanek, M., Kim, J. J., Woodruff, T. K., Burdette, J. E. & Russo, A., Sep 1 2020, In : Human reproduction (Oxford, England). 35, 9, p. 2086-2096 11 p.

Research output: Contribution to journalArticle

Female fertility in the cancer setting: availability and quality of online health information

de Man, A. M., Rashedi, A., Nelen, W., Anazodo, A., Rademaker, A., de Roo, S., Beerendonk, C. & Woodruff, T. K., Jul 2 2020, In : Human Fertility. 23, 3, p. 170-178 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology

Abrisch, R. G., Gumbin, S. C., Wisniewski, B. T., Lackner, L. L. & Voeltz, G. K., Apr 6 2020, In : The Journal of cell biology. 219, 4

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Fly-QMA: Automated analysis of mosaic imaginal discs in Drosophila

Bernasek, S. M., Peláez, N., Carthew, R. W., Bagheri, N. & Amaral, L. A. N., 2020, In : PLoS computational biology. 16, 3, e1007406.

Research output: Contribution to journalArticle

Open Access

Hypercapnia suppresses macrophage antiviral activity and increases mortality of influenza a infection via akt1

Casalino-Matsuda, S. M., Chen, F., Gonzalez-Gonzalez, F. J., Nair, A., Dib, S., Yemelyanov, A., Gates, K. L., Budinger, G. R. S., Beitel, G. J. & Sporn, P. H. S., Jul 15 2020, In : Journal of Immunology. 205, 2, p. 489-501 13 p.

Research output: Contribution to journalArticle

Identification of Plasmodium falciparum proteoforms from liver stage models

Winer, B., Edgel, K. A., Zou, X., Sellau, J., Hadiwidjojo, S., Garver, L. S., McDonough, C. E., Kelleher, N. L., Thomas, P. M., Villasante, E., Ploss, A. & Gerbasi, V. R., Jan 7 2020, In : Malaria journal. 19, 1, 10.

Research output: Contribution to journalArticle

Open Access

Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top-Down Mass Spectrometry

Kafader, J. O., Durbin, K. R., Melani, R. D., Des Soye, B. J., Schachner, L. F., Senko, M. W., Compton, P. D. & Kelleher, N. L., Mar 6 2020, In : Journal of Proteome Research. 19, 3, p. 1346-1350 5 p.

Research output: Contribution to journalArticle

Installing oncofertility programs for common cancers in limited resource settings (Repro-Can-OPEN Study): An extrapolation during the global crisis of Coronavirus (COVID-19) pandemic

Salama, M., Ataman-Millhouse, L., Braham, M., Berjeb, K., Khrouf, M., Rodrigues, J. K., Reis, F. M., Silva, T. C., Sánchez, F., Romero, S., Smitz, J., Vásquez, L., Vega, M., Sobral, F., Terrado, G., Lombardi, M. G., Scarella, A., Bourlon, M. T., Verduzco-Aguirre, H., Sánchez, A. M. & 31 others, Adiga, S. K., Tholeti, P., Udupa, K. S., Mahajan, N., Patil, M., Dalvi, R., Venter, C., Demetriou, G., Geel, J., Quintana, R., Rodriguez, G., Quintana, T., Viale, L., Fraguglia, M., Coirini, M., Remolina-Bonilla, Y. A., Noguera, J. A. R., Velásquez, J. C., Suarez, A., Arango, G. D., Pineda, J. I. D., Aldecoa, M. D. C., Javed, M., Al Sufyan, H., Daniels, N., Oranye, B. C., Ogunmokun, A. A., Onwuzurigbo, K. I., Okereke, C. J., Whesu, T. C. & Woodruff, T. K., Jul 1 2020, In : Journal of Assisted Reproduction and Genetics. 37, 7, p. 1567-1577 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Ligands, Receptors, and Transcription Factors that Mediate Inter-Cellular and Intra-Cellular Communication during Ovarian Follicle Development

Bernabé, B. P., Woodruff, T., Broadbelt, L. J. & Shea, L. D., Feb 1 2020, In : Reproductive Sciences. 27, 2, p. 690-703 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase

Shen, S., Doubleday, P. F., Weerawarna, P. M., Zhu, W., Kelleher, N. L. & Silverman, R. B., Jan 1 2020, (Accepted/In press) In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Micromanipulation of prophase I chromosomes from mouse spermatocytes reveals high stiffness and gel-like chromatin organization

Biggs, R. J., Liu, N., Peng, Y., Marko, J. F. & Qiao, H., Dec 1 2020, In : Communications Biology. 3, 1, 542.

Research output: Contribution to journalArticle

Open Access

MicroRNA miR-7 Regulates Secretion of Insulin-Like Peptides

Agbu, P., Cassidy, J. J., Braverman, J., Jacobson, A. & Carthew, R. W., Feb 1 2020, In : Endocrinology (United States). 161, 2, bqz040.

Research output: Contribution to journalArticle

1 Scopus citations

Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes

Kafader, J. O., Melani, R. D., Durbin, K. R., Ikwuagwu, B., Early, B. P., Fellers, R. T., Beu, S. C., Zabrouskov, V., Makarov, A. A., Maze, J. T., Shinholt, D. L., Yip, P. F., Tullman-Ercek, D., Senko, M. W., Compton, P. D. & Kelleher, N. L., Apr 1 2020, In : Nature Methods. 17, 4, p. 391-394 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response

Béguelin, W., Teater, M., Meydan, C., Hoehn, K. B., Phillip, J. M., Soshnev, A. A., Venturutti, L., Rivas, M. A., Calvo-Fernández, M. T., Gutierrez, J., Camarillo, J. M., Takata, K., Tarte, K., Kelleher, N. L., Steidl, C., Mason, C. E., Elemento, O., Allis, C. D., Kleinstein, S. H. & Melnick, A. M., May 11 2020, In : Cancer Cell. 37, 5, p. 655-673.e11

Research output: Contribution to journalArticle

2 Scopus citations

Native vs Denatured: An in Depth Investigation of Charge State and Isotope Distributions

Kafader, J. O., Melani, R. D., Schachner, L. F., Ives, A. N., Patrie, S. M., Kelleher, N. L. & Compton, P. D., Mar 4 2020, In : Journal of the American Society for Mass Spectrometry. 31, 3, p. 574-581 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Natural variation in a glucuronosyltransferase modulates propionate sensitivity in a C. elegans propionic acidemia model

Na, H., Zdraljevic, S., Tanny, R. E., Walhout, A. J. M. & Andersen, E. C., Aug 28 2020, In : PLoS genetics. 16, 8 August, e1008984.

Research output: Contribution to journalArticle

Open Access

Ndr/Lats Kinases Bind Specific Mob-Family Coactivators through a Conserved and Modular Interface

Parker, B. W., Gogl, G., Bálint, M., Hetényi, C., Reményi, A. & Weiss, E. L., May 5 2020, In : Biochemistry. 59, 17, p. 1688-1700 13 p.

Research output: Contribution to journalArticle

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle

Kosciuk, T., Price, I. R., Zhang, X., Zhu, C., Johnson, K. N., Zhang, S., Halaby, S. L., Komaniecki, G. P., Yang, M., DeHart, C. J., Thomas, P. M., Kelleher, N. L., Christopher Fromme, J. & Lin, H., Dec 1 2020, In : Nature communications. 11, 1, 1067.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry

Park, H. M., Winton, V. J., Drader, J. J., Manalili Wheeler, S., Lazar, G. A., Kelleher, N. L., Liu, Y., Tran, J. C. & Compton, P. D., Jan 21 2020, In : Analytical Chemistry. 92, 2, p. 2186-2193 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Oncofertility as a universal right and a global oncology priority

Bourlon, M. T., Anazodo, A., Woodruff, T. K. & Segelov, E., 2020, In : Journal of Global Oncology. 6, p. 314-316 3 p.

Research output: Contribution to journalEditorial

Open Access
3 Scopus citations

Ordered patterning of the sensory system is susceptible to stochastic features of gene expression

Giri, R., Papadopoulos, D. K., Posadas, D. M., Potluri, H. K., Tomancak, P., Mani, M. & Carthew, R. W., Feb 2020, In : eLife. 9, e53638.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Ovarian tissue cryopreservation as standard of care: what does this mean for pediatric populations?

Nahata, L., Woodruff, T. K., Quinn, G. P., Meacham, L. R., Chen, D., Appiah, L. C., Finlayson, C., Orwig, K. E., Laronda, M. M., Rowell, E. E., Anazodo, A., Frias, O., Rios, J. S., Whiteside, S., Gomez-Lobo, V., Dwiggins, M., Childress, K. J., Hoefgen, H. R., Levine, J. M., Jayasinghe, Y. & 1 others, Moravek, M., Jun 1 2020, In : Journal of Assisted Reproduction and Genetics. 37, 6, p. 1323-1326 4 p.

Research output: Contribution to journalComment/debate

Open Access

Phylogenetics Identifies Two Eumetazoan TRPM Clades and an Eighth TRP Family, TRP Soromelastatin (TRPS)

Himmel, N. J., Gray, T. R., Cox, D. N. & Ruvinsky, I., Jul 1 2020, In : Molecular biology and evolution. 37, 7, p. 2034-2044 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Physics and Biology (of Chromosomes)

Marko, J. F., Jan 17 2020, In : Journal of Molecular Biology. 432, 2, p. 621-631 11 p.

Research output: Contribution to journalArticle

1 Scopus citations