Research Output

2019

Coordinated Behavioral and Physiological Responses to a Social Signal Are Regulated by a Shared Neuronal Circuit

Aprison, E. Z. & Ruvinsky, I., Dec 2 2019, In : Current Biology. 29, 23, p. 4108-4115.e4

Research output: Contribution to journalArticle

3 Scopus citations

Coupling Fluorescence-Activated Cell Sorting and Targeted Analysis of Histone Modification Profiles in Primary Human Leukocytes

Camarillo, J. M., Swaminathan, S., Abshiru, N. A., Sikora, J. W., Thomas, P. M. & Kelleher, N. L., Dec 1 2019, In : Journal of the American Society for Mass Spectrometry. 30, 12, p. 2526-2534 9 p.

Research output: Contribution to journalArticle

Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing

Grandjean, J. M. D., Plate, L., Morimoto, R. I., Bollong, M. J., Powers, E. T. & Luke Wiseman, R., Apr 19 2019, In : ACS chemical biology. 14, 4, p. 784-795 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations

Crombie, T. A., Zdraljevic, S., Cook, D. E., Tanny, R. E., Brady, S. C., Wang, Y., Evans, K. S., Hahnel, S., Lee, D., Rodriguez, B. C., Zhang, G., van der Zwagg, J., Kiontke, K. & Andersen, E. C., Dec 2019, In : eLife. 8, e50465.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding

Huang, X., LeDuc, R. D., Fornelli, L., Schunter, A. J., Bennett, R. L., Kelleher, N. L. & Licht, J. D., Aug 16 2019, In : Journal of Biological Chemistry. 294, 33, p. 12459-12471 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry

Melani, R. D., Srzentić, K., Gerbasi, V. R., McGee, J. P., Huguet, R., Fornelli, L. & Kelleher, N. L., Nov 17 2019, In : mAbs. 11, 8, p. 1351-1357 7 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Discovery and Characterization of a Nitroreductase Capable of Conferring Bacterial Resistance to Chloramphenicol

Crofts, T. S., Sontha, P., King, A. O., Wang, B., Biddy, B. A., Zanolli, N., Gaumnitz, J. & Dantas, G., Apr 18 2019, In : Cell Chemical Biology. 26, 4, p. 559-570.e6

Research output: Contribution to journalArticle

7 Scopus citations

DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes

Marko, J. F., De Los Rios, P., Barducci, A. & Gruber, S., Jul 26 2019, In : Nucleic acids research. 47, 13, p. 6956-6972 17 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Dynamic Regulation of Adult-Specific Functions of the Nervous System by Signaling from the Reproductive System

Aprison, E. Z. & Ruvinsky, I., Dec 2 2019, In : Current Biology. 29, 23, p. 4116-4123.e3

Research output: Contribution to journalArticle

3 Scopus citations

Effects of altering histone posttranslational modifications on mitotic chromosome structure and mechanics

Biggs, R., Liu, P. Z., Stephens, A. D. & Marko, J. F., 2019, In : Molecular biology of the cell. 30, 7, p. 820-827 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans

Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, Berdnikovs, S. & Sznajder, J. I., Dec 1 2019, In : Scientific reports. 9, 1, 18251.

Research output: Contribution to journalArticle

Open Access

Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 503 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Escalating Threat Levels of Bacterial Infection Can Be Discriminated by Distinct MAPK and NF-κB Signaling Dynamics in Single Host Cells

Lane, K. M., Andres-Terre, M., Kudo, T., Monack, D. M. & Covert, M. W., Mar 27 2019, In : Cell Systems. 8, 3, p. 183-196.e4

Research output: Contribution to journalArticle

4 Scopus citations

Factors Affecting Fertility Decision-Making Among Transgender Adolescents and Young Adults

Chen, D., Kyweluk, M. A., Sajwani, A., Gordon, E. J., Johnson, E. K., Finlayson, C. A. & Woodruff, T. K., Apr 1 2019, In : LGBT Health. 6, 3, p. 107-115 9 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Female oncofertility attitude and knowledge: A survey of reproductive health professionals in Shanghai, China

Wang, Y., Chen, H., Ju, K., Kopp, M. F., Johnson, S. B., Farrell, K. K., Yuan, G., Ataman, L. M., Zheng, W., Woodruff, T. K. & Xiao, S., Feb 2019, In : Future Oncology. 15, 4, p. 371-379 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Formation and Electronic Structure of an Atypical CuA Site

Ross, M. O., Fisher, O. S., Morgada, M. N., Krzyaniak, M. D., Wasielewski, M. R., Vila, A. J., Hoffman, B. M. & Rosenzweig, A. C., Mar 20 2019, In : Journal of the American Chemical Society. 141, 11, p. 4678-4686 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

How can we improve oncofertility care for patients? A systematic scoping review of current international practice and models of care

Anazodo, A., Laws, P., Logan, S., Saunders, C., Travaglia, J., Gerstl, B., Bradford, N., Cohn, R., Birdsall, M., Barr, R., Suzuki, N., Takae, S., Marinho, R., Xiao, S., Qiong-Hua, C., Mahajan, N., Patil, M., Gunasheela, D., Smith, K., Sender, L. & 12 others, Melo, C., Almeida-Santos, T., Salama, M., Appiah, L., Su, I., Lane, S., Woodruff, T. K., Pacey, A., Anderson, R. A., Shenfield, F., Ledger, W. & Sullivan, E., Mar 1 2019, In : Human Reproduction Update. 25, 2, p. 159-179 21 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

How do DNA-bound proteins leave their binding sites? The role of facilitated dissociation

Erbaş, A. & Marko, J. F., Dec 2019, In : Current Opinion in Chemical Biology. 53, p. 118-124 7 p.

Research output: Contribution to journalReview article

1 Scopus citations

ICTV Virus Taxonomy Profile: Paramyxoviridae

Rima, B., Balkema-Buschmann, A., Dundon, W. G., Duprex, P., Easton, A., Fouchier, R., Kurath, G., Lamb, R., Lee, B., Rota, P., Wang, L. & Ictv Report Consortium, R. C., Dec 1 2019, In : The Journal of general virology. 100, 12, p. 1593-1594 2 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Identification and Quantification of Proteoforms by Mass Spectrometry

Schaffer, L. V., Millikin, R. J., Miller, R. M., Anderson, L. C., Fellers, R. T., Ge, Y., Kelleher, N. L., LeDuc, R. D., Liu, X., Payne, S. H., Sun, L., Thomas, P. M., Tucholski, T., Wang, Z., Wu, S., Wu, Z., Yu, D., Shortreed, M. R. & Smith, L. M., May 2019, In : Proteomics. 19, 10, 1800361.

Research output: Contribution to journalReview article

26 Scopus citations

Including sex and gender in the scientific conversation

Karczmar, A. L. & Woodruff, T. K., Jan 2019, In : Clinical chemistry. 65, 1, p. 36-38 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Inhibitors of apoptosis protect the ovarian reserve from cyclophosphamide

Luan, Y., Edmonds, M. E., Woodruff, T. K. & Kim, S. Y., Feb 1 2019, In : Journal of Endocrinology. 240, 2, p. 243-256 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Inositol phosphates and core subunits of the Sin3L/Rpd3L histone deacetylase (HDAC) complex up-regulate deacetylase activity

Marcum, R. D. & Radhakrishnan, I., Sep 20 2019, In : Journal of Biological Chemistry. 294, 38, p. 13928-13938 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

In vitro and in vivo assays for mitochondrial fission and fusion

Hoppins, S., Lackner, L. L., Lee, J. E. & Mears, J. A., Jan 1 2019, (Accepted/In press) Methods in Cell Biology. Academic Press Inc, (Methods in Cell Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

In vivo structure of the Legionella type II secretion system by electron cryotomography

Ghosal, D., Kim, K. W., Zheng, H., Kaplan, M., Truchan, H. K., Lopez, A. E., McIntire, I. E., Vogel, J. P., Cianciotto, N. P. & Jensen, G. J., Dec 1 2019, In : Nature Microbiology. 4, 12, p. 2101-2108 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Long-read sequencing reveals intra-species tolerance of substantial structural variations and new subtelomere formation in C. elegans

Kim, C., Kim, J., Kim, S., Cook, D. E., Evans, K. S., Andersen, E. C. & Lee, J., Jan 1 2019, In : Genome research. 29, 6, p. 1023-1035 13 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Mapping low-affinity/high-specificity peptide–protein interactions using ligand-footprinting mass spectrometry

Parker, B. W., Goncz, E. J., Krist, D. T., Statsyuk, A. V., Nesvizhskii, A. I. & Weiss, E. L., Oct 15 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 42, p. 21001-21011 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

MbnH is a diheme MauG-like protein associated with microbial copper homeostasis

Kenney, G. E., Dassama, L. M. K., Manesis, A. C., Ross, M. O., Chen, S., Hoffman, B. M. & Rosenzweig, A. C., Nov 1 2019, In : Journal of Biological Chemistry. 294, 44, p. 16141-16151 11 p.

Research output: Contribution to journalArticle

Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins

Kafader, J. O., Melani, R. D., Senko, M. W., Makarov, A. A., Kelleher, N. L. & Compton, P. D., Feb 19 2019, In : Analytical Chemistry. 91, 4, p. 2776-2783 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mechanical unfolding of spectrin reveals a super-exponential dependence of unfolding rate on force

Renn, J. P., Bhattacharyya, S., Bai, H., He, C., Li, H., Oberhauser, A. F., Marko, J. F., Makarov, D. E. & Matouschek, A., Jul 31 2019, In : Scientific reports. 9, 1, p. 11101 1 p., 11101.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Mechanism of Inactivation of Ornithine Aminotransferase by (1 S,3 S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid

Moschitto, M. J., Doubleday, P. F., Catlin, D. S., Kelleher, N. L., Liu, D. & Silverman, R. B., Jul 10 2019, In : Journal of the American Chemical Society. 141, 27, p. 10711-10721 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Mo-, V-, and Fe-Nitrogenases Use a Universal Eight-Electron Reductive-Elimination Mechanism to Achieve N2 Reduction

Harris, D. F., Lukoyanov, D. A., Kallas, H., Trncik, C., Yang, Z. Y., Compton, P., Kelleher, N., Einsle, O., Dean, D. R., Hoffman, B. M. & Seefeldt, L. C., Jul 30 2019, In : Biochemistry. 58, 30, p. 3293-3301 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol

Park, H. M., Satta, R., Davis, R. G., Goo, Y. A., Leduc, R. D., Fellers, R. T., Greer, J. B., Romanova, E. V., Rubakhin, S. S., Tai, R., Thomas, P. M., Sweedler, J. V., Kelleher, N. L., Patrie, S. M. & Lasek, A. W., Nov 1 2019, In : Journal of Proteome Research. 18, 11, p. 3999-4012 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Multimodal interference-based imaging of nanoscale structure and macromolecular motion uncovers UV induced cellular paroxysm

Gladstein, S., Almassalha, L. M., Cherkezyan, L., Chandler, J. E., Eshein, A., Eid, A., Zhang, D., Wu, W., Bauer, G. M., Stephens, A. D., Morochnik, S., Subramanian, H., Marko, J. F., Ameer, G. A., Szleifer, I. & Backman, V., Dec 1 2019, In : Nature communications. 10, 1, 1652.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Multiple Independent Recruitment of Sodefrin Precursor-Like Factors in Anuran Sexually Dimorphic Glands

Bossuyt, F., Schulte, L. M., Maex, M., Janssenswillen, S., Novikova, P. Y., Biju, S. D., Van De Peer, Y., Matthijs, S., Roelants, K., Martel, A., Van Bocxlaer, I. & Ruvinsky, I., Sep 1 2019, In : Molecular biology and evolution. 36, 9, p. 1921-1930 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Native top-down mass spectrometry provides insights into the copper centers of membrane-bound methane monooxygenase

Ro, S. Y., Schachner, L. F., Koo, C. W., Purohit, R., Remis, J. P., Kenney, G. E., Liauw, B. W., Thomas, P. M., Patrie, S. M., Kelleher, N. L. & Rosenzweig, A. C., Dec 1 2019, In : Nature communications. 10, 1, 2675.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Natural variation and genetic determinants of caenorhabditis elegans sperm size

Gimond, C., Vielle, A., Silva-Soares, N., Zdraljevic, S., McGrath, P. T., Andersen, E. C. & Braendle, C., 2019, In : Genetics. 213, 2, p. 615-632 18 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Natural variation in C. Elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

Zdraljevic, S., Fox, B. W., Strand, C., Panda, O., Tenjo, F. J., Brady, S. C., Crombie, T. A., Doench, J. G., Schroeder, F. C. & Andersen, E. C., Apr 2019, In : eLife. 8, e40260.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

New Year's Resolutions - New Year Reviewers - New Year of Review

Woodruff, T. K., Jan 1 2019, In : Endocrinology. 160, 1, p. 36-37 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations
3 Scopus citations

Particulate methane monooxygenase contains only mononuclear copper centers

Ross, M. O., MacMillan, F., Wang, J., Nisthal, A., Lawton, T. J., Olafson, B. D., Mayo, S. L., Rosenzweig, A. C. & Hoffman, B. M., 2019, In : Science. 364, 6440, p. 566-570 5 p.

Research output: Contribution to journalArticle

34 Scopus citations

PCuAC domains from methane-oxidizing bacteria use a histidine brace to bind copper

Fisher, O. S., Sendzik, M. R., Ross, M. O., Lawton, T. J., Hoffman, B. M. & Rosenzweig, A. C., Nov 1 2019, In : Journal of Biological Chemistry. 294, 44, p. 16351-16353 3 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

Stephens, A. D., Liu, P. Z., Kandula, V., Chen, H., Almassalha, L. M., Herman, C., Backman, V., O'Halloran, T., Adam, S. A., Goldman, R. D., Banigan, E. J. & Marko, J. F., Aug 1 2019, In : Molecular biology of the cell. 30, 17, p. 2320-2330 11 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2 Scopus citations

Poorly-controlled type 1 diabetes mellitus impairs LH-LHCGR signaling in the ovaries and decreases female fertility in mice

Lee, J., Lee, H. C., Kim, S. Y., Cho, G. J. & Woodruff, T. K., Jul 2019, In : Yonsei medical journal. 60, 7, p. 667-678 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Population Selection and Sequencing of Caenorhabditis elegans Wild Isolates Identifies a Region on Chromosome III Affecting Starvation Resistance

Webster, A. K., Hung, A., Moore, B. T., Guzman, R., Jordan, J. M., Kaplan, R. E. W., Hibshman, J. D., Tanny, R. E., Cook, D. E., Andersen, E. & Ryan Baugh, L., Oct 1 2019, In : G3: Genes, Genomes, Genetics. 9, 10, p. 3477-3488 12 p.

Research output: Contribution to journalArticle

Open Access

Precision targeting with EZH2 and HDAC inhibitors in epigenetically dysregulated lymphomas

Lue, J. K., Prabhu, S. A., Liu, Y., Gonzalez, Y., Verma, A., Mundi, P. S., Abshiru, N., Camarillo, J. M., Mehta, S., Chen, E. I., Qiao, C., Nandakumar, R., Cremers, S., Kelleher, N. L., Elemento, O. & Amengual, J. E., Sep 1 2019, In : Clinical Cancer Research. 25, 17, p. 5271-5283 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms

Huguet, R., Mullen, C., Srzentić, K., Greer, J. B., Fellers, R. T., Zabrouskov, V., Syka, J. E. P., Kelleher, N. L. & Fornelli, L., Dec 17 2019, In : Analytical Chemistry. 91, 24, p. 15732-15739 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Publishing past, present, and future

Woodruff, T. K., Jul 11 2019, In : Endocrinology. 160, 9, p. 2115-2116 2 p.

Research output: Contribution to journalEditorial

Open Access