Research Output

A genetic approach to determining glycoprotein topology: The influenza B NB glycoprotein has an extracellular NH2-terminal domain containing two N-linked carbohydrate chains

Lamb, R. A. & Williams, M. A., 1988, Modern Trends in Virology. Bauer, H., Klenk, H. D. & Scholtissek, C. (eds.). Berlin: Springer-Verlag, p. 1-14

Research output: Chapter in Book/Report/Conference proceedingChapter

A genetic screen for components of the mammalian RNA interference pathway in Bloom-deficient mouse embryonic stem cells

Trombly, M. I., Su, H. & Wang, X., 2009, In : Nucleic acids research. 37, 4, e34.

Research output: Contribution to journalArticle

12 Scopus citations

A genetic screening strategy identifies novel regulators of the proteostasis network

Silva, M. C., Fox, S., Beam, M., Thakkar, H., Amaral, M. D. & Morimoto, R. I., Dec 2011, In : PLoS genetics. 7, 12, e1002438.

Research output: Contribution to journalArticle

73 Scopus citations

A glycine to alanine substitution in the paramyxovirus SV5 fusion peptide increases the initial rate of fusion

Bagai, S. & Lamb, R. A., Nov 24 1997, In : Virology. 238, 2, p. 283-290 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Ago-2-Mediated slicer activity is essential for Anti-Flaviviral efficacy of RNAi

Chen, S., Chahar, H. S., Abraham, S., Wu, H., Pierson, T. C., Wang, X. A. & Manjunath, N., Nov 10 2011, In : PloS one. 6, 11, e27551.

Research output: Contribution to journalArticle

11 Scopus citations

A growth-related mRNA in cultured mouse cells encodes a placental calcium binding protein

Jackson-Grusby, L. L., Swiergiel, J. & Linzer, D. I. H., Aug 25 1987, In : Nucleic acids research. 15, 16, p. 6677-6690 14 p.

Research output: Contribution to journalArticle

89 Scopus citations

A head-to-head comparison of eneamide and epoxyamide inhibitors of glucosamine-6-phosphate synthase from the dapdiamide biosynthetic pathway

Hollenhorst, M. A., Ntai, I., Badet, B., Kelleher, N. L. & Walsh, C. T., May 17 2011, In : Biochemistry. 50, 19, p. 3859-3861 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

A Highly Productive, One-Pot Cell-Free Protein Synthesis Platform Based on Genomically Recoded Escherichia coli

Des Soye, B. J., Gerbasi, V. R., Thomas, P. M., Kelleher, N. L. & Jewett, M. C., Dec 19 2019, In : Cell Chemical Biology. 26, 12, p. 1743-1754.e9

Research output: Contribution to journalArticle

9 Scopus citations

A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response

Kraus, T. A., Lau, J. F., Parisien, J. P. & Horvath, C. M., Apr 11 2003, In : Journal of Biological Chemistry. 278, 15, p. 13033-13038 6 p.

Research output: Contribution to journalArticle

70 Scopus citations
82 Scopus citations

A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both α- and β-ketone reduction during chain growth

Calderone, C. T., Bumpus, S. B., Kelleher, N. L., Walsh, C. T. & Magarvey, N. A., Sep 2 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 35, p. 12809-12814 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

A kinetic and thermodynamic analysis of cleavage site mutations in the hammerhead ribozyme

Baidya, N. & Uhlenbeck, O. C., Feb 4 1997, In : Biochemistry. 36, 5, p. 1108-1114 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

A Kinetic and Thermodynamic Framework for the Hammerhead Ribozyme Reaction

Hertel, K. J., Herschlag, D. & Uhlenbeck, O. C., Mar 1 1994, In : Biochemistry. 33, 11, p. 3374-3385 12 p.

Research output: Contribution to journalArticle

244 Scopus citations

A kinetic proofreading mechanism for disentanglement of DNA by topoisomerases

Yan, J., Magnasco, M. O. & Marko, J. F., Oct 28 1999, In : Nature. 401, 6756, p. 932-935 4 p.

Research output: Contribution to journalArticle

97 Scopus citations

Alanine scanning of MS2 coat protein reveals protein-phosphate contacts involved in thermodynamic hot spots

Hobson, D. & Uhlenbeck, O. C., Feb 24 2006, In : Journal of Molecular Biology. 356, 3, p. 613-624 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

A light-harvesting antenna protein retains its folded conformation in the absence of protein-lipid and protein-pigment interactions

Kikuchi, J., Asakura, T., Loach, P. A., Parkes-Loach, P. S., Shimada, K., Hunter, C. N., Conroy, M. J. & Williamson, M. P., Apr 15 1999, In : Biopolymers. 49, 5, p. 361-372 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

A little lesson in growth regulation

Mayo, K. E., Jan 1996, In : Nature Genetics. 12, 1, p. 8-9 2 p.

Research output: Contribution to journalArticle

10 Scopus citations

Allele-specific suppression of a defective trans-Golgi network (TGN) localization signal in Kex2p identifies three genes involved in localization of TGN transmembrane proteins

Redding, K., Brickner, J. H., Marschall, L. G., Wylie Nichols, J. & Fuller, R. S., 1996, In : Molecular and cellular biology. 16, 11, p. 6208-6217 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Allosteric transcriptional regulation via changes in the overall topology of the core promoter

Philips, S. J., Canalizo-Hernandez, M., Yildirim, I., Schatz, G. C., Mondragón, A. & O'Halloran, T. V., Aug 21 2015, In : Science. 349, 6250, p. 877-881 5 p.

Research output: Contribution to journalArticle

59 Scopus citations

A low-resolution study of testicular lactate dehydrogenase using the molecular replacement technique

Donald, W., Musick, L., Adams, A. D., Rossmann, M. G., Wheat, T. E. & Goldberg, E., Jul 5 1976, In : Journal of Molecular Biology. 104, 3, p. 659-668 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Alterations to influenza virus hemagglutinin cytoplasmic tail modulate virus infectivity

Simpson, D. A. & Lamb, R. A., 1992, In : Journal of virology. 66, 2, p. 790-803 14 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations

Altered Regulation of the Mouse Metallothionein-I Gene Following Gene Amplification or Transfection

Mayo, K. E. & Palmiter, R. D., 1981, Gene Amplification. Schimke, R. (ed.). Cold Spring Harbor Press, p. 67-73

Research output: Chapter in Book/Report/Conference proceedingChapter

A matrix metalloproteinase mediates airway remodeling in Drosophila

Glasheen, B. M., Robbins, R. M., Piette, C., Beitel, G. J. & Page-McCaw, A., Aug 2010, In : Developmental Biology. 344, 2, p. 772-783 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

A metastable subproteome underlies inclusion formation in muscle proteinopathies

Ciryam, P., Antalek, M., Cid, F., Tartaglia, G. G., Dobson, C. M., Guettsches, A. K., Eggers, B., Vorgerd, M., Marcus, K., Kley, R. A., Morimoto, R. I., Vendruscolo, M. & Weihl, C. C., Dec 3 2019, In : Acta Neuropathologica Communications. 7, 1, 197.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A method for label-free, differential top-down proteomics

Ntai, I., Toby, T. K., Leduc, R. D. & Kelleher, N. L., Feb 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 121-133 13 p. (Methods in Molecular Biology; vol. 1410).

Research output: Chapter in Book/Report/Conference proceedingChapter

21 Scopus citations

A method for the quantitative analysis of human heat shock gene expression using a multiplex RT-PCR assay

Wang, S. M., Khandekar, J. D., Kaul, K. L., Winchester, D. J. & Morimoto, R. I., Sep 1 1999, In : Cell Stress and Chaperones. 4, 3, p. 153-161 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

A method of estimating the numbers of human and mouse immunoglobulin V- genes

Johnson, G. & Wu, T. T., Mar 1 1997, In : Genetics. 145, 3, p. 777-786 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

A method of estimating the numbers of human and mouse T cell receptors for antigen α and β chain V-genes

Johnson, G. & Wu, T. T., 1997, In : Immunology and Cell Biology. 75, 6, p. 580-583 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

A MicroRNA Imparts Robustness against Environmental Fluctuation during Development

Li, X., Cassidy, J. J., Reinke, C. A., Fischboeck, S. & Carthew, R. W., Apr 17 2009, In : Cell. 137, 2, p. 273-282 10 p.

Research output: Contribution to journalArticle

329 Scopus citations

A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye

Li, X. & Carthew, R. W., Dec 29 2005, In : Cell. 123, 7, p. 1267-1277 11 p.

Research output: Contribution to journalArticle

268 Scopus citations

Amino acid composition and properties of crystalline lactate dehydrogenase X from mouse testes.

Goldberg, E., Apr 10 1972, In : Journal of Biological Chemistry. 247, 7, p. 2044-2048 5 p.

Research output: Contribution to journalArticle

79 Scopus citations

Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post- transcriptional levels

Bruhat, A., Jousse, C., Wang, X. Z., Ron, D., Ferrara, M. & Fafournoux, P., Aug 5 1997, In : Journal of Biological Chemistry. 272, 28, p. 17588-17593 6 p.

Research output: Contribution to journalArticle

163 Scopus citations

Amino acid requirements for MDA5 and LGP2 recognition by paramyxovirus V proteins: A single arginine distinguishes MDA5 from RIG-I

Rodriguez, K. R. & Horvath, C. M., Mar 2013, In : Journal of virology. 87, 5, p. 2974-2978 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Amino acid sensing by Ssy1

Poulsen, P., Wu, B., Gaber, R. F., Ottow, K., Andersen, H. A. & Kielland-Brandt, M. C., Feb 1 2005, In : Biochemical Society transactions. 33, 1, p. 261-264 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Amino acid specificity in translation

Dale, T. & Uhlenbeck, O. C., Dec 2005, In : Trends in Biochemical Sciences. 30, 12, p. 659-665 7 p.

Research output: Contribution to journalArticle

56 Scopus citations
22 Scopus citations

Aminoacylation of Anticodon Loop Substituted Yeast Tyrosine Transfer RNA

Bare, L. & Uhlenbeck, O. C., Apr 1 1985, In : Biochemistry. 24, 9, p. 2354-2360 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria

Hoppins, S., Collins, S. R., Cassidy-Stone, A., Hummel, E., DeVay, R. M., Lackner, L. L., Westermann, B., Schuldiner, M., Weissman, J. S. & Nunnari, J., Oct 17 2011, In : Journal of Cell Biology. 195, 2, p. 323-340 18 p.

Research output: Contribution to journalArticle

292 Scopus citations

Ammonia affects the glycosylation patterns of recombinant mouse placental lactogen‐I by chinese hamster ovary cells in a pH‐dependent manner

Borys, M. C., Linzer, D. I. H. & Papoutsakis, E. T., Mar 15 1994, In : Biotechnology and Bioengineering. 43, 6, p. 505-514 10 p.

Research output: Contribution to journalArticle

90 Scopus citations

A model for the tertiary structure of transfer ribonucleic acids

Te Wu, T., Jun 1969, In : The bulletin of mathematical biophysics. 31, 2, p. 395-402 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

A model for three-point analysis of random general transduction.

Wu, T. T., Aug 1 1966, In : Genetics. 54, 2, p. 405-410 6 p.

Research output: Contribution to journalArticle

151 Scopus citations

A monovalent streptavidin with a single femtomolar biotin binding site

Howarth, M., Chinnapen, D. J. F., Gerrow, K., Dorrestein, P. C., Grandy, M. R., Kelleher, N. L., El-Husseini, A. & Ting, A. Y., Apr 1 2006, In : Nature Methods. 3, 4, p. 267-273 7 p.

Research output: Contribution to journalArticle

235 Scopus citations

A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction

Rapoport, I., Boll, W., Yu, A., Böcking, T. & Kirchhausen, T., Jan 2008, In : Molecular biology of the cell. 19, 1, p. 405-413 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Amphiphilic, hydrophilic, or hydrophobic synthetic bacteriochlorins in biohybrid light-harvesting architectures: Consideration of molecular designs

Jiang, J., Reddy, K. R., Pavan, M. P., Lubian, E., Harris, M. A., Jiao, J., Niedzwiedzki, D. M., Kirmaier, C., Parkes-Loach, P. S., Loach, P. A., Bocian, D. F., Holten, D. & Lindsey, J. S., Nov 2014, In : Photosynthesis Research. 122, 2, p. 187-202 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Amplifiers co-translationally enhance CFTR biosynthesis via PCBP1-mediated regulation of CFTR mRNA

Dukovski, D., Villella, A., Bastos, C., King, R., Finley, D., Kelly, J. W., Morimoto, R. I., Hartl, F. U., Munoz, B., Lee, P. S., Zecevic, M. & Miller, J. P., Sep 2020, In : Journal of Cystic Fibrosis. 19, 5, p. 733-741 9 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

A MUC16 IgG binding activity selects for a restricted subset of IgG enriched for certain simian immunodeficiency virus epitope specificities

Schneider, J. R., Shen, X., Orlandi, C., Nyanhete, T., Sawant, S., Carias, A. M., Smith, A. D., Kelleher, N. L., Veazey, R. S., Lewis, G. K., Tomaras, G. D. & Hope, T. J., Mar 1 2020, In : Journal of virology. 94, 5, e01246-19.

Research output: Contribution to journalArticle

A mutant lactogenic hormone binds, but does not activate, the prolactin receptor

Davis, J. A. & Linzer, D. I. H., Jun 1989, In : Molecular Endocrinology. 3, 6, p. 949-953 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

A mutation in histone H2B represents a new class of oncogenic driver

Bennett, R. L., Bele, A., Small, E. C., Will, C. M., Nabet, B., Oyer, J. A., Huang, X., Ghosh, R. P., Grzybowski, A. T., Yu, T., Zhang, Q., Riva, A., Lele, T. P., Schatz, G. C., Kelleher, N. L., Ruthenburg, A. J., Liphardt, J. & Licht, J. D., Oct 2019, In : Cancer discovery. 9, 10, p. 1438-1451 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
10 Scopus citations

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia

Swaroop, A., Oyer, J. A., Will, C. M., Huang, X., Yu, W., Troche, C., Bulic, M., Durham, B. H., Wen, Q. J., Crispino, J. D., MacKerell, A. D., Bennett, R. L., Kelleher, N. L. & Licht, J. D., Jan 31 2019, In : Oncogene. 38, 5, p. 671-686 16 p.

Research output: Contribution to journalArticle

7 Scopus citations