Research Output

2017

Mitochondria-driven assembly of a cortical anchor for mitochondria and dynein

Kraft, L. M. & Lackner, L. L., Oct 1 2017, In : Journal of Cell Biology. 216, 10, p. 3061-3071 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging

Labbadia, J., Brielmann, R. M., Neto, M. F., Lin, Y. F., Haynes, C. M. & Morimoto, R. I., Nov 7 2017, In : Cell reports. 21, 6, p. 1481-1494 14 p.

Research output: Contribution to journalArticle

40 Scopus citations

Modulation of Protein Fragmentation Through Carbamylation of Primary Amines

Greer, S. M., Holden, D. D., Fellers, R., Kelleher, N. L. & Brodbelt, J. S., Aug 1 2017, In : Journal of the American Society for Mass Spectrometry. 28, 8, p. 1587-1599 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Molecular envelope and atomic model of an anti-terminated glyQS T-box regulator in complex with tRNAGly

Chetnani, B. & Mondragón, A., Jul 1 2017, In : Nucleic acids research. 45, 13, p. 8079-8090 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C. I., Anekalla, K. R., Joshi, N., Williams, K. J. N., Abdala-Valencia, H., Yacoub, T. J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Gates, K., Lam, A. P., Nicholson, T. T., Homan, P. J., Soberanes, S. & 23 others, Dominguez, S., Morgan, V. K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S. A., Bharat, A., Berdnikovs, S., Bhorade, S. M., Bartom, E. T., Morimoto, R. I., Balch, W. E., Sznajder, J. I., Chandel, N. S., Mutlu, G. M., Jain, M., Gottardi, C. J., Singer, B. D., Ridge, K. M., Bagheri, N., Shilatifard, A., Budinger, G. R. S. & Perlman, H., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2387-2404 18 p.

Research output: Contribution to journalArticle

216 Scopus citations

Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation

Wong, J. J. W., Young, T. A., Zhang, J., Liu, S., Leser, G. P., Komives, E. A., Lamb, R. A., Zhou, Z. H., Salafsky, J. & Jardetzky, T. S., Dec 1 2017, In : Nature communications. 8, 1, 781.

Research output: Contribution to journalArticle

12 Scopus citations

Native Electron Capture Dissociation Maps to Iron-Binding Channels in Horse Spleen Ferritin

Skinner, O. S., McAnally, M. O., Van Duyne, R. P., Schatz, G. C., Breuker, K., Compton, P. D. & Kelleher, N. L., Oct 17 2017, In : Analytical Chemistry. 89, 20, p. 10711-10716 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Natural diversity facilitates the discovery of conserved chemotherapeutic response mechanisms

Zdraljevic, S. & Andersen, E. C., Dec 2017, In : Current Opinion in Genetics and Development. 47, p. 41-47 7 p.

Research output: Contribution to journalReview article

4 Scopus citations

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons

Zdraljevic, S., Strand, C., Seidel, H. S., Cook, D. E., Doench, J. G. & Andersen, E. C., Jul 2017, In : PLoS genetics. 13, 7, e1006891.

Research output: Contribution to journalArticle

14 Scopus citations

Natural Variation in the Distribution and Abundance of Transposable Elements Across the Caenorhabditis elegans Species

Laricchia, K. M., Zdraljevic, S., Cook, D. E. & Andersen, E. C., Sep 1 2017, In : Molecular biology and evolution. 34, 9, p. 2187-2202 16 p.

Research output: Contribution to journalArticle

15 Scopus citations

Next-generation approaches to understand and combat the antibiotic resistome

Crofts, T. S., Gasparrini, A. J. & Dantas, G., Jun 13 2017, In : Nature Reviews Microbiology. 15, 7, p. 422-434 13 p.

Research output: Contribution to journalReview article

155 Scopus citations

Nuclear Pore Complexes: A Scaffold Regulating Developmental Transcription?

Satomura, A. & Brickner, J. H., Sep 2017, In : Trends in Cell Biology. 27, 9, p. 621-622 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Nucleation of Multiple Buckled Structures in Intertwined DNA Double Helices

Brahmachari, S., Gunn, K. H., Giuntoli, R. D., Mondragón, A. & Marko, J. F., Oct 31 2017, In : Physical review letters. 119, 18, 188103.

Research output: Contribution to journalArticle

4 Scopus citations

Nup98 regulation of histone methylation promotes normal gene expression and may drive leukemogenesis

Sump, B. & Brickner, J. H., Nov 30 2017, In : Genes and Development. 31, 22, p. 2201-2203 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Oligomerization and ATP stimulate condensin-mediated DNA compaction

Keenholtz, R. A., Dhanaraman, T., Palou, R., Yu, J., D'amours, D. & Marko, J. F., Dec 1 2017, In : Scientific reports. 7, 1, 14279.

Research output: Contribution to journalArticle

16 Scopus citations

Out of the testis: Biological impacts of new genes

Nyberg, K. G. & Carthew, R. W., Sep 15 2017, In : Genes and Development. 31, 18, p. 1825-1826 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Possibility and challenges of conversion of current virus species names to Linnaean binomials

Postler, T. S., Clawson, A. N., Amarasinghe, G. K., Basler, C. F., Bavari, S., Benko, M., Blasdell, K. R., Briese, T., Buchmeier, M. J., Bukreyev, A., Calisher, C. H., Chandran, K., Charrel, R., Clegg, C. S., Collins, P. L., De La Torre, J. C., DeRisi, J. L., Dietzgen, R. G., Dolnik, O., Dürrwald, R. & 52 others, Dye, J. M., Easton, A. J., Emonet, S., Formenty, P., Fouchier, R. A. M., Ghedin, E., Gonzalez, J. P., Harrach, B., Hewson, R., Horie, M., Jiāng, D., Kobinger, G., Kondo, H., Kropinski, A. M., Krupovic, M., Kurath, G., Lamb, R. A., Leroy, E. M., Lukashevich, I. S., Maisner, A., Mushegian, A. R., Netesov, S. V., Nowotny, N., Patterson, J. L., Payne, S. L., Paweska, J. T., Peters, C. J., Radoshitzky, S. R., Rima, B. K., Romanowski, V., Rubbenstroth, D., Sabanadzovic, S., Sanfaçon, H., Salvato, M. S., Schwemmle, M., Smither, S. J., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Volchkov, V. E., Wahl-Jensen, V., Walker, P. J., Wang, L. F., Varsani, A., Whitfield, A. E., Murilo Zerbini, F. & Kuhn, J. H., May 1 2017, In : Systematic Biology. 66, 3, p. 463-473 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Practices and Attitudes Regarding Women Undergoing Fertility Preservation: A Survey of the National Physicians Cooperative

Bortoletto, P., Confino, R., Smith, B. M., Woodruff, T. K. & Pavone, M. E., Sep 1 2017, In : Journal of adolescent and young adult oncology. 6, 3, p. 444-449 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Protein homeostasis of a metastable subproteome associated with Alzheimer's disease

Kundra, R., Ciryam, P., Morimoto, R. I., Dobson, C. M. & Vendruscolo, M., Jul 11 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 28, p. E5703-E5711

Research output: Contribution to journalArticle

31 Scopus citations

Proteoforms in Peripheral Blood Mononuclear Cells as Novel Rejection Biomarkers in Liver Transplant Recipients

Toby, T. K., Abecassis, M., Kim, K., Thomas, P. M., Fellers, R. T., LeDuc, R. D., Kelleher, N. L., Demetris, J. & Levitsky, J., Sep 2017, In : American Journal of Transplantation. 17, 9, p. 2458-2467 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Regeneration: Organizing the Blastema in Planarians

Petersen, C. P., Mar 6 2017, In : Current Biology. 27, 5, p. R181-R183

Research output: Contribution to journalShort survey

3 Scopus citations

Rethinking HSF1 in Stress, Development, and Organismal Health

Li, J., Labbadia, J. & Morimoto, R. I., Dec 2017, In : Trends in Cell Biology. 27, 12, p. 895-905 11 p.

Research output: Contribution to journalReview article

66 Scopus citations

Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5′-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover

Mascarenhas, R., Le, H. V., Clevenger, K. D., Lehrer, H. J., Ringe, D., Kelleher, N. L., Silverman, R. B. & Liu, D., Sep 19 2017, In : Biochemistry. 56, 37, p. 4951-4961 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Selective whole-genome amplification is a robust method that enables scalable whole-genome sequencing of Plasmodium vivax from unprocessed clinical samples

Cowell, A. N., Loy, D. E., Sundararaman, S. A., Valdivia, H., Fisch, K., Lescano, A. G., Baldeviano, G. C., Durand, S., Gerbasi, R. V., Sutherland, C. J., Nolder, D., Vinetz, J. M., Hahn, B. H. & Winzeler, E. A., Jan 1 2017, In : mBio. 8, 1, e02257-16.

Research output: Contribution to journalArticle

18 Scopus citations

Shaping proteostasis at the cellular, tissue, and organismal level

Sala, A. J., Bott, L. C. & Morimoto, R. I., May 1 2017, In : Journal of Cell Biology. 216, 5, p. 1231-1241 11 p.

Research output: Contribution to journalReview article

75 Scopus citations

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS

Ciryam, P., Lambert-Smith, I. A., Bean, D. M., Freer, R., Cid, F., Tartaglia, G. G., Saunders, D. N., Wilson, M. R., Oliver, S. G., Morimoto, R. I., Dobson, C. M., Vendruscolo, M., Favrin, G. & Yerbury, J. J., May 16 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 20, p. E3935-E3943

Research output: Contribution to journalArticle

37 Scopus citations

Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus

Wen, X., Mousa, J. J., Bates, J. T., Lamb, R. A., Crowe, J. E. & Jardetzky, T. S., Jan 30 2017, In : Nature Microbiology. 2, 16272.

Research output: Contribution to journalArticle

24 Scopus citations

Structural Insights into the Eukaryotic Transcription Initiation Machinery

Nogales, E., Louder, R. K. & He, Y., May 22 2017, In : Annual Review of Biophysics. 46, p. 59-83 25 p.

Research output: Contribution to journalReview article

35 Scopus citations

Structural mechanism of ATP-independent transcription initiation by RNA polymerase I

Han, Y., Yan, C., Nguyen, T. H. D., Jackobel, A. J., Ivanov, I., Knutson, B. A. & He, Y., Jun 17 2017, In : eLife. 6, e27414.

Research output: Contribution to journalArticle

29 Scopus citations

Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ

Clevenger, K. D., Mascarenhas, R., Catlin, D., Wu, R., Kelleher, N. L., Drake, E. J., Gulick, A. M., Liu, D. & Fast, W., Mar 17 2017, In : ACS chemical biology. 12, 3, p. 643-647 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Supercoiling DNA Locates Mismatches

Dittmore, A., Brahmachari, S., Takagi, Y., Marko, J. F. & Neuman, K. C., Oct 3 2017, In : Physical review letters. 119, 14, 147801.

Research output: Contribution to journalArticle

9 Scopus citations

Taxonomy of the order Mononegavirales: update 2017

Amarasinghe, G. K., Bào, Y., Basler, C. F., Bavari, S., Beer, M., Bejerman, N., Blasdell, K. R., Bochnowski, A., Briese, T., Bukreyev, A., Calisher, C. H., Chandran, K., Collins, P. L., Dietzgen, R. G., Dolnik, O., Dürrwald, R., Dye, J. M., Easton, A. J., Ebihara, H., Fang, Q. & 53 others, Formenty, P., Fouchier, R. A. M., Ghedin, E., Harding, R. M., Hewson, R., Higgins, C. M., Hong, J., Horie, M., James, A. P., Jiāng, D., Kobinger, G. P., Kondo, H., Kurath, G., Lamb, R. A., Lee, B., Leroy, E. M., Li, M., Maisner, A., Mühlberger, E., Netesov, S. V., Nowotny, N., Patterson, J. L., Payne, S. L., Paweska, J. T., Pearson, M. N., Randall, R. E., Revill, P. A., Rima, B. K., Rota, P., Rubbenstroth, D., Schwemmle, M., Smither, S. J., Song, Q., Stone, D. M., Takada, A., Terregino, C., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Volchkov, V. E., Wahl-Jensen, V., Walker, P. J., Wang, B., Wang, D., Wang, F., Wang, L. F., Werren, J. H., Whitfield, A. E., Yan, Z., Ye, G. & Kuhn, J. H., Aug 1 2017, In : Archives of Virology. 162, 8, p. 2493-2504 12 p.

Research output: Contribution to journalArticle

126 Scopus citations

The dynamic three-dimensional organization of the diploid yeast genome

Kim, S., Liachko, I., Brickner, D. G., Cook, K., Noble, W. S., Brickner, J. H., Shendure, J. & Dunham, M. J., May 24 2017, In : eLife. 6

Research output: Contribution to journalArticle

4 Scopus citations

The dynamic three-dimensional organization of the diploid yeast genome

Kim, S., Liachko, I., Brickner, D. G., Cook, K., Noble, W. S., Brickner, J. H., Shendure, J. & Dunham, M. J., May 24 2017, In : eLife. 6, e23623.

Research output: Contribution to journalArticle

20 Scopus citations

The genetic basis of natural variation in a phoretic behavior

Lee, D., Yang, H., Kim, J., Brady, S., Zdraljevic, S., Zamanian, M., Kim, H., Paik, Y. K., Kruglyak, L., Andersen, E. C. & Lee, J., Dec 1 2017, In : Nature communications. 8, 1, 273.

Research output: Contribution to journalArticle

17 Scopus citations

The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop

Budinger, G. S., Kohanski, R. A., Gan, W., Kobor, M. S., Amaral, L. A., Armanios, M., Kelsey, K. T., Pardo, A., Tuder, R., Macian, F., Chandel, N., Vaughan, D., Rojas, M., Mora, A. L., Kovacs, E., Duncan, S. R., Finkel, T., Choi, A., Eickelberg, O., Chen, D. & 8 others, Agusti, A., Selman, M., Balch, W. E., Busse, P., Lin, A., Morimoto, R., Sznajder, J. I. & Thannickal, V. J., Nov 1 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 11, p. 1492-1500 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

The mechanisms and functions of interorganelle interactions

Lackner, L. L. & Voeltz, G. K., Mar 15 2017, In : Molecular biology of the cell. 28, 6, p. 703-704 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

The promise of organ and tissue preservation to transform medicine

Giwa, S., Lewis, J. K., Alvarez, L., Langer, R., Roth, A. E., Church, G. M., Markmann, J. F., Sachs, D. H., Chandraker, A., Wertheim, J. A., Rothblatt, M., Boyden, E. S., Eidbo, E., Lee, W. P. A., Pomahac, B., Brandacher, G., Weinstock, D. M., Elliott, G., Nelson, D., Acker, J. P. & 22 others, Uygun, K., Schmalz, B., Weegman, B. P., Tocchio, A., Fahy, G. M., Storey, K. B., Rubinsky, B., Bischof, J., Elliott, J. A. W., Woodruff, T. K., Morris, G. J., Demirci, U., Brockbank, K. G. M., Woods, E. J., Ben, R. N., Baust, J. G., Gao, D., Fuller, B., Rabin, Y., Kravitz, D. C., Taylor, M. J. & Toner, M., Jun 7 2017, In : Nature biotechnology. 35, 6, p. 530-542 13 p.

Research output: Contribution to journalReview article

112 Scopus citations

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

Piunti, A., Hashizume, R., Morgan, M. A., Bartom, E. T., Horbinski, C. M., Marshall, S. A., Rendleman, E. J., Ma, Q., Takahashi, Y. H., Woodfin, A. R., Misharin, A. V., Abshiru, N. A., Lulla, R. R., Saratsis, A. M., Kelleher, N. L., James, C. D. & Shilatifard, A., Apr 1 2017, In : Nature Medicine. 23, 4, p. 493-500 8 p.

Research output: Contribution to journalArticle

121 Scopus citations

The role of Notch signaling in the mammalian ovary

Vanorny, D. A. & Mayo, K. E., 2017, In : Reproduction. 153, 6, p. R187-R204

Research output: Contribution to journalReview article

23 Scopus citations

Torque and buckling in stretched intertwined double-helix DNAs

Brahmachari, S. & Marko, J. F., May 1 2017, In : Physical Review E. 95, 5, 052401.

Research output: Contribution to journalArticle

7 Scopus citations

Translation system engineering in Escherichia coli enhances non-canonical amino acid incorporation into proteins

Gan, R., Perez, J. G., Carlson, E. D., Ntai, I., Isaacs, F. J., Kelleher, N. L. & Jewett, M. C., May 1 2017, In : Biotechnology and Bioengineering. 114, 5, p. 1074-1086 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

Type II secretion substrates of Legionella pneumophila translocate out of the pathogen-occupied vacuole via a semipermeable membrane

Truchan, H. K., Christman, H. D., White, R. C., Rutledge, N. S. & Cianciotto, N. P., May 1 2017, In : mBio. 8, 3, e00870-17.

Research output: Contribution to journalArticle

14 Scopus citations

UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition

Ezponda, T., Dupéré-Richer, D., Will, C. M., Small, E. C., Varghese, N., Patel, T., Nabet, B., Popovic, R., Oyer, J., Bulic, M., Zheng, Y., Huang, X., Shah, M. Y., Maji, S., Riva, A., Occhionorelli, M., Tonon, G., Kelleher, N., Keats, J. & Licht, J. D., Oct 17 2017, In : Cell reports. 21, 3, p. 628-640 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

VCF-kit: Assorted utilities for the variant call format

Cook, D. E. & Andersen, E. C., May 15 2017, In : Bioinformatics. 33, 10, p. 1581-1582 2 p.

Research output: Contribution to journalArticle

19 Scopus citations
5 Scopus citations

Zinc sparks induce physiochemical changes in the egg zona pellucida that prevent polyspermy

Que, E. L., Duncan, F. E., Bayer, A. R., Philips, S. J., Roth, E. W., Bleher, R., Gleber, S. C., Vogt, S., Woodruff, T. K. & O'Halloran, T. V., Feb 2017, In : Integrative Biology (United Kingdom). 9, 2, p. 135-144 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

“When You’re a Baby You Don’t Have Puberty”: Understanding of Puberty and Human Reproduction in Late Childhood and Early Adolescence

Hurwitz, L. B., Lauricella, A. R., Hightower, B., Sroka, I., Woodruff, T. K. & Wartella, E., Aug 1 2017, In : Journal of Early Adolescence. 37, 7, p. 925-947 23 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV

Wen, X., Pickens, J., Mousa, J. J., Leser, G. P., Lamb, R. A., Crowe, J. E. & Jardetzky, T. S., May 2016, In : PloS one. 11, 5, e0155917.

Research output: Contribution to journalArticle

9 Scopus citations

A method for label-free, differential top-down proteomics

Ntai, I., Toby, T. K., Leduc, R. D. & Kelleher, N. L., Feb 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 121-133 13 p. (Methods in Molecular Biology; vol. 1410).

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations