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2015

A powerful new quantitative genetics platform, combining caenorhabditis elegans high-throughput fitness assays with a large collection of recombinant strains

Andersen, E. C., Shimko, T. C., Crissman, J. R., Ghosh, R., Bloom, J. S., Seidel, H. S., Gerke, J. P. & Kruglyak, L., Jan 1 2015, In : G3: Genes, Genomes, Genetics. 5, 5, p. 911-920 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Architecture of the human XPC DNA repair and stem cell coactivator complex

Zhang, E. T., He, Y., Grob, P., Fong, Y. W., Nogales, E. & Tjian, R., Dec 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 48, p. 14817-14822 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

A Small Molecule That Switches a Ubiquitin Ligase from a Processive to a Distributive Enzymatic Mechanism

Kathman, S. G., Span, I., Smith, A. T., Xu, Z., Zhan, J., Rosenzweig, A. C. & Statsyuk, A. V., Oct 7 2015, In : Journal of the American Chemical Society. 137, 39, p. 12442-12445 4 p.

Research output: Contribution to journalArticle

35 Scopus citations

A Wild C. Elegans Strain Has Enhanced Epithelial Immunity to a Natural Microsporidian Parasite

Balla, K. M., Andersen, E. C., Kruglyak, L. & Troemel, E. R., Jan 1 2015, In : PLoS pathogens. 11, 2, e1004583.

Research output: Contribution to journalArticle

20 Scopus citations

Biophysics of protein-DNA interactions and chromosome organization

Marko, J. F., Jan 15 2015, In : Physica A: Statistical Mechanics and its Applications. 418, p. 126-153 28 p.

Research output: Contribution to journalArticle

28 Scopus citations

Cell division: Stem cells take the stage

Wignall, S. M., May 4 2015, In : Current Biology. 25, p. 376-378

Research output: Contribution to journalArticle

1 Scopus citations

Change in the gastro-intestinal tract by overexpressed activin beta A

Kim, M. N., Kim, Y. I., Cho, C., Mayo, K. E. & Cho, B. N., Nov 24 2015, In : Molecules and Cells. 38, 12, p. 1079-1085 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Comparative genomic analysis of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis

Valdivia, H. O., Reis-Cunha, J. L., Rodrigues-Luiz, G. F., Baptista, R. P., Baldeviano, G. C., Gerbasi, R. V., Dobson, D. E., Pratlong, F., Bastien, P., Lescano, A. G., Beverley, S. M. & Bartholomeu, D. C., Sep 18 2015, In : BMC Genomics. 16, 1, 715.

Research output: Contribution to journalArticle

30 Scopus citations

Conformational dynamics of a class C G-protein-coupled receptor

Vafabakhsh, R., Levitz, J. & Isacoff, E. Y., Aug 27 2015, In : Nature. 524, 7566, p. 497-501 5 p.

Research output: Contribution to journalArticle

81 Scopus citations

Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases

Brigui, A., Hofmann, L., Argüelles, C., Sanial, M., Holmgren, R. A. & Plessis, A., Oct 7 2015, In : Open Biology. 5, 10, 150112.

Research output: Contribution to journalArticle

4 Scopus citations

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

Nillegoda, N. B., Kirstein, J., Szlachcic, A., Berynskyy, M., Stank, A., Stengel, F., Arnsburg, K., Gao, X., Scior, A., Aebersold, R., Guilbride, D. L., Wade, R. C., Morimoto, R. I., Mayer, M. P. & Bukau, B., Aug 13 2015, In : Nature. 524, 7564, p. 247-251 5 p.

Research output: Contribution to journalArticle

141 Scopus citations

Defining the neuropeptidome of the spiny lobster Panulirus interruptus brain using a multidimensional mass spectrometry-based platform

Ye, H., Wang, J., Zhang, Z., Jia, C., Schmerberg, C., Catherman, A. D., Thomas, P. M., Kelleher, N. L. & Li, L., Nov 6 2015, In : Journal of Proteome Research. 14, 11, p. 4776-4791 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

Design and Mechanism of Tetrahydrothiophene-Based γ-Aminobutyric Acid Aminotransferase Inactivators

Le, H. V., Hawker, D. D., Wu, R., Doud, E., Widom, J., Sanishvili, R., Liu, D., Kelleher, N. L. & Silverman, R. B., Mar 17 2015, In : Journal of the American Chemical Society. 137, 13, p. 4525-4533 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Differential association of chromatin proteins identifies BAF60a/SMARCD1 as a regulator of embryonic stem cell differentiation

Alajem, A., Biran, A., Harikumar, A., Sailaja, B. S., Aaronson, Y., Livyatan, I., Nissim-Rafinia, M., Sommer, A. G., Mostoslavsky, G., Gerbasi, V. R., Golden, D. E., Datta, A., Sze, S. K. & Meshorer, E., Mar 31 2015, In : Cell reports. 10, 12, p. 2019-2031 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Differential nucleosome occupancies across Oct4-Sox2 binding sites in murine embryonic stem cells

Sebeson, A., Xi, L., Zhang, Q., Sigmund, A., Wang, J. P., Widom, J. & Wang, X., May 18 2015, In : PloS one. 10, 5, e0127214.

Research output: Contribution to journalArticle

5 Scopus citations

Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs

Kim, T. J., Joo, C., Seong, J., Vafabakhsh, R., Botvinick, E. L., Berns, M. W., Palmer, A. E., Wang, N., Ha, T., Jakobsson, E., Sun, J. & Wang, Y., Feb 10 2015, In : eLife. 2015, 4, e04876.

Research output: Contribution to journalArticle

29 Scopus citations

DNA-Segment-Facilitated Dissociation of Fis and NHP6A from DNA Detected via Single-Molecule Mechanical Response

Giuntoli, R. D., Linzer, N. B., Banigan, E. J., Sing, C. E., De La Cruz, M. O., Graham, J. S., Johnson, R. C. & Marko, J. F., Sep 25 2015, In : Journal of Molecular Biology. 427, 19, p. 3123-3136 14 p.

Research output: Contribution to journalArticle

24 Scopus citations

DNase H Activity of Neisseria meningitidis Cas9

Zhang, Y., Rajan, R., Seifert, H., Mondragon, A. & Sontheimer, E. J., Oct 15 2015, In : Molecular cell. 60, 2, p. 242-255 14 p.

Research output: Contribution to journalArticle

33 Scopus citations

Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation

Peláez, N., Gavalda-Miralles, A., Wang, B., Navarro, H. T., Gudjonson, H., Rebay, I., Dinner, A. R., Katsaggelos, A. K., Amaral, L. A. N. & Carthew, R. W., Nov 19 2015, In : eLife. 4, NOVEMBER2015, e08924.

Research output: Contribution to journalArticle

13 Scopus citations

Enzymatic oxidation of methane

Sirajuddin, S. & Rosenzweig, A. C., Apr 14 2015, In : Biochemistry. 54, 14, p. 2283-2294 12 p.

Research output: Contribution to journalArticle

119 Scopus citations

Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids

Amiram, M., Haimovich, A. D., Fan, C., Wang, Y. S., Aerni, H. R., Ntai, I., Moonan, D. W., Ma, N. J., Rovner, A. J., Hong, S. H., Kelleher, N. L., Goodman, A. L., Jewett, M. C., Söll, D., Rinehart, J. & Isaacs, F. J., Dec 1 2015, In : Nature biotechnology. 33, 12, p. 1272-1279 8 p.

Research output: Contribution to journalArticle

104 Scopus citations

Experience modulates the reproductive response to heat stress in C. elegans via multiple physiological processes

Gouvêa, D. Y., Aprison, E. Z. & Ruvinsky, I., Dec 1 2015, In : PloS one. 10, 12, e0145925.

Research output: Contribution to journalArticle

8 Scopus citations

Fungal artificial chromosomes for mining of the fungal secondary metabolome

Bok, J. W., Ye, R., Clevenger, K. D., Mead, D., Wagner, M., Krerowicz, A., Albright, J. C., Goering, A. W., Thomas, P. M., Kelleher, N. L., Keller, N. P. & Wu, C. C., Dec 12 2015, In : BMC Genomics. 16, 1, 343.

Research output: Contribution to journalArticle

33 Scopus citations
27 Scopus citations

Identification of specific corrinoids reveals corrinoid modification in dechlorinating microbial communities

Men, Y., Seth, E. C., Yi, S., Crofts, T. S., Allen, R. H., Taga, M. E. & Alvarez-Cohen, L., Dec 1 2015, In : Environmental Microbiology. 17, 12, p. 4873-4884 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Improving cell-free protein synthesis through genome engineering of Escherichia coli lacking release factor 1

Hong, S. H., Kwon, Y. C., Martin, R. W., Des Soye, B. J., De Paz, A. M., Swonger, K. N., Ntai, I., Kelleher, N. L. & Jewett, M. C., Mar 23 2015, In : ChemBioChem. 16, 5, p. 844-853 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Influenza a virus uses intercellular connections to spread to neighboring cells

Roberts, K. L., Manicassamy, B. & Lamb, R. A., Jan 1 2015, In : Journal of virology. 89, 3, p. 1537-1549 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

In memoriam--Richard M. Elliott (1954-2015)

Brennan, B., Weber, F., Kormelink, R., Schnettler, E., Bouloy, M., Failloux, A. B., Weaver, S. C., Fazakerley, J. K., Fragkoudis, R., Harris, M., Barr, J. N., Palese, P., García-Sastre, A., Dalziel, R. G., Dutia, B. M., Lowen, A. C., Steel, J., Randall, R. E., Paul Duprex, W., Rice, C. M. & 30 others, Tesh, R. B., Murphy, F. A., Ebihara, H., Vasconcelos, P. F. C., Nunes, M. R., Fooks, A. R., Smith, G. L., Goodfellow, I., Pappu, H. R., Lamb, R. A., Paterson, R. G., Higgs, S., Vanlandingham, D. L., Dietzgen, R. G., Stephen Lodmell, J., Nichol, S. T., Daly, J., Ullman, D. E., Plyusnin, A., Plyusnina, A., Efstathiou, S., Hewson, R., Tordo, N., Cherry, S., Boutell, C., Hosie, M. J., Murcia, P. R., Neil, J. C., Palmarini, M. & Patel, A. H., Aug 1 2015, In : The Journal of general virology. 96, 8, p. 1975-1978 4 p.

Research output: Contribution to journalArticle

INO1 transcriptional memory leads to DNA zip code-dependent interchromosomal clustering

Brickner, D. G., Coukos, R. & Brickner, J. H., Dec 1 2015, In : Microbial Cell. 2, 12, p. 481-490 10 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Investigating the spreading and toxicity of prion-like proteins using the metazoan model organism C. Elegans

Nussbaum-Krammer, C. I., Neto, M. F., Brielmann, R. M., Pedersen, J. S. & Morimoto, R. I., Jan 8 2015, In : Journal of Visualized Experiments. 95, e52321.

Research output: Contribution to journalArticle

55 Scopus citations

In vitro selection of DNAs with an increased propensity to form small circles

Rosanio, G., Widom, J. & Uhlenbeck, O. C., Jan 1 2015, In : Biopolymers. 103, 6, p. 303-320 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

Kinetochore-independent chromosome segregation driven by lateral microtubule bundles

Muscat, C. C., Torre-Santiago, K. M., Tran, M. V., Powers, J. A. & Wignall, S. M., May 30 2015, In : eLife.

Research output: Contribution to journalArticle

33 Scopus citations

Large-Scale Metabolomics Reveals a Complex Response of Aspergillus nidulans to Epigenetic Perturbation

Albright, J. C., Henke, M. T., Soukup, A. A., McClure, R. A., Thomson, R. J., Keller, N. P. & Kelleher, N. L., Jun 19 2015, In : ACS chemical biology. 10, 6, p. 1535-1541 7 p.

Research output: Contribution to journalArticle

40 Scopus citations

Loss of BAP1 function leads to EZH2-dependent transformation

Lafave, L. M., Béguelin, W., Koche, R., Teater, M., Spitzer, B., Chramiec, A., Papalexi, E., Keller, M. D., Hricik, T., Konstantinoff, K., Micol, J. B., Durham, B., Knutson, S. K., Campbell, J. E., Blum, G., Shi, X., Doud, E. H., Krivtsov, A. V., Chung, Y. R., Khodos, I. & 11 others, De Stanchina, E., Ouerfelli, O., Adusumilli, P. S., Thomas, P. M., Kelleher, N. L., Luo, M., Keilhack, H., Abdel-Wahab, O., Melnick, A., Armstrong, S. A. & Levine, R. L., Nov 1 2015, In : Nature Medicine. 21, 11, p. 1344-1349 6 p.

Research output: Contribution to journalArticle

137 Scopus citations

Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis

Cleland, T. P., Schroeter, E. R., Zamdborg, L., Zheng, W., Lee, J. E., Tran, J. C., Bern, M., Duncan, M. B., Lebleu, V. S., Ahlf, D. R., Thomas, P. M., Kalluri, R., Kelleher, N. L. & Schweitzer, M. H., Dec 4 2015, In : Journal of Proteome Research. 14, 12, p. 5252-5262 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid

Lee, H., Le, H. V., Wu, R., Doud, E., Sanishvili, R., Kellie, J. F., Compton, P. D., Pachaiyappan, B., Liu, D., Kelleher, N. L. & Silverman, R. B., Sep 18 2015, In : ACS chemical biology. 10, 9, p. 2087-2098 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid

Tang, W., Li, H., Doud, E. H., Chen, Y., Choing, S., Plaza, C., Kelleher, N. L., Poulos, T. L. & Silverman, R. B., May 13 2015, In : Journal of the American Chemical Society. 137, 18, p. 5980-5989 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1 S,3 S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115)

Lee, H., Doud, E. H., Wu, R., Sanishvili, R., Juncosa, J. I., Liu, D., Kelleher, N. L. & Silverman, R. B., Feb 25 2015, In : Journal of the American Chemical Society. 137, 7, p. 2628-2640 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Molecular Basis for the Mechanism of Constitutive CBP/p300 Coactivator Recruitment by CRTC1-MAML2 and Its Implications in cAMP Signaling

Clark, M. D., Kumar, G. S., Marcum, R., Luo, Q., Zhang, Y. & Radhakrishnan, I., Sep 8 2015, In : Biochemistry. 54, 35, p. 5439-5446 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Native GELFrEE: A new separation technique for biomolecular assemblies

Skinner, O. S., Do Vale, L. H. F., Catherman, A. D., Havugimana, P. C., Sousa, M. V. D., Compton, P. D. & Kelleher, N. L., Mar 3 2015, In : Analytical Chemistry. 87, 5, p. 3032-3038 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Neuronal serotonin release triggers the heat shock response in C elegans in the absence of temperature increase

Tatum, M. C., Ooi, F. K., Chikka, M. R., Chauve, L., Martinez-Velazquez, L. A., Steinbusch, H. W. M., Morimoto, R. I. & Prahlad, V., Jan 19 2015, In : Current Biology. 25, 2, p. 163-174 12 p.

Research output: Contribution to journalArticle

58 Scopus citations

Online matrix removal platform for coupling gel-based separations to whole protein electrospray ionization mass spectrometry

Kim, K. H., Compton, P. D., Tran, J. C. & Kelleher, N. L., May 1 2015, In : Journal of Proteome Research. 14, 5, p. 2199-2206 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

On the stability of parainfluenza virus 5 F proteins

Poor, T. A., Song, A. S., Welch, B. D., Kors, C. A., Jardetzky, T. S. & Lamb, R. A., Jan 1 2015, In : Journal of virology. 89, 6, p. 3438-3441 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Pan-cancer analysis of TCGA data reveals notable signaling pathways

Neapolitan, R. E., Horvath, C. M. & Jiang, X., Jul 14 2015, In : BMC cancer. 15, 1, 516.

Research output: Contribution to journalArticle

17 Scopus citations

Phylum-Level Conservation of Regulatory Information in Nematodes despite Extensive Non-coding Sequence Divergence

Gordon, K. L., Arthur, R. K. & Ruvinsky, I., May 1 2015, In : PLoS genetics. 11, 5, e1005268.

Research output: Contribution to journalArticle

6 Scopus citations

Probing asymmetric charge partitioning of protein oligomers during tandem mass spectrometry

Compton, P. D., Fornelli, L., Kelleher, N. L. & Skinner, O. S., Aug 29 2015, In : International Journal of Mass Spectrometry. 390, p. 132-136 5 p., 15491.

Research output: Contribution to journalArticle

6 Scopus citations

ProSight Lite: Graphical software to analyze top-down mass spectrometry data

Fellers, R. T., Greer, J. B., Early, B. P., Yu, X., Leduc, R. D., Kelleher, N. L. & Thomas, P. M., Apr 1 2015, In : Proteomics. 15, 7, p. 1235-1238 4 p.

Research output: Contribution to journalArticle

97 Scopus citations

Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments

Kirstein, J., Morito, D., Kakihana, T., Sugihara, M., Minnen, A., Hipp, M. S., Nussbaum-Krammer, C., Kasturi, P., Hartl, F. U., Nagata, K. & Morimoto, R. I., Sep 1 2015, In : EMBO Journal. 34, 18, p. 2334-2349 16 p.

Research output: Contribution to journalArticle

47 Scopus citations

Redox metabolites signal polymicrobial biofilm development via the napa oxidative stress cascade in aspergillus

Zheng, H., Kim, J., Liew, M., Yan, J. K., Herrera, O., Bok, J. W., Kelleher, N. L., Keller, N. P. & Wang, Y., Jan 5 2015, In : Current Biology. 25, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
5 Scopus citations