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2015

Remarkably divergent regions punctuate the genome assembly of the Caenorhabditis elegans hawaiian strain CB4856

Thompson, O. A., Snoek, L. B., Nijveen, H., Sterken, M. G., Volkers, R. J. M., Brenchley, R., van’t Hof, A., Bevers, R. P. J., Cossins, A. R., Yanai, I., Hajnal, A., Schmid, T., Perkins, J. D., Spencer, D., Kruglyak, L., Andersen, E. C., Moerman, D. G., Hillier, L. D. W., Kammenga, J. E. & Waterston, R. H., Jul 1 2015, In : Genetics. 200, 3, p. 975-989 15 p.

Research output: Contribution to journalArticle

43 Scopus citations

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

Labbadia, J. & Morimoto, R. I., Aug 20 2015, In : Molecular Cell. 59, 4, p. 639-650 12 p.

Research output: Contribution to journalArticle

107 Scopus citations

Scaling, selection, and evolutionary dynamics of the mitotic spindle

Farhadifar, R., Baer, C. F., Valfort, A. C., Andersen, E. C., Müller-Reichert, T., Delattre, M. & Needleman, D. J., Mar 16 2015, In : Current Biology. 25, 6, p. 732-740 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease

Teixeira-Castro, A., Jalles, A., Esteves, S., Kang, S., Da Silva Santos, L., Silva-Fernandes, A., Neto, M. F., Brielmann, R. M., Bessa, C., Duarte-Silva, S., Miranda, A., Oliveira, S., Neves-Carvalho, A., Bessa, J., Summavielle, T., Silverman, R. B., Oliveira, P., Morimoto, R. I. & Maciel, P., Nov 2015, In : Brain. 138, 11, p. 3221-3237 17 p.

Research output: Contribution to journalArticle

35 Scopus citations

Sex Pheromones of C. elegans Males Prime the Female Reproductive System and Ameliorate the Effects of Heat Stress

Aprison, E. Z. & Ruvinsky, I., Jan 1 2015, In : PLoS genetics. 11, 12, e1005729.

Research output: Contribution to journalArticle

17 Scopus citations

Shared regulatory programs suggest retention of blastula-stage potential in neural crest cells

Buitrago-Delgado, E., Nordin, K., Rao, A., Geary, L. & LaBonne, C., Jun 19 2015, In : Science. 348, 6241, p. 1332-1335 4 p.

Research output: Contribution to journalArticle

70 Scopus citations
2 Scopus citations

Structural Basis for Multi-specificity of MRG Domains

Xie, T., Zmyslowski, A. M., Zhang, Y. & Radhakrishnan, I., Jun 3 2015, In : Structure. 23, 6, p. 1049-1057 9 p., 3153.

Research output: Contribution to journalArticle

9 Scopus citations

Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex

Clark, M. D., Marcum, R., Graveline, R., Chan, C. W., Xie, T., Chen, Z., Ding, Y., Zhang, Y., Mondragón, A., David, G. & Radhakrishnan, I., Jul 14 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 28, p. E3669-E3678

Research output: Contribution to journalArticle

15 Scopus citations

Structure of Full-Length Human PDGFRβ Bound to Its Activating Ligand PDGF-B as Determined by Negative-Stain Electron Microscopy

Chen, P. H., Unger, V. & He, X., Dec 4 2015, In : Journal of Molecular Biology. 427, 24, p. 3921-3934 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Structure of the paramyxovirus parainfluenza virus 5 nucleoprotein-RNA complex

Alayyoubi, M., Leser, G. P., Kors, C. A. & Lamb, R. A., Apr 7 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 14, p. E1792-E1799

Research output: Contribution to journalArticle

50 Scopus citations

Teashirt is required for head-versus-tail regeneration polarity in planarians

Owen, J. H., Wagner, D. E., Chen, C. C., Petersen, C. P. & Reddien, P. W., Mar 15 2015, In : Development (Cambridge). 142, 6, p. 1062-1072 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Tertiary Amine Pyrazolones and Their Salts as Inhibitors of Mutant Superoxide Dismutase 1-Dependent Protein Aggregation for the Treatment of Amyotrophic Lateral Sclerosis

Zhang, Y., Zhao, K. T., Fox, S. G., Kim, J., Kirsch, D. R., Ferrante, R. J., Morimoto, R. I. & Silverman, R. B., Jul 17 2015, In : Journal of Medicinal Chemistry. 58, 15, p. 5942-5949 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

The red death meets the abdominal bristle: Polygenic mutation for susceptibility to a bacterial pathogen in Caenorhabditis elegans

Etienne, V., Andersen, E. C., Ponciano, J. M., Blanton, D., Cadavid, A., Joyner-Matos, J., Matsuba, C., Tabman, B. & Baer, C. F., Feb 1 2015, In : Evolution. 69, 2, p. 508-519 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

The Structure of an NDR/LATS Kinase–Mob Complex Reveals a Novel Kinase–Coactivator System and Substrate Docking Mechanism

Gógl, G., Schneider, K. D., Yeh, B. J., Alam, N., Nguyen Ba, A. N., Moses, A. M., Hetényi, C., Reményi, A. & Weiss, E. L., May 12 2015, In : PLoS biology. 13, 5, e1002146.

Research output: Contribution to journalArticle

26 Scopus citations

Top down proteomics reveals mature proteoforms expressed in subcellular fractions of the Echinococcus granulosus preadult stage

Lorenzatto, K. R., Kim, K., Ntai, I., Paludo, G. P., Camargo De Lima, J., Thomas, P. M., Kelleher, N. L. & Ferreira, H. B., Nov 6 2015, In : Journal of Proteome Research. 14, 11, p. 4805-4814 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tunable loading of oligonucleotides with secondary structure on gold nanoparticles through a pH-driven method

Dam, D. H. M., Lee, H., Lee, R. C., Kim, K. H., Kelleher, N. L. & Odom, T. W., Feb 18 2015, In : Bioconjugate Chemistry. 26, 2, p. 279-285 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Type II integral membrane protein, TM of J paramyxovirus promotes cell-to-cell fusion

Li, Z., Hung, C., Paterson, R. G., Michel, F., Fuentes, S., Place, R., Lin, Y., Hogan, R. J., Lamb, R. A. & He, B., Oct 6 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 40, p. 12504-12509 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Widespread proteome remodeling and aggregation in aging C. elegans

Walther, D. M., Kasturi, P., Zheng, M., Pinkert, S., Vecchi, G., Ciryam, P., Morimoto, R. I., Dobson, C. M., Vendruscolo, M., Mann, M. & Hartl, F. U., May 7 2015, In : Cell. 161, 4, p. 919-932 14 p.

Research output: Contribution to journalArticle

229 Scopus citations

Wnt/Notum spatial feedback inhibition controls neoblast differentiation to regulate reversible growth of the planarian brain

Hill, E. M. & Petersen, C. P., Dec 15 2015, In : Development (Cambridge). 142, 24, p. 4217-4229 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

Zygotic genome activation triggers the DNA replication checkpoint at the midblastula transition

Blythe, S. A. & Wieschaus, E. F., Mar 15 2015, In : Cell. 160, 6, p. 1169-1181 13 p.

Research output: Contribution to journalArticle

78 Scopus citations
2014

A bioassay for the detection of benzimidazoles reveals their presence in a range of environmental samples

Crofts, T. S., Men, Y., Alvarez-Cohen, L. & Taga, M. E., Jan 1 2014, In : Frontiers in Microbiology. 5, NOV, 592.

Research output: Contribution to journalArticle

13 Scopus citations

A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease

Brehme, M., Voisine, C., Rolland, T., Wachi, S., Soper, J. H., Zhu, Y., Orton, K., Villella, A., Garza, D., Vidal, M., Ge, H. & Morimoto, R. I., Jan 1 2014, In : Cell reports. 9, 3, p. 1135-1150 16 p.

Research output: Contribution to journalArticle

196 Scopus citations

A comparative study of pointed and yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling

Boisclair Lachance, J. F., Peláez, N., Cassidy, J. J., Webber, J. L., Rebay, I. & Carthew, R. W., Jan 15 2014, In : Developmental Biology. 385, 2, p. 263-278 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

Amphiphilic, hydrophilic, or hydrophobic synthetic bacteriochlorins in biohybrid light-harvesting architectures: Consideration of molecular designs

Jiang, J., Reddy, K. R., Pavan, M. P., Lubian, E., Harris, M. A., Jiao, J., Niedzwiedzki, D. M., Kirmaier, C., Parkes-Loach, P. S., Loach, P. A., Bocian, D. F., Holten, D. & Lindsey, J. S., Nov 2014, In : Photosynthesis Research. 122, 2, p. 187-202 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Antiviral RNA recognition and assembly by RLR family innate immune sensors

Bruns, A. M. & Horvath, C. M., Oct 1 2014, In : Cytokine and Growth Factor Reviews. 25, 5, p. 507-512 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Applying label-free quantitation to top down proteomics

Ntai, I., Kim, K., Fellers, R. T., Skinner, O. S., Smith, A. D., Early, B. P., Savaryn, J. P., Leduc, R. D., Thomas, P. M. & Kelleher, N. L., May 20 2014, In : Analytical Chemistry. 86, 10, p. 4961-4968 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Aroadmap for natural product discovery based on large-scale genomics and metabolomics

Doroghazi, J. R., Albright, J. C., Goering, A. W., Ju, K. S., Haines, R. R., Tchalukov, K. A., Labeda, D. P., Kelleher, N. L. & Metcalf, W. W., Nov 1 2014, In : Nature Chemical Biology. 10, 11, p. 963-968 6 p.

Research output: Contribution to journalArticle

218 Scopus citations

A Role for WDR5 in Integrating Threonine 11 Phosphorylation to Lysine 4 Methylation on Histone H3 during Androgen Signaling and in Prostate Cancer

Kim, J. Y., Banerjee, T., Vinckevicius, A., Luo, Q., Parker, J. B., Baker, M. R., Radhakrishnan, I., Wei, J. J., Barish, G. D. & Chakravarti, D., May 22 2014, In : Molecular cell. 54, 4, p. 613-625 13 p.

Research output: Contribution to journalArticle

59 Scopus citations

A Synthetic Biology Approach Identifies the Mammalian UPR RNA Ligase RtcB

Lu, Y., Liang, F. X. & Wang, X., Jan 1 2014, In : Molecular cell. 55, 5, p. 758-770 13 p.

Research output: Contribution to journalArticle

92 Scopus citations

Autopilot: An online data acquisition control system for the enhanced high-throughput characterization of intact proteins

Durbin, K. R., Fellers, R. T., Ntai, I., Kelleher, N. L. & Compton, P. D., Feb 4 2014, In : Analytical Chemistry. 86, 3, p. 1485-1492 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

A Variant in the Neuropeptide Receptor npr-1 is a Major Determinant of Caenorhabditis elegans Growth and Physiology

Andersen, E. C., Bloom, J. S., Gerke, J. P. & Kruglyak, L., Feb 1 2014, In : PLoS genetics. 10, 2, e1004156.

Research output: Contribution to journalArticle

50 Scopus citations

Balanced trade-offs between alternative strategies shape the response of C. elegans reproduction to chronic heat stress

Aprison, E. Z. & Ruvinsky, I., Aug 28 2014, In : PloS one. 9, 8, e105513.

Research output: Contribution to journalArticle

13 Scopus citations

Biochemical characterization of the topoisomerase domain of Methanopyrus kandleri topoisomerase V

Rajan, R., Osterman, A. K., Gast, A. T. & Mondragón, A., Oct 17 2014, In : Journal of Biological Chemistry. 289, 42, p. 28898-28909 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
29 Scopus citations

Cell-free protein synthesis from a release factor 1 deficient escherichia coli activates efficient and multiple site-specific nonstandard amino acid incorporation

Hong, S. H., Ntai, I., Haimovich, A. D., Kelleher, N. L., Isaacs, F. J. & Jewett, M. C., Jun 20 2014, In : ACS synthetic biology. 3, 6, p. 398-409 12 p.

Research output: Contribution to journalArticle

76 Scopus citations

Cell morphogenesis proteins are translationally controlled through UTRs by the Ndr/LATS target Ssd1

Wanless, A. G., Lin, Y. & Weiss, E. L., Jan 21 2014, In : PloS one. 9, 1, e85212.

Research output: Contribution to journalArticle

15 Scopus citations

Characterization of a cross-linked protein-nucleic acid substrate radical in the reaction catalyzed by RlmN

Silakov, A., Grove, T. L., Radle, M. I., Bauerle, M. R., Green, M. T., Rosenzweig, A. C., Boal, A. K. & Booker, S. J., Jun 11 2014, In : Journal of the American Chemical Society. 136, 23, p. 8221-8228 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1

Ryno, L. M., Genereux, J. C., Naito, T., Morimoto, R. I., Powers, E. T., Shoulders, M. D. & Wiseman, R. L., Jun 20 2014, In : ACS chemical biology. 9, 6, p. 1273-1283 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Comparing label-free quantitative peptidomics approaches to characterize diurnal variation of peptides in the rat suprachiasmatic nucleus

Southey, B. R., Lee, J. E., Zamdborg, L., Atkins, N., Mitchell, J. W., Li, M., Gillette, M. U., Kelleher, N. L. & Sweedler, J. V., Jan 7 2014, In : Analytical Chemistry. 86, 1, p. 443-452 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

COPASutils: An R package for reading, processing, and visualizing data from copas large-particle flow cytometers

Shimko, T. C. & Andersen, E. C., Oct 20 2014, In : PloS one. 9, 10, 0111090.

Research output: Contribution to journalArticle

12 Scopus citations

Designing a nine cysteine-less DNA packaging motor from bacteriophage T4 reveals new insights into ATPase structure and function

Kondabagil, K., Dai, L., Vafabakhsh, R., Ha, T., Draper, B. & Rao, V. B., Nov 1 2014, In : Virology. 468, p. 660-668 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Detecting Functional Divergence after Gene Duplication through Evolutionary Changes in Posttranslational Regulatory Sequences

Nguyen Ba, A. N., Strome, B., Hua, J. J., Desmond, J., Gagnon-Arsenault, I., Weiss, E. L., Landry, C. R. & Moses, A. M., Dec 1 2014, In : PLoS computational biology. 10, 12

Research output: Contribution to journalArticle

19 Scopus citations

Deuteration and fluorination of 1,3-bis(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione to improve its pharmacokinetic properties

Xia, G., Benmohamed, R., Morimoto, R. I., Kirsch, D. R. & Silverman, R. B., Nov 1 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 21, p. 5098-5101 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant

Izumo, M., Pejchal, M., Schook, A. C., Lange, R. P., Walisser, J. A., Sato, T. R., Wang, X., Bradfield, C. A. & Takahashi, J. S., Jan 1 2014, In : eLife. 3

Research output: Contribution to journalArticle

72 Scopus citations

Diversity of the metal-transporting P1B-type ATPases

Smith, A. T., Smith, K. P. & Rosenzweig, A. C., Jan 1 2014, In : Journal of Biological Inorganic Chemistry. 19, 6, p. 947-960 14 p.

Research output: Contribution to journalArticle

47 Scopus citations

Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1

Kitamura, A., Inada, N., Kubota, H., Matsumoto, G., Kinjo, M., Morimoto, R. I. & Nagata, K., Mar 1 2014, In : Genes to Cells. 19, 3, p. 209-224 16 p.

Research output: Contribution to journalArticle

26 Scopus citations

Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus

Rey-Carrizo, M., Barniol-Xicota, M., Ma, C., Frigolé-Vivas, M., Torres, E., Naesens, L., Llabrés, S., Juárez-Jiménez, J., Luque, F. J., Degrado, W. F., Lamb, R. A., Pinto, L. H. & Vázquez, S., Jul 10 2014, In : Journal of Medicinal Chemistry. 57, 13, p. 5738-5747 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Effects of lipid environment on the conformational changes of an ABC importer

Rice, A. J., Alvarez, F. J. D., Davidson, A. L. & Pinkett, H. W., Jan 1 2014, In : Channels. 8, 4, p. 327-333 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Effects of zinc on particulate methane monooxygenase activity and structure

Sirajuddin, S., Barupala, D., Helling, S., Marcus, K., Stemmler, T. L. & Rosenzweig, A. C., Aug 1 2014, In : Journal of Biological Chemistry. 289, 31, p. 21782-21794 13 p.

Research output: Contribution to journalArticle

23 Scopus citations