Northwestern Synchrotron Research Center - LS CAT

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Crystal structure Chemical Compounds
Catalytic Domain Medicine & Life Sciences
Sterol 14-Demethylase Medicine & Life Sciences
Conformations Chemical Compounds
scytalone dehydratase Medicine & Life Sciences
Enzymes Medicine & Life Sciences
X-Rays Medicine & Life Sciences
Hydrogen Medicine & Life Sciences

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Research Output 1981 2019

1 Citation (Scopus)

Structural and Antiviral Studies of the Human Norovirus GII.4 Protease

Muzzarelli, K. M., Kuiper, B., Spellmon, N., Brunzelle, J. S., Hackett, J., Amblard, F., Zhou, S., Liu, P., Kovari, I. A., Yang, Z., Schinazi, R. F. & Kovari, L. C., Jan 1 2019, (Accepted/In press) In : Biochemistry.

Research output: Contribution to journalArticle

Norovirus
Antiviral Agents
Peptide Hydrolases
Pharmaceutical Preparations
Disease Outbreaks
2 Citations (Scopus)

Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states

Yan, Y., Edward Zhou, X., Novick, S. J., Shaw, S. J., Li, Y., Brunzelle, J. S., Hitoshi, Y., Griffin, P. R., Eric Xu, H. & Melcher, K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 3, p. 953-967 15 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Nucleotides
Pharmacology
Chemical activation
Phosphotransferases
1 Citation (Scopus)

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

Hargrove, T. Y., Wawrzak, Z., Fisher, P. M., Child, S. A., David Nes, W., Peter Guengerich, F., Waterman, M. R. & Lepesheva, G. I., Jan 1 2018, In : Journal of Biological Chemistry. 293, 50, p. 19344-19353 10 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Cytochrome P-450 Enzyme System
Sterols
Ligands
Catalysis

Grants 2001 2019