Surgery, Transplant Surgery Division

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Novel Therapies of Chronic Allograft Dysfunction (B-Cell Depletion by Anti-CD20 (Rituximab) in RA Recipients Who Develop Early de novo Anti-HLA Alloantibodies will Result in Inhibition of Alloantibody Production and Attenuation of CHR (CTOT-2])
Friedewald, J. J. (PD/PI) & Abecassis, M. M. (Co-PD/PI)
Brigham and Women’s Hospital, National Institute of Allergy and Infectious Diseases
9/1/05 → 8/31/12
Project: Research project
Permeability Changes in Small Bowel Allograft Rejection
Fryer, J. P. (PD/PI) & Zhang, Z. J. (Co-PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
8/15/05 → 6/30/07
Project: Research project
Permeability Changes in Small Bowel Allograft Rejection
Fryer, J. P. (PD/PI) & Zhang, Z. J. (Co-PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
8/15/05 → 6/30/07
Project: Research project
Prot# IM103027: Belatacept Evaluation of Nephroprotection and Efficacy as First-Line Immunosuppression Trial -- Extended Criteria Donors (BENEFIT-EXT) [Phase 3, Randomized, Partially-Blinded, Active-Controlled, Parallel-Group, Multicenter Clinical Trial]
Gallon, L. (PD/PI), Abecassis, M. M. (Co-PD/PI), Baker, T. B. (Co-PD/PI), Gallon, L. (Co-PD/PI) & Leventhal, J. R. (Co-PD/PI)
ICON Clinical Research, LLC, Bristol-Myers Squibb Company
6/15/05 → 12/1/14
Project: Research project
Prot# A3921009: 6-Mnth, Phz 2, Mltctr, Rndmzd, Opn-Lbl, Cmp'tv Study of 2 Dose Levels of CP-690,550 Admin'd Concomitantly w/ IL-2 Receptor Antagonist Induction Therapy, Mycophenolate Mofetil & Corticosteroids vs Tacrolimus-Based Immunosuppressive Regimen
Leventhal, J. R. (PD/PI), Abecassis, M. M. (Co-PD/PI), Baker, T. B. (Co-PD/PI), Fryer, J. P. (Co-PD/PI) & Gallon, L. (Co-PD/PI)
CTI Clinical Trial and Consulting Services, Pfizer Inc.
6/13/05 → 1/12/10
Project: Research project
Prot# ML18124: A Prospective, Randomized, Multicenter, Open-Label, Comparative Safety & Efficacy Study of Prophylactically Administered Pegylated Interferon alfa-2a (Pegasys®) + Ribavirin vs. No Prophylaxis Following Liver Transplantation for Hepatitis C
Kulik, L. M. (PD/PI), Abecassis, M. M. (Co-PD/PI), Baker, T. B. (Co-PD/PI) & Fryer, J. P. (Co-PD/PI)
Roche Laboratories Inc.
2/4/05 → 11/1/11
Project: Research project
Prot# CEL220: A Phase IV, Single Center Pilot Study Using Alemtuzumab (CAMPATH-1H) Induction Combined with Prednisone-Free and Calcineurin-Inhibitor-Free Immunosuppression in Kidney Transplantation
Leventhal, J. R. (PD/PI) & Gallon, L. (Co-PD/PI)
Roche Laboratories Inc.
1/25/05 → 11/1/11
Project: Research project
Piscine Islet Transplantation for Treatment of Diabetes: A Pilot Study in Non-Human Primates
Leventhal, J. R. (PD/PI)
Northwestern Memorial Foundation
1/1/05 → 12/31/05
Project: Research project
Piscine Islet Transplantation for Treatment of Diabetes: A Pilot Study in Non-Human Primates
Leventhal, J. R. (PD/PI)
Northwestern Memorial Foundation
1/1/05 → 12/31/05
Project: Research project
Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT): A Randomized, Controlled Clinical Trial of the Effect of a High Dose Combination of Folic Acid, Vitamin B6 and Vitamin B12, on Arteriosclerotic Cardiovascular Disease Outcomes in Chro
Gallon, L. (PD/PI), Abecassis, M. M. (Co-PD/PI) & Leventhal, J. R. (Co-PD/PI)
Rhode Island Hospital, National Institute of Diabetes and Digestive and Kidney Diseases
10/1/04 → 1/31/09
Project: Research project
Molecular Profiling and Immunomodulatory Intervention
Abecassis, M. M. (PD/PI), Friedewald, J. J. (Co-PD/PI), Gallon, L. (Co-PD/PI), Kulik, L. M. (Co-PD/PI) & Friedewald, J. J. (Co-Investigator)
University of Pennsylvania, National Institute of Allergy and Infectious Diseases
9/15/04 → 8/31/11
Project: Research project
Desensitization of Cross Match Positive Renal Transplant Recipients Using Alemtuzumab: An Investigator Initiated Proposal (ICAM085)
Leventhal, J. R. (PD/PI) & Gallon, L. (Co-PD/PI)
ILEX Oncology, Inc.
8/20/04 → 1/14/10
Project: Research project
Desensitization of Cross Match Positive Renal Transplant Recipients Using Alemtuzumab: An Investigator Initiated Proposal (ICAM085)
Leventhal, J. R. (PD/PI) & Gallon, L. (Co-PD/PI)
ILEX Oncology, Inc.
8/20/04 → 1/14/10
Project: Research project
CD4+CD25+ Regulatory T Cells as Cellular Therapy for Prevention of Kidney Allograft Rejection
Leventhal, J. R. (PD/PI) & Zhang, Z. J. (Co-PD/PI)
National Kidney Foundation of Illinois
7/1/04 → 6/30/06
Project: Research project
Prot# 0468H1-313-US: A Randomized, Open-Label, Comparative Evaluation of Conversion from Calcineurin Inhibitor Treatment to Sirolimus Treatment vs. Continued Calcineurin Inhibitor Treatment in Liver Allograft Recipients Undergoing Maintenance Therapy
Levitsky, J. (PD/PI), Abecassis, M. M. (Co-PD/PI), Fryer, J. P. (Co-PD/PI) & Kulik, L. M. (Co-PD/PI)
Wyeth
6/18/04 → 3/1/12
Project: Research project
Prot# 02-01-L: An Open-Label, Randomized, Prospective Multicenter Study to Compare Efficacy & Safety Among 3 Immunosuppressant Treatment Regimens in Patients Receiving a Liver Transplant for End-Stage Liver Disease Caused by Chronic Hepatitis C Infection
Abecassis, M. M. (PD/PI), Fryer, J. P. (Co-PD/PI) & Kulik, L. M. (Co-PD/PI)
Baylor College of Medicine, Roche Laboratories Inc.
1/30/04 → 8/30/06
Project: Research project
Prot# 02-01-L: An Open-Label, Randomized, Prospective Multicenter Study to Compare Efficacy & Safety Among 3 Immunosuppressant Treatment Regimens in Patients Receiving a Liver Transplant for End-Stage Liver Disease Caused by Chronic Hepatitis C Infection
Abecassis, M. M. (PD/PI), Fryer, J. P. (Co-PD/PI) & Kulik, L. M. (Co-PD/PI)
Baylor College of Medicine, Roche Laboratories Inc.
1/30/04 → 8/30/06
Project: Research project
Prot# CRAD001A US09: A Prospective, Multicenter, Open-Label, Randomized Study of Safety, Tolerability & Efficacy of Certican® (RAD001) w/ Simulect®, Corticosteroids & Lower Levels Versus Higher Levels of Tacrolimus in de novo Renal Transplant Recipients
Abecassis, M. M. (PD/PI), Gallon, L. (Co-PD/PI) & Leventhal, J. R. (Co-PD/PI)
Novartis Pharmaceuticals Corporation
10/17/03 → 4/30/05
Project: Research project
An Open-Label, Randomized Study of Recurrent Hepatitis C Post-Liver Transplant with Prograf® to Neoral® Conversion and C2 Monitoring - An Investigator Initiated Trial
Abecassis, M. M. (Co-PD/PI), Fryer, J. P. (Co-PD/PI) & Kulik, L. M. (Co-PD/PI)
Novartis Pharmaceuticals Corporation
10/21/02 → 1/1/11
Project: Research project
Adult Live Donor Liver Transplant: A Comparative Analysis
Abecassis, M. M. (Co-PD/PI), Baker, T. B. (Co-PD/PI), Borensztajn, J. (Co-PD/PI), Kulik, L. M. (Co-PD/PI), Miller, F. H. (Co-PD/PI), Mulcahy, M. F. (Co-PD/PI) & Musunuri, S. R. (Co-PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
9/17/02 → 8/31/09
Project: Research project
The A2ALL LADR Protocol: Pre-Transplant Treatment to Prevent Recurrence of Hepatitis C After Living Donor Liver Transplantation
Kulik, L. M. (PD/PI) & Abecassis, M. M. (Co-PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
9/17/02 → 8/31/09
Project: Research project
Adult Live Donor Liver Transplant: A Comparative Analysis
Abecassis, M. M. (Co-PD/PI), Baker, T. B. (Co-PD/PI), Borensztajn, J. (Co-PD/PI), Kulik, L. M. (Co-PD/PI), Miller, F. H. (Co-PD/PI), Mulcahy, M. F. (Co-PD/PI) & Musunuri, S. R. (Co-PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
9/17/02 → 8/31/09
Project: Research project
The A2ALL LADR Protocol: Pre-Transplant Treatment to Prevent Recurrence of Hepatitis C After Living Donor Liver Transplantation
Kulik, L. M. (PD/PI) & Abecassis, M. M. (Co-PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
9/17/02 → 8/31/09
Project: Research project
A Single Center, Open-Label Study of Rapid Corticosteroid Withdrawal in Kidney Transplantation: A Randomized Trial of Sirolimus vs Mycophenolate Mofetil in Transplant Recipients Receiving Tacrolimus-Based Immunotherapy (Study# KAB-00-001)
Abecassis, M. M. (Co-PD/PI), Fryer, J. P. (Co-PD/PI) & Leventhal, J. R. (Co-PD/PI)
Fujisawa Healthcare, Inc.
9/20/00 → 8/7/09
Project: Research project
A Single Center, Open-Label Study of Rapid Corticosteroid Withdrawal in Kidney Transplantation: A Randomized Trial of Sirolimus vs Mycophenolate Mofetil in Transplant Recipients Receiving Tacrolimus-Based Immunotherapy (Study# KAB-00-001)
Abecassis, M. M. (Co-PD/PI), Fryer, J. P. (Co-PD/PI) & Leventhal, J. R. (Co-PD/PI)
Fujisawa Healthcare, Inc.
9/20/00 → 8/7/09
Project: Research project