Aaron Hamvas

  • 4480 Citations
1990 …2021
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Personal profile

Research Interests

Mutations in pulmonary surfactant associated genes result in newborn respiratory distress but can also contribute to idiopathic pulmonary fibrosis in adults. We use exome sequencing to identify genes and gene pathways that might inform variability in penetrance of these mutations and also provide further insights into the development of chronic lung disease (bronchopulmonary dysplasia) in premature newborns. We are also part of an NIH-funded clinical observational study that combines analysis of continuous physiologic data streams, echocardiographic measures, and measures of autonomic nervous system function to identify physiologic perturbations that have an impact on cardiac, respiratory, and neurologic outcomes of premature babies.

Dr. Hamvas has a longstanding interest in genetic contributions to lung diseases that affect newborns, children and adults, he has combined his clinical interests in the care of newborn respiratory diseases with an integrated investigative program to understand the modifiable factors that influence outcomes of newborns.

Diffuse lung diseases in newborns and children

Certifications and Licenses

Neonatal-Perinatal Medicine

Training Experience

1984Residency, Saint Louis Children's Hospital
1990Fellowship, Saint Louis Children's Hospital

Education/Academic qualification

MD, Washington University

… → 1981

Keywords

  • Developmental Biology
  • Genomics
  • Neonatology
  • Prenatal Environment and Developmental Outcomes
  • Respiratory Diseases

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Grants 2014 2021

Research Output 1990 2019

1 Citation (Scopus)

Black Race Is Associated with a Lower Risk of Bronchopulmonary Dysplasia

Prematurity and Respiratory Outcome Program (PROP) Investigators, Apr 1 2019, In : Journal of Pediatrics. 207, p. 130-135.e2

Research output: Contribution to journalArticle

Bronchopulmonary Dysplasia
Gestational Age
Parturition
Intubation
Premature Infants

Novel parent-of-origin-specific differentially methylated loci on chromosome 16

Schulze, K. V., Szafranski, P., Lesmana, H., Hopkin, R. J., Hamvas, A., Wambach, J. A., Shinawi, M., Zapata, G., Carvalho, C. M. B., Liu, Q., Karolak, J. A., Lupski, J. R., Hanchard, N. A. & Stankiewicz, P., Apr 8 2019, In : Clinical Epigenetics. 11, 1, 60.

Research output: Contribution to journalArticle

Open Access
Persistent Fetal Circulation Syndrome
Chromosomes, Human, Pair 16
Methylation
Mothers
DNA Methylation

Pre-Vent: the prematurity-related ventilatory control study

Dennery, P. A., Di Fiore, J. M., Ambalavanan, N., Bancalari, E., Carroll, J. L., Claure, N., Hamvas, A., Hibbs, A. M., Indic, P., Kemp, J., Krahn, K. N., Lake, D., Laposky, A., Martin, R. J., Natarajan, A., Rand, C., Schau, M., Weese-Mayer, D. E., Zimmet, A. M. & Moorman, J. R., Jan 1 2019, In : Pediatric research.

Research output: Contribution to journalArticle

Premature Infants
Oxygen
Bronchopulmonary Dysplasia
Hyperoxia
Hypercapnia
7 Citations (Scopus)

Acute Responses to Diuretic Therapy in Extremely Low Gestational Age Newborns: Results from the Prematurity and Respiratory Outcomes Program Cohort Study

Prematurity and Respiratory Outcomes Program, Jun 1 2018, In : Journal of Pediatrics. 197, p. 42-47.e1

Research output: Contribution to journalArticle

Diuretics
Gestational Age
Cohort Studies
Newborn Infant
Neonatal Intensive Care Units

A Novel Noninvasive Index to Characterize Right Ventricle Pulmonary Arterial Vascular Coupling in Children

Levy, P. T., El Khuffash, A., Woo, K. V., Hauck, A., Hamvas, A. & Singh, G. K., Dec 6 2018, In : JACC. Cardiovascular imaging.

Research output: Contribution to journalArticle