Grants per year
Personal profile
Research Interests
Dr. Hamvas has a longstanding interest in genetic contributions to lung diseases that affect newborns, children and adults, he has combined his clinical interests in the care of newborn respiratory diseases with an integrated investigative program to understand the modifiable factors that influence outcomes of newborns.
Mutations in pulmonary surfactant associated genes result in newborn respiratory distress but can also contribute to idiopathic pulmonary fibrosis in adults. We use exome sequencing to identify genes and gene pathways that might inform variability in penetrance of these mutations and also provide further insights into the development of chronic lung disease (bronchopulmonary dysplasia) in premature newborns. We are also part of an NIH-funded clinical observational study that combines analysis of continuous physiologic data streams, echocardiographic measures, and measures of autonomic nervous system function to identify physiologic perturbations that have an impact on cardiac, respiratory, and neurologic outcomes of premature babies.
Diffuse lung diseases in newborns and children
Certifications and Licenses
Neonatal-Perinatal Medicine |
Training Experience
1984 | Residency, Saint Louis Children's Hospital |
1990 | Fellowship, Saint Louis Children's Hospital |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, Washington University
… → 1981
Research interests keywords
- Developmental Biology
- Genomics
- Neonatology
- Prenatal Environment and Developmental Outcomes
- Respiratory Diseases
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Collaborations and top research areas from the last five years
Grants
- 18 Finished
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Epidermal Wearable Patch: An Innovative Solution to the Lack of Continuous, Non-Invasive Blood Pressure Monitoring in the NICU
Hamvas, A. (PD/PI) & Weese-Mayer, D. E. (PD/PI)
The Gerber Companies Foundation
3/15/18 → 12/31/21
Project: Research project
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No Strings Attached: Wireless Sensor Technology in the Prentice NICU
Paller, A. (PD/PI), Hamvas, A. (Co-PD/PI), Rogers, J. A. (Co-PD/PI) & Weese-Mayer, D. E. (Co-PD/PI)
Northwestern Memorial Hospital
9/1/17 → 8/31/19
Project: Research project
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Integrated analysis of autonomic biomarkers in prematurity-related ventilatory control: determination of neurorespiratory maturation and predictors of co-morbidity risk
Hamvas, A. (PD/PI), Carroll, M. S. (Co-Investigator) & Weese-Mayer, D. E. (Co-Investigator)
National Heart, Lung, and Blood Institute
9/1/16 → 6/30/21
Project: Research project
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Integrated analysis of autonomic biomarkers in prematurity-related ventilatory control: determination of neurorespiratory maturation and predictors of co-morbidity risk
Hamvas, A. (PD/PI), Carroll, M. S. (Co-Investigator) & Weese-Mayer, D. E. (Co-Investigator)
National Heart, Lung, and Blood Institute
9/1/16 → 6/30/21
Project: Research project
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Genetic Testing Utilization in the U.S. Registry for Childhood Interstitial and Diffuse Lung Diseases
for the chILD Registry Collaborative, Apr 2025, In: Pediatric Pulmonology. 60, 4, e71073.Research output: Contribution to journal › Article › peer-review
Open Access -
Apnea, Intermittent Hypoxemia, and Bradycardia Events Predict Late-Onset Sepsis in Infants Born Extremely Preterm
the Prematurity-Related Ventilatory Control (Pre-Vent) Investigators, Aug 2024, In: journal of pediatrics. 271, 114042.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates
Chawla, S., Laptook, A. R., Smith, E. A., Tan, S., Natarajan, G., Wyckoff, M. H., Greenberg, R. G., Ambalavanan, N., Bell, E. F., Van Meurs, K. P., Hintz, S. R., Vohr, B. R., Werner, E. F., Das, A., Shankaran, S., Carlo, W. A., Hibbs, A. M., Merhar, S., Cotten, C. M. & Patel, R. M. & 8 others, , Jun 2024, In: Journal of Perinatology. 44, 6, p. 802-810 9 p.Research output: Contribution to journal › Article › peer-review
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Corrigendum: Highly comparative time series analysis of oxygen saturation and heart rate to predict respiratory outcomes in extremely preterm infants (2024Physiol. Meas. 45 055025)
Qiu, J., M Di Fiore, J., Krishnamurthi, N., Indic, P., Carroll, J. L., Claure, N., Kemp, J. S., Dennery, P. A., Ambalavanan, N., Weese-Mayer, D. E., Hibbs, A. M., Martin, R. J., Bancalari, E., Hamvas, A., Randall Moorman, J. & Lake, D. E., Oct 21 2024, In: Physiological Measurement. 45, 10Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Extending the Environmental influences on Child Health Outcomes (ECHO) Cohort through 2030: Rationale and study protocol
ECHO Cohort Consortium, Dec 2024, In: PloS one. 19, 12 December, e0312677.Research output: Contribution to journal › Article › peer-review
Datasets
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Additional file 1: of Novel parent-of-origin-specific differentially methylated loci on chromosome 16
Schulze, K. V. (Creator), Szafranski, P. (Creator), Lesmana, H. (Creator), Hopkin, R. J. (Creator), Hamvas, A. (Creator), Wambach, J. A. (Creator), Shinawi, M. (Creator), Zapata, G. (Creator), Carvalho, C. M. B. (Creator), Liu, Q. (Creator), Karolak, J. A. (Creator), Lupski, J. R. (Creator), Hanchard, N. A. (Creator) & Stankiewicz, P. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.7968188, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Novel_parent-of-origin-specific_differentially_methylated_loci_on_chromosome_16/7968188
Dataset
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Novel parent-of-origin-specific differentially methylated loci on chromosome 16
Schulze, K. V. (Creator), Szafranski, P. (Creator), Lesmana, H. (Creator), Hopkin, R. J. (Creator), Hamvas, A. (Creator), Wambach, J. A. (Creator), Shinawi, M. (Creator), Zapata, G. (Creator), Carvalho, C. M. B. (Creator), Liu, Q. (Creator), Karolak, J. A. (Creator), Lupski, J. R. (Creator), Hanchard, N. A. (Creator) & Stankiewicz, P. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4463939, https://springernature.figshare.com/collections/Novel_parent-of-origin-specific_differentially_methylated_loci_on_chromosome_16/4463939
Dataset
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Exome sequencing identifies gene variants and networks associated with extreme respiratory outcomes following preterm birth
Hamvas, A. (Creator), Feng, R. (Creator), Bi, Y. (Creator), Wang, F. (Creator), Bhattacharya, S. (Creator), Mereness, J. (Creator), Kaushal, M. (Creator), Cotten, C. M. (Creator), Ballard, P. L. (Creator) & Mariani, T. J. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.c.4273670, https://springernature.figshare.com/collections/Exome_sequencing_identifies_gene_variants_and_networks_associated_with_extreme_respiratory_outcomes_following_preterm_birth/4273670
Dataset