Grants per year
Personal profile
Research Interests
Dr. Hamvas has a longstanding interest in genetic contributions to lung diseases that affect newborns, children and adults, he has combined his clinical interests in the care of newborn respiratory diseases with an integrated investigative program to understand the modifiable factors that influence outcomes of newborns.
Mutations in pulmonary surfactant associated genes result in newborn respiratory distress but can also contribute to idiopathic pulmonary fibrosis in adults. We use exome sequencing to identify genes and gene pathways that might inform variability in penetrance of these mutations and also provide further insights into the development of chronic lung disease (bronchopulmonary dysplasia) in premature newborns. We are also part of an NIH-funded clinical observational study that combines analysis of continuous physiologic data streams, echocardiographic measures, and measures of autonomic nervous system function to identify physiologic perturbations that have an impact on cardiac, respiratory, and neurologic outcomes of premature babies.
Diffuse lung diseases in newborns and children
Certifications and Licenses
Neonatal-Perinatal Medicine |
Training Experience
1984 | Residency, Saint Louis Children's Hospital |
1990 | Fellowship, Saint Louis Children's Hospital |
Education/Academic qualification
Medicine, MD, Washington University
… → 1981
Research interests
- Developmental Biology
- Genomics
- Neonatology
- Prenatal Environment and Developmental Outcomes
- Respiratory Diseases
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Network
Grants
- 18 Finished
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No Strings Attached: Wireless Sensor Technology in the Prentice NICU
Paller, A., Hamvas, A., Rogers, J. A. & Weese-Mayer, D. E.
Northwestern Memorial Hospital
9/1/17 → 8/31/19
Project: Research project
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The Role of FOXF1 in Placental Vascular Dysfunction and Bronchopulmonary Dysplasia
Northwestern Memorial Hospital
9/1/16 → 8/31/18
Project: Research project
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Biologic characterization of ABCA3 variants in lung tissue from infants and children with ABCA3 deficiency
Xu, K. K., Wegner, D. J., Geurts, L. C., Heins, H. B., Yang, P., Hamvas, A., Eghtesady, P., Sweet, S. C., Sessions Cole, F. & Wambach, J. A., May 2022, In: Pediatric Pulmonology. 57, 5, p. 1325-1330 6 p.Research output: Contribution to journal › Article › peer-review
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The association between pulmonary vascular disease and respiratory improvement in infants with type I severe bronchopulmonary dysplasia
Carpenter, R. J., Srdanovic, N., Rychlik, K., Sen, S. K., Porta, N. F. M., Hamvas, A. E., Murthy, K. & Hauck, A. L., 2022, (Accepted/In press) In: Journal of Perinatology.Research output: Contribution to journal › Article › peer-review
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Cardiac Performance in the First Year of Age among Preterm Infants Fed Maternal Breast Milk
El-Khuffash, A., Lewandowski, A. J., Jain, A., Hamvas, A., Singh, G. K. & Levy, P. T., Aug 27 2021, In: JAMA network open. 4, 8, e2121206.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Left ventricle phenotyping utilizing tissue doppler imaging in premature infants with varying severity of bronchopulmonary dysplasia
Torres, E., Levy, P. T., El-Khuffash, A., Gu, H., Hamvas, A. & Singh, G. K., May 2 2021, In: Journal of Clinical Medicine. 10, 10, 2211.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease
Alysandratos, K. D., Russo, S. J., Petcherski, A., Taddeo, E. P., Acín-Pérez, R., Villacorta-Martin, C., Jean, J. C., Mulugeta, S., Rodriguez, L. R., Blum, B. C., Hekman, R. M., Hix, O. T., Minakin, K., Vedaie, M., Kook, S., Tilston-Lunel, A. M., Varelas, X., Wambach, J. A., Cole, F. S., Hamvas, A. & 7 others, , Aug 31 2021, In: Cell reports. 36, 9, 109636.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations