Aaron Hamvas

  • 4902 Citations
1990 …2021
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Personal profile

Research Interests

Dr. Hamvas has a longstanding interest in genetic contributions to lung diseases that affect newborns, children and adults, he has combined his clinical interests in the care of newborn respiratory diseases with an integrated investigative program to understand the modifiable factors that influence outcomes of newborns.

Mutations in pulmonary surfactant associated genes result in newborn respiratory distress but can also contribute to idiopathic pulmonary fibrosis in adults. We use exome sequencing to identify genes and gene pathways that might inform variability in penetrance of these mutations and also provide further insights into the development of chronic lung disease (bronchopulmonary dysplasia) in premature newborns. We are also part of an NIH-funded clinical observational study that combines analysis of continuous physiologic data streams, echocardiographic measures, and measures of autonomic nervous system function to identify physiologic perturbations that have an impact on cardiac, respiratory, and neurologic outcomes of premature babies.

Diffuse lung diseases in newborns and children

Certifications and Licenses

Neonatal-Perinatal Medicine

Training Experience

1984Residency, Saint Louis Children's Hospital
1990Fellowship, Saint Louis Children's Hospital

Education/Academic qualification

MD, Washington University

… → 1981

Research interests

  • Developmental Biology
  • Genomics
  • Neonatology
  • Prenatal Environment and Developmental Outcomes
  • Respiratory Diseases

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  • 12 Similar Profiles
Surface-Active Agents Medicine & Life Sciences
Premature Infants Medicine & Life Sciences
Mutation Medicine & Life Sciences
Pulmonary Surfactants Medicine & Life Sciences
Newborn Infant Medicine & Life Sciences
Newborn Respiratory Distress Syndrome Medicine & Life Sciences
Lung Medicine & Life Sciences
Lung Diseases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2014 2021

Research Output 1990 2019

Basic Genetics and Epigenetics of Childhood Lung Disease

Wambach, J., Chaudhari, B. P. & Hamvas, A., Jan 1 2019, Kendig's Disorders of the Respiratory Tract in Children. Elsevier Inc, p. 40-48.e2

Research output: Chapter in Book/Report/Conference proceedingChapter

Genetic Testing
Lung Diseases
31 Citations (Scopus)

Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care

Chung, H. U., Kim, B. H., Lee, J. Y., Lee, J., Xie, Z., Ibler, E. M., Lee, K. H., Banks, A., Jeong, J. Y., Kim, J., Ogle, C., Grande, D., Yu, Y., Jang, H., Assem, P., Ryu, D., Kwak, J. W., Namkoong, M., Park, J. B., Lee, Y. & 25 others, Kim, D. H., Ryu, A., Jeong, J., You, K., Ji, B., Liu, Z., Huo, Q., Feng, X., Deng, Y., Xu, Y., Jang, K. I., Kim, J., Zhang, Y., Ghaffari, R., Rand, C. M., Schau, M., Hamvas, A., Weese-Mayer, D. E., Huang, Y., Lee, S. M., Lee, C. H., Shanbhag, N. R., Paller, A. S., Xu, S. & Rogers, J. A., Jan 1 2019, In : Science. 363, 6430

Research output: Contribution to journalArticle

Open Access
Neonatal Intensive Care
Neonatal Intensive Care Units
Vital Signs
Diagnostic Imaging
5 Citations (Scopus)

Black Race Is Associated with a Lower Risk of Bronchopulmonary Dysplasia

Prematurity and Respiratory Outcome Program (PROP) Investigators, Apr 2019, In : Journal of Pediatrics. 207, p. 130-135.e2

Research output: Contribution to journalArticle

Bronchopulmonary Dysplasia
Gestational Age
Premature Infants
1 Citation (Scopus)

Echocardiographic Assessment of Right Ventricular Afterload in Preterm Infants: Maturational Patterns of Pulmonary Artery Acceleration Time Over the First Year of Age and Implications for Pulmonary Hypertension

Patel, M. D., Breatnach, C. R., James, A. T., Choudhry, S., McNamara, P. J., Jain, A., Franklin, O., Hamvas, A., Mertens, L., Singh, G. K., EL-Khuffash, A. & Levy, P. T., Jul 2019, In : Journal of the American Society of Echocardiography. 32, 7, p. 884-894.e4

Research output: Contribution to journalArticle

Pulmonary Hypertension
Premature Infants
Pulmonary Artery
Bronchopulmonary Dysplasia

Novel parent-of-origin-specific differentially methylated loci on chromosome 16

Schulze, K. V., Szafranski, P., Lesmana, H., Hopkin, R. J., Hamvas, A., Wambach, J. A., Shinawi, M., Zapata, G., Carvalho, C. M. B., Liu, Q., Karolak, J. A., Lupski, J. R., Hanchard, N. A. & Stankiewicz, P., Apr 8 2019, In : Clinical Epigenetics. 11, 1, 60.

Research output: Contribution to journalArticle

Open Access
Persistent Fetal Circulation Syndrome
Chromosomes, Human, Pair 16
DNA Methylation