Grants per year
Personal profile
Research Interests
Dr. Hamvas has a longstanding interest in genetic contributions to lung diseases that affect newborns, children and adults, he has combined his clinical interests in the care of newborn respiratory diseases with an integrated investigative program to understand the modifiable factors that influence outcomes of newborns.
Mutations in pulmonary surfactant associated genes result in newborn respiratory distress but can also contribute to idiopathic pulmonary fibrosis in adults. We use exome sequencing to identify genes and gene pathways that might inform variability in penetrance of these mutations and also provide further insights into the development of chronic lung disease (bronchopulmonary dysplasia) in premature newborns. We are also part of an NIH-funded clinical observational study that combines analysis of continuous physiologic data streams, echocardiographic measures, and measures of autonomic nervous system function to identify physiologic perturbations that have an impact on cardiac, respiratory, and neurologic outcomes of premature babies.
Diffuse lung diseases in newborns and children
Certifications and Licenses
Neonatal-Perinatal Medicine |
Training Experience
1984 | Residency, Saint Louis Children's Hospital |
1990 | Fellowship, Saint Louis Children's Hospital |
Education/Academic qualification
Medicine, MD, Washington University
… → 1981
Research interests keywords
- Developmental Biology
- Genomics
- Neonatology
- Prenatal Environment and Developmental Outcomes
- Respiratory Diseases
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Collaborations and top research areas from the last five years
Grants
- 18 Finished
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Epidermal Wearable Patch: An Innovative Solution to the Lack of Continuous, Non-Invasive Blood Pressure Monitoring in the NICU
Hamvas, A. (PD/PI) & Weese-Mayer, D. E. (PD/PI)
The Gerber Companies Foundation
3/15/18 → 12/31/21
Project: Research project
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No Strings Attached: Wireless Sensor Technology in the Prentice NICU
Paller, A. (PD/PI), Hamvas, A. (Co-PD/PI), Rogers, J. A. (Co-PD/PI) & Weese-Mayer, D. E. (Co-PD/PI)
Northwestern Memorial Hospital
9/1/17 → 8/31/19
Project: Research project
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Integrated analysis of autonomic biomarkers in prematurity-related ventilatory control: determination of neurorespiratory maturation and predictors of co-morbidity risk
Hamvas, A. (PD/PI) & Weese-Mayer, D. E. (Co-Investigator)
National Heart, Lung, and Blood Institute
9/1/16 → 6/30/21
Project: Research project
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Integrated analysis of autonomic biomarkers in prematurity-related ventilatory control: determination of neurorespiratory maturation and predictors of co-morbidity risk
Hamvas, A. (PD/PI), Carroll, M. S. (Co-Investigator), Weese-Mayer, D. E. (Co-Investigator) & de Regnier, R.-A. O. (Co-Investigator)
National Heart, Lung, and Blood Institute
9/1/16 → 6/30/22
Project: Research project
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Integrated analysis of autonomic biomarkers in prematurity-related ventilatory control: determination of neurorespiratory maturation and predictors of co-morbidity risk
Hamvas, A. (PD/PI) & Weese-Mayer, D. E. (Co-Investigator)
National Heart, Lung, and Blood Institute
9/1/16 → 6/30/21
Project: Research project
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Apnea, Intermittent Hypoxemia, and Bradycardia Events Predict Late-Onset Sepsis in Infants Born Extremely Preterm
the Prematurity-Related Ventilatory Control (Pre-Vent) Investigators, Aug 2024, In: journal of pediatrics. 271, 114042.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates
Chawla, S., Laptook, A. R., Smith, E. A., Tan, S., Natarajan, G., Wyckoff, M. H., Greenberg, R. G., Ambalavanan, N., Bell, E. F., Van Meurs, K. P., Hintz, S. R., Vohr, B. R., Werner, E. F., Das, A., Shankaran, S., Carlo, W. A., Hibbs, A. M., Merhar, S., Cotten, C. M. & Patel, R. M. & 8 others, , Jun 2024, In: Journal of Perinatology. 44, 6, p. 802-810 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Genetic testing for diffuse lung diseases in children
Hamvas, A., Chaudhari, B. P. & Nogee, L. M., Sep 2024, In: Pediatric Pulmonology. 59, 9, p. 2286-2297 12 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Highly comparative time series analysis of oxygen saturation and heart rate to predict respiratory outcomes in extremely preterm infants
Qiu, J., Di Fiore, J. M., Krishnamurthi, N., Indic, P., Carroll, J. L., Claure, N., Kemp, J. S., Dennery, P. A., Ambalavanan, N., Weese-Mayer, D. E., Maria Hibbs, A., Martin, R. J., Bancalari, E., Hamvas, A., Randall Moorman, J. & Lake, D. E., May 1 2024, In: Physiological Measurement. 45, 5, 055025.Research output: Contribution to journal › Article › peer-review
Open Access -
Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium
McKee, K., Bassis, C. M., Golob, J., Palazzolo, B., Sen, A., Comstock, S. S., Rosas-Salazar, C., Stanford, J. B., O’Connor, T., Gern, J. E., Paneth, N., Dunlop, A. L., Smith, P. B., Newby, L. K., Adair, L., Jacobson, L. P., Catellier, D., McGrath, M., Douglas, C. & Duggal, P. & 271 others, , Dec 2024, In: Scientific reports. 14, 1, 11798.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Exome sequencing identifies gene variants and networks associated with extreme respiratory outcomes following preterm birth
Hamvas, A. (Creator), Feng, R. (Creator), Bi, Y. (Creator), Wang, F. (Creator), Bhattacharya, S. (Creator), Mereness, J. (Creator), Kaushal, M. (Creator), Cotten, C. M. (Creator), Ballard, P. L. (Creator) & Mariani, T. J. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.c.4273670, https://springernature.figshare.com/collections/Exome_sequencing_identifies_gene_variants_and_networks_associated_with_extreme_respiratory_outcomes_following_preterm_birth/4273670
Dataset
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Novel parent-of-origin-specific differentially methylated loci on chromosome 16
Schulze, K. V. (Creator), Szafranski, P. (Creator), Lesmana, H. (Creator), Hopkin, R. J. (Creator), Hamvas, A. (Creator), Wambach, J. A. (Creator), Shinawi, M. (Creator), Zapata, G. (Creator), Carvalho, C. M. B. (Creator), Liu, Q. (Creator), Karolak, J. A. (Creator), Lupski, J. R. (Creator), Hanchard, N. A. (Creator) & Stankiewicz, P. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4463939, https://springernature.figshare.com/collections/Novel_parent-of-origin-specific_differentially_methylated_loci_on_chromosome_16/4463939
Dataset
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Additional file 1: of Novel parent-of-origin-specific differentially methylated loci on chromosome 16
Schulze, K. V. (Creator), Szafranski, P. (Creator), Lesmana, H. (Creator), Hopkin, R. J. (Creator), Hamvas, A. (Creator), Wambach, J. A. (Creator), Shinawi, M. (Creator), Zapata, G. (Creator), Carvalho, C. M. B. (Creator), Liu, Q. (Creator), Karolak, J. A. (Creator), Lupski, J. R. (Creator), Hanchard, N. A. (Creator) & Stankiewicz, P. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.7968188, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Novel_parent-of-origin-specific_differentially_methylated_loci_on_chromosome_16/7968188
Dataset