Grants per year
Personal profile
Research Interests
Our laboratory investigates the pathogenesis of the multidrug resistant gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumonia. We focus on virulence factors such as the type III secretion, an apparatus that injects toxins directly into host cells. Other interests are the use of genomic approaches for the identification of novel virulence determinants and the development of novel translational approaches to treat bacterial infections. Our studies utilize a broad range of techniques, including molecular and cellular assays as well as animal models and epidemiologic studies on human populations.
Certifications and Licenses
| Internal Medicine | |
| Infectious Disease |
Training Experience
| 1994 | Internship, University of Minnesota Medical Center |
| 1994 | Residency, University of Minnesota Medical Center |
| 1996 | Fellowship, Univ. of CA-San Francisco Med. Ctr. |
| 1998 | Postdoctoral Fellowship, University of California, San Francisco |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, University of Minnesota
… → 1992
Microbiology, PhD, University of Minnesota
… → 1990
Research interests keywords
- Infectious Diseases: Bacteria
- Microbiology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Northwestern University Infectious Diseases Education and Science (NuIDeas)
Hauser, A. R. (PD/PI), Hawkins, C. A. (PD/PI), Taiwo, B. O. (PD/PI) & Taiwo, B. O. (PD/PI)
National Institute of Allergy and Infectious Diseases
8/1/23 → 7/31/28
Project: Research project
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Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center
Wunderink, R. G. (PD/PI), Wunderink, R. G. (PD/PI), Abdala-Valencia, H. (Co-Investigator), Abdala-Valencia, H. (Co-Investigator), Budinger, G. S. (Co-Investigator), Budinger, G. S. (Co-Investigator), Etemadi, M. (Co-Investigator), Etemadi, M. (Co-Investigator), Hartmann, E. M. (Co-Investigator), Hartmann, E. M. (Co-Investigator), Hultquist, J. F. (Co-Investigator), Hultquist, J. F. (Co-Investigator), Lorenzo Redondo, R. (Co-Investigator), Lorenzo Redondo, R. (Co-Investigator), Luo, Y. (Co-Investigator), Luo, Y. (Co-Investigator), Misharin, A. (Co-Investigator), Misharin, A. (Co-Investigator), Morales-Nebreda, L. (Co-Investigator), Morales-Nebreda, L. (Co-Investigator), Ozer, E. A. (Co-Investigator), Ozer, E. A. (Co-Investigator), Pickens, C. I. (Co-Investigator), Pickens, C. I. (Co-Investigator), Qi, C. (Co-Investigator), Qi, C. (Co-Investigator), Scholtens, D. M. (Co-Investigator), Scholtens, D. M. (Co-Investigator), Singer, B. (Co-Investigator), Singer, B. (Co-Investigator), Stoeger, T. (Co-Investigator), Stoeger, T. (Co-Investigator), Swaminathan, S. (Co-Investigator), Swaminathan, S. (Co-Investigator), Walter, J. M. (Co-Investigator), Walter, J. M. (Co-Investigator), Wunderink, R. G. (Co-Investigator), Wunderink, R. G. (Co-Investigator), Amaral, L. A. N. (Other), Amaral, L. A. N. (Other), Budinger, G. S. (Other), Budinger, G. S. (Other), Hartmann, E. M. (Other), Hartmann, E. M. (Other), Hauser, A. R. (Other), Hauser, A. R. (Other), Misharin, A. (Other), Misharin, A. (Other), Ozer, E. A. (Other), Ozer, E. A. (Other), Pickens, C. I. (Other), Pickens, C. I. (Other), Qi, C. (Other), Qi, C. (Other), Singer, B. (Other), Singer, B. (Other), Starren, J. (Other), Stoeger, T. (Other), Walter, J. M. (Other), Walter, J. M. (Other), Wunderink, R. G. (Other) & Wunderink, R. G. (Other)
National Institute of Allergy and Infectious Diseases
1/1/23 → 12/31/27
Project: Research project
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Precise Combination Strategies Targeting Carbapenem-Resistant Klebsiella pneumoniae
Hauser, A. R. (PD/PI), Hauser, A. R. (PD/PI), Ozer, E. A. (Co-Investigator) & Ozer, E. A. (Co-Investigator)
University of Illinois at Chicago, National Institute of Allergy and Infectious Diseases
12/5/22 → 11/30/27
Project: Research project
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Systems-based pharmacologic modeling to elucidate beta-lactam clinical pharmacodynamics and define optimal dosing regimens in severe pneumonia
Wunderink, R. G. (PD/PI), Wunderink, R. G. (PD/PI), Hauser, A. R. (Co-Investigator), Hauser, A. R. (Co-Investigator), Ozer, E. A. (Co-Investigator) & Ozer, E. A. (Co-Investigator)
Midwestern University, National Institute of Allergy and Infectious Diseases
7/11/22 → 6/30/27
Project: Research project
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Medical Scientist Training Program
Ardehali, H. (PD/PI), Hauser, A. R. (PD/PI), Hauser, A. R. (PD/PI), Brown, M. A. (Other), Brown, M. A. (Other), Kalb, R. G. (Other) & Kalb, R. G. (Other)
National Institute of General Medical Sciences
7/1/22 → 6/30/27
Project: Research project
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Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
The NU SCRIPT Study Investigators, 2024, (Accepted/In press) In: Nature Immunology. 25, 9, p. 1607-1622 16 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Phenotypes of a Pseudomonas aeruginosa hypermutator lineage that emerged during prolonged mechanical ventilation in a patient without cystic fibrosis
Nozick, S. H., Ozer, E. A., Medernach, R., Kochan, T. J., Kumar, R., Mills, J. O., Wunderlink, R. G., Qi, C. & Hauser, A. R., Jan 2024, In: mSystems. 9, 1Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
The global population stru cture of Lacticaseibacillus rhamnosus and its application to an investigation of a rare case of infective endocarditis
Santoiemma, P. P., Cohn, S. E., Gatesy, S. W. M., Hauser, A. R., Agrawal, S., Theodorou, M. E., Bachta, K. E. R. & Ozer, E. A., Aug 2024, In: PloS one. 19, 8, e0300843.Research output: Contribution to journal › Article › peer-review
Open Access -
Association between Clostridium innocuum and Antibiotic-Associated Diarrhea in Adults and Children: A Cross-sectional Study and Comparative Genomics Analysis
Cherny, K. E., Muscat, E. B., Balaji, A., Mukherjee, J., Ozer, E. A., Angarone, M. P., Hauser, A. R., Sichel, J. S., Amponsah, E. & Kociolek, L. K., Feb 1 2023, In: Clinical Infectious Diseases. 76, 3, p. E1244-E1251Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Genome-wide screens reveal shared and strain-specific genes that facilitate enteric colonization by Klebsiella pneumoniae
Cheung, B. H., Alisoltani, A., Kochan, T. J., Lebrun-Corbin, M., Nozick, S. H., Axline, C. M. R., Bachta, K. E. R., Ozer, E. A. & Hauser, A. R., Dec 2023, In: mBio. 14, 6Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Datasets
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Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates
Kochan, T. J. (Creator), Nozick, S. H. (Creator), Medernach, R. L. (Creator), Cheung, B. H. (Creator), Gatesy, S. W. M. (Creator), Lebrun-Corbin, M. (Creator), Mitra, S. D. (Creator), Khalatyan, N. (Creator), Krapp, F. (Creator), Qi, C. (Creator), Ozer, E. A. (Creator) & Hauser, A. R. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6085856, https://springernature.figshare.com/collections/Genomic_surveillance_for_multidrug-resistant_or_hypervirulent_Klebsiella_pneumoniae_among_United_States_bloodstream_isolates/6085856
Dataset
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Additional file 18 of Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates
Kochan, T. J. (Creator), Nozick, S. H. (Creator), Medernach, R. L. (Creator), Cheung, B. H. (Creator), Gatesy, S. W. M. (Creator), Lebrun-Corbin, M. (Creator), Mitra, S. D. (Creator), Khalatyan, N. (Creator), Krapp, F. (Creator), Qi, C. (Creator), Ozer, E. A. (Creator) & Hauser, A. R. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.20267541, https://springernature.figshare.com/articles/dataset/Additional_file_18_of_Genomic_surveillance_for_multidrug-resistant_or_hypervirulent_Klebsiella_pneumoniae_among_United_States_bloodstream_isolates/20267541
Dataset
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Crystal Structure of the Sugar Binding Domain of LacI Family Protein from Klebsiella pneumoniae
Inniss, N. L. (Contributor), Kochan, T. J. (Contributor), Minasov, G. (Contributor), Wawrzak, Z. (Contributor), Chang, C. (Contributor), Tan, K. (Contributor), Shuvalova, L. (Contributor), Kiryukhina, O. (Contributor), Pshenychnyi, S. (Contributor), Wu, R. (Contributor), Dubrovska, I. (Contributor), Babnigg, G. (Contributor), Endres, M. (Contributor), Anderson, W. F. (Contributor), Hauser, A. R. (Contributor), Joachimiak, A. (Contributor) & Satchell, K. J. F. (Contributor), Protein Data Bank (PDB), Dec 26 2018
DOI: 10.2210/pdb6NDI/pdb, https://www.wwpdb.org/pdb?id=pdb_00006ndi
Dataset
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1.2 Angstrom Resolution Crystal Structure of Nucleoside Triphosphatase NudI from Klebsiella pneumoniae in Complex with HEPES
Inniss, N. L. (Contributor), Kochan, T. J. (Contributor), Minasov, G. (Contributor), Wawrzak, Z. (Contributor), Chang, C. (Contributor), Tan, K. (Contributor), Shuvalova, L. (Contributor), Kiryukhina, O. (Contributor), Pshenychnyi, S. (Contributor), Wu, R. (Contributor), Dubrovska, I. (Contributor), Babnigg, G. (Contributor), Endres, M. (Contributor), Anderson, W. F. (Contributor), Hauser, A. R. (Contributor), Joachimiak, A. (Contributor) & Satchell, K. J. F. (Contributor), Protein Data Bank (PDB), Jun 27 2018
DOI: 10.2210/pdb6DT3/pdb, https://www.wwpdb.org/pdb?id=pdb_00006dt3
Dataset
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1.92 Angstrom resolution crystal structure of the full-length SpcU in complex with full-length ExoU from the type III secretion system of Pseudomonas aeruginosa
Halavaty, A. S. (Contributor), Borek, D. (Contributor), Tyson, G. H. (Contributor), Veesenmeyer, J. L. (Contributor), Shuvalova, L. (Contributor), Minasov, G. (Contributor), Otwinowski, Z. (Contributor), Hauser, A. R. (Contributor) & Anderson, W. F. (Contributor), Protein Data Bank (PDB), May 23 2012
DOI: 10.2210/pdb3TU3/pdb, https://www.wwpdb.org/pdb?id=pdb_00003tu3
Dataset