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Alan R Hauser

  • 5426 Citations
1988 …2020

Research output per year

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Personal profile

Research Interests

Our laboratory investigates the pathogenesis of the multidrug resistant gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumonia. We focus on virulence factors such as the type III secretion, an apparatus that injects toxins directly into host cells. Other interests are the use of genomic approaches for the identification of novel virulence determinants and the development of novel translational approaches to treat bacterial infections. Our studies utilize a broad range of techniques, including molecular and cellular assays as well as animal models and epidemiologic studies on human populations.

Certifications and Licenses

Internal Medicine
Infectious Disease

Training Experience

1994Internship, University of Minnesota Medical Center
1994Residency, University of Minnesota Medical Center
1996Fellowship, Univ. of CA-San Francisco Med. Ctr.
1998Postdoctoral Fellowship, University of California, San Francisco

Education/Academic qualification

MD, University of Minnesota

… → 1992

PhD, University of Minnesota

… → 1990

Research interests

  • Infectious Diseases: Bacteria
  • Microbiology

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Grants

Patient-Oriented Research on Pseudomonas aeruginosa

Hauser, A. R.

National Institute of Allergy and Infectious Diseases

2/22/20 → 1/31/25

Project: Research project

    • Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center

    Abdala-Valencia, H., Amaral, L. A. N., Bartom, E. T., Budinger, G. S., Davuluri, R. V., Hauser, A. R., Horvath, C. M., Kandpal, M., Misharin, A., Ozer, E. A., Qi, C., Singer, B., Starren, J. B., Wehbe, F., Winter, D. R. & Wunderink, R. G.

    National Institute of Allergy and Infectious Diseases

    1/17/18 → 12/31/22

    Project: Research project

    • Project 2: Pathogen and Microbiome Temporal Changes During Resolution of HAP

    Hauser, A. R.

    National Institute of Allergy and Infectious Diseases

    1/17/18 → 12/31/22

    Project: Research project

    • Nanoparticle-Polymyxin B Conjugates for Treating Infections in CF Patients

    Hauser, A. R. & Lee, A.

    Cystic Fibrosis Foundation

    11/1/17 → 10/31/20

    Project: Research project

    • Biomarkers for Highly Virulent Pseudomonas aeruginosa Strains

    Bi, Y. & Hauser, A. R.

    National Institute of Allergy and Infectious Diseases

    8/11/17 → 7/31/20

    Project: Research project

    • Research Output

    A comparative genomics approach identifies contact-dependent growth inhibition as a virulence determinant

    Allen, J. P., Ozer, E. A., Minasov, G., Shuvalova, L., Kiryukhina, O., Satchell, K. J. F. & Hauser, A. R., Mar 24 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 12, p. 6811-6821 11 p.

    Research output: Contribution to journal › Article

    • Complete genome sequence of klebsiella pneumoniae strain TK421, a conjugative hypervirulent isolate

    Kochan, T. J., Ozer, E. A., Pincus, N. B., Fitzpatrick, M. A. & Hauser, A. R., Jan 16 2020, In : Microbiology Resource Announcements. 9, 3, e01408-19.

    Research output: Contribution to journal › Article

    Open Access

    • Evaluation of dose-fractionated polymyxin B on acute kidney injury using a translational in vivo rat model

    Liu, J., Pais, G. M., Avedissian, S. N., Gilchrist, A., Lee, A., Rhodes, N. J., Hauser, A. R. & Scheetz, M. H., May 1 2020, In : Antimicrobial agents and chemotherapy. 64, 5, e02300-19.

    Research output: Contribution to journal › Article

    • Natural Clostridioides difficile Toxin Immunization in Colonized Infants

    Kociolek, L. K., Espinosa, R. O., Gerding, D. N., Hauser, A. R., Ozer, E. A., Budz, M., Balaji, A., Chen, X., Tanz, R. R., Yalcinkaya, N., Conner, M. E., Savidge, T. & Kelly, C. P., May 6 2020, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 70, 10, p. 2095-2102 8 p.

    Research output: Contribution to journal › Article

    • 3 Scopus citations

    Systemic infection facilitates transmission of Pseudomonas aeruginosa in mice

    Bachta, K. E. R., Allen, J. P., Cheung, B. H., Chiu, C. H. & Hauser, A. R., Dec 1 2020, In : Nature communications. 11, 1, 543.

    Research output: Contribution to journal › Article

    Open Access