Grants per year
Personal profile
Research Interests
Our laboratory investigates the pathogenesis of the multidrug resistant gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumonia. We focus on virulence factors such as the type III secretion, an apparatus that injects toxins directly into host cells. Other interests are the use of genomic approaches for the identification of novel virulence determinants and the development of novel translational approaches to treat bacterial infections. Our studies utilize a broad range of techniques, including molecular and cellular assays as well as animal models and epidemiologic studies on human populations.
Certifications and Licenses
Internal Medicine | |
Infectious Disease |
Training Experience
1994 | Internship, University of Minnesota Medical Center |
1994 | Residency, University of Minnesota Medical Center |
1996 | Fellowship, Univ. of CA-San Francisco Med. Ctr. |
1998 | Postdoctoral Fellowship, University of California, San Francisco |
Education/Academic qualification
MD, University of Minnesota Twin Cities
… → 1992
PhD, University of Minnesota Twin Cities
… → 1990
Research interests
- Infectious Diseases: Bacteria
- Microbiology
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Grants
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Dynamics of Pseudomonas aeruginosa During Bacteremia
National Institute of Allergy and Infectious Diseases
7/24/20 → 6/30/22
Project: Research project
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Patient-Oriented Research on Pseudomonas aeruginosa
National Institute of Allergy and Infectious Diseases
2/22/20 → 1/31/25
Project: Research project
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Project 2: Pathogen and Microbiome Temporal Changes During Resolution of HAP
National Institute of Allergy and Infectious Diseases
1/17/18 → 12/31/22
Project: Research project
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Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center
Abdala-Valencia, H., Amaral, L. A. N., Bartom, E. T., Budinger, G. S., Davuluri, R. V., Hauser, A. R., Horvath, C. M., Kandpal, M., Misharin, A., Ozer, E. A., Qi, C., Singer, B., Starren, J. B., Wehbe, F., Winter, D. R. & Wunderink, R. G.
National Institute of Allergy and Infectious Diseases
1/17/18 → 12/31/22
Project: Research project
Research Output
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A clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways
Lorenzo-Redondo, R., Nam, H. H., Roberts, S. C., Simons, L. M., Jennings, L. J., Qi, C., Achenbach, C. J., Hauser, A. R., Ison, M. G., Hultquist, J. F. & Ozer, E. A., Dec 2020, In: EBioMedicine. 62, 103112.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
A comparative genomics approach identifies contact-dependent growth inhibition as a virulence determinant
Allen, J. P., Ozer, E. A., Minasov, G., Shuvalova, L., Kiryukhina, O., Satchell, K. J. F. & Hauser, A. R., Mar 24 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 12, p. 6811-6821 11 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
A genome-based model to predict the virulence of pseudomonas aeruginosa isolates
Pincus, N. B., Ozer, E. A., Allen, J. P., Nguyen, M., Davis, J. J., Winter, D. R., Chuang, C. H., Chiu, C. H., Zamorano, L., Oliver, A. & Hauser, A. R., Jul 1 2020, In: mBio. 11, 4, p. 1-19 19 p., e01527-20.Research output: Contribution to journal › Article › peer-review
Open Access -
A structure-function-inhibition analysis of the pseudomonas aeruginosa type III secretion needle protein pscF
Moir, D. T., Bowlin, N. O., Berube, B. J., Yabut, J., Mills, D. M., Nguyen, G. T., Aron, Z. D., Williams, J. D., Mecsas, J., Hauser, A. R. & Bowlina, T. L., Sep 1 2020, In: Journal of bacteriology. 202, 18, e00055-20.Research output: Contribution to journal › Article › peer-review
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Complete genome sequence of klebsiella pneumoniae strain TK421, a conjugative hypervirulent isolate
Kochan, T. J., Ozer, E. A., Pincus, N. B., Fitzpatrick, M. A. & Hauser, A. R., Jan 16 2020, In: Microbiology Resource Announcements. 9, 3, e01408-19.Research output: Contribution to journal › Article › peer-review
Open Access