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Personal profile

Research Interests

Our laboratory investigates the pathogenesis of the multidrug resistant gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumonia. We focus on virulence factors such as the type III secretion, an apparatus that injects toxins directly into host cells. Other interests are the use of genomic approaches for the identification of novel virulence determinants and the development of novel translational approaches to treat bacterial infections. Our studies utilize a broad range of techniques, including molecular and cellular assays as well as animal models and epidemiologic studies on human populations.

Certifications and Licenses

Internal Medicine
Infectious Disease

Training Experience

1994Internship, University of Minnesota Medical Center
1994Residency, University of Minnesota Medical Center
1996Fellowship, Univ. of CA-San Francisco Med. Ctr.
1998Postdoctoral Fellowship, University of California, San Francisco

Education/Academic qualification

MD, University of Minnesota

… → 1992

PhD, University of Minnesota

… → 1990

Research interests

  • Infectious Diseases: Bacteria
  • Microbiology

Fingerprint Dive into the research topics where Alan R Hauser is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Pseudomonas aeruginosa Medicine & Life Sciences
Virulence Medicine & Life Sciences
Pneumonia Medicine & Life Sciences
Pseudomonas Infections Medicine & Life Sciences
Genome Medicine & Life Sciences
Infection Medicine & Life Sciences
Proteins Medicine & Life Sciences
Acinetobacter baumannii Medicine & Life Sciences

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Grants 2002 2022

Polymyxin B
Cystic Fibrosis
Nanoparticles
Infection
Anti-Bacterial Agents
Pseudomonas aeruginosa
Biomarkers
Bacteremia
Virulence
Lethal Dose 50

Research Output 1988 2019

Acinetobacter baumannii
Klebsiella pneumoniae
Pneumonia
Lung
Microbiota
1 Citation (Scopus)

A review of the clinical pharmacokinetics of polymyxin b

Avedissian, S. N., Liu, J., Rhodes, N. J., Lee, A., Pais, G. M., Hauser, A. R. & Scheetz, M. H., Mar 1 2019, In : Antibiotics. 8, 1, 31.

Research output: Contribution to journalArticle

Open Access
Polymyxins
Polymyxin B
Pharmacokinetics
Colistin
Toxicity

Draft genome sequence of pseudomonas aeruginosa strain BWH047, a sequence type 235 multidrug-resistant clinical isolate expressing high levels of colistin resistance

Bachta, K. E. R., Ozer, E. A., Pandit, A., Marty, F. M., Mekalanos, J. J. & Hauser, A. R., Jul 18 2019, In : Microbiology Resource Announcements. 8, 29, e00623-19.

Research output: Contribution to journalArticle

Open Access
Colistin
Pseudomonas aeruginosa
Genome
Gram-Negative Bacteria
Disease Outbreaks
1 Citation (Scopus)

In Vivo Proteome of Pseudomonas aeruginosa in Airways of Cystic Fibrosis Patients

Wu, X., Siehnel, R. J., Garudathri, J., Staudinger, B. J., Hisert, K. B., Ozer, E. A., Hauser, A. R., Eng, J. K., Manoil, C., Singh, P. K. & Bruce, J. E., Jun 7 2019, In : Journal of Proteome Research. 18, 6, p. 2601-2612 12 p.

Research output: Contribution to journalArticle

Proteome
Cystic Fibrosis
Pseudomonas aeruginosa
Physiology
Sputum
1 Citation (Scopus)

Multidimensional assessment of the host response in mechanically ventilated patients with suspected pneumonia

Walter, J. M., Ren, Z., Yacoub, T., Reyfman, P. A., Shah, R. D., Abdala-Valencia, H., Nam, K., Morgan, V. K., Anekalla, K. R., Joshi, N., McQuattie-Pimentel, A. C., Chen, C. I., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Aillon, R. P., Watanabe, S., Williams, K. J. N., Lu, Z. & 13 others, Paonessa, J., Hountras, P., Breganio, M., Borkowski, N., Donnelly, H. K., Allen, J. P., Amaral, L. A. N., Bharat, A., Misharin, A., Bagheri, N., Hauser, A. R., Budinger, GR. S. & Wunderink, R. G., May 15 2019, In : American journal of respiratory and critical care medicine. 199, 10, p. 1225-1237 13 p.

Research output: Contribution to journalArticle

Bacterial Pneumonia
Pneumonia
Macrophages
Bronchoalveolar Lavage Fluid
Alveolar Macrophages