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Alan R Hauser

  • 5123 Citations
1988 …2022
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Personal profile

Research Interests

Our laboratory investigates the pathogenesis of the multidrug resistant gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumonia. We focus on virulence factors such as the type III secretion, an apparatus that injects toxins directly into host cells. Other interests are the use of genomic approaches for the identification of novel virulence determinants and the development of novel translational approaches to treat bacterial infections. Our studies utilize a broad range of techniques, including molecular and cellular assays as well as animal models and epidemiologic studies on human populations.

Certifications and Licenses

Internal Medicine
Infectious Disease

Training Experience

1994Internship, University of Minnesota Medical Center
1994Residency, University of Minnesota Medical Center
1996Fellowship, Univ. of CA-San Francisco Med. Ctr.
1998Postdoctoral Fellowship, University of California, San Francisco

Education/Academic qualification

MD, University of Minnesota

… → 1992

PhD, University of Minnesota

… → 1990

Research interests

  • Infectious Diseases: Bacteria
  • Microbiology

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  • 6 Similar Profiles
Pseudomonas aeruginosa Medicine & Life Sciences
Virulence Medicine & Life Sciences
Pneumonia Medicine & Life Sciences
Pseudomonas Infections Medicine & Life Sciences
Infection Medicine & Life Sciences
Genome Medicine & Life Sciences
Proteins Medicine & Life Sciences
Acinetobacter baumannii Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2002 2022

Project 2: Pathogen and Microbiome Temporal Changes During Resolution of HAP

Hauser, A. R.

National Institute of Allergy and Infectious Diseases

1/17/18 → 12/31/22

Project: Research project

Microbiota
Pneumonia
Biomarkers
Fungal DNA
RNA

Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center

Abdala-Valencia, H., Amaral, L. A. N., Bartom, E. T., Budinger, G. S., Davuluri, R. V., Hauser, A. R., Horvath, C. M., Kandpal, M., Misharin, A., Ozer, E. A., Qi, C., Singer, B., Starren, J. B., Wehbe, F., Winter, D. R. & Wunderink, R. G.

National Institute of Allergy and Infectious Diseases

1/17/18 → 12/31/22

Project: Research project

Systems Biology
Pneumonia
Microbiota
Biomarkers
Fungal DNA

Nanoparticle-Polymyxin B Conjugates for Treating Infections in CF Patients

Hauser, A. R. & Lee, A.

Cystic Fibrosis Foundation

11/1/17 → 10/31/19

Project: Research project

Polymyxin B
Cystic Fibrosis
Nanoparticles
Infection
Anti-Bacterial Agents

Biomarkers for Highly Virulent Pseudomonas aeruginosa Strains

Bi, Y. & Hauser, A. R.

National Institute of Allergy and Infectious Diseases

8/11/17 → 7/31/20

Project: Research project

Pseudomonas aeruginosa
Biomarkers
Bacteremia
Virulence
Lethal Dose 50

Subproject for SP0038369 - identify novel antibiotic resistance determinants and addresses the public health response to the ntibiotic Resistance (AR) threat to our Nation’s public health

Hauser, A. R.

National Institute of Allergy and Infectious Diseases

8/11/17 → 7/31/20

Project: Research project

Microbial Drug Resistance
Pseudomonas aeruginosa
Public Health
Bacteremia
Virulence

Research Output 1988 2019

2 Citations (Scopus)

A genomic approach to identify klebsiella pneumoniae and acinetobacter baumannii strains with enhanced competitive fitness in the lungs during multistrain pneumonia

Agard, M. J., Ozer, E. A., Morris, A. R., Piseaux, R. & Hauser, A. R., Jan 1 2019, In : Infection and immunity. 87, 6, e00871-18.

Research output: Contribution to journal › Article

Acinetobacter baumannii
Klebsiella pneumoniae
Pneumonia
Lung
Microbiota
3 Citations (Scopus)

A review of the clinical pharmacokinetics of polymyxin b

Avedissian, S. N., Liu, J., Rhodes, N. J., Lee, A., Pais, G. M., Hauser, A. R. & Scheetz, M. H., Mar 1 2019, In : Antibiotics. 8, 1, 31.

Research output: Contribution to journal › Article

Open Access
Polymyxins
Polymyxin B
Pharmacokinetics
Colistin
Toxicity
2 Citations (Scopus)

Diversity of Contact-Dependent Growth Inhibition Systems of Pseudomonas aeruginosa

Allen, J. P. & Hauser, A. R., Jan 1 2019, In : Journal of bacteriology. 201, 14, e00776-18.

Research output: Contribution to journal › Article

Pseudomonas aeruginosa
Growth
Ecology
Nucleic Acids
Immunity

Draft genome sequence of pseudomonas aeruginosa strain BWH047, a sequence type 235 multidrug-resistant clinical isolate expressing high levels of colistin resistance

Bachta, K. E. R., Ozer, E. A., Pandit, A., Marty, F. M., Mekalanos, J. J. & Hauser, A. R., Jul 18 2019, In : Microbiology Resource Announcements. 8, 29, e00623-19.

Research output: Contribution to journal › Article

Open Access
Colistin
Pseudomonas aeruginosa
Genome
Gram-Negative Bacteria
Disease Outbreaks
2 Citations (Scopus)

In Vivo Proteome of Pseudomonas aeruginosa in Airways of Cystic Fibrosis Patients

Wu, X., Siehnel, R. J., Garudathri, J., Staudinger, B. J., Hisert, K. B., Ozer, E. A., Hauser, A. R., Eng, J. K., Manoil, C., Singh, P. K. & Bruce, J. E., Jun 7 2019, In : Journal of Proteome Research. 18, 6, p. 2601-2612 12 p.

Research output: Contribution to journal › Article

Proteome
Cystic Fibrosis
Pseudomonas aeruginosa
Physiology
Sputum