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Personal profile

Research Interests

Our laboratory investigates the pathogenesis of the multidrug resistant gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumonia. We focus on virulence factors such as the type III secretion, an apparatus that injects toxins directly into host cells. Other interests are the use of genomic approaches for the identification of novel virulence determinants and the development of novel translational approaches to treat bacterial infections. Our studies utilize a broad range of techniques, including molecular and cellular assays as well as animal models and epidemiologic studies on human populations.

Certifications and Licenses

Internal Medicine
Infectious Disease

Training Experience

1994Internship, University of Minnesota Medical Center
1994Residency, University of Minnesota Medical Center
1996Fellowship, Univ. of CA-San Francisco Med. Ctr.
1998Postdoctoral Fellowship, University of California, San Francisco

Education/Academic qualification

MD, University of Minnesota

… → 1992

PhD, University of Minnesota

… → 1990

Keywords

  • Infectious Diseases: Bacteria
  • Microbiology

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Grants 2002 2022

Polymyxin B
Cystic Fibrosis
Nanoparticles
Infection
Anti-Bacterial Agents
Pseudomonas aeruginosa
Biomarkers
Bacteremia
Virulence
Lethal Dose 50

Research Output 1988 2019

A review of the clinical pharmacokinetics of polymyxin b

Avedissian, S. N., Liu, J., Rhodes, N. J., Lee, A., Pais, G. M., Hauser, A. R. & Scheetz, M. H., Mar 1 2019, In : Antibiotics. 8, 1, 31.

Research output: Contribution to journalArticle

Open Access
Polymyxins
Polymyxin B
Pharmacokinetics
Colistin
Toxicity

ASC acts in a caspase-1-independent manner to worsen acute pneumonia caused by Pseudomonas aeruginosa

Hughes, A. J., Knoten, C. A., Morris, A. R. & Hauser, A. R., Aug 1 2018, In : Journal of Medical Microbiology. 67, 8, p. 1168-1180 13 p., 000782.

Research output: Contribution to journalArticle

Caspase 1
Pseudomonas aeruginosa
Pneumonia
Macrophages
Inflammasomes
Klebsiella Infections
Klebsiella pneumoniae
Pharmaceutical Preparations
Genome
Genes

Environmental reservoirs for exoS+ and exoU+ strains of Pseudomonas aeruginosa

Rutherford, V., Yom, K., Ozer, E. A., Pura, O., Hughes, A., Murphy, K. R., Cudzilo, L., Mitchell, D. & Hauser, A. R., Aug 1 2018, In : Environmental Microbiology Reports. 10, 4, p. 485-492 8 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa
secretion
type III secretion system
relatedness
phylogeny