Grants per year
Personal profile
Research Interests
Our laboratory investigates the pathogenesis of the multidrug resistant gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumonia. We focus on virulence factors such as the type III secretion, an apparatus that injects toxins directly into host cells. Other interests are the use of genomic approaches for the identification of novel virulence determinants and the development of novel translational approaches to treat bacterial infections. Our studies utilize a broad range of techniques, including molecular and cellular assays as well as animal models and epidemiologic studies on human populations.
Certifications and Licenses
| Internal Medicine | |
| Infectious Disease |
Training Experience
| 1994 | Internship, University of Minnesota Medical Center |
| 1994 | Residency, University of Minnesota Medical Center |
| 1996 | Fellowship, Univ. of CA-San Francisco Med. Ctr. |
| 1998 | Postdoctoral Fellowship, University of California, San Francisco |
Education/Academic qualification
MD, University of Minnesota
… → 1992
PhD, University of Minnesota
… → 1990
Research interests
- Infectious Diseases: Bacteria
- Microbiology
Fingerprint Dive into the research topics where Alan R Hauser is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 6 Similar Profiles
Pseudomonas aeruginosa
Medicine & Life Sciences
Virulence
Medicine & Life Sciences
Pneumonia
Medicine & Life Sciences
Pseudomonas Infections
Medicine & Life Sciences
Genome
Medicine & Life Sciences
Infection
Medicine & Life Sciences
Proteins
Medicine & Life Sciences
Acinetobacter baumannii
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2002 2022
Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center
Abdala-Valencia, H., Amaral, L. A. N., Bartom, E. T., Budinger, G. S., Davuluri, R. V., Hauser, A. R., Horvath, C. M., Kandpal, M., Misharin, A., Ozer, E. A., Qi, C., Singer, B., Starren, J. B., Wehbe, F., Winter, D. R. & Wunderink, R. G.
National Institute of Allergy and Infectious Diseases
1/17/18 → 12/31/22
Project: Research project
Systems Biology
Pneumonia
Microbiota
Biomarkers
Fungal DNA
Project 2: Pathogen and Microbiome Temporal Changes During Resolution of HAP
National Institute of Allergy and Infectious Diseases
1/17/18 → 12/31/22
Project: Research project
Microbiota
Pneumonia
Biomarkers
Fungal DNA
RNA
Nanoparticle-Polymyxin B Conjugates for Treating Infections in CF Patients
11/1/17 → 10/31/19
Project: Research project
Polymyxin B
Cystic Fibrosis
Nanoparticles
Infection
Anti-Bacterial Agents
Subproject for SP0038369 - identify novel antibiotic resistance determinants and addresses the public health response to the ntibiotic Resistance (AR) threat to our Nation’s public health
National Institute of Allergy and Infectious Diseases
8/11/17 → 7/31/20
Project: Research project
Microbial Drug Resistance
Pseudomonas aeruginosa
Public Health
Bacteremia
Virulence
Biomarkers for Highly Virulent Pseudomonas aeruginosa Strains
Bi, Y. & Hauser, A. R.
National Institute of Allergy and Infectious Diseases
8/11/17 → 7/31/20
Project: Research project
Pseudomonas aeruginosa
Biomarkers
Bacteremia
Virulence
Lethal Dose 50
Research Output 1988 2019
A genomic approach to identify klebsiella pneumoniae and acinetobacter baumannii strains with enhanced competitive fitness in the lungs during multistrain pneumonia
Agard, M. J., Ozer, E. A., Morris, A. R., Piseaux, R. & Hauser, A. R., Jan 1 2019, In : Infection and immunity. 87, 6, e00871-18.Research output: Contribution to journal › Article
Acinetobacter baumannii
Klebsiella pneumoniae
Pneumonia
Lung
Microbiota
1
Citation
(Scopus)
A review of the clinical pharmacokinetics of polymyxin b
Avedissian, S. N., Liu, J., Rhodes, N. J., Lee, A., Pais, G. M., Hauser, A. R. & Scheetz, M. H., Mar 1 2019, In : Antibiotics. 8, 1, 31.Research output: Contribution to journal › Article
Open Access
Polymyxins
Polymyxin B
Pharmacokinetics
Colistin
Toxicity
Draft genome sequence of pseudomonas aeruginosa strain BWH047, a sequence type 235 multidrug-resistant clinical isolate expressing high levels of colistin resistance
Bachta, K. E. R., Ozer, E. A., Pandit, A., Marty, F. M., Mekalanos, J. J. & Hauser, A. R., Jul 18 2019, In : Microbiology Resource Announcements. 8, 29, e00623-19.Research output: Contribution to journal › Article
Open Access
Colistin
Pseudomonas aeruginosa
Genome
Gram-Negative Bacteria
Disease Outbreaks
1
Citation
(Scopus)
In Vivo Proteome of Pseudomonas aeruginosa in Airways of Cystic Fibrosis Patients
Wu, X., Siehnel, R. J., Garudathri, J., Staudinger, B. J., Hisert, K. B., Ozer, E. A., Hauser, A. R., Eng, J. K., Manoil, C., Singh, P. K. & Bruce, J. E., Jun 7 2019, In : Journal of Proteome Research. 18, 6, p. 2601-2612 12 p.Research output: Contribution to journal › Article
Proteome
Cystic Fibrosis
Pseudomonas aeruginosa
Physiology
Sputum
1
Citation
(Scopus)
Multidimensional assessment of the host response in mechanically ventilated patients with suspected pneumonia
Walter, J. M., Ren, Z., Yacoub, T., Reyfman, P. A., Shah, R. D., Abdala-Valencia, H., Nam, K., Morgan, V. K., Anekalla, K. R., Joshi, N., McQuattie-Pimentel, A. C., Chen, C. I., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Aillon, R. P., Watanabe, S., Williams, K. J. N., Lu, Z. & 13 others, , May 15 2019, In : American journal of respiratory and critical care medicine. 199, 10, p. 1225-1237 13 p.Research output: Contribution to journal › Article
Bacterial Pneumonia
Pneumonia
Macrophages
Bronchoalveolar Lavage Fluid
Alveolar Macrophages