Grants per year
Personal profile
Research Interests
Our laboratory investigates the pathogenesis of the multidrug resistant gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumonia. We focus on virulence factors such as the type III secretion, an apparatus that injects toxins directly into host cells. Other interests are the use of genomic approaches for the identification of novel virulence determinants and the development of novel translational approaches to treat bacterial infections. Our studies utilize a broad range of techniques, including molecular and cellular assays as well as animal models and epidemiologic studies on human populations.
Certifications and Licenses
| Internal Medicine | |
| Infectious Disease |
Training Experience
| 1994 | Internship, University of Minnesota Medical Center |
| 1994 | Residency, University of Minnesota Medical Center |
| 1996 | Fellowship, Univ. of CA-San Francisco Med. Ctr. |
| 1998 | Postdoctoral Fellowship, University of California, San Francisco |
Education/Academic qualification
MD, University of Minnesota
… → 1992
PhD, University of Minnesota
… → 1990
Keywords
- Infectious Diseases: Bacteria
- Microbiology
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2002 2022
Project 2: Pathogen and Microbiome Temporal Changes During Resolution of HAP
National Institute of Allergy and Infectious Diseases
1/17/18 → 12/31/22
Project: Research project
Microbiota
Pneumonia
Biomarkers
Fungal DNA
RNA
Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center
Abdala-Valencia, H., Amaral, L. A. N., Bartom, E. T., Budinger, G. S., Davuluri, R. V., Hauser, A. R., Horvath, C. M., Kandpal, M., Misharin, A., Ozer, E. A., Qi, C., Singer, B., Starren, J. B., Wehbe, F., Winter, D. R. & Wunderink, R. G.
National Institute of Allergy and Infectious Diseases
1/17/18 → 12/31/22
Project: Research project
Systems Biology
Pneumonia
Microbiota
Biomarkers
Fungal DNA
Nanoparticle-Polymyxin B Conjugates for Treating Infections in CF Patients
11/1/17 → 10/31/19
Project: Research project
Polymyxin B
Cystic Fibrosis
Nanoparticles
Infection
Anti-Bacterial Agents
Biomarkers for Highly Virulent Pseudomonas aeruginosa Strains
Bi, Y. & Hauser, A. R.
National Institute of Allergy and Infectious Diseases
8/11/17 → 7/31/19
Project: Research project
Pseudomonas aeruginosa
Biomarkers
Bacteremia
Virulence
Lethal Dose 50
Subproject for SP0038369 - identify novel antibiotic resistance determinants and addresses the public health response to the ntibiotic Resistance (AR) threat to our Nation’s public health
National Institute of Allergy and Infectious Diseases
8/11/17 → 7/31/19
Project: Research project
Microbial Drug Resistance
Pseudomonas aeruginosa
Public Health
Bacteremia
Virulence
Research Output 1988 2019
A review of the clinical pharmacokinetics of polymyxin b
Avedissian, S. N., Liu, J., Rhodes, N. J., Lee, A., Pais, G. M., Hauser, A. R. & Scheetz, M. H., Mar 1 2019, In : Antibiotics. 8, 1, 31.Research output: Contribution to journal › Article
Open Access
Polymyxins
Polymyxin B
Pharmacokinetics
Colistin
Toxicity
Antibiotic Basics for Clinicians: Choosing the right antibacterial agent, 3rd edition
Hauser, A. R., 2018, Philadelphia: Wolters Kluwer: Lippincott Williams & Wilkins.Research output: Book/Report › Book
ASC acts in a caspase-1-independent manner to worsen acute pneumonia caused by Pseudomonas aeruginosa
Hughes, A. J., Knoten, C. A., Morris, A. R. & Hauser, A. R., Aug 1 2018, In : Journal of Medical Microbiology. 67, 8, p. 1168-1180 13 p., 000782.Research output: Contribution to journal › Article
Caspase 1
Pseudomonas aeruginosa
Pneumonia
Macrophages
Inflammasomes
Case Report of an Extensively Drug-Resistant Klebsiella pneumoniae Infection With Genomic Characterization of the Strain and Review of Similar Cases in the United States
Krapp, F., Ozer, E. A., Qi, C. & Hauser, A. R., May 2018, In : Open Forum Infectious Diseases. 5, 5, ofy074.Research output: Contribution to journal › Article
Klebsiella Infections
Klebsiella pneumoniae
Pharmaceutical Preparations
Genome
Genes
Environmental reservoirs for exoS+ and exoU+ strains of Pseudomonas aeruginosa
Rutherford, V., Yom, K., Ozer, E. A., Pura, O., Hughes, A., Murphy, K. R., Cudzilo, L., Mitchell, D. & Hauser, A. R., Aug 1 2018, In : Environmental Microbiology Reports. 10, 4, p. 485-492 8 p.Research output: Contribution to journal › Article
Pseudomonas aeruginosa
secretion
type III secretion system
relatedness
phylogeny