Grants per year
Personal profile
Research Interests
Our research program is aimed at understanding the genetic program that underlies the pathogenesis of Glioblastoma multiforme (GBM), the most prevalent and malignant form of brain cancer. Applying a combination of cell/molecular biology, oncogenomic and mouse engineering approaches, we are dedicated to systematically characterize novel gliomagenic oncogenes and tumor suppressors. We will functionally delineate and validate these pathways towards pharmaceutical opportunities using sophisticated cell culture and animal models.
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Leibniz University Hannover
… → 2000
Research interests
- Brain Cancer / Nervous System Cancer
- Cancer Biology
- Cancer Genetics
- Cell Biology
- Neuro-Oncology
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SPORE for Translational Approaches to Brain Cancer
Lesniak, M. S., Chandler, J. P., Hu, B., Kumthekar, P. U., Leikin, R. G., Liu, B. P., Sachdev, S., Ahmed, A. U., Balyasnikova, I. V., Bartom, E. T., Brat, D. J., Cheng, S., Horbinski, C. M., James, C. D., Lukas, R. V., Platanias, L. C., Scholtens, D. M., Stegh, A. H., Stupp, R. & Wainwright, D. A.
8/17/18 → 7/31/23
Project: Research project
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Systemic RNA interference to reactivate p53 tumor suppression
Stegh, A. H., Horbinski, C. M. & James, C. D.
3/1/17 → 2/28/22
Project: Research project
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Characterizing Epilepsy-Induced Changes in the Glioma Microenvironment
American Society for Radiation Oncology
8/20/20 → 8/19/21
Project: Research project
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A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma
Kumthekar, P., Ko, C. H., Paunesku, T., Dixit, K., Sonabend, A. M., Bloch, O., Tate, M., Schwartz, M., Zuckerman, L., Lezon, R., Lukas, R. V., Jovanovic, B., McCortney, K., Colman, H., Chen, S., Lai, B., Antipova, O., Deng, J., Li, L., Tommasini-Ghelfi, S. & 17 others, , Mar 10 2021, In: Science translational medicine. 13, 584, eabb3945.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease
Tommasini-Ghelfi, S., Murnan, K., Kouri, F. M., Mahajan, A. S., May, J. L. & Stegh, A. H., 2019, In: Science Advances. 5, 5, aaw4543.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
IDH3α regulates one-carbon metabolism in glioblastoma
May, J. L., Kouri, F., Hurley, L. A., Liu, J., Tommasini-Ghelfi, S., Ji, Y., Gao, P., Calvert, A. E., Lee, A., Chandel, N., Davuluri, R. V., Horbinski, C. M., Locasale, J. W. & Stegh, A. H., 2019, In: Science Advances. 5, 1, eaat0456.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Synthesis, physicochemical, and biological evaluation of spherical nucleic acids for RNAi-based therapy in glioblastoma
Tommasini-Ghelfi, S., Lee, A., Mirkin, C. A. & Stegh, A. H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 371-391 21 p. (Methods in Molecular Biology; vol. 1974).Research output: Chapter in Book/Report/Conference proceeding › Chapter
3 Scopus citations -
Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation
Calvert, A. E., Chalastanis, A., Wu, Y., Hurley, L. A., Kouri, F., Bi, Y., Kachman, M., May, J. L., Bartom, E. T., Hua, Y., Mishra, R. K., Schiltz, G. E., Dubrovskyi, O., Mazar, A. P., Peter, M. E., Zheng, H., James, C. D., Burant, C. F., Chandel, N., Davuluri, R. V. & 2 others, , May 30 2017, In: Cell reports. 19, 9, p. 1858-1873 16 p.Research output: Contribution to journal › Article › peer-review
78 Scopus citations