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Alexander H Stegh

  • 4242 Citations
19982023

Research output per year

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Personal profile

Research Interests

Our research program is aimed at understanding the genetic program that underlies the pathogenesis of Glioblastoma multiforme (GBM), the most prevalent and malignant form of brain cancer. Applying a combination of cell/molecular biology, oncogenomic and mouse engineering approaches, we are dedicated to systematically characterize novel gliomagenic oncogenes and tumor suppressors. We will functionally delineate and validate these pathways towards pharmaceutical opportunities using sophisticated cell culture and animal models.

Education/Academic qualification

PhD, Leibniz University Hannover

… → 2000

Research interests

  • Brain Cancer / Nervous System Cancer
  • Cancer Biology
  • Cancer Genetics
  • Cell Biology
  • Neuro-Oncology

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Grants

Project 3: Using RNAi-based Spherical Nucleic Acid (SNA) Nanoconjugates Targeting Bcl2L12 to Promote Therapy-Induced Apoptosis in Glioblastoma Subproject for Institution # SP0045923

Kumthekar, P. U. & Stegh, A. H.

National Cancer Institute

8/17/18 → 7/31/23

Project: Research project

    • SPORE for Translational Approaches to Brain Cancer

    Ahmed, A. U., Balyasnikova, I. V., Bartom, E. T., Brat, D. J., Chandler, J. P., Cheng, S., Horbinski, C. M., Hu, B., James, C. D., Kumthekar, P. U., Leikin, R. G., Lesniak, M. S., Liu, B. P., Lukas, R. V., Platanias, L. C., Sachdev, S., Scholtens, D. M., Stegh, A. H., Stupp, R. & Wainwright, D. A.

    National Cancer Institute

    8/17/18 → 7/31/23

    Project: Research project

    • Identification of small molecule inhibitors for IDH1

    Stegh, A. H.

    Stephen M. Coffman Charitable Trust

    5/1/18 → 4/30/20

    Project: Research project

    • Systemic RNA interference to reactivate p53 tumor suppression

    Horbinski, C. M., James, C. D., Mirkin, C. A. & Stegh, A. H.

    National Cancer Institute

    3/1/17 → 2/28/22

    Project: Research project

    • CCNE Project #2: Spherical Nucleic Acids for Metabolic Reprogramming of Malignant Glioma (Stegh)

    Stegh, A. H.

    National Cancer Institute

    9/1/15 → 7/31/20

    Project: Research project

    • Research Output

    Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease

    Tommasini-Ghelfi, S., Murnan, K., Kouri, F. M., Mahajan, A. S., May, J. L. & Stegh, A. H., Jan 1 2019, In : Science Advances. 5, 5, aaw4543.

    Research output: Contribution to journal › Article

    Open Access
    • 4 Scopus citations

    IDH3α regulates one-carbon metabolism in glioblastoma

    May, J. L., Kouri, F., Hurley, L. A., Liu, J., Tommasini-Ghelfi, S., Ji, Y., Gao, P., Calvert, A. E., Lee, A., Chandel, N., Davuluri, R. V., Horbinski, C. M., Locasale, J. W. & Stegh, A. H., Jan 1 2019, In : Science Advances. 5, 1, eaat0456.

    Research output: Contribution to journal › Article

    • 6 Scopus citations

    Synthesis, physicochemical, and biological evaluation of spherical nucleic acids for RNAi-based therapy in glioblastoma

    Tommasini-Ghelfi, S., Lee, A., Mirkin, C. A. & Stegh, A. H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 371-391 21 p. (Methods in Molecular Biology; vol. 1974).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

    • Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

    Calvert, A. E., Chalastanis, A., Wu, Y., Hurley, L. A., Kouri, F., Bi, Y., Kachman, M., May, J. L., Bartom, E. T., Hua, Y., Mishra, R. K., Schiltz, G. E., Dubrovskyi, O., Mazar, A. P., Peter, M. E., Zheng, H., James, C. D., Burant, C. F., Chandel, N., Davuluri, R. V. & 2 others, Horbinski, C. M. & Stegh, A. H., May 30 2017, In : Cell reports. 19, 9, p. 1858-1873 16 p.

    Research output: Contribution to journal › Article

    • 39 Scopus citations

    Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo

    Sita, T. L., Kouri, F. M., Hurley, L. A., Merkel, T. J., Chalastanis, A., May, J. L., Ghelfi, S. T., Cole, L. E., Cayton, T. C., Barnaby, S. N., Sprangers, A. J., Savalia, N., James, C. D., Lee, A., Mirkin, C. A. & Stegh, A. H., Apr 18 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. 4129-4134 6 p.

    Research output: Contribution to journal › Article

    • 17 Scopus citations