Grants per year
Personal profile
Research Interests
Our research program is aimed at understanding the genetic program that underlies the pathogenesis of Glioblastoma multiforme (GBM), the most prevalent and malignant form of brain cancer. Applying a combination of cell/molecular biology, oncogenomic and mouse engineering approaches, we are dedicated to systematically characterize novel gliomagenic oncogenes and tumor suppressors. We will functionally delineate and validate these pathways towards pharmaceutical opportunities using sophisticated cell culture and animal models.
Education/Academic qualification
PhD, Leibniz University Hannover
… → 2000
Research interests
- Brain Cancer / Nervous System Cancer
- Cancer Biology
- Cancer Genetics
- Cell Biology
- Neuro-Oncology
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Grants
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Characterizing Epilepsy-Induced Changes in the Glioma Microenvironment
American Society for Radiation Oncology
8/20/20 → 8/19/21
Project: Research project
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SPORE for Translational Approaches to Brain Cancer
Ahmed, A. U., Balyasnikova, I. V., Bartom, E. T., Brat, D. J., Chandler, J. P., Cheng, S., Horbinski, C. M., Hu, B., James, C. D., Kumthekar, P. U., Lesniak, M. S., Liu, B. P., Lukas, R. V., Sachdev, S., Scholtens, D. M., Stegh, A. H., Stupp, R., Wainwright, D. A., Leikin, R. G. & Platanias, L. C.
8/17/18 → 7/31/23
Project: Research project
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Identification of small molecule inhibitors for IDH1
Stephen M. Coffman Charitable Trust
5/1/18 → 4/30/21
Project: Research project
Research Output
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Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease
Tommasini-Ghelfi, S., Murnan, K., Kouri, F. M., Mahajan, A. S., May, J. L. & Stegh, A. H., 2019, In: Science Advances. 5, 5, aaw4543.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
IDH3α regulates one-carbon metabolism in glioblastoma
May, J. L., Kouri, F., Hurley, L. A., Liu, J., Tommasini-Ghelfi, S., Ji, Y., Gao, P., Calvert, A. E., Lee, A., Chandel, N., Davuluri, R. V., Horbinski, C. M., Locasale, J. W. & Stegh, A. H., 2019, In: Science Advances. 5, 1, eaat0456.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Synthesis, physicochemical, and biological evaluation of spherical nucleic acids for RNAi-based therapy in glioblastoma
Tommasini-Ghelfi, S., Lee, A., Mirkin, C. A. & Stegh, A. H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 371-391 21 p. (Methods in Molecular Biology; vol. 1974).Research output: Chapter in Book/Report/Conference proceeding › Chapter
2 Scopus citations -
Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation
Calvert, A. E., Chalastanis, A., Wu, Y., Hurley, L. A., Kouri, F., Bi, Y., Kachman, M., May, J. L., Bartom, E. T., Hua, Y., Mishra, R. K., Schiltz, G. E., Dubrovskyi, O., Mazar, A. P., Peter, M. E., Zheng, H., James, C. D., Burant, C. F., Chandel, N., Davuluri, R. V. & 2 others, , May 30 2017, In: Cell reports. 19, 9, p. 1858-1873 16 p.Research output: Contribution to journal › Article › peer-review
63 Scopus citations -
Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo
Sita, T. L., Kouri, F. M., Hurley, L. A., Merkel, T. J., Chalastanis, A., May, J. L., Ghelfi, S. T., Cole, L. E., Cayton, T. C., Barnaby, S. N., Sprangers, A. J., Savalia, N., James, C. D., Lee, A., Mirkin, C. A. & Stegh, A. H., Apr 18 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. 4129-4134 6 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations