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Alexander H Stegh

  • 3957 Citations
19982023
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Personal profile

Research Interests

Our research program is aimed at understanding the genetic program that underlies the pathogenesis of Glioblastoma multiforme (GBM), the most prevalent and malignant form of brain cancer. Applying a combination of cell/molecular biology, oncogenomic and mouse engineering approaches, we are dedicated to systematically characterize novel gliomagenic oncogenes and tumor suppressors. We will functionally delineate and validate these pathways towards pharmaceutical opportunities using sophisticated cell culture and animal models.

Education/Academic qualification

PhD, Leibniz University Hannover

… → 2000

Research interests

  • Brain Cancer / Nervous System Cancer
  • Cancer Biology
  • Cancer Genetics
  • Cell Biology
  • Neuro-Oncology

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  • 12 Similar Profiles
Glioblastoma Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Glioma Medicine & Life Sciences
Nucleic Acids Medicine & Life Sciences
Effector Caspases Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Nanoconjugates Medicine & Life Sciences

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Grants 2009 2023

Project 3: Using RNAi-based Spherical Nucleic Acid (SNA) Nanoconjugates Targeting Bcl2L12 to Promote Therapy-Induced Apoptosis in Glioblastoma Subproject for Institution # SP0045923

Kumthekar, P. U. & Stegh, A. H.

National Cancer Institute

8/17/18 → 7/31/23

Project: Research project

Nanoconjugates
Glioblastoma
RNA Interference
Nucleic Acids
Brain Neoplasms

SPORE for Translational Approaches to Brain Cancer

Ahmed, A. U., Balyasnikova, I. V., Bartom, E. T., Brat, D. J., Chandler, J. P., Cheng, S., Horbinski, C. M., Hu, B., James, C. D., Kumthekar, P. U., Leikin, R. G., Lesniak, M. S., Liu, B. P., Lukas, R. V., Mirkin, C. A., Platanias, L. C., Sachdev, S., Scholtens, D. M., Stegh, A. H., Stupp, R. & Wainwright, D. A.

National Cancer Institute

8/17/18 → 7/31/23

Project: Research project

Brain Neoplasms
Glioblastoma
Therapeutics
Neoplasms
Survival

Identification of small molecule inhibitors for IDH1

Stegh, A. H.

Stephen M. Coffman Charitable Trust

5/1/18 → 4/30/20

Project: Research project

Isocitrate Dehydrogenase
Molecules
Tumors
Cells
Lipids

Systemic RNA interference to reactivate p53 tumor suppression

Horbinski, C. M., James, C. D., Mirkin, C. A. & Stegh, A. H.

National Cancer Institute

3/1/17 → 2/28/22

Project: Research project

Glioblastoma
RNA Interference
Nucleic Acids
Melanoma
Neoplasms

Nucleic Acid-Based Nanoconstructs for the Treatment of Cancer

Bagheri, N., Catalona, W. J., Espinosa, H. D., James, C. D., Lee, A., Mirkin, C. A., Mrksich, M., Nguyen, S., Odom, T. W., Platanias, L. C., Stegh, A. H., Woloschak, G. E. & Zhang, B.

National Cancer Institute

9/1/15 → 7/31/20

Project: Research project

Nucleic Acids
Nanostructures
Neoplasms
Therapeutics
Nanotechnology

Research Output 1998 2019

Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease

Tommasini-Ghelfi, S., Murnan, K., Kouri, F. M., Mahajan, A. S., May, J. L. & Stegh, A. H., Jan 1 2019, In : Science Advances. 5, 5, aaw4543.

Research output: Contribution to journal › Article

Open Access
dehydrogenases
mutations
biology
emerging
cancer
2 Citations (Scopus)

IDH3α regulates one-carbon metabolism in glioblastoma

May, J. L., Kouri, F., Hurley, L. A., Liu, J., Tommasini-Ghelfi, S., Ji, Y., Gao, P., Calvert, A. E., Lee, A., Chandel, N., Davuluri, R. V., Horbinski, C. M., Locasale, J. W. & Stegh, A. H., Jan 1 2019, In : Science Advances. 5, 1, eaat0456.

Research output: Contribution to journal › Article

Glioblastoma
Glycine Hydroxymethyltransferase
Carbon
Methionine
Activity Cycles

Synthesis, physicochemical, and biological evaluation of spherical nucleic acids for RNAi-based therapy in glioblastoma

Tommasini-Ghelfi, S., Lee, A., Mirkin, C. A. & Stegh, A. H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc, p. 371-391 21 p. (Methods in Molecular Biology; vol. 1974).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Glioblastoma
Nucleic Acids
MicroRNAs
Brain Neoplasms
Small Interfering RNA
20 Citations (Scopus)
Bearings (structural)
Isocitrate Dehydrogenase
Gene encoding
Methylation
Differentiation Antigens
12 Citations (Scopus)

Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo

Sita, T. L., Kouri, F., Hurley, L. A., Merkel, T. J., Chalastanis, A., May, J. L., Ghelfi, S. T., Cole, L. E., Cayton, T. C., Barnaby, S. N., Sprangers, A. J., Savalia, N., James, C. D., Lee, A., Mirkin, C. A. & Stegh, A. H., Apr 18 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. 4129-4134 6 p.

Research output: Contribution to journal › Article

Nanoconjugates
Nucleic Acids
Fluorescence
Methyltransferases
Heterografts