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Personal profile

Research Interests

Our research program is aimed at understanding the genetic program that underlies the pathogenesis of Glioblastoma multiforme (GBM), the most prevalent and malignant form of brain cancer. Applying a combination of cell/molecular biology, oncogenomic and mouse engineering approaches, we are dedicated to systematically characterize novel gliomagenic oncogenes and tumor suppressors. We will functionally delineate and validate these pathways towards pharmaceutical opportunities using sophisticated cell culture and animal models.

Education/Academic qualification

PhD, Leibniz University Hannover

… → 2000

Research interests

  • Brain Cancer / Nervous System Cancer
  • Cancer Biology
  • Cancer Genetics
  • Cell Biology
  • Neuro-Oncology

Fingerprint Dive into the research topics where Alexander H Stegh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Glioblastoma Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Glioma Medicine & Life Sciences
Nucleic Acids Medicine & Life Sciences
Effector Caspases Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Nanoconjugates Medicine & Life Sciences

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Grants 2009 2023

Isocitrate Dehydrogenase
Molecules
Tumors
Cells
Lipids
Glioblastoma
RNA Interference
Nucleic Acids
Melanoma
Neoplasms

Research Output 1998 2019

Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease

Tommasini-Ghelfi, S., Murnan, K., Kouri, F. M., Mahajan, A. S., May, J. L. & Stegh, A. H., Jan 1 2019, In : Science Advances. 5, 5, aaw4543.

Research output: Contribution to journalArticle

Open Access
dehydrogenases
mutations
biology
emerging
cancer
2 Citations (Scopus)

IDH3α regulates one-carbon metabolism in glioblastoma

May, J. L., Kouri, F., Hurley, L. A., Liu, J., Tommasini-Ghelfi, S., Ji, Y., Gao, P., Calvert, A. E., Lee, A., Chandel, N., Davuluri, R. V., Horbinski, C. M., Locasale, J. W. & Stegh, A. H., Jan 1 2019, In : Science Advances. 5, 1, eaat0456.

Research output: Contribution to journalArticle

Glioblastoma
Glycine Hydroxymethyltransferase
Carbon
Methionine
Activity Cycles

Synthesis, physicochemical, and biological evaluation of spherical nucleic acids for RNAi-based therapy in glioblastoma

Tommasini-Ghelfi, S., Lee, A., Mirkin, C. A. & Stegh, A. H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc, p. 371-391 21 p. (Methods in Molecular Biology; vol. 1974).

Research output: Chapter in Book/Report/Conference proceedingChapter

Glioblastoma
Nucleic Acids
MicroRNAs
Brain Neoplasms
Small Interfering RNA
22 Citations (Scopus)

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

Calvert, A. E., Chalastanis, A., Wu, Y., Hurley, L. A., Kouri, F., Bi, Y., Kachman, M., May, J. L., Bartom, E. T., Hua, Y., Mishra, R. K., Schiltz, G. E., Dubrovskyi, O., Mazar, A. P., Peter, M. E., Zheng, H., James, C. D., Burant, C. F., Chandel, N., Davuluri, R. V. & 2 others, Horbinski, C. M. & Stegh, A. H., May 30 2017, In : Cell reports. 19, 9, p. 1858-1873 16 p.

Research output: Contribution to journalArticle

Bearings (structural)
Isocitrate Dehydrogenase
Gene encoding
Methylation
Differentiation Antigens
12 Citations (Scopus)

Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo

Sita, T. L., Kouri, F., Hurley, L. A., Merkel, T. J., Chalastanis, A., May, J. L., Ghelfi, S. T., Cole, L. E., Cayton, T. C., Barnaby, S. N., Sprangers, A. J., Savalia, N., James, C. D., Lee, A., Mirkin, C. A. & Stegh, A. H., Apr 18 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. 4129-4134 6 p.

Research output: Contribution to journalArticle

Nanoconjugates
Nucleic Acids
Fluorescence
Methyltransferases
Heterografts