Grants per year
Grants 2009 2023
Active
Project 3: Using RNAi-based Spherical Nucleic Acid (SNA) Nanoconjugates Targeting Bcl2L12 to Promote Therapy-Induced Apoptosis in Glioblastoma Subproject for Institution # SP0045923
Kumthekar, P. U. & Stegh, A. H.
8/17/18 → 7/31/23
Project: Research project
Nanoconjugates
Glioblastoma
RNA Interference
Nucleic Acids
Brain Neoplasms
SPORE for Translational Approaches to Brain Cancer
Ahmed, A. U., Balyasnikova, I. V., Bartom, E. T., Brat, D. J., Chandler, J. P., Cheng, S., Horbinski, C. M., Hu, B., James, C. D., Kumthekar, P. U., Leikin, R. G., Lesniak, M. S., Liu, B. P., Lukas, R. V., Mirkin, C. A., Platanias, L. C., Sachdev, S., Scholtens, D. M., Stegh, A. H., Stupp, R. & Wainwright, D. A.
8/17/18 → 7/31/23
Project: Research project
Brain Neoplasms
Glioblastoma
Therapeutics
Neoplasms
Survival
Identification of small molecule inhibitors for IDH1
Stephen M. Coffman Charitable Trust
5/1/18 → 4/30/20
Project: Research project
Isocitrate Dehydrogenase
Molecules
Tumors
Cells
Lipids
Systemic RNA interference to reactivate p53 tumor suppression
Horbinski, C. M., James, C. D., Mirkin, C. A. & Stegh, A. H.
3/1/17 → 2/28/22
Project: Research project
Glioblastoma
RNA Interference
Nucleic Acids
Melanoma
Neoplasms
CCNE Project #2: Spherical Nucleic Acids for Metabolic Reprogramming of Malignant Glioma (Stegh)
9/1/15 → 7/31/20
Project: Research project
Glioma
Nucleic Acids
Nanostructures
Therapeutics
Neoplasms
Nucleic Acid-Based Nanoconstructs for the Treatment of Cancer
Bagheri, N., Catalona, W. J., Espinosa, H. D., James, C. D., Lee, A., Mirkin, C. A., Mrksich, M., Nguyen, S., Odom, T. W., Platanias, L. C., Stegh, A. H., Woloschak, G. E. & Zhang, B.
9/1/15 → 7/31/20
Project: Research project
Nucleic Acids
Nanostructures
Neoplasms
Therapeutics
Nanotechnology
Finished
Preclinical Evaluation of Small Molecule Inhibitors of IDH1 as an effective treatment of GBM and Lung Cancers
Stephen M. Coffman Charitable Trust
6/1/16 → 5/31/19
Project: Research project
Isocitrate Dehydrogenase
Lung Neoplasms
Neoplasms
Therapeutics
Brain Neoplasms
Year 3 Spherical Nucleic Acids for the treatment of pediatric high-grade gliomas
Ann & Robert H. Lurie Children's Hospital of Chicago, John McNicholas Pediatric Brain Tumor Foundation
1/1/16 → 12/31/18
Project: Research project
Glioma
Nucleic Acids
Neoplasm Genes
Pediatrics
Glioblastoma
Spherical Nucleic Acids for the treatment of pediatric high-grade gliomas
Ann & Robert H. Lurie Children's Hospital of Chicago, John McNicholas Pediatric Brain Tumor Foundation
1/1/16 → 12/31/18
Project: Research project
Glioma
Nucleic Acids
Neoplasm Genes
Pediatrics
Glioblastoma
Safety evaluation of Bcl2L12-targeting SNAs in non-human primates
Mirkin, C. A., Raizer, J. J. & Stegh, A. H.
Stephen M. Coffman Charitable Trust
8/1/14 → 10/31/14
Project: Research project
Nucleic Acids
Primates
Safety
Blood-Brain Barrier
Glioblastoma
Defining and overcoming Bcl2L12-driven therapy resistance in GBM
7/1/14 → 6/30/19
Project: Research project
Glioma
Therapeutics
RNA Interference
Effector Caspases
Apoptosis Regulatory Proteins
RNAi-based spherical nucleic acid nanoconjugates for the treatment of pediatric high-grade glioma
John McNicholas Pediatric Brain Tumor Foundation
3/1/14 → 2/28/16
Project: Research project
Nanoconjugates
RNA Interference
Glioma
Nucleic Acids
Neoplasm Genes
Defining and targeting IDH1-dependent metabolic vulnerabilities in GBM
Alliance for Cancer Gene Therapy
5/1/13 → 4/30/15
Project: Research project
Receptor Protein-Tyrosine Kinases
Glioblastoma
Isocitrate Dehydrogenase
RNA Interference
NADP
Pre-Clinical Drug Sequencing of Receptor Tyrosine Kinase Inhibitors (RTK-Is) to Optimize Treatment for Patients with Malignant Glioma
Raizer, J. J. & Stegh, A. H.
Stephen M. Coffman Charitable Trust
4/1/12 → 3/31/15
Project: Research project
The Role of Bcl2L13 in the Genesis of Malignant Glioma
American Cancer Society, Illinois Division, Inc.
1/1/12 → 12/31/12
Project: Research project
Developing Polyvalent Nano-RNA1-Based Inhibitors of Anti-Apoptotic Bcl-2 Signaling as Anti-Glioma Therapeutics
Northwestern Memorial Foundation
1/1/12 → 12/31/14
Project: Research project
Pre-Clinical Drug Sequencing to Determine Optimal Schedules to Better Treat Malignant Gliomas
Raizer, J. J. & Stegh, A. H.
Stephen M. Coffman Charitable Trust
1/1/11 → 7/31/13
Project: Research project
Nanomaterials for Cancer Diagnostics and Therapeutics
Benson III, A. B., Bentrem, D. J., Cheng, C., Kessler, J., Khan, S. A., Larson, A. C., Meade, T. J., Mirkin, C. A., Mirkin, C. A., Mulcahy, M. F., Munshi, H. G., Rademaker, A. W., Rademaker, A. W., Stegh, A. H., Stoddart, J. F., Stupp, S., Thaxton, C. S., Tomita, T., Woloschak, G. E., Woloschak, G. E., Wu, J. & Yang, G.
9/21/10 → 7/31/16
Project: Research project
CCNE Project #5: Preclinical Validation of Polyvalent siRNA Gold Nanoparticle Conjugates as anti-Glioma Therapeutics (Stegh)
Kessler, J., Kessler, J., Paller, A., Stegh, A. H., Stegh, A. H. & Wu, J.
9/21/10 → 7/31/16
Project: Research project
Development and Characterization of Bc12L12-Driven GBM Mouse Models
Sidney Kimmel Foundation for Cancer Research
7/1/10 → 6/30/12
Project: Research project