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Research Output

2019

Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease

Tommasini-Ghelfi, S., Murnan, K., Kouri, F. M., Mahajan, A. S., May, J. L. & Stegh, A. H., 2019, In : Science Advances. 5, 5, aaw4543.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

IDH3α regulates one-carbon metabolism in glioblastoma

May, J. L., Kouri, F., Hurley, L. A., Liu, J., Tommasini-Ghelfi, S., Ji, Y., Gao, P., Calvert, A. E., Lee, A., Chandel, N., Davuluri, R. V., Horbinski, C. M., Locasale, J. W. & Stegh, A. H., 2019, In : Science Advances. 5, 1, eaat0456.

Research output: Contribution to journalArticle

10 Scopus citations

Synthesis, physicochemical, and biological evaluation of spherical nucleic acids for RNAi-based therapy in glioblastoma

Tommasini-Ghelfi, S., Lee, A., Mirkin, C. A. & Stegh, A. H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 371-391 21 p. (Methods in Molecular Biology; vol. 1974).

Research output: Chapter in Book/Report/Conference proceedingChapter

2017

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

Calvert, A. E., Chalastanis, A., Wu, Y., Hurley, L. A., Kouri, F., Bi, Y., Kachman, M., May, J. L., Bartom, E. T., Hua, Y., Mishra, R. K., Schiltz, G. E., Dubrovskyi, O., Mazar, A. P., Peter, M. E., Zheng, H., James, C. D., Burant, C. F., Chandel, N., Davuluri, R. V. & 2 others, Horbinski, C. M. & Stegh, A. H., May 30 2017, In : Cell reports. 19, 9, p. 1858-1873 16 p.

Research output: Contribution to journalArticle

48 Scopus citations

Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo

Sita, T. L., Kouri, F. M., Hurley, L. A., Merkel, T. J., Chalastanis, A., May, J. L., Ghelfi, S. T., Cole, L. E., Cayton, T. C., Barnaby, S. N., Sprangers, A. J., Savalia, N., James, C. D., Lee, A., Mirkin, C. A. & Stegh, A. H., Apr 18 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. 4129-4134 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A

Wang, W., Zhang, H., Liu, S., Kim, C. K., Xu, Y., Hurley, L. A., Nishikawa, R., Nagane, M., Hu, B., Stegh, A. H., Cheng, S. Y. & Cheng, C., Aug 1 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. 8366-8371 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
2016

Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth

Hashizume, R., Zhang, A., Mueller, S., Prados, M. D., Lulla, R. R., Goldman, S., Saratsis, A. M., Mazar, A. P., Stegh, A. H., Cheng, S. Y., Horbinski, C., Haas-Kogan, D. A., Sarkaria, J. N., Waldman, T. & James, C. D., Nov 1 2016, In : Neuro-oncology. 18, 11, p. 1519-1528 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
2015

MiR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma

Kouri, F. M., Hurley, L. A., Daniel, W. L., Day, E. S., Hua, Y., Hao, L., Peng, C. Y., Merkel, T. J., Queisser, M. A., Ritner, C., Zhang, H., David James, C., Sznajder, J. I., Chin, L., Giljohann, D. A., Kessler, J. A., Peter, M. E., Mirkin, C. A. & Stegh, A. H., 2015, In : Genes and Development. 29, 7, p. 732-745 14 p.

Research output: Contribution to journalArticle

121 Scopus citations

miRNA-182 and the regulation of the glioblastoma phenotype - toward miRNA-based precision therapeutics

Kouri, F., Ritner, C. & Stegh, A. H., Jan 1 2015, In : Cell Cycle. 14, 24, p. 3794-3800 7 p.

Research output: Contribution to journalArticle

33 Scopus citations
Open Access

Preface

Mirkin, C. A., Meade, T. A., Petrosko, S. H. U. & Stegh, A. H., Jan 1 2015, In : Cancer Treatment and Research. 166, p. v-vii

Research output: Contribution to journalEditorial

Ribozyme-Spherical Nucleic Acids

Rouge, J. L., Sita, T. L., Hao, L., Kouri, F. M., Briley, W. E., Stegh, A. H. & Mirkin, C. A., Aug 14 2015, In : Journal of the American Chemical Society. 137, 33, p. 10528-10531 4 p.

Research output: Contribution to journalArticle

27 Scopus citations

Therapeutic applications of spherical nucleic acids

Barnaby, S. N., Sita, T. L., Petrosko, S. H., Stegh, A. H. & Mirkin, C. A., Jan 1 2015, In : Cancer treatment and research. 166, p. 23-50 28 p.

Research output: Contribution to journalArticle

18 Scopus citations
2014

Bcl2L13 is a ceramide synthase inhibitor in glioblastoma

Jensen, S. A., Calvert, A. E., Volpert, G., Kouri, F. M., Hurley, L. A., Luciano, J. P., Wu, Y., Chalastanis, A., Futerman, A. H. & Stegh, A. H., Apr 15 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 15, p. 5682-5687 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth

Queisser, M. A., Dada, L. A., Deiss-Yehiely, N., Angulo, M., Zhou, G., Kouri, F. M., Knab, L. M., Liu, J., Stegh, A. H., DeCamp, M. M., Budinger, G. R. S., Chandel, N. S., Ciechanover, A., Iwai, K. & Sznajder, J. I., Sep 15 2014, In : American journal of respiratory and critical care medicine. 190, 6, p. 688-698 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

NT113, A pan-ERBB inhibitor with high brain penetrance, inhibits the growth of glioblastoma xenografts with EGFR amplification

Yoshida, Y., Ozawa, T., Yao, T. W., Shen, W., Brown, D., Parsa, A. T., Raizer, J. J., Cheng, S. Y., Stegh, A. H., Mazar, A. P., Giles, F. J., Sarkaria, J. N., Butowski, N., Nicolaides, T. & James, C. D., Dec 1 2014, In : Molecular cancer therapeutics. 13, 12, p. 2919-2929 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Spherical nucleic acids for precision medicine

Mirkin, C. A. & Stegh, A. H., Jan 2014, In : Oncotarget. 5, 1, p. 9-10 2 p.

Research output: Contribution to journalEditorial

5 Scopus citations
2013

Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma

Jensen, S. A., Day, E. S., Ko, C. H., Hurley, L. A., Luciano, J. P., Kouri, F. M., Merkel, T. J., Luthi, A. C., Patel, P. C., Cutler, J. I., Daniel, W. L., Scott, A. W., Rotz, M. W., Meade, T. J., Giljohann, D. A., Mirkin, C. A. & Stegh, A. H., Oct 30 2013, In : Science translational medicine. 5, 209, 209ra152.

Research output: Contribution to journalArticle

306 Scopus citations

Toward personalized cancer nanomedicine-past, present, and future

Stegh, A. H., Jan 2013, In : Integrative Biology (United Kingdom). 5, 1, p. 48-65 18 p.

Research output: Contribution to journalReview article

30 Scopus citations
2012

Targeting the p53 signaling pathway in cancer therapy the promises, challenges and perils

Stegh, A. H., Jan 1 2012, In : Expert Opinion on Therapeutic Targets. 16, 1, p. 67-83 17 p.

Research output: Contribution to journalReview article

115 Scopus citations

The role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyond

Kouri, F. M., Jensen, S. A. & Stegh, A. H., 2012, In : The Scientific World Journal. 2012, 838916.

Research output: Contribution to journalReview article

30 Scopus citations
2011

Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma

Stegh, A. H. & DePinho, R. A., Jan 1 2011, In : Cell Cycle. 10, 1, p. 33-38 6 p.

Research output: Contribution to journalReview article

58 Scopus citations

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

Ding, Z., Wu, C. J., Chu, G. C., Xiao, Y., Ho, D., Zhang, J., Perry, S. R., Labrot, E. S., Wu, X., Lis, R., Hoshida, Y., Hiller, D., Hu, B., Jiang, S., Zheng, H., Stegh, A. H., Scott, K. L., Signoretti, S., Bardeesy, N., Wang, Y. A. & 8 others, Hill, D. E., Golub, T. R., Stampfer, M. J., Wong, W. H., Loda, M., Mucci, L., Chin, L. & Depinho, R. A., Feb 10 2011, In : Nature. 470, 7333, p. 269-276 8 p.

Research output: Contribution to journalArticle

334 Scopus citations
2010

Glioma oncoprotein Bc12L12 inhibits the p53 tumor suppressor

Stegh, A. H., Brennan, C., Mahoney, J. A., Forloney, K. L., Jenq, H. T., Luciano, J. P., Protopopov, A., Chin, L. & DePinho, R. A., Oct 1 2010, In : Genes and Development. 24, 19, p. 2194-2204 11 p.

Research output: Contribution to journalArticle

63 Scopus citations
2008

Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma

Stegh, A. H., Kesari, S., Mahoney, J. E., Jenq, H. T., Forloney, K. L., Protopopov, A., Louis, D. N., Chin, L. & DePinho, R. A., Aug 5 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 31, p. 10703-10708 6 p.

Research output: Contribution to journalArticle

116 Scopus citations

What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator

Stegh, A. H., Chin, L., Louis, D. N. & DePinho, R. A., Sep 15 2008, In : Cell Cycle. 7, 18, p. 2833-2839 7 p.

Research output: Contribution to journalReview article

50 Scopus citations
2007

Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma

Stegh, A. H., Kim, H., Bachoo, R. M., Forloney, K. L., Zhang, J., Schulze, H., Park, K., Hannon, G. J., Yuan, J., Louis, D. N., DePinho, R. A. & Chin, L., Jan 1 2007, In : Genes and Development. 21, 1, p. 98-111 14 p.

Research output: Contribution to journalArticle

106 Scopus citations

Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

Stommel, J. M., Kimmelman, A. C., Ying, H., Nabioullin, R., Ponugoti, A. H., Wiedemeyer, R., Stegh, A. H., Bradner, J. E., Ligon, K. L., Brennan, C., Chin, L. & DePinho, R. A., Oct 12 2007, In : Science. 318, 5848, p. 287-290 4 p.

Research output: Contribution to journalArticle

702 Scopus citations

Erratum: Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma (Ecography (2007) 21 (98-111))

Stegh, A. H., Kim, H., Bachoo, R. M., Forloney, K. L., Zhang, J., Schulze, H., Park, K., Hannon, G. J., Yuan, J., Louis, D. N., DePinho, R. A. & Chin, L., Feb 15 2007, In : Genes and Development. 21, 4, 1 p.

Research output: Contribution to journalComment/debate

Malignant astrocytic glioma: Genetics, biology, and paths to treatment

Furnari, F. B., Fenton, T., Bachoo, R. M., Mukasa, A., Stommel, J. M., Stegh, A., Hahn, W. C., Ligon, K. L., Louis, D. N., Brennan, C., Chin, L., DePinho, R. A. & Cavenee, W. K., Nov 1 2007, In : Genes and Development. 21, 21, p. 2683-2710 28 p.

Research output: Contribution to journalReview article

1568 Scopus citations
2002

DEDD regulates degradation of intermediate filaments during apoptosis

Lee, J. C., Schickling, O., Stegh, A. H., Oshima, R. G., Dinsdale, D., Cohen, G. M. & Peter, M. E., Sep 16 2002, In : Journal of Cell Biology. 158, 6, p. 1051-1066 16 p.

Research output: Contribution to journalArticle

68 Scopus citations

Inactivation of caspase-8 on mitochondria of Bcl-XL-expressing MCF7-Fas cells role for the bifunctional apoptosis regulator protein

Stegh, A. H., Barnhart, B. C., Volkland, J., Algeciras-Schimnich, A., Ke, N., Reed, J. C. & Peter, M. E., Feb 8 2002, In : Journal of Biological Chemistry. 277, 6, p. 4351-4360 10 p.

Research output: Contribution to journalArticle

99 Scopus citations
2001

Apoptosis and caspases

Stegh, A. H. & Peter, M. E., Jan 1 2001, In : Cardiology Clinics. 19, 1, p. 13-29 17 p.

Research output: Contribution to journalArticle

40 Scopus citations
52 Scopus citations
2000

Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor- mediated apoptosis

Stegh, A. H., Herrmann, H., Lampel, S., Weisenberger, D., Andrä, K., Seper, M., Wiche, G., Krammer, P. H. & Peter, M. E., Aug 1 2000, In : Molecular and Cellular Biology. 20, 15, p. 5665-5679 15 p.

Research output: Contribution to journalArticle

129 Scopus citations
1998

DEDD, a novel death effector domain-containing protein, targeted to the nucleolus

Stegh, A. H., Schickling, O., Ehret, A., Scaffidi, C., Peterhänsel, C., Hofmann, T. G., Grummt, I., Krammer, P. H. & Peter, M. E., Oct 15 1998, In : EMBO Journal. 17, 20, p. 5974-5986 13 p.

Research output: Contribution to journalArticle

109 Scopus citations