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Research Output 1998 2019

39 Citations (Scopus)

Apoptosis and caspases

Stegh, A. H. & Peter, M. E., Jan 1 2001, In : Cardiology Clinics. 19, 1, p. 13-29 17 p.

Research output: Contribution to journalArticle

Caspases
Apoptosis
Cell Death
Effector Caspases
Expeditions
103 Citations (Scopus)

Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma

Stegh, A. H., Kim, H., Bachoo, R. M., Forloney, K. L., Zhang, J., Schulze, H., Park, K., Hannon, G. J., Yuan, J., Louis, D. N., DePinho, R. A. & Chin, L., Jan 1 2007, In : Genes and Development. 21, 1, p. 98-111 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Apoptosis
Apoptosomes
Effector Caspases
Caspase 7
110 Citations (Scopus)

Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma

Stegh, A. H., Kesari, S., Mahoney, J. E., Jenq, H. T., Forloney, K. L., Protopopov, A., Louis, D. N., Chin, L. & DePinho, R. A., Aug 5 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 31, p. 10703-10708 6 p.

Research output: Contribution to journalArticle

Effector Caspases
Caspase 7
Crystallins
Glioblastoma
Caspase 3
39 Citations (Scopus)

Bcl2L13 is a ceramide synthase inhibitor in glioblastoma

Jensen, S. A., Calvert, A. E., Volpert, G., Kouri, F., Hurley, L. A., Luciano, J. P., Wu, Y., Chalastanis, A., Futerman, A. H. & Stegh, A. H., Apr 15 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 15, p. 5682-5687 6 p.

Research output: Contribution to journalArticle

Glioblastoma
Neoplasms
Therapeutics
bcl-2-Associated X Protein
Mitochondrial Membranes
55 Citations (Scopus)

Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma

Stegh, A. H. & DePinho, R. A., Jan 1 2011, In : Cell Cycle. 10, 1, p. 33-38 6 p.

Research output: Contribution to journalReview article

Effector Caspases
Glioblastoma
Glioma
Neoplasms
Oncogene Proteins
29 Citations (Scopus)

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

Calvert, A. E., Chalastanis, A., Wu, Y., Hurley, L. A., Kouri, F., Bi, Y., Kachman, M., May, J. L., Bartom, E. T., Hua, Y., Mishra, R. K., Schiltz, G. E., Dubrovskyi, O., Mazar, A. P., Peter, M. E., Zheng, H., James, C. D., Burant, C. F., Chandel, N., Davuluri, R. V. & 2 others, Horbinski, C. M. & Stegh, A. H., May 30 2017, In : Cell reports. 19, 9, p. 1858-1873 16 p.

Research output: Contribution to journalArticle

Bearings (structural)
Isocitrate Dehydrogenase
Gene encoding
Methylation
Differentiation Antigens
1 Citation (Scopus)

Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease

Tommasini-Ghelfi, S., Murnan, K., Kouri, F. M., Mahajan, A. S., May, J. L. & Stegh, A. H., Jan 1 2019, In : Science Advances. 5, 5, aaw4543.

Research output: Contribution to journalArticle

Open Access
dehydrogenases
mutations
biology
emerging
cancer
688 Citations (Scopus)

Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

Stommel, J. M., Kimmelman, A. C., Ying, H., Nabioullin, R., Ponugoti, A. H., Wiedemeyer, R., Stegh, A. H., Bradner, J. E., Ligon, K. L., Brennan, C., Chin, L. & DePinho, R. A., Oct 12 2007, In : Science. 318, 5848, p. 287-290 4 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Phosphatidylinositol 3-Kinase
Neoplasms
Glioblastoma
Therapeutics
108 Citations (Scopus)

DEDD, a novel death effector domain-containing protein, targeted to the nucleolus

Stegh, A. H., Schickling, O., Ehret, A., Scaffidi, C., Peterhänsel, C., Hofmann, T. G., Grummt, I., Krammer, P. H. & Peter, M. E., Oct 15 1998, In : EMBO Journal. 17, 20, p. 5974-5986 13 p.

Research output: Contribution to journalArticle

Death Domain Receptor Signaling Adaptor Proteins
Caspase 8
Transcription
RNA Polymerase I
Pol1 Transcription Initiation Complex Proteins
66 Citations (Scopus)

DEDD regulates degradation of intermediate filaments during apoptosis

Lee, J. C., Schickling, O., Stegh, A. H., Oshima, R. G., Dinsdale, D., Cohen, G. M. & Peter, M. E., Sep 16 2002, In : Journal of Cell Biology. 158, 6, p. 1051-1066 16 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Caspase 3
Apoptosis
Death Domain Receptor Signaling Adaptor Proteins
Effector Caspases
13 Citations (Scopus)

Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo

Sita, T. L., Kouri, F., Hurley, L. A., Merkel, T. J., Chalastanis, A., May, J. L., Ghelfi, S. T., Cole, L. E., Cayton, T. C., Barnaby, S. N., Sprangers, A. J., Savalia, N., James, C. D., Lee, A., Mirkin, C. A. & Stegh, A. H., Apr 18 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. 4129-4134 6 p.

Research output: Contribution to journalArticle

Nanoconjugates
Nucleic Acids
Fluorescence
Methyltransferases
Heterografts

Erratum: Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma (Ecography (2007) 21 (98-111))

Stegh, A. H., Kim, H., Bachoo, R. M., Forloney, K. L., Zhang, J., Schulze, H., Park, K., Hannon, G. J., Yuan, J., Louis, D. N., DePinho, R. A. & Chin, L., Feb 15 2007, In : Genes and Development. 21, 4, 1 p.

Research output: Contribution to journalComment/debate

Glioblastoma
Apoptosis
62 Citations (Scopus)

Glioma oncoprotein Bc12L12 inhibits the p53 tumor suppressor

Stegh, A. H., Brennan, C., Mahoney, J. A., Forloney, K. L., Jenq, H. T., Luciano, J. P., Protopopov, A., Chin, L. & DePinho, R. A., Oct 1 2010, In : Genes and Development. 24, 19, p. 2194-2204 11 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Glioblastoma
Glioma
Apoptosis
DNA Damage
15 Citations (Scopus)

HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth

Queisser, M. A., Dada, L., Deiss-Yehiely, N., Angulo, M., Zhou, G., Kouri, F., Knab, L. M., Liu, J., Stegh, A. H., DeCamp Jr, M. M., Budinger, GR. S., Chandel, N., Ciechanover, A., Iwai, K. & Sznajder, J. I., Sep 15 2014, In : American journal of respiratory and critical care medicine. 190, 6, p. 688-698 11 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Heme
Lung
Growth
128 Citations (Scopus)

Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor- mediated apoptosis

Stegh, A. H., Herrmann, H., Lampel, S., Weisenberger, D., Andrä, K., Seper, M., Wiche, G., Krammer, P. H. & Peter, M. E., Aug 1 2000, In : Molecular and Cellular Biology. 20, 15, p. 5665-5679 15 p.

Research output: Contribution to journalArticle

Plectin
Caspase 8
Tumor Necrosis Factor Receptors
Apoptosis
Actin Cytoskeleton
4 Citations (Scopus)

IDH3α regulates one-carbon metabolism in glioblastoma

May, J. L., Kouri, F., Hurley, L. A., Liu, J., Tommasini-Ghelfi, S., Ji, Y., Gao, P., Calvert, A. E., Lee, A., Chandel, N., Davuluri, R. V., Horbinski, C. M., Locasale, J. W. & Stegh, A. H., Jan 1 2019, In : Science Advances. 5, 1, eaat0456.

Research output: Contribution to journalArticle

Glioblastoma
Glycine Hydroxymethyltransferase
Carbon
Methionine
Activity Cycles
95 Citations (Scopus)

Inactivation of caspase-8 on mitochondria of Bcl-XL-expressing MCF7-Fas cells role for the bifunctional apoptosis regulator protein

Stegh, A. H., Barnhart, B. C., Volkland, J., Algeciras-Schimnich, A., Ke, N., Reed, J. C. & Peter, M. E., Feb 8 2002, In : Journal of Biological Chemistry. 277, 6, p. 4351-4360 10 p.

Research output: Contribution to journalArticle

Mitochondria
Caspase 8
MCF-7 Cells
Apoptosis
Death Domain Receptor Signaling Adaptor Proteins
23 Citations (Scopus)

Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth

Hashizume, R., Zhang, A., Mueller, S., Prados, M. D., Lulla, R. R., Goldman, S., Saratsis, A. M., Mazar, A. P., Stegh, A. H., Cheng, S. Y., Horbinski, C., Haas-Kogan, D. A., Sarkaria, J. N., Waldman, T. & James, C. D., Nov 1 2016, In : Neuro-oncology. 18, 11, p. 1519-1528 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Heterografts
DNA Repair
DNA Damage
Radiation
12 Citations (Scopus)

Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A

Wang, W., Zhang, H., Liu, S., Kim, C. K., Xu, Y., Hurley, L. A., Nishikawa, R., Nagane, M., Hu, B., Stegh, A. H., Cheng, S. Y. & Cheng, C., Aug 1 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. 8366-8371 6 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Protein Isoforms
Lysosomes
Monomeric GTP-Binding Proteins
Endosomes
1488 Citations (Scopus)

Malignant astrocytic glioma: Genetics, biology, and paths to treatment

Furnari, F. B., Fenton, T., Bachoo, R. M., Mukasa, A., Stommel, J. M., Stegh, A., Hahn, W. C., Ligon, K. L., Louis, D. N., Brennan, C., Chin, L., DePinho, R. A. & Cavenee, W. K., Nov 1 2007, In : Genes and Development. 21, 21, p. 2683-2710 28 p.

Research output: Contribution to journalReview article

Astrocytoma
Glioblastoma
Glioma
Genetic Models
Brain
101 Citations (Scopus)

MiR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma

Kouri, F., Hurley, L. A., Daniel, W. L., Day, E. S., Hua, Y., Hao, L., Peng, C-Y., Merkel, T. J., Queisser, M. A., Ritner, C., Zhang, H., James, C. D., Sznajder, J. I., Chin, L., Giljohann, D. A., Kessler, J., Peter, M. E., Mirkin, C. A. & Stegh, A. H., Jan 1 2015, In : Genes and Development. 29, 7, p. 732-745 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Apoptosis
Glioma
Growth
Neoplasms
26 Citations (Scopus)

miRNA-182 and the regulation of the glioblastoma phenotype - toward miRNA-based precision therapeutics

Kouri, F., Ritner, C. & Stegh, A. H., Jan 1 2015, In : Cell Cycle. 14, 24, p. 3794-3800 7 p.

Research output: Contribution to journalArticle

Glioblastoma
MicroRNAs
temozolomide
Phenotype
Glioma
Open Access
Nanotechnology
Neoplasms
Therapeutics
Precision Medicine
Nanostructures
8 Citations (Scopus)

NT113, A pan-ERBB inhibitor with high brain penetrance, inhibits the growth of glioblastoma xenografts with EGFR amplification

Yoshida, Y., Ozawa, T., Yao, T. W., Shen, W., Brown, D., Parsa, A. T., Raizer, J. J., Cheng, S. Y., Stegh, A. H., Mazar, A. P., Giles, F. J., Sarkaria, J. N., Butowski, N., Nicolaides, T. & James, C. D., Dec 1 2014, In : Molecular cancer therapeutics. 13, 12, p. 2919-2929 11 p.

Research output: Contribution to journalArticle

Penetrance
Glioblastoma
Heterografts
Brain
Growth
51 Citations (Scopus)
Caspase 6
RNA Polymerase I
Nuclear Localization Signals
Apoptosis
Caspase 8

Preface

Mirkin, C. A., Meade, T. A., Petrosko, S. H. U. & Stegh, A. H., Jan 1 2015, In : Cancer Treatment and Research. 166, p. v-vii

Research output: Contribution to journalEditorial

Nanomedicine
Neoplasms
20 Citations (Scopus)

Ribozyme-Spherical Nucleic Acids

Rouge, J. L., Sita, T. L., Hao, L., Kouri, F., Briley, W. E., Stegh, A. H. & Mirkin, C. A., Aug 14 2015, In : Journal of the American Chemical Society. 137, 33, p. 10528-10531 4 p.

Research output: Contribution to journalArticle

Catalytic RNA
Nucleic acids
Nucleic Acids
DNA
RNA
314 Citations (Scopus)

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

Ding, Z., Wu, C. J., Chu, G. C., Xiao, Y., Ho, D., Zhang, J., Perry, S. R., Labrot, E. S., Wu, X., Lis, R., Hoshida, Y., Hiller, D., Hu, B., Jiang, S., Zheng, H., Stegh, A. H., Scott, K. L., Signoretti, S., Bardeesy, N., Wang, Y. A. & 8 others, Hill, D. E., Golub, T. R., Stampfer, M. J., Wong, W. H., Loda, M., Mucci, L., Chin, L. & Depinho, R. A., Feb 10 2011, In : Nature. 470, 7333, p. 269-276 8 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Growth
Prostate
Neoplasm Metastasis
Biological Phenomena
264 Citations (Scopus)

Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma

Jensen, S. A., Day, E. S., Ko, C. H., Hurley, L. A., Luciano, J. P., Kouri, F. M., Merkel, T. J., Luthi, A. C., Patel, P. C., Cutler, J. I., Daniel, W. L., Scott, A. W., Rotz, M. W., Meade, T. J., Giljohann, D. A., Mirkin, C. A. & Stegh, A. H., Oct 30 2013, In : Science translational medicine. 5, 209, 209ra152.

Research output: Contribution to journalArticle

Glioblastoma
RNA Interference
Nanoparticles
Nucleic Acids
Oncogenes
5 Citations (Scopus)

Spherical nucleic acids for precision medicine

Mirkin, C. A. & Stegh, A. H., Jan 1 2014, In : Oncotarget. 5, 1, p. 9-10 2 p.

Research output: Contribution to journalEditorial

Nanoconjugates
Metal Nanoparticles
Nucleic Acid Conformation
Precision Medicine
Nanotechnology

Synthesis, physicochemical, and biological evaluation of spherical nucleic acids for RNAi-based therapy in glioblastoma

Tommasini-Ghelfi, S., Lee, A., Mirkin, C. A. & Stegh, A. H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc, p. 371-391 21 p. (Methods in Molecular Biology; vol. 1974).

Research output: Chapter in Book/Report/Conference proceedingChapter

Glioblastoma
Nucleic Acids
MicroRNAs
Brain Neoplasms
Small Interfering RNA
101 Citations (Scopus)

Targeting the p53 signaling pathway in cancer therapy the promises, challenges and perils

Stegh, A. H., Jan 1 2012, In : Expert Opinion on Therapeutic Targets. 16, 1, p. 67-83 17 p.

Research output: Contribution to journalReview article

Tumors
Neoplasms
Mutant Proteins
Therapeutics
Repair
14 Citations (Scopus)

Therapeutic applications of spherical nucleic acids

Barnaby, S. N., Sita, T. L., Petrosko, S. H., Stegh, A. H. & Mirkin, C. A., Jan 1 2015, In : Cancer treatment and research. 166, p. 23-50 28 p.

Research output: Contribution to journalArticle

Nucleic Acids
Oligonucleotides
Therapeutics
Platinum
Epidermis
29 Citations (Scopus)

The role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyond

Kouri, F., Jensen, S. A. & Stegh, A. H., Mar 16 2012, In : The Scientific World Journal. 2012, 838916.

Research output: Contribution to journalReview article

Astrocytoma
Glioma
Tumors
Glioblastoma
temozolomide
27 Citations (Scopus)

Toward personalized cancer nanomedicine-past, present, and future

Stegh, A. H., Jan 1 2013, In : Integrative Biology (United Kingdom). 5, 1, p. 48-65 18 p.

Research output: Contribution to journalReview article

Nanomedicine
Medical nanotechnology
Tumors
Genes
Neoplasms
48 Citations (Scopus)

What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator

Stegh, A. H., Chin, L., Louis, D. N. & DePinho, R. A., Sep 15 2008, In : Cell Cycle. 7, 18, p. 2833-2839 7 p.

Research output: Contribution to journalReview article

Glioblastoma
Cell Death
Necrosis
Apoptosis
Caspase 7