Grants per year
Personal profile
Research Interests
Our laboratory is focused on understanding the relationship between atomic structure and biological function of important proteins and nucleic acids. Traditionally most structural work has been focused on obtaining atomic pictures of molecules, but biological macromolecules are dynamic and understanding their function requires the convergence of many approaches to provide information from complementary perspectives at different time and length scales. To this end, we combine a variety of structural approaches with a wide range of biophysical and biochemical techniques to understand the workings of some of the most ubiquitous molecules in the cell.
Education/Academic qualification
Biophysics, PhD, University of Cambridge
… → 1985
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
-
Structural and biophysical studies of proteins, nucleic acids, and their complexes
Mondragon, A. (PD/PI)
National Institute of General Medical Sciences
5/1/23 → 2/29/28
Project: Research project
-
Supplement for Structural and biophysical studies of proteins, nucleic acids, and their complexes
Mondragon, A. (PD/PI)
National Institute of General Medical Sciences
5/1/23 → 2/29/28
Project: Research project
-
Structural and Mechanistic Studies of DNA Gyrase
Mondragon, A. (PD/PI)
9/1/20 → 10/22/21
Project: Research project
-
Acquisition of an MD3-UP microdiffractometer for macromolecular crystallography
Mondragon, A. (PD/PI), O'Halloran, T. V. (Other), Pinkett, H. W. (Other), Rosenzweig, A. C. (Other) & Satchell, K. J. (Other)
Office of the Director, National Institutes of Health
8/26/20 → 8/25/22
Project: Research project
-
RNA interacts with topoisomerase I to adjust DNA topology
Bhola, M., Abe, K., Orozco, P., Rahnamoun, H., Avila-Lopez, P., Taylor, E., Muhammad, N., Liu, B., Patel, P., Marko, J. F., Starner, A. C., He, C., Van Nostrand, E. L., Mondragón, A. & Lauberth, S. M., Sep 5 2024, In: Molecular cell. 84, 17, p. 3192-3208.e11Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Translational T-box riboswitches bind tRNA by modulating conformational flexibility
Campos-Chavez, E., Paul, S., Zhou, Z., Alonso, D., Verma, A. R., Fei, J. & Mondragón, A., Dec 2024, In: Nature communications. 15, 1, 6592.Research output: Contribution to journal › Article › peer-review
Open Access -
Pneumococcal capsule expression is controlled through a conserved, distal cisregulatory element during infection
Glanville, D. G., Gazioglu, O., Marra, M., Tokars, V. L., Kushnir, T., Habtom, M., Croucher, N. J., Nebenzahl, Y. M., Mondragón, A., Yesilkaya, H. & Ulijasz, A. T., Jan 2023, In: PLoS pathogens. 19, 1, e1011035.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Structures of an active type III-A CRISPR effector complex
Smith, E. M., Ferrell, S., Tokars, V. L. & Mondragón, A., Aug 4 2022, In: Structure. 30, 8, p. 1109-1128.e6Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Structures of topoisomerase V in complex with DNA reveal unusual DNA-binding mode and novel relaxation mechanism
Osterman, A. & Mondragón, A., Aug 2022, In: eLife. 11, e72702.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations
Datasets
-
Crystal Structure of the Sds3 Dimerization Domain
Clark, M. D. (Contributor), Marcum, R. (Contributor), Graveline, R. (Contributor), Chan, C. W. (Contributor), Xie, T. (Contributor), Chen, Z. (Contributor), Ding, Y. (Contributor), Zhang, Y. (Contributor), Mondragón, A. (Contributor), David, G. (Contributor) & Radhakrishnan, I. (Contributor), Protein Data Bank (PDB), Jul 15 2015
DOI: 10.2210/pdb4ZQA/pdb, https://www.wwpdb.org/pdb?id=pdb_00004zqa
Dataset
-
Data from: Structural and mechanistic basis of zinc regulation across the E. coli Zur regulon
Gilston, B. A. (Contributor), Wang, S. (Contributor), Marcus, M. D. (Contributor), Canalizo-Hernández, M. A. (Contributor), Swindell, E. P. (Contributor), Xue, Y. (Contributor), Mondragón, A. (Contributor) & O'Halloran, T. V. (Contributor), ZENODO, Sep 25 2015
DOI: 10.5061/dryad.vn6dv, https://zenodo.org/records/4946161
Dataset
-
2O54 : Structure of E. coli topoisomerase III in complex with an 8-base single stranded oligonucleotide. Frozen in glycerol at pH 7.0
Changela, A. (Contributor), DiGate, R. J. (Contributor) & Mondragón, A. (Contributor), RCSB-PDB, 2007
DOI: 10.2210/pdb2o54/pdb, https://www.rcsb.org/structure/2O54
Dataset
-
1Q06 : Crystal structure of the Ag(I) form of E. coli CueR, a copper efflux regulator
Changela, A. (Contributor), Chen, K. (Contributor), Xue, Y. (Contributor), Holschen, J. (Contributor), Outten, C. E. (Contributor), O'Halloran, T. V. (Contributor) & Mondragón, A. (Contributor), RCSB-PDB, 2003
DOI: 10.2210/pdb1q06/pdb, https://www.rcsb.org/structure/1Q06
Dataset
-
Crystal structure of human erythroid beta spectrin repeats 14 and 15 (ankyrin binding domain)
Ipsaro, J. J. (Contributor), Huang, L. (Contributor) & Mondragón, A. (Contributor), Protein Data Bank (PDB), Feb 24 2009
DOI: 10.2210/pdb3F57/pdb, https://www.wwpdb.org/pdb?id=pdb_00003f57
Dataset