• 3666 Citations
1988 …2020

Research output per year

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Personal profile

Research Interests

Our laboratory is focused on understanding the relationship between atomic structure and biological function of important proteins and nucleic acids. Traditionally most structural work has been focused on obtaining atomic pictures of molecules, but biological macromolecules are dynamic and understanding their function requires the convergence of many approaches to provide information from complementary perspectives at different time and length scales. To this end, we combine a variety of structural approaches with a wide range of biophysical and biochemical techniques to understand the workings of some of the most ubiquitous molecules in the cell.

Education/Academic qualification

Biophysics, PhD, University of Cambridge

… → 1985

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SBF Shared Resource

Mondragon, A.

National Cancer Institute


Project: Research project

  • Research Output

    Crystal structures of an unmodified bacterial tRNA reveal intrinsic structural flexibility and plasticity as general properties of unbound tRNAs

    Chan, C. W., Badong, D., Rajan, R. & Mondragón, A., Jan 1 2020, In : RNA. 26, 3, p. 278-289 12 p.

    Research output: Contribution to journalArticle

  • Structural organization of a Type III-A CRISPR effector subcomplex determined by X-ray crystallography and cryo-EM

    Dorsey, B. W., Huang, L. & Mondragón, A., 2019, In : Nucleic acids research. 47, 7, p. 3765-3783 19 p.

    Research output: Contribution to journalArticle

    Open Access
  • CryoEM structures of open dimers of gyrase A in complex with DNA illuminate mechanism of strand passage

    Soczek, K. M., Grant, T., Rosenthal, P. B. & Mondragón, A., Nov 1 2018, In : eLife. 7, e41215.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Crystal Structure of Human Rpp20/Rpp25 Reveals Quaternary Level Adaptation of the Alba Scaffold as Structural Basis for Single-stranded RNA Binding

    Chan, C. W., Kiesel, B. R. & Mondragón, A., May 11 2018, In : Journal of Molecular Biology. 430, 10, p. 1403-1416 14 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Single-molecule magnetic tweezer analysis of topoisomerases

    Gunn, K. H., Marko, J. F. & Mondragón, A., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 139-152 14 p. (Methods in Molecular Biology; vol. 1703).

    Research output: Chapter in Book/Report/Conference proceedingChapter