• 3456 Citations
1988 …2023
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Personal profile

Research Interests

Our laboratory is focused on understanding the relationship between atomic structure and biological function of important proteins and nucleic acids. Traditionally most structural work has been focused on obtaining atomic pictures of molecules, but biological macromolecules are dynamic and understanding their function requires the convergence of many approaches to provide information from complementary perspectives at different time and length scales. To this end, we combine a variety of structural approaches with a wide range of biophysical and biochemical techniques to understand the workings of some of the most ubiquitous molecules in the cell.

Education/Academic qualification

Biophysics, PhD, Cambridge University

… → 1985

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Grants 2000 2023

SBF Shared Resource

Mondragon, A.

National Cancer Institute

8/10/187/31/23

Project: Research project

Neoplasms
Medicine
Research
Population
Macromolecules
Nucleic Acids
Proteins
DNA Topoisomerases
DNA
Molecules
Repair
DNA Gyrase

Research Output 1988 2019

Structural organization of a Type III-A CRISPR effector subcomplex determined by X-ray crystallography and cryo-EM

Dorsey, B. W., Huang, L. & Mondragon, A., Apr 23 2019, In : Nucleic acids research. 47, 7, p. 3765-3783 19 p.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Cryoelectron Microscopy
X Ray Crystallography
Guide RNA
RNA Cleavage

CryoEM structures of open dimers of gyrase A in complex with DNA illuminate mechanism of strand passage

Soczek, K. M., Grant, T., Rosenthal, P. B. & Mondragon, A., Nov 1 2018, In : eLife. 7, e41215.

Research output: Contribution to journalArticle

Dimers
DNA
DNA Gyrase
Bacterial DNA
DNA Cleavage
2 Citations (Scopus)

Crystal Structure of Human Rpp20/Rpp25 Reveals Quaternary Level Adaptation of the Alba Scaffold as Structural Basis for Single-stranded RNA Binding

Chan, C. W., Kiesel, B. R. & Mondragon, A., May 11 2018, In : Journal of Molecular Biology. 430, 10, p. 1403-1416 14 p.

Research output: Contribution to journalArticle

Ribonuclease P
Catalytic RNA
Ribonucleoproteins
RNA
Catalytic Domain

Single-molecule magnetic tweezer analysis of topoisomerases

Gunn, K. H., Marko, J. F. & Mondragon, A., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc, p. 139-152 14 p. (Methods in Molecular Biology; vol. 1703).

Research output: Chapter in Book/Report/Conference proceedingChapter

Digoxigenin
DNA
Magnetic Fields
Microscopy
Enzymes
2 Citations (Scopus)

Specific structural elements of the t-box riboswitch drive the two-step binding of the tRNA ligand

Zhang, J., Chetnani, B., Cormack, E. D., Alonso, D., Liu, W., Mondragon, A. & Fei, J., Sep 1 2018, In : eLife. 7, e39518.

Research output: Contribution to journalArticle

Riboswitch
Transfer RNA
Ligands
Aminoacylation
Anticodon