Grants per year
Personal profile
Research Interests
Our research program is focused on the structure, function, pharmacology, and molecular genetics of ion channels. His laboratory has contributed greatly to understanding the mechanisms by which ion channel mutations cause a variety of inherited disorders of membrane excitability including congenital cardiac arrhythmia susceptibility and epilepsy. These basic and translational investigations have provided many opportunities to investigate the relationship between structure and function in ion channels and have helped establish important genotype-phenotype correlations for several human diseases and certain animal models. We were first to elucidate the functional consequences of an ion channel mutation linked to an inherited cardiac arrhythmia (Long-QT Syndrome). This discovery contributed greatly to understanding arrhythmia susceptibility in the disease and inspired use of drugs targeting persistent sodium current as a therapeutic strategy. Recently, the use of exome sequencing enabled us to discover human calmodulin mutations in congenital arrhythmia syndromes. Our studies of the molecular basis for genetic epilepsy have revealed new targets for antiepileptic drug development.
Training Experience
1986 | Residency, Vanderbilt University |
1987 | Fellowship, University of Pennsylvania |
1988 | Postdoctoral Fellowship, Institut Suisse de Recherches Experimentales sur le Cancer, Lausanne |
1992 | Postdoctoral Fellowship, University of Pennsylvania |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, University of Rochester
… → 1982
Research interests keywords
- Arrhythmias
- Cellular Electrophysiology
- Epilepsy
- Genetics
- Genomics
- Ion Channels
- Neurogenetics
- Pharmacology
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Collaborations and top research areas from the last five years
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Project 2 - George
George, A. L. (PD/PI), Guemez Gamboa, A. D. (Co-Investigator), Guemez Gamboa, A. D. (Co-Investigator), Simmons, C. (Co-Investigator), Thompson, C. H. (Co-Investigator) & George, A. L. (Other)
National Institute of Mental Health
5/1/24 → 2/28/29
Project: Research project
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ATP1A3 Prime Editing Project
George, A. L. (PD/PI) & Simmons, C. (Co-Investigator)
4/1/24 → 3/31/25
Project: Research project
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Role of Endothelin-1 signaling in the development and progression of atrial fibrillation
Pfenniger, A. (PD/PI), Pfenniger, A. (PD/PI), Pfenniger, A. (Co-PD/PI), Arora, R. K. (Other), George, A. L. (Other), George, A. L. (Other), Lee, D. C. (Other), Lee, D. C. (Other), Passman, R. S. (Other), Passman, R. S. (Other), Roy-Puckelwartz, M. J. (Other), Roy-Puckelwartz, M. J. (Other), Shah, S. J. (Other), Shah, S. J. (Other), Vaughan, D. E. (Other), Vaughan, D. E. (Other), Wasserstrom, J. A. (Other) & Wasserstrom, J. A. (Other)
National Heart, Lung, and Blood Institute
9/1/23 → 8/31/28
Project: Research project
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Administrative Core - Main
George, A. L. (PD/PI), George, A. L. (PD/PI), Judge, S. M. (PD/PI), Judge, S. M. (PD/PI), Quaggin, S. E. (PD/PI) & Quaggin, S. E. (PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
9/1/23 → 6/30/28
Project: Research project
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Determining Effects of BVH-7000 on Diverse KCNQ2 Pathogenic Variants
George, A. L. (PD/PI), George, A. L. (PD/PI), Vanoye, C. G. (Co-Investigator) & Vanoye, C. G. (Co-Investigator)
Biohaven Pharmaceuticals, Inc.
8/30/23 → 12/31/24
Project: Research project
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Altered neurological and neurobehavioral phenotypes in a mouse model of the recurrent KCNB1-p.R306C voltage-sensor variant
Kang, S. K., Hawkins, N. A., Thompson, C. H., Baker, E. M., Echevarria-Cooper, D. M., Barse, L., Thenstedt, T., Dixon, C. J., Speakes, N., George, A. L. & Kearney, J. A., May 2024, In: Neurobiology of Disease. 194, 106470.Research output: Contribution to journal › Article › peer-review
Open Access -
Concentrations of Fluoxetine Enantiomers Decline During Pregnancy and Increase After Birth
Wisner, K. L., Avram, M. J., George, A. L., Abramova, T. V., Yang, A., Caritis, S. N., Costantine, M. M. & Stika, C. S., Mar 1 2024, In: Journal of clinical psychopharmacology. 44, 2, p. 100-106 7 p.Research output: Contribution to journal › Article › peer-review
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Engineered cocultures of iPSC-derived atrial cardiomyocytes and atrial fibroblasts for modeling atrial fibrillation
Brown, G. E., Han, Y. D., Michell, A. R., Ly, O. T., Vanoye, C. G., Spanghero, E., George, A. L., Darbar, D. & Khetani, S. R., 2024, In: Science Advances. 10, 3Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Erratum: Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing (Cell Reports (2023) 42(6), (S2211124723005740), (10.1016/j.celrep.2023.112563))
Pablo, J. L. B., Cornett, S. L., Wang, L. A., Jo, S., Brünger, T., Budnik, N., Hegde, M., DeKeyser, J. M., Thompson, C. H., Doench, J. G., Lal, D., George, A. L. & Pan, J. Q., Jun 25 2024, In: Cell reports. 43, 6, 114327.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Exome sequencing of ATP1A3-negative cases of alternating hemiplegia of childhood reveals SCN2A as a novel causative gene
Panagiotakaki, E., Tiziano, F. D., Mikati, M. A., Vijfhuizen, L. S., Nicole, S., Lesca, G., Abiusi, E., Novelli, A., Di Pietro, L., Harder, A. V. E., Walley, N. M., De Grandis, E., Poulat, A. L., Portes, V. D., Lépine, A., Nassogne, M. C., Arzimanoglou, A., Vavassori, R., Koenderink, J. & Thompson, C. H. & 4 others, , Feb 2024, In: European Journal of Human Genetics. 32, 2, p. 224-231 8 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Datasets
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Solution NMR structure of the KCNQ1 voltage-sensing domain
Taylor, K. C. (Contributor), Kang, P. W. (Contributor), Hou, P. (Contributor), Yang, N.-D. (Contributor), Kuenze, G. (Contributor), Smith, J. A. (Contributor), Shi, J. (Contributor), Huang, H. (Contributor), White, K. M. (Contributor), Peng, D. (Contributor), George, A. L. (Contributor), Meiler, J. (Contributor), McFeeters, R. L. (Contributor), Cui, J. (Contributor) & Sanders, C. R. (Contributor), Protein Data Bank (PDB), Mar 4 2020
DOI: 10.2210/pdb6MIE/pdb, https://www.wwpdb.org/pdb?id=pdb_00006mie
Dataset
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2NDJ : Structural Basis for KCNE3 and Estrogen Modulation of the KCNQ1 Channel
Kroncke, B. M. (Contributor), Van Horn, W. D. (Contributor), Smith, J. (Contributor), Kang, C. (Contributor), Welch, R. C. (Contributor), Song, Y. (Contributor), Nannemann, D. P. (Contributor), Sisco, N. J. (Contributor), George, A. L. (Contributor), Meiler, J. (Contributor), Vanoye, C. G. (Contributor) & Sanders, C. R. (Contributor), RCSB-PDB, 2016
DOI: 10.2210/pdb2ndj/pdb, https://www.rcsb.org/structure/2NDJ
Dataset
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Structure of calmodulin with KN93
Johnson, C. N. (Contributor), Pattanayek, R. (Contributor), Potet, F. (Contributor), Rebbeck, R. T. (Contributor), Blackwell, D. J. (Contributor), Nikolaienko, R. (Contributor), Sequeira, V. (Contributor), Le Meur, R. (Contributor), Radwański, P. B. (Contributor), Davis, J. P. (Contributor), Zima, A. V. (Contributor), Cornea, R. L. (Contributor), Damo, S. M. (Contributor), Györke, S. (Contributor), George, A. L. (Contributor) & Knollmann, B. C. (Contributor), Protein Data Bank (PDB), Aug 28 2019
DOI: 10.2210/pdb6M7H/pdb, https://www.wwpdb.org/pdb?id=pdb_00006m7h
Dataset
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Structural Basis for KCNE3 and Estrogen Modulation of the KCNQ1 Channel
Kroncke, B. M. (Contributor), Van Horn, W. D. (Contributor), Smith, J. (Contributor), Kang, C. (Contributor), Welch, R. C. (Contributor), Song, Y. (Contributor), Nannemann, D. P. (Contributor), Taylor, K. C. (Contributor), Sisco, N. J. (Contributor), George, A. L. (Contributor), Meiler, J. (Contributor), Vanoye, C. G. (Contributor) & Sanders, C. R. (Contributor), Protein Data Bank (PDB), Sep 21 2016
DOI: 10.2210/pdb2NDJ/pdb, https://www.wwpdb.org/pdb?id=pdb_00002ndj
Dataset