Grants per year
Personal profile
Research Interests
Our research program is focused on the structure, function, pharmacology, and molecular genetics of ion channels. His laboratory has contributed greatly to understanding the mechanisms by which ion channel mutations cause a variety of inherited disorders of membrane excitability including congenital cardiac arrhythmia susceptibility and epilepsy. These basic and translational investigations have provided many opportunities to investigate the relationship between structure and function in ion channels and have helped establish important genotype-phenotype correlations for several human diseases and certain animal models. We were first to elucidate the functional consequences of an ion channel mutation linked to an inherited cardiac arrhythmia (Long-QT Syndrome). This discovery contributed greatly to understanding arrhythmia susceptibility in the disease and inspired use of drugs targeting persistent sodium current as a therapeutic strategy. Recently, the use of exome sequencing enabled us to discover human calmodulin mutations in congenital arrhythmia syndromes. Our studies of the molecular basis for genetic epilepsy have revealed new targets for antiepileptic drug development.
Training Experience
1986 | Residency, Vanderbilt University |
1987 | Fellowship, University of Pennsylvania |
1988 | Postdoctoral Fellowship, Institut Suisse de Recherches Experimentales sur le Cancer, Lausanne |
1992 | Postdoctoral Fellowship, University of Pennsylvania |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, University of Rochester
… → 1982
Research interests keywords
- Arrhythmias
- Cellular Electrophysiology
- Epilepsy
- Genetics
- Genomics
- Ion Channels
- Neurogenetics
- Pharmacology
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Neurophysiological consequences of pathogenic SCN2A variants
George, A. L. (PD/PI)
7/1/25 → 6/30/26
Project: Research project
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Study of KCNQ2 epileptic encephalopathy
George, A. L. (PD/PI)
6/23/25 → 12/22/25
Project: Research project
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Base Editing for KCNH1-Related Disorder
George, A. L. (PD/PI), Hawkins, N. A. (Co-Investigator), Kearney, J. A. (Co-Investigator) & Simmons, C. (Co-Investigator)
2/1/25 → 2/1/26
Project: Research project
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Project 2 - George
George, A. L. (PD/PI), Guemez Gamboa, A. D. (Co-Investigator), Guemez Gamboa, A. D. (Co-Investigator), Simmons, C. (Co-Investigator), Thompson, C. H. (Co-Investigator) & George, A. L. (Other)
National Institute of Mental Health
5/1/24 → 2/28/29
Project: Research project
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Administrative Core - Main
George, A. L. (PD/PI), George, A. L. (PD/PI), Judge, S. M. (PD/PI), Judge, S. M. (PD/PI), Quaggin, S. E. (PD/PI) & Quaggin, S. E. (PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
9/1/23 → 6/30/28
Project: Research project
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ATP1A3 Variants, Variably Penetrant Short QT Intervals, and Lethal Ventricular Arrhythmias
Moya-Mendez, M. E., Bidzimou, M. T., Muralidharan, P., Zhang, Z., Ezekian, J. E., Perelli, R. M., Parker, L. E., Prange, L., Boggs, A., Kim, J. J., Howard, T. S., Word, T. A., Wehrens, X. H. T., Reyes Valenzuela, G., Caraballo, R., Garone, G., Vigevano, F., Weckhuysen, S., Millevert, C. & Troncoso, M. & 28 others, , May 5 2025, In: JAMA Pediatrics. 179, 5, p. 529-539 11 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Changes in S-Citalopram Plasma Concentrations Across Pregnancy and Postpartum
Stika, C. S., Avram, M. J., George, A. L., Yang, A., Ciolino, J. D., Jeong, H., Venkataramanan, R., Caritis, S. N., Costantine, M. M. & Wisner, K. L., Jul 2025, In: Clinical pharmacology and therapeutics. 118, 1, p. 106-117 12 p.Research output: Contribution to journal › Article › peer-review
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Genotype-function-phenotype correlations for SCN1A variants identified by clinical genetic testing
Knox, A. T., Thompson, C. H., Scott, D., Abramova, T. V., Stieve, B., Freeman, A. & George, A. L., Mar 2025, In: Annals of clinical and translational neurology. 12, 3, p. 499-511 13 p.Research output: Contribution to journal › Article › peer-review
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Integrative analysis of KCNQ1 variants reveals molecular mechanisms of type 1 long QT syndrome pathogenesis
Brewer, K. R., Vanoye, C. G., Huang, H., Clowes Moster, K. R., Desai, R. R., Hayes, J. B., Burnette, D. T., George, A. L. & Sanders, C. R., Feb 25 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 8, e2412971122.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy
Abreo, T. J., Thompson, E. C., Madabushi, A., Park, K. L., Soh, H., Varghese, N., Vanoye, C. G., Springer, K., Johnson, J., Sims, S., Ji, Z., Chavez, A. G., Jankovic, M. J., Habte, B., Zuberi, A. R., Lutz, C. M., Wang, Z., Krishnan, V., Dudler, L. & Einsele-Scholz, S. & 5 others, , Dec 6 2025, In: eLife. 13Research output: Contribution to journal › Article › peer-review
Datasets
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Structure of calmodulin with KN93
Johnson, C. N. (Contributor), Pattanayek, R. (Contributor), Potet, F. (Contributor), Rebbeck, R. T. (Contributor), Blackwell, D. J. (Contributor), Nikolaienko, R. (Contributor), Sequeira, V. (Contributor), Le Meur, R. (Contributor), Radwański, P. B. (Contributor), Davis, J. P. (Contributor), Zima, A. V. (Contributor), Cornea, R. L. (Contributor), Damo, S. M. (Contributor), Györke, S. (Contributor), George, A. L. (Contributor) & Knollmann, B. C. (Contributor), Protein Data Bank (PDB), Aug 28 2019
DOI: 10.2210/pdb6M7H/pdb, https://www.wwpdb.org/pdb?id=pdb_00006m7h
Dataset
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Structural Basis for KCNE3 and Estrogen Modulation of the KCNQ1 Channel
Kroncke, B. M. (Contributor), Van Horn, W. D. (Contributor), Smith, J. (Contributor), Kang, C. (Contributor), Welch, R. C. (Contributor), Song, Y. (Contributor), Nannemann, D. P. (Contributor), Taylor, K. C. (Contributor), Sisco, N. J. (Contributor), George, A. L. (Contributor), Meiler, J. (Contributor), Vanoye, C. G. (Contributor) & Sanders, C. R. (Contributor), Protein Data Bank (PDB), Sep 21 2016
DOI: 10.2210/pdb2NDJ/pdb, https://www.wwpdb.org/pdb?id=pdb_00002ndj
Dataset
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Solution NMR structure of the KCNQ1 voltage-sensing domain
Taylor, K. C. (Contributor), Kang, P. W. (Contributor), Hou, P. (Contributor), Yang, N.-D. (Contributor), Kuenze, G. (Contributor), Smith, J. A. (Contributor), Shi, J. (Contributor), Huang, H. (Contributor), White, K. M. (Contributor), Peng, D. (Contributor), George, A. L. (Contributor), Meiler, J. (Contributor), McFeeters, R. L. (Contributor), Cui, J. (Contributor) & Sanders, C. R. (Contributor), Protein Data Bank (PDB), Mar 4 2020
DOI: 10.2210/pdb6MIE/pdb, https://www.wwpdb.org/pdb?id=pdb_00006mie
Dataset
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2NDJ : Structural Basis for KCNE3 and Estrogen Modulation of the KCNQ1 Channel
Kroncke, B. M. (Contributor), Van Horn, W. D. (Contributor), Smith, J. (Contributor), Kang, C. (Contributor), Welch, R. C. (Contributor), Song, Y. (Contributor), Nannemann, D. P. (Contributor), Sisco, N. J. (Contributor), George, A. L. (Contributor), Meiler, J. (Contributor), Vanoye, C. G. (Contributor) & Sanders, C. R. (Contributor), RCSB-PDB, 2016
DOI: 10.2210/pdb2ndj/pdb, https://www.rcsb.org/structure/2NDJ
Dataset