• 20704 Citations
1978 …2018
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Personal profile

Training Experience

1986Residency, Vanderbilt University
1987Fellowship, University of Pennsylvania
1988Postdoctoral Fellowship, Institut Suisse de Recherches Experimentales sur le Cancer, Lausanne
1992Postdoctoral Fellowship, University of Pennsylvania

Education/Academic qualification

MD, University of Rochester

… → 1982

Keywords

  • Ion Channels
  • Neurogenetics
  • Epilepsy
  • Genomics
  • Genetics
  • Cellular Electrophysiology
  • Pharmacology
  • Arrhythmias

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Research Output 1978 2018

A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel

Johnson, C. N., Potet, F., Thompson, M. K., Kroncke, B. M., Glazer, A. M., Voehler, M. W., Knollmann, B. C., George, A. L. & Chazin, W. J. May 1 2018 In : Structure. 26, 5, p. 683-694.e3

Research output: Contribution to journalArticle

Sodium Channels
Calmodulin
Calcium
Magnetic Resonance Spectroscopy
Binding Sites

Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update

Phillips, E. J., Sukasem, C., Whirl-Carrillo, M., Müller, D. J., Dunnenberger, H. M., Chantratita, W., Goldspiel, B., Chen, Y. T., Carleton, B. C., George, A. L., Mushiroda, T., Klein, T., Gammal, R. S. & Pirmohamed, M. Jan 1 2018 (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Pharmacogenetics
Carbamazepine
Stevens-Johnson Syndrome
Genotype
Guidelines

Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood

Simmons, C. Q., Thompson, C. H., Cawthon, B. E., Westlake, G., Swoboda, K. J., Kiskinis, E., Ess, K. C. & George, A. L. Jul 1 2018 In : Neurobiology of Disease. 115, p. 29-38 10 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Neurons
Membrane Potentials
Mutation
Evoked Potentials

Long QT syndrome KCNH2 mutation with sequential fetal and maternal sudden death

Tuveng, J. M., Berling, B. M., Bunford, G., Vanoye, C. G., Welch, R. C., Leren, T. P., George, A. L. & Rognum, T. O. Jun 8 2018 (Accepted/In press) In : Forensic Science, Medicine, and Pathology. p. 1-5 5 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Maternal Death
Sudden Death
Fetal Death
Mothers

Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity

Chai, S., Wan, X., Ramirez-Navarro, A., Tesar, P. J., Kaufman, E. S., Ficker, E., George, A. L. & Deschênes, I. Mar 1 2018 In : Journal of Clinical Investigation. 128, 3, p. 1043-1056 14 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Induced Pluripotent Stem Cells
Genomics
Cardiac Myocytes
Exome