• 22937 Citations
1978 …2023

Research output per year

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Personal profile

Research Interests

Our research program is focused on the structure, function, pharmacology, and molecular genetics of ion channels. His laboratory has contributed greatly to understanding the mechanisms by which ion channel mutations cause a variety of inherited disorders of membrane excitability including congenital cardiac arrhythmia susceptibility and epilepsy. These basic and translational investigations have provided many opportunities to investigate the relationship between structure and function in ion channels and have helped establish important genotype-phenotype correlations for several human diseases and certain animal models. We were first to elucidate the functional consequences of an ion channel mutation linked to an inherited cardiac arrhythmia (Long-QT Syndrome). This discovery contributed greatly to understanding arrhythmia susceptibility in the disease and inspired use of drugs targeting persistent sodium current as a therapeutic strategy. Recently, the use of exome sequencing enabled us to discover human calmodulin mutations in congenital arrhythmia syndromes. Our studies of the molecular basis for genetic epilepsy have revealed new targets for antiepileptic drug development.

Training Experience

1986Residency, Vanderbilt University
1987Fellowship, University of Pennsylvania
1988Postdoctoral Fellowship, Institut Suisse de Recherches Experimentales sur le Cancer, Lausanne
1992Postdoctoral Fellowship, University of Pennsylvania

Education/Academic qualification

MD, University of Rochester

… → 1982

Research interests

  • Arrhythmias
  • Cellular Electrophysiology
  • Epilepsy
  • Genetics
  • Genomics
  • Ion Channels
  • Neurogenetics
  • Pharmacology

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Grants

  • Project 2

    Burridge, P., George Jr, A. L. & Potet, F.

    American Heart Association

    7/1/196/30/23

    Project: Research project

  • Research Output

    Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants

    Thompson, C. H., Ben-Shalom, R., Bender, K. J. & George, A. L., Mar 2 2020, In : The Journal of general physiology. 152, 3

    Research output: Contribution to journalArticle

    Open Access
  • Decoding KCNH2 variants of unknown significance

    Vanoye, C. G. & George, A. L., Mar 2020, In : Heart rhythm. 17, 3, p. 501-502 2 p.

    Research output: Contribution to journalEditorial

    1 Scopus citations

    Impact of CYP2C9-Interacting Drugs on Warfarin Pharmacogenomics

    Agrawal, S., Heiss, M. S., Fenter, R. B., Abramova, T. V., Perera, M. A., Pacheco, J. A., Smith, M. E., Rasmussen-Torvik, L. J. & George, A. L., Jan 1 2020, (Accepted/In press) In : Clinical and Translational Science.

    Research output: Contribution to journalArticle

    Open Access
  • Long QT Syndrome Type 1 in an Australian Indigenous Patient

    Ganesan, A. N., Vanoye, C. G., Alam, F., Waddell-Smith, K. E., McGavigan, A. D., Correnti, G., Haan, E., Brown, A., Vandenberg, J. & George, A. L., Jan 1 2020, (Accepted/In press) In : Circulation: Genomic and Precision Medicine. p. 93-94 2 p.

    Research output: Contribution to journalLetter

    Negligible-Cost and Weekend-Free Chemically Defined Human iPSC Culture

    Kuo, H. H., Gao, X., DeKeyser, J. M., Fetterman, K. A., Pinheiro, E. A., Weddle, C. J., Fonoudi, H., Orman, M. V., Romero-Tejeda, M., Jouni, M., Blancard, M., Magdy, T., Epting, C. L., George, A. L. & Burridge, P. W., Feb 11 2020, In : Stem cell reports. 14, 2, p. 256-270 15 p.

    Research output: Contribution to journalArticle

    Open Access