• 21869 Citations
1978 …2023
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Personal profile

Research Interests

Our research program is focused on the structure, function, pharmacology, and molecular genetics of ion channels. His laboratory has contributed greatly to understanding the mechanisms by which ion channel mutations cause a variety of inherited disorders of membrane excitability including congenital cardiac arrhythmia susceptibility and epilepsy. These basic and translational investigations have provided many opportunities to investigate the relationship between structure and function in ion channels and have helped establish important genotype-phenotype correlations for several human diseases and certain animal models. We were first to elucidate the functional consequences of an ion channel mutation linked to an inherited cardiac arrhythmia (Long-QT Syndrome). This discovery contributed greatly to understanding arrhythmia susceptibility in the disease and inspired use of drugs targeting persistent sodium current as a therapeutic strategy. Recently, the use of exome sequencing enabled us to discover human calmodulin mutations in congenital arrhythmia syndromes. Our studies of the molecular basis for genetic epilepsy have revealed new targets for antiepileptic drug development.

Training Experience

1986Residency, Vanderbilt University
1987Fellowship, University of Pennsylvania
1988Postdoctoral Fellowship, Institut Suisse de Recherches Experimentales sur le Cancer, Lausanne
1992Postdoctoral Fellowship, University of Pennsylvania

Education/Academic qualification

MD, University of Rochester

… → 1982


  • Arrhythmias
  • Cellular Electrophysiology
  • Epilepsy
  • Genetics
  • Genomics
  • Ion Channels
  • Neurogenetics
  • Pharmacology

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Grants 2014 2023

Brain Diseases
Drug Approval
Ion Channels
Ion Channels

Research Output 1978 2019

Myoclonic Epilepsy
GABA-A Receptors
Inhibitory Postsynaptic Potentials
Hypnotics and Sedatives

Protein structure aids predicting functional perturbation of missense variants in SCN5A and KCNQ1

Kroncke, B. M., Mendenhall, J., Smith, D. K., Sanders, C. R., Capra, J. A., George Jr, A. L., Blume, J. D., Meiler, J. & Roden, D. M., Jan 1 2019, In : Computational and Structural Biotechnology Journal. 17, p. 206-214 9 p.

Research output: Contribution to journalArticle

Open Access
Area Under Curve
Position-Specific Scoring Matrices
Brugada Syndrome

The importance of being selective

George Jr, A. L., Feb 1 2019, In : Heart Rhythm. 16, 2, p. 279-280 2 p.

Research output: Contribution to journalEditorial

7 Citations (Scopus)

A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel

Johnson, C. N., Potet, F., Thompson, M. K., Kroncke, B. M., Glazer, A. M., Voehler, M. W., Knollmann, B. C., George Jr, A. L. & Chazin, W. J., May 1 2018, In : Structure. 26, 5, p. 683-694.e3

Research output: Contribution to journalArticle

Sodium Channels
Magnetic Resonance Spectroscopy
Binding Sites
11 Citations (Scopus)

Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update

Phillips, E. J., Sukasem, C., Whirl-Carrillo, M., Müller, D. J., Dunnenberger, H. M., Chantratita, W., Goldspiel, B., Chen, Y. T., Carleton, B. C., George Jr, A. L., Mushiroda, T., Klein, T., Gammal, R. S. & Pirmohamed, M., Apr 1 2018, In : Clinical pharmacology and therapeutics. 103, 4, p. 574-581 8 p.

Research output: Contribution to journalArticle

Stevens-Johnson Syndrome