• 21980 Citations
1991 …2024
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Research Output 1991 2020

2020

A non-canonical monovalent zinc finger stabilizes the integration of Cfp1 into the H3K4 methyltransferase complex COMPASS

Yang, Y., Joshi, M., Takahashi, Y. H., Ning, Z., Qu, Q., Brunzelle, J. S., Skiniotis, G., Figeys, D., Shilatifard, A. & Couture, J. F., Jan 10 2020, In : Nucleic acids research. 48, 1, p. 421-431 11 p.

Research output: Contribution to journalArticle

Open Access
Zinc Fingers
Methyltransferases
Proteins
Genetic Promoter Regions
Epigenomics
2019
1 Citation (Scopus)

Catacomb: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Piunti, A., Smith, E. R., Morgan, M. A. J., Ugarenko, M., Khaltyan, N., Helmin, K. A., Ryan, C. A., Murray, D. C., Rickels, R. A., Yilmaz, B. D., Rendleman, E. J., Savas, J. N., Singer, B. D., Bulun, S. E. & Shilatifard, A., Jan 1 2019, In : Science Advances. 5, 7, eaax2887.

Research output: Contribution to journalArticle

Open Access
methionine
methylation
genes
deoxyribonucleic acid
COMPASS (programming language)
Open Access
Post Translational Protein Processing
Glioma
Histones
Immunohistochemistry
Pediatrics

Correction to: Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity (Nature Communications, (2018), 9, 1, (4406), 10.1038/s41467-018-06543-0)

Chung, C. Y., Berson, A., Kennerdell, J. R., Sartoris, A., Unger, T., Porta, S., Kim, H. J., Smith, E. R., Shilatifard, A., Van Deerlin, V., Lee, V. M. Y., Chen-Plotkin, A. & Bonini, N. M., Dec 1 2019, In : Nature communications. 10, 1, 555.

Research output: Contribution to journalComment/debate

document markup languages
neurology
Untranslated RNA
HTML
Neurology
1 Citation (Scopus)

Epigenetic modifications of histones in cancer

Zhao, Z. & Shilatifard, A., Nov 20 2019, In : Genome biology. 20, 1, 245.

Research output: Contribution to journalReview article

Open Access
Histone Code
Epigenomics
histones
epigenetics
cancer
1 Citation (Scopus)

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells

LeRoy, G., Oksuz, O., Descostes, N., Aoi, Y., Ganai, R. A., Kara, H. O., Yu, J. R., Lee, C. H., Stafford, J., Shilatifard, A. & Reinberg, D., Oct 2 2019, In : Science Advances. 5, 10, eaay3068.

Research output: Contribution to journalArticle

Open Access
epithelium
lenses
cells
chromatin
genes
3 Citations (Scopus)

Radiosensitization by histone H3 demethylase inhibition in diffuse intrinsic pontine glioma

Katagi, H., Louis, N., Unruh, D., Sasaki, T., He, X., Zhang, A., Ma, Q., Piunti, A., Shimazu, Y., Lamano, J. B., Carcaboso, A. M., Tian, X., Seluanov, A., Gorbunova, V., Laurie, K. L., Kondo, A., Wadhwani, N. R., Lulla, R., Goldman, S., Venneti, S. & 4 others, Becher, O. J., Zou, L., Shilatifard, A. & Hashizume, R., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5572-5583 12 p.

Research output: Contribution to journalArticle

Histone Demethylases
Glioma
Histones
Radiotherapy
Double-Stranded DNA Breaks
5 Citations (Scopus)

Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia

Zhao, Z., Wang, L., Volk, A. G., Birch, N. W., Stoltz, K. L., Bartom, E. T., Marshall, S. A., Rendleman, E. J., Nestler, C. M., Shilati, J., Schiltz, G. E., Crispino, J. D. & Shilatifard, A., Jan 1 2019, In : Genes and Development. 33, 1-2, p. 61-74 14 p.

Research output: Contribution to journalArticle

Aspartate Ammonia-Lyase
Threonine
Leukemia
Casein Kinase II
Therapeutics

Selective inhibition of metastasis in vivo, partly through disruption of nucleoli

Frankowski, K. J., Wang, C., Patnaik, S., Schoenen, F. J., Southall, N., Li, D., Te-Per, Y., Sun, W., Kandela, I., Hu, D., Dextras, C., Knotts, Z., Bian, Y., Norton, J., Titus, S., Lewandowska, M. A., Wen, Y., Farley, K. I., Griner, L. M., Sultan, J. & 28 others, Meng, Z., Zhou, M., Vilimas, T., Powers, A. S., Kozlov, S., Nagashima, K., Quadri, H. S., Fang, M., Long, C., Khanolkar, O., Chen, W., Kang, J., Huang, H., Chow, E., Goldberg, E., Feldman, C., Xi, R., Kim, H. R., Sahagian, G., Baserga, S. J., Mazar, A., Ferrer, M., Zheng, W., Shilati-Fard, A., Aubé, J., Rudloff, U., Marugan, J. J. & Huang, S., Jan 1 2019, In : Biopolymers and Cell. 35, 3, 1 p.

Research output: Contribution to journalArticle

Open Access
Cells
Neoplasm Metastasis
Heterografts
Neoplasms
Animals
38 Citations (Scopus)

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.

Research output: Contribution to journalArticle

Open Access
Single-Cell Analysis
Pulmonary Fibrosis
Lung
RNA Sequence Analysis
Alveolar Macrophages
8 Citations (Scopus)

The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity–independent genomic targeting

Pan, J., McKenzie, Z. M., D’Avino, A. R., Mashtalir, N., Lareau, C. A., St. Pierre, R., Wang, L., Shilatifard, A. & Kadoch, C., Apr 1 2019, In : Nature Genetics. 51, 4, p. 618-626 9 p.

Research output: Contribution to journalLetter

Adenosine Triphosphatases
Sucrose
Small Cell Carcinoma
Chromatin
Ovary
9 Citations (Scopus)

USP7 cooperates with NOTch1 to drive the oncogenic transcriptional program in T-cell leukemia

Jin, Q., Martinez, C. A., Arcipowski, K. M., Zhu, Y., Gutierrez-Diaz, B. T., Wang, K. K., Johnson, M. R., Volk, A. G., Wang, F., Wu, J., Grove, C., Wang, H., Sokirniy, I., Thomas, P. M., Goo, Y. A., Abshiru, N. A., Hijiya, N., Peirs, S., Vandamme, N., Berx, G. & 27 others, Goosens, S., Marshall, S. A., Rendleman, E. J., Takahashi, Y. H., Wang, L., Rawat, R., Bartom, E. T., Collings, C. K., Van Vlierberghe, P., Strikoudis, A., Kelly, S., Ueberheide, B., Mantis, C., Kandela, I., Bourquin, J. P., Bornhauser, B., Serafin, V., Bresolin, S., Paganin, M., Accordi, B., Basso, G., Kelleher, N. L., Weinstock, J., Kumar, S., Crispino, J. D., Shilatifard, A. & Ntziachristos, P., Jan 1 2019, In : Clinical Cancer Research. 25, 1, p. 222-239 18 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin-Specific Proteases
T-Cell Leukemia
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Chromatin
4 Citations (Scopus)

UTX Mutations in Human Cancer

Wang, L. & Shilatifard, A., Feb 11 2019, In : Cancer Cell. 35, 2, p. 168-176 9 p.

Research output: Contribution to journalReview article

Lysine
Carcinogenesis
Histone Demethylases
Mutation
Homeobox Genes
2 Citations (Scopus)

β-Catenin/Tcf7l2–dependent transcriptional regulation of GLUT1 gene expression by Zic family proteins in colon cancer

Zhao, Z., Wang, L., Bartom, E., Marshall, S., Rendleman, E., Ryan, C., Shilati, A., Savas, J., Chandel, N. & Shilatifard, A., Jul 31 2019, In : Science Advances. 5, 7, eaax0698.

Research output: Contribution to journalArticle

Open Access
gene expression
cancer
proteins
glucose
chromatin
2018
7 Citations (Scopus)

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity

Chung, C. Y., Berson, A., Kennerdell, J. R., Sartoris, A., Unger, T., Porta, S., Kim, H. J., Smith, E. R., Shilatifard, A., Van Deerlin, V., Lee, V. M. Y., Chen-Plotkin, A. & Bonini, N. M., Dec 1 2018, In : Nature communications. 9, 1, 4406.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Untranslated RNA
toxicity
elongation
Toxicity
23 Citations (Scopus)

A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer

Fantini, D., Glaser, A. P., Rimar, K. J., Wang, Y., Schipma, M. J., Varghese, N., Rademaker, A. W., Behdad, A., Yellapa, A., Yu, Y., Sze, C. C. L., Wang, L., Zhao, Z., Crawford, S. E., Hu, D., Licht, J. D., Collings, C. K., Bartom, E. T., Theodorescu, D., Shilatifard, A. & 1 others, Meeks, J. J., Apr 1 2018, In : Oncogene. 37, 14, p. 1911-1925 15 p.

Research output: Contribution to journalArticle

Molecular Models
Urinary Bladder Neoplasms
Carcinogens
Muscles
Neoplasms
8 Citations (Scopus)

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

Volk, A., Liang, K., Suraneni, P., Li, X., Zhao, J., Bulic, M., Marshall, S., Pulakanti, K., Malinge, S., Taub, J., Ge, Y., Rao, S., Bartom, E., Shilatifard, A. & Crispino, J. D., Nov 12 2018, In : Cancer Cell. 34, 5, p. 707-723.e7

Research output: Contribution to journalArticle

Hematopoiesis
Leukemia
Chromatin Assembly and Disassembly
Chromatin
Transcription Factors
12 Citations (Scopus)

An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells

Cao, K., Collings, C. K., Morgan, M. A., Marshall, S. A., Rendleman, E. J., Ozark, P. A., Smith, E. R. & Shilatifard, A., Jan 2018, In : Science Advances. 4, 1, eaap8747.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Epigenomics
Chromatin
Developmental Genes
Co-Repressor Proteins
34 Citations (Scopus)

Born to run: Control of transcription elongation by RNA polymerase II

Chen, F. X., Smith, E. & Shilatifard, A., Jul 1 2018, In : Nature Reviews Molecular Cell Biology. 19, 7, p. 464-478 15 p.

Research output: Contribution to journalReview article

RNA Polymerase II
Peptide Elongation Factors
Poly(ADP-ribose) Polymerases
Genetic Promoter Regions
Genes
2 Citations (Scopus)

Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis

Hong, S. H., Fang, S., Lu, B. C., Nofsinger, R., Kawakami, Y., Castro, G. L., Yin, Y., Lin, C., Yu, R. T., Downes, M., Belmonte, J. C. I., Shilatifard, A. & Evans, R. M., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. 10381-10386 6 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Retinoic Acid Receptors
Cytoplasmic and Nuclear Receptors
Thyroid Hormone Receptors
Neural Crest
1 Citation (Scopus)
Post Translational Protein Processing
Glioma
Histones
Immunohistochemistry
Pediatrics
27 Citations (Scopus)

Enhancer Logic and Mechanics in Development and Disease

Rickels, R. & Shilatifard, A., Aug 2018, In : Trends in Cell Biology. 28, 8, p. 608-630 23 p.

Research output: Contribution to journalReview article

Aptitude
Mechanics
DNA Sequence Analysis
Chromatin
Cues
1 Citation (Scopus)

Epigenetic ConFUSION: SS18-SSX Fusion Rewires BAF Complex to Activate Bivalent Genes in Synovial Sarcoma

Morgan, M. A. & Shilatifard, A., Jun 11 2018, In : Cancer Cell. 33, 6, p. 951-953 3 p.

Research output: Contribution to journalShort survey

Synovial Sarcoma
Epigenomics
Transcriptional Activation
Genes
Neoplasms

Impactful science as the guiding principle

Shilatifard, A., Jul 4 2018, In : Science Advances. 4, 7, eaau1696.

Research output: Contribution to journalEditorial

Editorial Policies
Research
7 Citations (Scopus)

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis

Frankowski, K. J., Wang, C., Patnaik, S., Schoenen, F. J., Southall, N., Li, D., Teper, Y., Sun, W., Kandela, I., Hu, D., Dextras, C., Knotts, Z., Bian, Y., Norton, J., Titus, S., Lewandowska, M. A., Wen, Y., Farley, K. I., Griner, L. M., Sultan, J. & 28 others, Meng, Z., Zhou, M., Vilimas, T., Powers, A. S., Kozlov, S., Nagashima, K., Quadri, H. S., Fang, M., Long, C., Khanolkar, O., Chen, W., Kang, J., Huang, H., Chow, E., Goldberg, E., Feldman, C., Xi, R., Kim, H. R., Sahagian, G., Baserga, S. J., Mazar, A., Ferrer, M., Zheng, W., Shilatifard, A., Aubé, J., Rudloff, U., Marugan, J. J. & Huang, S., May 16 2018, In : Science translational medicine. 10, 441, eaap8307.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Neoplasms
RNA Polymerase I
Peptide Elongation Factors
Pancreatic Neoplasms
22 Citations (Scopus)

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes

Dhar, S. S., Zhao, D., Lin, T., Gu, B., Pal, K., Wu, S. J., Alam, H., Lv, J., Yun, K., Gopalakrishnan, V., Flores, E. R., Northcott, P. A., Rajaram, V., Li, W., Shilatifard, A., Sillitoe, R. V., Chen, K. & Lee, M. G., Jun 7 2018, In : Molecular cell. 70, 5, p. 825-841.e6

Research output: Contribution to journalArticle

Tumor Suppressor Genes
Medulloblastoma
Epigenomics
Down-Regulation
Gene Expression
20 Citations (Scopus)

Promoter bivalency favors an open chromatin architecture in embryonic stem cells

Mas, G., Blanco, E., Ballaré, C., Sansó, M., Spill, Y. G., Hu, D., Aoi, Y., Le Dily, F., Shilatifard, A., Marti-Renom, M. A. & Di Croce, L., Oct 1 2018, In : Nature Genetics. 50, 10, p. 1452-1462 11 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Chromatin
Developmental Genes
Embryonic Development
Genome
26 Citations (Scopus)

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Wang, L., Zhao, Z., Ozark, P. A., Fantini, D., Marshall, S. A., Rendleman, E. J., Cozzolino, K. A., Louis, N., He, X., Morgan, M. A., Takahashi, Y. H., Collings, C. K., Smith, E. R., Ntziachristos, P., Savas, J. N., Zou, L., Hashizume, R., Meeks, J. J. & Shilatifard, A., Jun 1 2018, In : Nature Medicine. 24, 6, p. 758-769 12 p.

Research output: Contribution to journalArticle

Epigenomics
Tumors
Methyltransferases
Histones
Mutation
3 Citations (Scopus)

Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation

Haddad, J. F., Yang, Y., Takahashi, Y. H., Joshi, M., Chaudhary, N., Woodfin, A. R., Benyoucef, A., Yeung, S., Brunzelle, J. S., Skiniotis, G., Brand, M., Shilatifard, A. & Couture, J. F., Dec 4 2018, In : Structure. 26, 12, p. 1594-1603.e4

Research output: Contribution to journalArticle

Personnel Selection
Epigenomics
Methylation
Chromatin
Enzymes
17 Citations (Scopus)

Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex

Qu, Q., Takahashi, Y., Yang, Y., Hu, H., Zhang, Y., Brunzelle, J. S., Couture, J. F., Shilatifard, A. & Skiniotis, G., Aug 23 2018, In : Cell. 174, 5, p. 1117-1126.e12

Research output: Contribution to journalArticle

Methyltransferases
Histones
Cryoelectron Microscopy
Proteins
Methylation
11 Citations (Scopus)

Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy

Liang, K., Smith, E. R., Aoi, Y., Stoltz, K. L., Katagi, H., Woodfin, A. R., Rendleman, E. J., Marshall, S. A., Murray, D. C., Wang, L., Ozark, P. A., Mishra, R. K., Hashizume, R., Schiltz, G. E. & Shilatifard, A., Oct 18 2018, In : Cell. 175, 3, p. 766-779.e17

Research output: Contribution to journalArticle

Transcription
Elongation
Positive Transcriptional Elongation Factor B
Neoplasms
Peptidomimetics
10 Citations (Scopus)

TET2 coactivates gene expression through demethylation of enhancers

Wang, L., Ozark, P. A., Smith, E. R., Zhao, Z., Marshall, S. A., Rendleman, E. J., Piunti, A., Ryan, C., Whelan, A. L., Helmin, K. A., Morgan, M. A., Zou, L., Singer, B. D. & Shilatifard, A., Nov 7 2018, In : Science Advances. 4, 11, eaau6986.

Research output: Contribution to journalArticle

DNA Methylation
Estrogen Receptors
Estrogens
Clustered Regularly Interspaced Short Palindromic Repeats
5-Methylcytosine
2017
11 Citations (Scopus)

A cryptic tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation

Morgan, M. A. J., Rickels, R. A., Collings, C. K., He, X., Cao, K., Herz, H. M., Cozzolino, K. A., Abshiru, N. A., Marshall, S. A., Rendleman, E. J., Sze, C. C., Piunti, A., Kelleher, N. L., Savas, J. N. & Shilatifard, A., Oct 1 2017, In : Genes and Development. 31, 19, p. 2003-2014 12 p.

Research output: Contribution to journalArticle

Histones
Methylation
Chromatin
Drosophila
Clustered Regularly Interspaced Short Palindromic Repeats
16 Citations (Scopus)

A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism

Wang, L., Collings, C. K., Zhao, Z., Cozzolino, K. A., Ma, Q., Liang, K., Marshall, S. A., Sze, C. C., Hashizume, R., Savas, J. N. & Shilatifard, A., Oct 15 2017, In : Genes and Development. 31, 20, p. 2056-2066 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Cell Survival
Adiponectin Receptors
Proteins
Histone-Lysine N-Methyltransferase
39 Citations (Scopus)
Glioma
Histones
Cerebrospinal Fluid
Mutation
DNA
13 Citations (Scopus)

Histone H3K4 methylation-dependent and -independent functions of set1A/COMPASS in embryonic stem cell self-renewal and differentiation

Sze, C. C., Cao, K., Collings, C. K., Marshall, S. A., Rendleman, E. J., Ozark, P. A., Chen, F. X., Morgan, M. A., Wang, L. & Shilatifard, A., Sep 1 2017, In : Genes and Development. 31, 17, p. 1732-1737 6 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Histones
Methylation
Proteins
Methyltransferases
36 Citations (Scopus)

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

Rickels, R., Herz, H. M., Sze, C. C., Cao, K., Morgan, M. A., Collings, C. K., Gause, M., Takahashi, Y. H., Wang, L., Rendleman, E. J., Marshall, S. A., Krueger, A., Bartom, E. T., Piunti, A., Smith, E. R., Abshiru, N. A., Kelleher, N. L., Dorsett, D. & Shilatifard, A., Nov 1 2017, In : Nature Genetics. 49, 11, p. 1647-1653 7 p.

Research output: Contribution to journalArticle

Histones
Drosophila
Embryonic Structures
Alleles
Methyltransferases
28 Citations (Scopus)

Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications

Ebmeier, C. C., Erickson, B., Allen, B. L., Allen, M. A., Kim, H., Fong, N., Jacobsen, J. R., Liang, K., Shilatifard, A., Dowell, R. D., Old, W. M., Bentley, D. L. & Taatjes, D. J., Aug 1 2017, In : Cell reports. 20, 5, p. 1173-1186 14 p.

Research output: Contribution to journalArticle

Positive Transcriptional Elongation Factor B
Transcription
Chromatin
Phosphotransferases
RNA Polymerase II
25 Citations (Scopus)

Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma

Vo, B. H. T., Li, C., Morgan, M. A., Theurillat, I., Finkelstein, D., Wright, S., Hyle, J., Smith, S. M. C., Fan, Y., Wang, Y. D., Wu, G., Orr, B. A., Northcott, P. A., Shilatifard, A., Sherr, C. J. & Roussel, M. F., Mar 21 2017, In : Cell reports. 18, 12, p. 2907-2917 11 p.

Research output: Contribution to journalArticle

Medulloblastoma
Tumors
Up-Regulation
Neoplasms
Histones
150 Citations (Scopus)

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C. I., Anekalla, K. R., Joshi, N., Williams, K. J. N., Abdala-Valencia, H., Yacoub, T. J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Gates, K., Lam, A. P., Nicholson, T. T., Homan, P. J., Soberanes, S. & 23 others, Dominguez, S., Morgan, V. K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S. A., Bharat, A., Berdnikovs, S., Bhorade, S. M., Bartom, E. T., Morimoto, R. I., Balch, W. E., Sznajder, J. I., Chandel, N. S., Mutlu, G. M., Jain, M., Gottardi, C. J., Singer, B. D., Ridge, K. M., Bagheri, N., Shilatifard, A., Budinger, G. R. S. & Perlman, H., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2387-2404 18 p.

Research output: Contribution to journalArticle

Alveolar Macrophages
Fibrosis
Macrophages
Lung
Monocytes
31 Citations (Scopus)

Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification

Hu, D., Gao, X., Cao, K., Morgan, M. A., Mas, G., Smith, E. R., Volk, A. G., Bartom, E. T., Crispino, J. D., Di Croce, L. & Shilatifard, A., Feb 2 2017, In : Molecular cell. 65, 3, p. 460-475.e6

Research output: Contribution to journalArticle

Epigenomics
Germ Cells
Methylation
Embryonic Development
Gene Expression Regulation
21 Citations (Scopus)

PAF1 regulation of promoter-proximal pause release via enhancer activation

Chen, F. X., Xie, P., Collings, C. K., Cao, K., Aoi, Y., Marshall, S. A., Rendleman, E. J., Ugarenko, M., Ozark, P. A., Zhang, A., Shiekhattar, R., Smith, E. R., Zhang, M. Q. & Shilatifard, A., Sep 22 2017, In : Science. 357, 6357, p. 1294-1298 5 p.

Research output: Contribution to journalArticle

Gene Expression
RNA Polymerase II
Genes
45 Citations (Scopus)

Precancer atlas to drive precision prevention trials

Spira, A., Yurgelun, M. B., Alexandrov, L., Rao, A., Bejar, R., Polyak, K., Giannakis, M., Shilatifard, A., Finn, O. J., Dhodapkar, M., Kay, N. E., Braggio, E., Vilar, E., Mazzilli, S. A., Rebbeck, T. R., Garber, J. E., Velculescu, V. E., Disis, M. L., Wallace, D. C. & Lippman, S. M., Jan 1 2017, In : Cancer Research. 77, 7, p. 1510-1541 32 p.

Research output: Contribution to journalReview article

Atlases
Neoplasms
Immunity
Clone Cells
Drive
13 Citations (Scopus)

SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression

Cao, K., Collings, C. K., Marshall, S. A., Morgan, M. A., Rendleman, E. J., Wang, L., Sze, C. C., Sun, T., Bartom, E. T. & Shilatifard, A., Apr 15 2017, In : Genes and Development. 31, 8, p. 787-801 15 p.

Research output: Contribution to journalArticle

Homeobox Genes
Gene Expression Regulation
Transcriptional Activation
Long Noncoding RNA
Untranslated RNA
39 Citations (Scopus)

The evolving genomic landscape of urothelial carcinoma

Glaser, A. P., Fantini, D., Shilatifard, A., Schaeffer, E. M. & Meeks, J. J., Apr 1 2017, In : Nature Reviews Urology. 14, 4, p. 215-229 15 p.

Research output: Contribution to journalReview article

Carcinoma
Neoplasms
Virus Integration
Precision Medicine
Mutation
42 Citations (Scopus)

Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

Liang, K., Volk, A. G., Haug, J. S., Marshall, S. A., Woodfin, A. R., Bartom, E. T., Gilmore, J. M., Florens, L., Washburn, M. P., Sullivan, K. D., Espinosa, J. M., Cannova, J., Zhang, J., Smith, E. R., Crispino, J. D. & Shilatifard, A., Jan 12 2017, In : Cell. 168, 1-2, p. 59-72.e13

Research output: Contribution to journalArticle

Leukemia
Genes
Degradation
Myeloid-Lymphoid Leukemia Protein
Cell proliferation
97 Citations (Scopus)

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

Piunti, A., Hashizume, R., Morgan, M. A., Bartom, E. T., Horbinski, C. M., Marshall, S. A., Rendleman, E. J., Ma, Q., Takahashi, Y. H., Woodfin, A. R., Misharin, A. V., Abshiru, N. A., Lulla, R. R., Saratsis, A. M., Kelleher, N. L., James, C. D. & Shilatifard, A., Apr 1 2017, In : Nature Medicine. 23, 4, p. 493-500 8 p.

Research output: Contribution to journalArticle

Polycomb Repressive Complex 2
Glioma
Tumors
Proteins
Nucleosomes
2016
23 Citations (Scopus)

An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS

Rickels, R., Hu, D., Collings, C. K., Woodfin, A. R., Piunti, A., Mohan, M., Herz, H. M., Kvon, E. & Shilatifard, A., Jul 21 2016, In : Molecular cell. 63, 2, p. 318-328 11 p.

Research output: Contribution to journalArticle

Response Elements
Epigenomics
Polycomb Repressive Complex 2
Drosophila
Developmental Genes
13 Citations (Scopus)

Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements

Swain, A., Misulovin, Z., Pherson, M., Gause, M., Mihindukulasuriya, K., Rickels, R. A., Shilatifard, A. & Dorsett, D., Sep 2016, In : PLoS genetics. 12, 9, e1006331.

Research output: Contribution to journalArticle

RNA-binding proteins
Chromatids
RNA-Binding Proteins
chromatids
response elements
Genomics
Genome
Neoplasms