• 22959 Citations
1991 …2020

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2020

A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress

Viéitez, C., Martínez-Cebrián, G., Solé, C., Böttcher, R., Potel, C. M., Savitski, M. M., Onnebo, S., Fabregat, M., Shilatifard, A., Posas, F. & de Nadal, E., Apr 17 2020, In : Nucleic acids research. 48, 7, p. 3455-3475 21 p.

Research output: Contribution to journalArticle

Open Access

A non-canonical monovalent zinc finger stabilizes the integration of Cfp1 into the H3K4 methyltransferase complex COMPASS

Yang, Y., Joshi, M., Takahashi, Y. H., Ning, Z., Qu, Q., Brunzelle, J. S., Skiniotis, G., Figeys, D., Shilatifard, A. & Couture, J. F., Jan 10 2020, In : Nucleic acids research. 48, 1, p. 421-431 11 p.

Research output: Contribution to journalArticle

Open Access

NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release

Aoi, Y., Smith, E. R., Shah, A. P., Rendleman, E. J., Marshall, S. A., Woodfin, A. R., Chen, F. X., Shiekhattar, R. & Shilatifard, A., Apr 16 2020, In : Molecular cell. 78, 2, p. 261-274.e5

Research output: Contribution to journalArticle

2 Scopus citations

Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation

Douillet, D., Sze, C. C., Ryan, C., Piunti, A., Shah, A. P., Ugarenko, M., Marshall, S. A., Rendleman, E. J., Zha, D., Helmin, K. A., Zhao, Z., Cao, K., Morgan, M. A., Singer, B. D., Bartom, E. T., Smith, E. R. & Shilatifard, A., Jun 1 2020, In : Nature Genetics. 52, 6, p. 615-625 11 p.

Research output: Contribution to journalArticle

2019

Catacomb: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Piunti, A., Smith, E. R., Morgan, M. A. J., Ugarenko, M., Khaltyan, N., Helmin, K. A., Ryan, C. A., Murray, D. C., Rickels, R. A., Yilmaz, B. D., Rendleman, E. J., Savas, J. N., Singer, B. D., Bulun, S. E. & Shilatifard, A., Jan 1 2019, In : Science Advances. 5, 7, eaax2887.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells

LeRoy, G., Oksuz, O., Descostes, N., Aoi, Y., Ganai, R. A., Kara, H. O., Yu, J. R., Lee, C. H., Stafford, J., Shilatifard, A. & Reinberg, D., Oct 2 2019, In : Science Advances. 5, 10, eaay3068.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Radiosensitization by histone H3 demethylase inhibition in diffuse intrinsic pontine glioma

Katagi, H., Louis, N., Unruh, D., Sasaki, T., He, X., Zhang, A., Ma, Q., Piunti, A., Shimazu, Y., Lamano, J. B., Carcaboso, A. M., Tian, X., Seluanov, A., Gorbunova, V., Laurie, K. L., Kondo, A., Wadhwani, N. R., Lulla, R. R., Goldman, S., Venneti, S. & 4 others, Becher, O. J., Zou, L., Shilatifard, A. & Hashizume, R., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5572-5583 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia

Zhao, Z., Wang, L., Volk, A. G., Birch, N. W., Stoltz, K. L., Bartom, E. T., Marshall, S. A., Rendleman, E. J., Nestler, C. M., Shilati, J., Schiltz, G. E., Crispino, J. D. & Shilatifard, A., Jan 1 2019, In : Genes and Development. 33, 1-2, p. 61-74 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Selective inhibition of metastasis in vivo, partly through disruption of nucleoli

Frankowski, K. J., Wang, C., Patnaik, S., Schoenen, F. J., Southall, N., Li, D., Te-Per, Y., Sun, W., Kandela, I., Hu, D., Dextras, C., Knotts, Z., Bian, Y., Norton, J., Titus, S., Lewandowska, M. A., Wen, Y., Farley, K. I., Griner, L. M., Sultan, J. & 28 others, Meng, Z., Zhou, M., Vilimas, T., Powers, A. S., Kozlov, S., Nagashima, K., Quadri, H. S., Fang, M., Long, C., Khanolkar, O., Chen, W., Kang, J., Huang, H., Chow, E., Goldberg, E., Feldman, C., Xi, R., Kim, H. R., Sahagian, G., Baserga, S. J., Mazar, A., Ferrer, M., Zheng, W., Shilati-Fard, A., Aubé, J., Rudloff, U., Marugan, J. J. & Huang, S., Jan 1 2019, In : Biopolymers and Cell. 35, 3, 1 p.

Research output: Contribution to journalArticle

Open Access

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations

USP7 cooperates with NOTch1 to drive the oncogenic transcriptional program in T-cell leukemia

Jin, Q., Martinez, C. A., Arcipowski, K. M., Zhu, Y., Gutierrez-Diaz, B. T., Wang, K. K., Johnson, M. R., Volk, A. G., Wang, F., Wu, J., Grove, C., Wang, H., Sokirniy, I., Thomas, P. M., Goo, Y. A., Abshiru, N. A., Hijiya, N., Peirs, S., Vandamme, N., Berx, G. & 27 others, Goosens, S., Marshall, S. A., Rendleman, E. J., Takahashi, Y. H., Wang, L., Rawat, R., Bartom, E. T., Collings, C. K., Van Vlierberghe, P., Strikoudis, A., Kelly, S., Ueberheide, B., Mantis, C., Kandela, I., Bourquin, J. P., Bornhauser, B., Serafin, V., Bresolin, S., Paganin, M., Accordi, B., Basso, G., Kelleher, N. L., Weinstock, J., Kumar, S., Crispino, J. D., Shilatifard, A. & Ntziachristos, P., Jan 1 2019, In : Clinical Cancer Research. 25, 1, p. 222-239 18 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

β-Catenin/Tcf7l2–dependent transcriptional regulation of GLUT1 gene expression by Zic family proteins in colon cancer

Zhao, Z., Wang, L., Bartom, E., Marshall, S., Rendleman, E., Ryan, C., Shilati, A., Savas, J., Chandel, N. & Shilatifard, A., Jul 31 2019, In : Science Advances. 5, 7, eaax0698.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity

Chung, C. Y., Berson, A., Kennerdell, J. R., Sartoris, A., Unger, T., Porta, S., Kim, H. J., Smith, E. R., Shilatifard, A., Van Deerlin, V., Lee, V. M. Y., Chen-Plotkin, A. & Bonini, N. M., Dec 1 2018, In : Nature communications. 9, 1, 4406.

Research output: Contribution to journalArticle

11 Scopus citations

A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer

Fantini, D., Glaser, A. P., Rimar, K. J., Wang, Y., Schipma, M., Varghese, N., Rademaker, A., Behdad, A., Yellapa, A., Yu, Y., Sze, C. C. L., Wang, L., Zhao, Z., Crawford, S. E., Hu, D., Licht, J. D., Collings, C. K., Bartom, E., Theodorescu, D., Shilatifard, A. & 1 others, Meeks, J. J., Apr 1 2018, In : Oncogene. 37, 14, p. 1911-1925 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

Volk, A., Liang, K., Suraneni, P., Li, X., Zhao, J., Bulic, M., Marshall, S., Pulakanti, K., Malinge, S., Taub, J., Ge, Y., Rao, S., Bartom, E., Shilatifard, A. & Crispino, J. D., Nov 12 2018, In : Cancer Cell. 34, 5, p. 707-723.e7

Research output: Contribution to journalArticle

11 Scopus citations

An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells

Cao, K., Collings, C. K., Morgan, M. A., Marshall, S. A., Rendleman, E. J., Ozark, P. A., Smith, E. R. & Shilatifard, A., Jan 2018, In : Science Advances. 4, 1, eaap8747.

Research output: Contribution to journalArticle

13 Scopus citations

Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis

Hong, S. H., Fang, S., Lu, B. C., Nofsinger, R., Kawakami, Y., Castro, G. L., Yin, Y., Lin, C., Yu, R. T., Downes, M., Belmonte, J. C. I., Shilatifard, A. & Evans, R. M., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. 10381-10386 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
1 Scopus citations

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis

Frankowski, K. J., Wang, C., Patnaik, S., Schoenen, F. J., Southall, N., Li, D., Teper, Y., Sun, W., Kandela, I., Hu, D., Dextras, C., Knotts, Z., Bian, Y., Norton, J., Titus, S., Lewandowska, M. A., Wen, Y., Farley, K. I., Griner, L. M., Sultan, J. & 28 others, Meng, Z., Zhou, M., Vilimas, T., Powers, A. S., Kozlov, S., Nagashima, K., Quadri, H. S., Fang, M., Long, C., Khanolkar, O., Chen, W., Kang, J., Huang, H., Chow, E., Goldberg, E., Feldman, C., Xi, R., Kim, H. R., Sahagian, G., Baserga, S. J., Mazar, A. P., Ferrer, M., Zheng, W., Shilatifard, A., Aubé, J., Rudloff, U., Marugan, J. J. & Huang, S., May 16 2018, In : Science translational medicine. 10, 441, eaap8307.

Research output: Contribution to journalArticle

13 Scopus citations

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes

Dhar, S. S., Zhao, D., Lin, T., Gu, B., Pal, K., Wu, S. J., Alam, H., Lv, J., Yun, K., Gopalakrishnan, V., Flores, E. R., Northcott, P. A., Rajaram, V., Li, W., Shilatifard, A., Sillitoe, R. V., Chen, K. & Lee, M. G., Jun 7 2018, In : Molecular cell. 70, 5, p. 825-841.e6

Research output: Contribution to journalArticle

26 Scopus citations

Promoter bivalency favors an open chromatin architecture in embryonic stem cells

Mas, G., Blanco, E., Ballaré, C., Sansó, M., Spill, Y. G., Hu, D., Aoi, Y., Le Dily, F., Shilatifard, A., Marti-Renom, M. A. & Di Croce, L., Oct 1 2018, In : Nature Genetics. 50, 10, p. 1452-1462 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Wang, L., Zhao, Z., Ozark, P. A., Fantini, D., Marshall, S. A., Rendleman, E. J., Cozzolino, K. A., Louis, N., He, X., Morgan, M. A., Takahashi, Y. H., Collings, C. K., Smith, E. R., Ntziachristos, P., Savas, J. N., Zou, L., Hashizume, R., Meeks, J. J. & Shilatifard, A., Jun 1 2018, In : Nature Medicine. 24, 6, p. 758-769 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation

Haddad, J. F., Yang, Y., Takahashi, Y. H., Joshi, M., Chaudhary, N., Woodfin, A. R., Benyoucef, A., Yeung, S., Brunzelle, J. S., Skiniotis, G., Brand, M., Shilatifard, A. & Couture, J. F., Dec 4 2018, In : Structure. 26, 12, p. 1594-1603.e4

Research output: Contribution to journalArticle

5 Scopus citations

Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex

Qu, Q., Takahashi, Y. H., Yang, Y., Hu, H., Zhang, Y., Brunzelle, J. S., Couture, J. F., Shilatifard, A. & Skiniotis, G., Aug 23 2018, In : Cell. 174, 5, p. 1117-1126.e12

Research output: Contribution to journalArticle

27 Scopus citations

Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy

Liang, K., Smith, E. R., Aoi, Y., Stoltz, K. L., Katagi, H., Woodfin, A. R., Rendleman, E. J., Marshall, S. A., Murray, D. C., Wang, L., Ozark, P. A., Mishra, R. K., Hashizume, R., Schiltz, G. E. & Shilatifard, A., Oct 18 2018, In : Cell. 175, 3, p. 766-779.e17

Research output: Contribution to journalArticle

20 Scopus citations

TET2 coactivates gene expression through demethylation of enhancers

Wang, L., Ozark, P. A., Smith, E. R., Zhao, Z., Marshall, S. A., Rendleman, E. J., Piunti, A., Ryan, C., Whelan, A. L., Helmin, K. A., Morgan, M. A., Zou, L., Singer, B. D. & Shilatifard, A., Nov 7 2018, In : Science Advances. 4, 11, eaau6986.

Research output: Contribution to journalArticle

18 Scopus citations
2017

A cryptic tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation

Morgan, M. A. J., Rickels, R. A., Collings, C. K., He, X., Cao, K., Herz, H. M., Cozzolino, K. A., Abshiru, N. A., Marshall, S. A., Rendleman, E. J., Sze, C. C., Piunti, A., Kelleher, N. L., Savas, J. N. & Shilatifard, A., Oct 1 2017, In : Genes and Development. 31, 19, p. 2003-2014 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism

Wang, L., Collings, C. K., Zhao, Z., Cozzolino, K. A., Ma, Q., Liang, K., Marshall, S. A., Sze, C. C., Hashizume, R., Savas, J. N. & Shilatifard, A., Oct 15 2017, In : Genes and Development. 31, 20, p. 2056-2066 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
46 Scopus citations

Histone H3K4 methylation-dependent and -independent functions of set1A/COMPASS in embryonic stem cell self-renewal and differentiation

Sze, C. C., Cao, K., Collings, C. K., Marshall, S. A., Rendleman, E. J., Ozark, P. A., Chen, F. X., Morgan, M. A., Wang, L. & Shilatifard, A., Sep 1 2017, In : Genes and Development. 31, 17, p. 1732-1737 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

Rickels, R., Herz, H. M., Sze, C. C., Cao, K., Morgan, M. A., Collings, C. K., Gause, M., Takahashi, Y. H., Wang, L., Rendleman, E. J., Marshall, S. A., Krueger, A., Bartom, E. T., Piunti, A., Smith, E. R., Abshiru, N. A., Kelleher, N. L., Dorsett, D. & Shilatifard, A., Nov 1 2017, In : Nature Genetics. 49, 11, p. 1647-1653 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications

Ebmeier, C. C., Erickson, B., Allen, B. L., Allen, M. A., Kim, H., Fong, N., Jacobsen, J. R., Liang, K., Shilatifard, A., Dowell, R. D., Old, W. M., Bentley, D. L. & Taatjes, D. J., Aug 1 2017, In : Cell reports. 20, 5, p. 1173-1186 14 p.

Research output: Contribution to journalArticle

40 Scopus citations

Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma

Vo, B. H. T., Li, C., Morgan, M. A., Theurillat, I., Finkelstein, D., Wright, S., Hyle, J., Smith, S. M. C., Fan, Y., Wang, Y. D., Wu, G., Orr, B. A., Northcott, P. A., Shilatifard, A., Sherr, C. J. & Roussel, M. F., Mar 21 2017, In : Cell reports. 18, 12, p. 2907-2917 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C. I., Anekalla, K. R., Joshi, N., Williams, K. J. N., Abdala-Valencia, H., Yacoub, T. J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Gates, K., Lam, A. P., Nicholson, T. T., Homan, P. J., Soberanes, S. & 23 others, Dominguez, S., Morgan, V. K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S. A., Bharat, A., Berdnikovs, S., Bhorade, S. M., Bartom, E. T., Morimoto, R. I., Balch, W. E., Sznajder, J. I., Chandel, N. S., Mutlu, G. M., Jain, M., Gottardi, C. J., Singer, B. D., Ridge, K. M., Bagheri, N., Shilatifard, A., Budinger, G. R. S. & Perlman, H., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2387-2404 18 p.

Research output: Contribution to journalArticle

182 Scopus citations
11 Scopus citations

Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification

Hu, D., Gao, X., Cao, K., Morgan, M. A., Mas, G., Smith, E. R., Volk, A. G., Bartom, E. T., Crispino, J. D., Di Croce, L. & Shilatifard, A., Feb 2 2017, In : Molecular cell. 65, 3, p. 460-475.e6

Research output: Contribution to journalArticle

33 Scopus citations

PAF1 regulation of promoter-proximal pause release via enhancer activation

Chen, F. X., Xie, P., Collings, C. K., Cao, K., Aoi, Y., Marshall, S. A., Rendleman, E. J., Ugarenko, M., Ozark, P. A., Zhang, A., Shiekhattar, R., Smith, E. R., Zhang, M. Q. & Shilatifard, A., Sep 22 2017, In : Science. 357, 6357, p. 1294-1298 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression

Cao, K., Collings, C. K., Marshall, S. A., Morgan, M. A., Rendleman, E. J., Wang, L., Sze, C. C., Sun, T., Bartom, E. T. & Shilatifard, A., Apr 15 2017, In : Genes and Development. 31, 8, p. 787-801 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

Liang, K., Volk, A. G., Haug, J. S., Marshall, S. A., Woodfin, A. R., Bartom, E. T., Gilmore, J. M., Florens, L., Washburn, M. P., Sullivan, K. D., Espinosa, J. M., Cannova, J., Zhang, J., Smith, E. R., Crispino, J. D. & Shilatifard, A., Jan 12 2017, In : Cell. 168, 1-2, p. 59-72.e13

Research output: Contribution to journalArticle

46 Scopus citations

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

Piunti, A., Hashizume, R., Morgan, M. A., Bartom, E. T., Horbinski, C. M., Marshall, S. A., Rendleman, E. J., Ma, Q., Takahashi, Y. H., Woodfin, A. R., Misharin, A. V., Abshiru, N. A., Lulla, R. R., Saratsis, A. M., Kelleher, N. L., James, C. D. & Shilatifard, A., Apr 1 2017, In : Nature Medicine. 23, 4, p. 493-500 8 p.

Research output: Contribution to journalArticle

113 Scopus citations
2016

An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS

Rickels, R., Hu, D., Collings, C. K., Woodfin, A. R., Piunti, A., Mohan, M., Herz, H. M., Kvon, E. & Shilatifard, A., Jul 21 2016, In : Molecular cell. 63, 2, p. 318-328 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements

Swain, A., Misulovin, Z., Pherson, M., Gause, M., Mihindukulasuriya, K., Rickels, R. A., Shilatifard, A. & Dorsett, D., Sep 2016, In : PLoS genetics. 12, 9, e1006331.

Research output: Contribution to journalArticle

14 Scopus citations

MLL3/MLL4/COMPASS family on epigenetic regulation of enhancer function and cancer

Sze, C. C. & Shilatifard, A., Nov 2016, In : Cold Spring Harbor Perspectives in Medicine. 6, 11, a026427.

Research output: Contribution to journalArticle

33 Scopus citations

Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity

Luo, Z., Lin, C., Woodfin, A. R., Bartom, E. T., Gao, X., Smith, E. R. & Shilatifard, A., Jan 1 2016, In : Genes and Development. 30, 1, p. 92-101 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Reprogramming of the epigenome by MLL1 links early-life environmental exposures to prostate cancer risk

Wang, Q., Trevino, L. S., Wong, R. L. Y., Medvedovic, M., Chen, J., Ho, S. M., Shen, J., Foulds, C. E., Coarfa, C., O’Malley, B. W., Shilatifard, A. & Walker, C. L., Aug 2016, In : Molecular Endocrinology. 30, 8, p. 856-871 16 p.

Research output: Contribution to journalArticle

30 Scopus citations

Set1/COMPASS and mediator are repurposed to promote epigenetic transcriptional memory

D’Urso, A., Takahashi, Y. H., Xiong, B., Marone, J., Coukos, R., Randise-Hinchliff, C., Wang, J. P., Shilatifard, A. & Brickner, J. H., Jun 23 2016, In : eLife. 5, JUN2016, e16691.

Research output: Contribution to journalArticle

45 Scopus citations
2015

Analysis of dynamic changes in retinoid-induced transcription and epigenetic profiles of murine Hox clusters in ES cells

De Kumar, B., Parrish, M. E., Slaughter, B. D., Unruh, J. R., Gogol, M., Seidel, C., Paulson, A., Li, H., Gaudenz, K., Peak, A., McDowell, W., Fleharty, B., Ahn, Y., Lin, C., Smith, E., Shilatifard, A. & Krumlauf, R., Aug 1 2015, In : Genome research. 25, 8, p. 1229-1243 15 p.

Research output: Contribution to journalArticle

32 Scopus citations

A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation

Zhang, P., Chaturvedi, C. P., Tremblay, V., Cramet, M., Brunzelle, J. S., Skiniotis, G., Brand, M., Shilatifard, A. & Couture, J. F., Jan 15 2015, In : Genes and Development. 29, 2, p. 123-128 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing

Liang, K., Gao, X., Gilmore, J. M., Florens, L., Washburn, M. P., Smith, E. & Shilatifard, A., Jan 1 2015, In : Molecular and cellular biology. 35, 6, p. 928-938 11 p.

Research output: Contribution to journalArticle

70 Scopus citations

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

Zhu, J., Sammons, M. A., Donahue, G., Dou, Z., Vedadi, M., Getlik, M., Barsyte-Lovejoy, D., Al-Awar, R., Katona, B. W., Shilatifard, A., Huang, J., Hua, X., Arrowsmith, C. H. & Berger, S. L., Sep 10 2015, In : Nature. 525, 7568, p. 206-211 6 p.

Research output: Contribution to journalArticle

213 Scopus citations