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Research Interests
Dr. Aline Martin, PhD, MSc, is a graduate of the University Jean Monnet, Saint-Etienne, France, and completed her postdoctoral training at the Jared Grantham Kidney Institute, Kansas University Medical Center, Kansas City, USA. Dr. Martin conducts basic and translational science research in the area of bone and mineral metabolism disorders and actively mentors undergraduate, graduate and postdoctoral trainees. Dr. Martin’s research involves multiple national and international collaborations. Dr. Martin is Principal Investigator and co-Investigator on multiple NIH-funded projects and US patents. She is a current member of the American Society for Bone and Mineral Research, American Society of Nephrology and American Heart Association.
Dr. Martin research focuses on the regulation of bone and mineral metabolism. The general focus of her lab is the regulation of osteocyte-derived molecules and their impact on bone, renal and cardiac health. She is particularly interested in the bone ECM protein DMP1 and its role in diseases associated with excessive production of the skeletal hormone FGF23. Her lab recently established the prevention of FGF23-associated cardiac hypertrophy by improving DMP1 signaling in mice with chronic kidney disease (CKD) resulting in improved lifespan.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Cell & Molecular Biology, PhD, Universite Jean Monnet Saint-Etienne
… → 2005
Research interests keywords
- Biomineralization
- Bones
- Cartilage
- Joints
- Muscles
- Cardiovascular Diseases
- Cell Biology
- Cell Imaging
- Genetics
- Metabolism
- Molecular Biology
- Renal Diseases
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Role of FGF23 peptides in chronic kidney disease (CKD)
David, N. V., Ji, P. & Martin, A.
National Institute of Diabetes and Digestive and Kidney Diseases
1/1/23 → 11/30/27
Project: Research project
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The role of DMP1 in FGF23-induced hypophosphatemia
National Institute of Diabetes and Digestive and Kidney Diseases
4/1/22 → 1/31/26
Project: Research project
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Role of FGF23 and Phosphate in Chronic Kidney Disease
Martin, A., Bass, J., David, N. V., Hong, H. & Kapitsinou, P.
National Institute of Diabetes and Digestive and Kidney Diseases
1/1/22 → 11/30/25
Project: Research project
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Professional Development Core
National Institute of Diabetes and Digestive and Kidney Diseases
9/15/21 → 5/31/26
Project: Research project
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Regulation of FGF23 in Chronic Kidney Disease (CKD) by iron and inflammation
David, N. V., Ji, P., Kapitsinou, P. & Martin, A.
National Institute of Diabetes and Digestive and Kidney Diseases
9/17/20 → 6/30/25
Project: Research project
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Antagonism Between PEDF and TGF-β Contributes to Type VI Osteogenesis Imperfecta Bone and Vascular Pathogenesis
Kang, H., Aryal AC, S., Barnes, A. M., Martin, A., David, V., Crawford, S. E. & Marini, J. C., May 2022, In: Journal of Bone and Mineral Research. 37, 5, p. 925-937 13 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Editorial: Narrow the gap, build a bridge: An inspirational approach to chronic kidney disease-mineral and bone disorder
Martin, A. & Isakova, T., Jul 1 2022, In: Current opinion in nephrology and hypertension. 31, 4, p. 303-305 3 p.Research output: Contribution to journal › Editorial › peer-review
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Editorial: A humble way forward amid hype and hope
Isakova, T. & Martin, A., Jul 1 2021, In: Current opinion in nephrology and hypertension. 30, 4, p. 385-386 2 p.Research output: Contribution to journal › Editorial › peer-review
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Editorial introductions
Martin, A., Isakova, T., Moe, O. W. & Quaggin, S. E., Jul 1 2021, In: Current opinion in nephrology and hypertension. 30, 4, p. V-VIResearch output: Contribution to journal › Editorial › peer-review
Open Access -
Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease
Courbon, G., Francis, C., Gerber, C., Neuburg, S., Wang, X., Lynch, E., Isakova, T., Babitt, J. L., Wolf, M., Martin, A. & David, V., Dec 2021, In: Bone Research. 9, 1, 35.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations