Aline Martin

  • 1720 Citations
20052022
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Personal profile

Research Interests

Dr. Aline Martin, PhD, MSc, is a graduate of the University Jean Monnet, Saint-Etienne, France, and completed her postdoctoral training at the Jared Grantham Kidney Institute, Kansas University Medical Center, Kansas City, USA. Dr. Martin conducts basic and translational science research in the area of bone and mineral metabolism disorders and actively mentors undergraduate, graduate and postdoctoral trainees. Dr. Martin’s research involves multiple national and international collaborations. Dr. Martin is Principal Investigator and co-Investigator on multiple NIH-funded projects and US patents. She is a current member of the American Society for Bone and Mineral Research, American Society of Nephrology and American Heart Association.

Dr. Martin research focuses on the regulation of bone and mineral metabolism. The general focus of her lab is the regulation of osteocyte-derived molecules and their impact on bone, renal and cardiac health. She is particularly interested in the bone ECM protein DMP1 and its role in diseases associated with excessive production of the skeletal hormone FGF23. Her lab recently established the prevention of FGF23-associated cardiac hypertrophy by improving DMP1 signaling in mice with chronic kidney disease (CKD) resulting in improved lifespan.

Education/Academic qualification

PhD, Universite Jean Monnet

… → 2005

Keywords

  • Biomineralization
  • Bones
  • Cartilage
  • Joints
  • Muscles
  • Cardiovascular Diseases
  • Cell Biology
  • Cell Imaging
  • Genetics
  • Metabolism
  • Molecular Biology
  • Renal Diseases

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Grants 2015 2022

Chronic Kidney Disease-Mineral and Bone Disorder
Osteocytes
Osteoblasts
Bone Matrix
Extracellular Matrix Proteins
Hepatocyte Nuclear Factor 4
Health
Chronic Renal Insufficiency
Bone and Bones
Osteoblasts
Sodium-Glucose Transport Proteins
Minerals
Chronic Renal Insufficiency
Type 2 Diabetes Mellitus
Blood Glucose
Chronic Renal Insufficiency
Health
Therapeutics

Research Output 2005 2019

  • 1720 Citations
  • 25 Article
  • 1 Chapter
  • 1 Short survey
  • 1 Review article

DMP1 prevents osteocyte alterations, FGF23 elevation and left ventricular hypertrophy in mice with chronic kidney disease

Dussold, C., Gerber, C., White, S., Wang, X., Qi, L., Francis, C., Capella, M., Courbon, G., Wang, J., Li, C., Feng, J. Q., Isakova, T., Wolf, M., David, N. V. & Martin, A., Dec 1 2019, In : Bone Research. 7, 1, 12.

Research output: Contribution to journalArticle

Open Access
Osteocytes
Left Ventricular Hypertrophy
Dentin
Chronic Renal Insufficiency
Proteins

Genetic background influences cardiac phenotype in murine chronic kidney disease

Neuburg, S., Dussold, C., Gerber, C., Wang, X., Francis, C., Qi, L., David, V., Wolf, M. & Martin, A., Jul 1 2018, In : NDT. 33, 7, p. 1129-1137 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Angiotensin-converting enzyme 2 amplification limited to the circulation does not protect mice from development of diabetic nephropathy

Wysocki, J., Ye, M., Khattab, A. M., Fogo, A., Martin, A., David, N. V., Kanwar, Y. S., Osborn, M. & Batlle, D., Jun 1 2017, In : Kidney international. 91, 6, p. 1336-1346 11 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Albuminuria
Renin-Angiotensin System
Streptozocin
angiotensin converting enzyme 2
18 Citations (Scopus)

Fibroblast growth factor 23 levels associate with AKI and death in critical illness

Leaf, D. E., Jacob, K. A., Srivastava, A., Chen, M. E., Christov, M., Jüppner, H., Sabbisetti, V. S., Martin, A., Wolf, M. & Waikar, S. S., Jun 1 2017, In : Journal of the American Society of Nephrology. 28, 6, p. 1877-1885 9 p.

Research output: Contribution to journalArticle

Critical Illness
Intensive Care Units
Biomarkers
fibroblast growth factor 23
Osteocytes
13 Citations (Scopus)

Fat and Sucrose Intake Induces Obesity-Related Bone Metabolism Disturbances: Kinetic and Reversibility Studies in Growing and Adult Rats

Lavet, C., Martin, A., Linossier, M. T., Bossche, A. V., Laroche, N., Thomas, M., Gerbaix, M., Ammann, P., Fraissenon, A., Lafage-Proust, M. H., Courteix, D. & Vico, L., Jan 1 2016, In : Journal of Bone and Mineral Research. 31, 1, p. 98-115 18 p.

Research output: Contribution to journalArticle

High Fat Diet
Sucrose
Obesity
Fats
Bone and Bones