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Personal profile

Research Interests

Dr. Aline Martin, PhD, MSc, is a graduate of the University Jean Monnet, Saint-Etienne, France, and completed her postdoctoral training at the Jared Grantham Kidney Institute, Kansas University Medical Center, Kansas City, USA. Dr. Martin conducts basic and translational science research in the area of bone and mineral metabolism disorders and actively mentors undergraduate, graduate and postdoctoral trainees. Dr. Martin’s research involves multiple national and international collaborations. Dr. Martin is Principal Investigator and co-Investigator on multiple NIH-funded projects and US patents. She is a current member of the American Society for Bone and Mineral Research, American Society of Nephrology and American Heart Association.

Dr. Martin research focuses on the regulation of bone and mineral metabolism. The general focus of her lab is the regulation of osteocyte-derived molecules and their impact on bone, renal and cardiac health. She is particularly interested in the bone ECM protein DMP1 and its role in diseases associated with excessive production of the skeletal hormone FGF23. Her lab recently established the prevention of FGF23-associated cardiac hypertrophy by improving DMP1 signaling in mice with chronic kidney disease (CKD) resulting in improved lifespan.

Education/Academic qualification

PhD, Universite Jean Monnet

… → 2005

Research interests

  • Biomineralization
  • Bones
  • Cartilage
  • Joints
  • Muscles
  • Cardiovascular Diseases
  • Cell Biology
  • Cell Imaging
  • Genetics
  • Metabolism
  • Molecular Biology
  • Renal Diseases

Fingerprint Dive into the research topics where Aline Martin is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Bone and Bones Medicine & Life Sciences
Chronic Renal Insufficiency Medicine & Life Sciences
Leptin Medicine & Life Sciences
Osteocytes Medicine & Life Sciences
Kidney Medicine & Life Sciences
Osteoblasts Medicine & Life Sciences
Dentin Medicine & Life Sciences
Bone Chemical Compounds

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Grants 2015 2022

Chronic Kidney Disease-Mineral and Bone Disorder
Osteocytes
Osteoblasts
Bone Matrix
Extracellular Matrix Proteins
Hepatocyte Nuclear Factor 4
Health
Chronic Renal Insufficiency
Bone and Bones
Osteoblasts
Sodium-Glucose Transport Proteins
Minerals
Chronic Renal Insufficiency
Type 2 Diabetes Mellitus
Blood Glucose
Chronic Renal Insufficiency
Health
Therapeutics

Research Output 2005 2019

  • 1862 Citations
  • 25 Article
  • 2 Review article
  • 1 Chapter
  • 1 Short survey
1 Citation (Scopus)

Bone and heart health in chronic kidney disease: Role of dentin matrix protein 1

Martin, A., Jul 1 2019, In : Current opinion in nephrology and hypertension. 28, 4, p. 297-303 7 p.

Research output: Contribution to journalReview article

Dentin
Chronic Renal Insufficiency
Osteocytes
Bone and Bones
Health
4 Citations (Scopus)

DMP1 prevents osteocyte alterations, FGF23 elevation and left ventricular hypertrophy in mice with chronic kidney disease

Dussold, C., Gerber, C., White, S., Wang, X., Qi, L., Francis, C., Capella, M., Courbon, G., Wang, J., Li, C., Feng, J. Q., Isakova, T., Wolf, M., David, N. V. & Martin, A., Dec 1 2019, In : Bone Research. 7, 1, 12.

Research output: Contribution to journalArticle

Open Access
Osteocytes
Left Ventricular Hypertrophy
Dentin
Chronic Renal Insufficiency
Proteins
2 Citations (Scopus)

Ferric citrate reduces fibroblast growth factor 23 levels and improves renal and cardiac function in a mouse model of chronic kidney disease

Francis, C., Courbon, G., Gerber, C., Neuburg, S., Wang, X., Dussold, C., Capella, M., Qi, L., Isakova, T., Mehta, R., Martin, A., Wolf, M. & David, V., Dec 2019, In : Kidney international. 96, 6, p. 1346-1358 13 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Kidney
Knockout Mice
Iron-Deficiency Anemias
Hyperphosphatemia

Genetic background influences cardiac phenotype in murine chronic kidney disease

Neuburg, S., Dussold, C., Gerber, C., Wang, X., Francis, C., Qi, L., David, V., Wolf, M. & Martin, A., Jul 1 2018, In : NDT. 33, 7, p. 1129-1137 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Angiotensin-converting enzyme 2 amplification limited to the circulation does not protect mice from development of diabetic nephropathy

Wysocki, J., Ye, M., Khattab, A. M., Fogo, A., Martin, A., David, N. V., Kanwar, Y. S., Osborn, M. & Batlle, D., Jun 1 2017, In : Kidney international. 91, 6, p. 1336-1346 11 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Albuminuria
Renin-Angiotensin System
Streptozocin
angiotensin converting enzyme 2