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Amanda Muhs Saratsis

  • 402 Citations
20112021

Research output per year

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Personal profile

Research Interests

Dr. Saratsis has clinical appointments in the Departments of Neurological Surgery at Northwestern Memorial and Lurie Children's Hospitals, caring for children and adults with congenital disorders of the central nervous system. Dr. Saratsis has expertise in the clinical management and molecular biology of pediatric brain tumors, with particular focus on pediatric high-grade and brainstem glioma. Dr. Saratsis's laboratory aims to characterize the molecular biology of pediatric brain tumors for indentification of biomarkers of disease and development of novel, targeted therapeutic approaches to improve clinical outcomes. Dr. Saratsis is involved in multiple laboratory and clinical studies for development and clinical trial of new treatments for children with brain tumors, working closely with the neurosurgery and neuro-oncology clinical and research teams at Northwestern University and Lurie Children’s.

Training Experience

2007Internship, Georgetown University Hospital
2007Residency, University of California, Irvine
2012Residency, Georgetown University Hospital
2012Residency, Georgetown University Hospital
2014Fellowship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital)

Education/Academic qualification

MD, University of Illinois at Chicago

… → 2006

Research interests

  • Brain Cancer / Nervous System Cancer
  • Cancer Biology
  • Cancer Genetics
  • Neurosurgery

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Grants

Cracking the Histone Code: A Novel Epigenetic Approach to Pediatric Glioma Diagnosis and Treatment

Saratsis, A. M. & Thomas, P. M.

Northwestern Memorial Hospital

1/1/18 → 12/31/20

Project: Research project

    • Investigation of Histone H3 Post-Translational Modifications in Pediatric Brainstem Glioma

    Saratsis, A. M.

    Northwestern University, National Institute of Neurological Disorders and Stroke

    7/15/16 → 6/30/21

    Project: Research project

    Investigation of Histone H3 Post-Translational Modifications in Pediatric Brainstem Glioma

    Saratsis, A. M.

    Northwestern University, National Institute of Neurological Disorders and Stroke

    7/15/16 → 6/30/21

    Project: Research project

    Investigation of Histone H3 Post-Translational Modifications in Pediatric Brainstem Glioma

    Saratsis, A. M.

    National Institute of Neurological Disorders and Stroke

    7/15/16 → 6/30/21

    Project: Research project

    • Investigation of Histone H3 Post-Translational Modifications in Pediatric Brainstem Glioma

    Saratsis, A. M.

    Northwestern University, National Institute of Neurological Disorders and Stroke

    7/15/16 → 6/30/21

    Project: Research project

    Research Output

    Choroidal artery embolization in the management of cerebrospinal fluid overproduction: Case report and review of the literature

    Li, D., Shokuhfar, T., Pantalone, J., Rothstein, B., Alden, T. D., Shaibani, A. & Saratsis, A. M., Jun 1 2019, In : Journal of Neurosurgery: Pediatrics. 23, 6, p. 737-748 12 p.

    Research output: Contribution to journal › Review article

    • Correction: Detection of histone H3 K27M mutation and post-translational modifications in pediatric diffuse midline glioma via tissue immunohistochemistry informs diagnosis and clinical outcomes (Oncotarget (2018) 9 (37112-37124) DOI: 10.18632/oncotarget.26430)

    Huang, T., Garcia, R., Qi, J., Lulla, R., Horbinski, C. M., Behdad, A., Wadhwani, N. R., Shilatifard, A., James, C. D. & Saratsis, A. M., Apr 12 2019, In : Oncotarget. 10, 28, 1 p.

    Research output: Contribution to journal › Comment/debate

    Open Access

    • Methylation-dependent Tissue Factor Suppression Contributes to the Reduced Malignancy of IDH1-mutant Gliomas

    Unruh, D., Mirkov, S., Wray, B., Drumm, M., Lamano, J., Li, Y. D., Haider, Q. F., Javier, R., McCortney, K., Saratsis, A., Scholtens, D. M., Sarkaria, J. N., David James, C. & Horbinski, C., Jan 15 2019, In : Clinical Cancer Research. 25, 2, p. 747-759 13 p.

    Research output: Contribution to journal › Article

    • 3 Scopus citations

    Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease

    Qi, J., Esfahani, D. R., Huang, T., Ozark, P., Bartom, E. T., Hashizume, R., Bonner, E. R., An, S., Horbinski, C. M., James, C. D. & Saratsis, A. M., May 15 2019, In : Acta Neuropathologica Communications. 7, 1, 75.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    Detection of histone H3 K27M mutation and post-translational modifications in pediatric diffuse midline glioma via tissue immunohistochemistry informs diagnosis and clinical outcomes

    Huang, T., Garcia, R., Qi, J., Lulla, R., Horbinski, C. M., Behdad, A., Wadhwani, N. R., Shilatifard, A., James, C. D. & Saratsis, A. M., Dec 1 2018, In : Oncotarget. 9, 98, p. 37112-37124 13 p.

    Research output: Contribution to journal › Article