Grants per year
Personal profile
Research Interests
Professor Rosenzweig’s research group is focused on understanding metalloprotein function on the molecular level. They use structural, spectroscopic, biochemical, genetic, and bioinformatic approaches to attack problems at the forefront of bioinorganic chemistry. Specific areas of interest include biological methane oxidation, oxygen activation by metalloenzymes, metal uptake and transport, and natural products biosynthesis.
Education/Academic qualification
Inorganic Chemistry, PhD, Massachusetts Institute of Technology
… → 1994
Chemistry, BA, Amherst College
… → 1988
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Dive into the research topics where Amy C Rosenzweig is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Hanna H. Gray Fellows Program
Rosenzweig, A. C. (PD/PI)
Howard Hughes Medical Institute
1/1/24 → 12/31/27
Project: Research project
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Biological pest control: natural product character
Rosenzweig, A. C. (PD/PI)
9/1/23 → 8/31/26
Project: Research project
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Chemistry of Life Processes Predoctoral Training Program
Kelleher, N. L. (PD/PI), Judge, S. M. (Other), Rosenzweig, A. C. (Other) & Thomson, R. J. (Other)
National Institute of General Medical Sciences
7/1/23 → 6/30/28
Project: Research project
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Metalloenzymes and metal homeostasis
Rosenzweig, A. C. (PD/PI) & Rosenzweig, A. C. (PD/PI)
National Institute of General Medical Sciences
4/1/21 → 3/31/26
Project: Research project
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Equipment Supplement #2 for Metalloenzymes and metal homeostasis
Rosenzweig, A. C. (PD/PI)
National Institute of General Medical Sciences
4/1/21 → 3/31/26
Project: Research project
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A multi-iron enzyme installs copper-binding oxazolone/ thioamide pairs on a nontypeable Haemophilus influenzae virulence factor
Manley, O. M., Shriver, T. J., Xu, T., Melendrez, I. A., Palacios, P., Robson, S. A., Guo, Y., Kelleher, N. L., Ziarek, J. J. & Rosenzweig, A. C., Jul 9 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 28, e2408092121.Research output: Contribution to journal › Article › peer-review
Open Access -
Direct Methane Oxidation by Copper- and Iron-Dependent Methane Monooxygenases
Tucci, F. J. & Rosenzweig, A. C., Feb 14 2024, In: Chemical Reviews. 124, 3, p. 1288-1320 33 p.Research output: Contribution to journal › Review article › peer-review
Open Access17 Scopus citations -
Purification and biochemical characterization of methanobactin biosynthetic enzymes
Reyes, R. M. & Rosenzweig, A. C., Jan 2024, Siderophore and Related Natural Products Biosynthesis. Wencewicz, T. (ed.). Academic Press Inc, p. 171-187 17 p. (Methods in Enzymology; vol. 702).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Capturing a bis-Fe(IV) State in Methylosinus trichosporium OB3b MbnH
Manesis, A. C., Slater, J. W., Cantave, K., Martin Bollinger, J., Krebs, C. & Rosenzweig, A. C., Mar 7 2023, In: Biochemistry. 62, 5, p. 1082-1092 11 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Product analogue binding identifies the copper active site of particulate methane monooxygenase
Tucci, F. J., Jodts, R. J., Hoffman, B. M. & Rosenzweig, A. C., Dec 2023, In: Nature Catalysis. 6, 12, p. 1194-1204 11 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations
Datasets
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Data for EMSL Project 51533 from January 2021
Novikova, I. (Creator), Koo, C. (Creator) & Rosenzweig, A. (Creator), Environmental Molecular Sciences Laboratory, 2021
DOI: 10.25582/data.2021-01.2142109/1931422, https://www.osti.gov/servlets/purl/1931422/
Dataset
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Data for EMSL Project 51533 from August 2020
Novikova, I. (Creator), Koo, C. (Creator) & Rosenzweig, A. (Creator), Environmental Molecular Sciences Laboratory, 2020
DOI: 10.25582/data.2020-08.2044682/1933499, https://www.osti.gov/servlets/purl/1933499/
Dataset
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Data for EMSL Project 51533 from April 2022
Novikova, I. (Creator), Koo, C. (Creator) & Rosenzweig, A. (Creator), Environmental Molecular Sciences Laboratory, 2022
DOI: 10.25582/data.2022-04.2504077/1932830, https://www.osti.gov/servlets/purl/1932830/
Dataset
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1JK9 : Heterodimer between H48F-ySOD1 and yCCS
Lamb, A. L. (Contributor), Torres, A. S. (Contributor), O'Halloran, T. V. (Contributor) & Rosenzweig, A. C. (Contributor), RCSB-PDB, 2001
DOI: 10.2210/pdb1jk9/pdb, https://www.rcsb.org/structure/1JK9
Dataset
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4OJ8 : Crystal structure of carbapenem synthase in complex with (3S,5S)-carbapenam
Rosenzweig, A. C. (Contributor) & Boal, A. K. (Contributor), RCSB-PDB, 2014
DOI: 10.2210/pdb4oj8/pdb, https://www.rcsb.org/structure/4OJ8
Dataset