Amy Paller

  • 18910 Citations
1982 …2020

Research output per year

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Personal profile

Research Interests

The Paller lab studies the role of topically-applied, nanotherapy based gene therapy to treat skin disease, particularly diabetic ulcers, psoriasis, atopic dermatitis (eczema), skin cancer, and rare genetic skin problems. Her lab also focuses on unraveling the mechanism by which membrane-based glycosphingolipids modulate signaling, especially of the insulin-like growth factor-1 receptor (IGF-1R) and the epidermal growth factor receptor (EGFR)and studying the mechanism of the abnormal innervation in skin related to pain. Dr. Paller is the PI of Northwestern's Skin Disease Research Center, which includes 3 Cores dedicated to providing service to researchers of skin biology. As a pediatric dermatologist, Dr. Paller specializes in genetic (esp. ichthyoses and epidermolysis bullosa) and immune-mediated inflammatory (esp. atopic dermatitis, psoriasis and autoimmune disorders) in children. As director of pediatric dermatology clinical research, Dr. Paller has led almost 100 clinical trials. Her most recent translational research has: a) defined the immunophenotypes in early atopic dermatitis in children, paving the way for targeted therapy; b) discovered the immune dysregulation that may lead to inflamed skin in the ichthyoses, leading to a novel clinical trial with repurposed medication; and c) discovered evidence for an important role for ganglioside GM3 as an intermediate in the insulin resistance in diabetic skin and also in development of diabetic neuropathy.

Certifications and Licenses

Pediatric Dermatology
Pediatrics
Dermatology

Training Experience

1981Residency, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital)
1983Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital)
1984Postdoctoral Fellowship, University of North Carolina
1984Fellowship, University of North Carolina School of Medicine

Education/Academic qualification

MD, Stanford University

… → 1978

Research interests

  • Biochemistry: Lipids
  • Dermatology
  • Diabetes
  • Genetics
  • Genomic Medicine/Personalized Medicine
  • Signal Transduction
  • Skin
  • Skin Cancer

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Grants

Research Output

A Comparison of Psoriasis Severity in Pediatric Patients Treated with Methotrexate vs Biologic Agents

Bronckers, I. M. G. J., Paller, A. S., West, D. P., Lara-Corrales, I., Tollefson, M. M., Tom, W. L., Hogeling, M., Belazarian, L., Zachariae, C., Mahé, E., Siegfried, E., Blume-Peytavi, U., Szalai, Z., Vleugels, R. A., Holland, K., Murphy, R., Puig, L., Cordoro, K. M., Lambert, J., Alexopoulos, A. & 3 others, Mrowietz, U., Kievit, W. & Seyger, M. M. B., Apr 2020, In : JAMA dermatology. 156, 4, p. 384-392 9 p.

Research output: Contribution to journalArticle

  • Association between the longitudinal course of AD, sleep disturbance, and overall health in US children

    McKenzie, C., Paller, A. S., Fishbein, A. & Silverberg, J. I., Feb 2020, In : Journal of Allergy and Clinical Immunology: In Practice. 8, 2, p. 812-814.e1

    Research output: Contribution to journalArticle

    Baricitinib in patients with moderate-to-severe atopic dermatitis and inadequate response to topical corticosteroids: results from two randomized monotherapy phase III trials

    Simpson, E. L., Lacour, J. P., Spelman, L., Galimberti, R., Eichenfield, L. F., Bissonnette, R., King, B. A., Thyssen, J. P., Silverberg, J. I., Bieber, T., Kabashima, K., Tsunemi, Y., Costanzo, A., Guttman-Yassky, E., Beck, L. A., Janes, J. M., DeLozier, A. M., Gamalo, M., Brinker, D. R., Cardillo, T. & 4 others, Nunes, F. P., Paller, A. S., Wollenberg, A. & Reich, K., Aug 1 2020, In : British Journal of Dermatology. 183, 2, p. 242-255 14 p.

    Research output: Contribution to journalArticle

  • 9 Scopus citations

    Baseline Characteristics from UNITE: An Observational, International, Multicentre Registry to Evaluate Hidradenitis Suppurativa (Acne Inversa) in Clinical Practice

    Prens, E. P., Lugo-Somolinos, A. M., Paller, A. S., Kerdel, F., Duan, Y., Teixeira, H. D., Longcore, M. & Kimball, A. B., Aug 1 2020, In : American Journal of Clinical Dermatology. 21, 4, p. 579-590 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • Clinically Meaningful Responses to Dupilumab in Adolescents with Uncontrolled Moderate-to-Severe Atopic Dermatitis: Post-hoc Analyses from a Randomized Clinical Trial

    Paller, A. S., Bansal, A., Simpson, E. L., Boguniewicz, M., Blauvelt, A., Siegfried, E. C., Guttman-Yassky, E., Hultsch, T., Chen, Z., Mina-Osorio, P., Lu, Y., Rossi, A. B., He, X., Kamal, M., Graham, N. M. H., Pirozzi, G., Ruddy, M., Eckert, L. & Gadkari, A., Feb 1 2020, In : American Journal of Clinical Dermatology. 21, 1, p. 119-131 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations