Amy Paller

  • 15549 Citations
1982 …2021
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

The Paller lab studies the role of topically-applied, nanotherapy based gene therapy to treat skin disease, particularly diabetic ulcers, psoriasis, atopic dermatitis (eczema), skin cancer, and rare genetic skin problems. Her lab also focuses on unraveling the mechanism by which membrane-based glycosphingolipids modulate signaling, especially of the insulin-like growth factor-1 receptor (IGF-1R) and the epidermal growth factor receptor (EGFR)and studying the mechanism of the abnormal innervation in skin related to pain. Dr. Paller is the PI of Northwestern's Skin Disease Research Center, which includes 3 Cores dedicated to providing service to researchers of skin biology. As a pediatric dermatologist, Dr. Paller specializes in genetic (esp. ichthyoses and epidermolysis bullosa) and immune-mediated inflammatory (esp. atopic dermatitis, psoriasis and autoimmune disorders) in children. As director of pediatric dermatology clinical research, Dr. Paller has led almost 100 clinical trials. Her most recent translational research has: a) defined the immunophenotypes in early atopic dermatitis in children, paving the way for targeted therapy; b) discovered the immune dysregulation that may lead to inflamed skin in the ichthyoses, leading to a novel clinical trial with repurposed medication; and c) discovered evidence for an important role for ganglioside GM3 as an intermediate in the insulin resistance in diabetic skin and also in development of diabetic neuropathy.

Certifications and Licenses

Pediatric Dermatology
Pediatrics
Dermatology

Training Experience

1981Residency, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital)
1983Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital)
1984Postdoctoral Fellowship, University of North Carolina
1984Fellowship, University of North Carolina School of Medicine

Education/Academic qualification

MD, Stanford University

… → 1978

Keywords

  • Biochemistry: Lipids
  • Dermatology
  • Diabetes
  • Genetics
  • Genomic Medicine/Personalized Medicine
  • Signal Transduction
  • Skin
  • Skin Cancer

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 8 Similar Profiles
Atopic Dermatitis Medicine & Life Sciences
Skin Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Psoriasis Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Mutation Medicine & Life Sciences
Skin Diseases Medicine & Life Sciences
Gangliosides Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2000 2021

Eczema
Cognitive Therapy
Atopic Dermatitis
Pain
Ambulatory Care
Allantoin
Genetic Therapy
Registries
Research Personnel
Clinical Trials
Scavenger Receptors
Toll-Like Receptors
Virus Diseases
Innate Immunity
Skin
Tight Junctions
Atopic Dermatitis
Ephrin-A1
Ligands
Skin

Research Output 1982 2019

3 Citations (Scopus)

A phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis

Peppers, J., Paller, A., Maeda-Chubachi, T., Wu, S., Robbins, K., Gallagher, K. & Kraus, J. E., Jan 1 2019, In : Journal of the American Academy of Dermatology. 80, 1, p. 89-98.e3

Research output: Contribution to journalArticle

Atopic Dermatitis
Therapeutics
Research Personnel
Body Surface Area
Eczema

Assessment of the Timing of Milestone Clinical Events in Patients with Epidermolysis Bullosa from North America

Feinstein, J. A., Jambal, P., Peoples, K., Lucky, A. W., Khuu, P., Tang, J. Y., Lara-Corrales, I., Pope, E., Wiss, K., Hook, K. P., Levin, L. E., Morel, K. D., Paller, A., McCuaig, C. C., Powell, J., Eichenfield, L. F., Price, H., Levy, M. L., Schachner, L. A., Browning, J. C. & 5 othersBayliss, S., Jahnke, M., Shwayder, T., Glick, S. A. & Bruckner, A. L., Feb 1 2019, In : JAMA Dermatology. 155, 2, p. 196-203 8 p.

Research output: Contribution to journalArticle

Epidermolysis Bullosa Dystrophica
Epidermolysis Bullosa
North America
Epidermolysis Bullosa Simplex
Junctional Epidermolysis Bullosa

Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients

Brunner, P. M., Israel, A., Leonard, A., Pavel, A. B., Kim, H. J., Zhang, N., Czarnowicki, T., Patel, K., Murphrey, M., Ramsey, K., Rangel, S. M., Zebda, R., Soundararajan, V., Zheng, X., Estrada, Y. D., Xu, H., Krueger, J. G., Paller, A. & Guttman-Yassky, E., Mar 1 2019, In : Annals of Allergy, Asthma and Immunology. 122, 3, p. 318-330.e3

Research output: Contribution to journalArticle

Atopic Dermatitis
Pediatrics
Skin
Interleukin-13
Biomarkers
3 Citations (Scopus)

Epidermolysis Bullosa Simplex with KLHL24 Mutations Is Associated with Dilated Cardiomyopathy

Schwieger-Briel, A., Fuentes, I., Castiglia, D., Barbato, A., Greutmann, M., Leppert, J., Duchatelet, S., Hovnanian, A., Burattini, S., Yubero, M. J., Ibañez-Arenas, R., Rebolledo-Jaramillo, B., Gräni, C., Ott, H., Theiler, M., Weibel, L., Paller, A., Zambruno, G., Fischer, J., Palisson, F. & 1 othersHas, C., Jan 1 2019, In : Journal of Investigative Dermatology. 139, 1, p. 244-249 6 p.

Research output: Contribution to journalArticle

Epidermolysis Bullosa Simplex
Dilated Cardiomyopathy
Mutation
1 Citations (Scopus)

Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council

Eyerich, K., Brown, S. J., Perez-White, B. E., Tanaka, R. J., Bissonette, R., Dhar, S., Bieber, T., Hijnen, D. J., Guttman-Yassky, E., Irvine, A., Thyssen, J. P., Vestergaard, C., Werfel, T., Wollenberg, A., Paller, A. & Reynolds, N. J., Jan 1 2019, In : Journal of Allergy and Clinical Immunology. 143, 1, p. 36-45 10 p.

Research output: Contribution to journalArticle

Eczema
Atopic Dermatitis
Therapeutics
Biological Models
Precision Medicine