Grants per year
Personal profile
Research Interests
The Paller lab studies the role of topically-applied, nanotherapy based gene therapy to treat skin disease, particularly diabetic ulcers, psoriasis, atopic dermatitis (eczema), skin cancer, and rare genetic skin problems. Her lab also focuses on unraveling the mechanism by which membrane-based glycosphingolipids modulate signaling, especially of the insulin-like growth factor-1 receptor (IGF-1R) and the epidermal growth factor receptor (EGFR)and studying the mechanism of the abnormal innervation in skin related to pain. Dr. Paller is the PI of Northwestern's Skin Disease Research Center, which includes 3 Cores dedicated to providing service to researchers of skin biology. As a pediatric dermatologist, Dr. Paller specializes in genetic (esp. ichthyoses and epidermolysis bullosa) and immune-mediated inflammatory (esp. atopic dermatitis, psoriasis and autoimmune disorders) in children. As director of pediatric dermatology clinical research, Dr. Paller has led almost 100 clinical trials. Her most recent translational research has: a) defined the immunophenotypes in early atopic dermatitis in children, paving the way for targeted therapy; b) discovered the immune dysregulation that may lead to inflamed skin in the ichthyoses, leading to a novel clinical trial with repurposed medication; and c) discovered evidence for an important role for ganglioside GM3 as an intermediate in the insulin resistance in diabetic skin and also in development of diabetic neuropathy.
Certifications and Licenses
Pediatric Dermatology | |
Pediatrics | |
Dermatology |
Training Experience
1981 | Residency, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital) |
1983 | Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) |
1984 | Postdoctoral Fellowship, University of North Carolina |
1984 | Fellowship, University of North Carolina School of Medicine |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, Stanford University
… → 1978
Research interests keywords
- Biochemistry: Lipids
- Dermatology
- Diabetes
- Genetics
- Genomic Medicine/Personalized Medicine
- Signal Transduction
- Skin
- Skin Cancer
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Admin Core
Paller, A. (PD/PI), Lu, K. (Co-Investigator), Yi, R. (Co-Investigator), Lu, K. (Other) & Yi, R. (Other)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
8/1/24 → 6/30/29
Project: Research project
-
Using Dupilumab to Improve Circadian Function, Sleep and Pruritus in Children with Moderate/Severe Atopic Dermatitis
Paller, A. (PD/PI)
Pediatric Dermatology Research Alliance, Inc
7/1/24 → 6/30/25
Project: Research project
-
Prot #AC-203-EBS-007: An International, Multicenter, Randomized, Double-Blind, Parallel Group, VehicleControlled, Phase 2/3 Study with Open-Label Extension Evaluating the Efficacy and Safety of Diacerein 1% Ointment for the Treatment of Generalized Epider
Paller, A. (PD/PI)
Cato Research Ltd., TWi Biotechnology, Inc.
6/26/24 → 6/26/27
Project: Research project
-
Prot #I4V-MC-JAIO: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, and Pharmacokinetics of Baricitinib in Children from 6 Years to Less than 18 Years of Age with Alopecia Areata
Paller, A. (PD/PI)
ICON Clinical Research, LLC, Lilly USA, LLC
3/12/24 → 3/12/27
Project: Research project
-
A Randomized, Double-Blind, Placebo-Controlled, Multicenter, 16-Week Trial to Evaluate the Efficacy and Safety of FB-401 in Children, Adolescents, and Adult Subjects (Ages 2 Years and Older) with Mild-to-Moderate Atopic Dermatitis
Jacobson, M. E., Myles, I. A., Paller, A. S., Eichenfield, L. F. & Simpson, E. L., Feb 1 2024, In: Dermatology. 240, 1, p. 85-94 10 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Atopic dermatitis: A global health perspective
Faye, O., Flohr, C., Kabashima, K., Ma, L., Paller, A. S., Rapelanoro, F. R., Steinhoff, M., Su, J. C., Takaoka, R., Wollenberg, A., Yew, Y. W., Postigo, J. A. R., Schmid-Grendelmeier, P. & Taïeb, A., May 2024, In: Journal of the European Academy of Dermatology and Venereology. 38, 5, p. 801-811 11 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Attentiveness and mental health in adolescents with moderate-to-severe atopic dermatitis without ADHD
Paller, A. S., Gonzalez, M. E., Barnum, S., Jaeger, J., Shao, L., Ozturk, Z. E. & Korotzer, A., Oct 2024, In: Archives of Dermatological Research. 316, 8, 497.Research output: Contribution to journal › Article › peer-review
Open Access -
Berdazimer gel for molluscum contagiosum: An integrated analysis of 3 randomized controlled trials
Sugarman, J. L., Hebert, A., Browning, J. C., Paller, A. S., Stripling, S., Green, L. J., Cartwright, M., Enloe, C., Wells, N. & Maeda-Chubachi, T., Feb 2024, In: Journal of the American Academy of Dermatology. 90, 2, p. 299-308 10 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Berdazimer gel for molluscum contagiosum in patients with atopic dermatitis
Paller, A. S., Green, L. J., Silverberg, N., Stripling, S., Cartwright, M., Enloe, C., Wells, N., Kowalewski, E. K. & Maeda-Chubachi, T., May 1 2024, In: Pediatric dermatology. 41, 3, p. 438-444 7 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Datasets
-
Additional file 4: of Replicated methylation changes associated with eczema herpeticum and allergic response
Boorgula, M. P. (Contributor), Taub, M. A. (Creator), Rafaels, N. (Creator), Daya, M. (Creator), Campbell, M. (Creator), Chavan, S. (Creator), Shetty, A. (Contributor), Cheadle, C. (Creator), Barkataki, S. (Contributor), Fan, J. (Contributor), David, G. (Creator), Beaty, T. H. (Creator), Ruczinski, I. (Creator), Hanifin, J. (Creator), Schneider, L. C. (Creator), Gallo, R. L. (Creator), Paller, A. S. (Creator), Beck, L. A. (Creator), Leung, D. Y. (Creator), Mathias, R. A. (Contributor), Barnes, K. C. (Creator), Taub, M. (Creator), Beaty, T. (Creator), Hanifin, J. (Creator), Paller, A. (Creator) & Barnes, K. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.9728489, https://springernature.figshare.com/articles/Additional_file_4_of_Replicated_methylation_changes_associated_with_eczema_herpeticum_and_allergic_response/9728489
Dataset
-
Infections in Children Aged 6 Months to 5 Years Treated With Dupilumab in a Placebo-Controlled Clinical Trial of Moderate-to-Severe Atopic Dermatitis
Paller, A. S. (Contributor), Siegfried, E. C. (Creator), Cork, M. J. (Creator), Arkwright, P. D. (Contributor), Eichenfield, L. F. (Creator), Ramien, M. (Creator), Khokhar, F. A. (Creator), Chen, Z. (Creator), Zhang, A. (Creator) & Cyr, S. L. (Creator), Adis Journals, 2024
DOI: 10.6084/m9.figshare.24718977.v1, https://adisjournals.figshare.com/articles/media/Infections_in_Children_Aged_6_Months_to_5_Years_Treated_With_Dupilumab_in_a_Placebo-Controlled_Clinical_Trial_of_Moderate-to-Severe_Atopic_Dermatitis/24718977/1
Dataset
-
Conjunctivitis in Dupilumab Clinical Trials for Adolescents With Atopic Dermatitis or Asthma
Bansal, A. (Creator), Simpson, E. L. (Creator), Paller, A. S. (Creator), Siegfried, E. C. (Creator), Blauvelt, A. (Creator), de Bruin-Weller, M. (Contributor), Corren, J. (Creator), Sher, L. (Creator), Guttman-Yassky, E. (Creator), Chen, Z. (Creator), Daizadeh, N. (Creator), Kamal, M. A. (Creator), Shumel, B. (Creator), Mina-Osorio, P. (Creator), Mannent, L. (Creator), Patel, N. (Creator), Graham, N. M. H. (Creator), Khokhar, F. A. (Creator), Ardeleanu, M. (Creator), Simpson, E. L. (Creator), Paller, A. S. (Creator), Siegfried, E. C. (Creator) & Bruin-Weller, M. D. (Creator), Adis Journals, 2021
DOI: 10.6084/m9.figshare.13251191.v1, https://adisjournals.figshare.com/articles/media/Conjunctivitis_in_Dupilumab_Clinical_Trials_for_Adolescents_With_Atopic_Dermatitis_or_Asthma/13251191/1
Dataset
-
Clinically meaningful responses with dupilumab in adolescents with uncontrolled moderate-to-severe atopic dermatitis: post hoc analyses from a randomized clinical trial
Paller, A. S. (Creator), Bansal, A. (Creator), Simpson, E. L. (Contributor), Boguniewicz, M. (Creator), Blauvelt, A. (Creator), Siegfried, E. C. (Creator), Guttman-Yassky, E. (Creator), Hultsch, T. (Creator), Chen, Z. (Creator), Mina-Osorio, P. (Creator), Lu, Y. (Creator), Rossi, A. B. (Creator), He, X. (Creator), Kamal, M. (Creator), Graham, N. M. H. (Creator), Pirozzi, G. (Creator), Ruddy, M. (Creator), Eckert, L. (Creator), Gadkari, A. (Creator), Paller, A. S. (Creator), Simpson, E. L. (Contributor), Siegfried, E. C. (Creator) & Xinyi, H. (Contributor), Adis Journals, 2019
DOI: 10.6084/m9.figshare.11309645.v1, https://adisjournals.figshare.com/articles/media/Clinically_meaningful_responses_with_dupilumab_in_adolescents_with_uncontrolled_moderate-to-severe_atopic_dermatitis_post_hoc_analyses_from_a_randomized_clinical_trial/11309645/1
Dataset
-
Dupilumab Demonstrates Rapid and Consistent Improvement in Extent and Signs of Atopic Dermatitis Across All Anatomical Regions in Pediatric Patients 6 Years of Age and Older
Simpson, E. L. (Creator), Paller, A. S. (Creator), Siegfried, E. C. (Creator), Thaçi, D. (Creator), Wollenberg, A. (Creator), Cork, M. J. (Creator), Marcoux, D. (Creator), Huang, R. (Creator), Chen, Z. (Creator), Rossi, A. B. (Creator), Shumel, B. (Creator), Sierka, D. (Creator), Bansal, A. (Creator), Simpson, E. L. (Creator), Paller, A. S. (Creator), Siegfried, E. C. (Creator), Wollenberg, A. (Creator) & Cork, M. J. (Creator), Adis Journals, 2021
DOI: 10.6084/m9.figshare.14779038.v1, https://adisjournals.figshare.com/articles/media/Dupilumab_Demonstrates_Rapid_and_Consistent_Improvement_in_Extent_and_Signs_of_Atopic_Dermatitis_Across_All_Anatomical_Regions_in_Pediatric_Patients_6_Years_of_Age_and_Older/14779038/1
Dataset