Grants per year
Personal profile
Research Interests
The Paller lab studies the role of topically-applied, nanotherapy based gene therapy to treat skin disease, particularly diabetic ulcers, psoriasis, atopic dermatitis (eczema), skin cancer, and rare genetic skin problems. Her lab also focuses on unraveling the mechanism by which membrane-based glycosphingolipids modulate signaling, especially of the insulin-like growth factor-1 receptor (IGF-1R) and the epidermal growth factor receptor (EGFR)and studying the mechanism of the abnormal innervation in skin related to pain. Dr. Paller is the PI of Northwestern's Skin Disease Research Center, which includes 3 Cores dedicated to providing service to researchers of skin biology. As a pediatric dermatologist, Dr. Paller specializes in genetic (esp. ichthyoses and epidermolysis bullosa) and immune-mediated inflammatory (esp. atopic dermatitis, psoriasis and autoimmune disorders) in children. As director of pediatric dermatology clinical research, Dr. Paller has led almost 100 clinical trials. Her most recent translational research has: a) defined the immunophenotypes in early atopic dermatitis in children, paving the way for targeted therapy; b) discovered the immune dysregulation that may lead to inflamed skin in the ichthyoses, leading to a novel clinical trial with repurposed medication; and c) discovered evidence for an important role for ganglioside GM3 as an intermediate in the insulin resistance in diabetic skin and also in development of diabetic neuropathy.
Certifications and Licenses
Pediatric Dermatology | |
Pediatrics | |
Dermatology |
Training Experience
1981 | Residency, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital) |
1983 | Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) |
1984 | Postdoctoral Fellowship, University of North Carolina |
1984 | Fellowship, University of North Carolina School of Medicine |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, Stanford University
… → 1978
Research interests keywords
- Biochemistry: Lipids
- Dermatology
- Diabetes
- Genetics
- Genomic Medicine/Personalized Medicine
- Signal Transduction
- Skin
- Skin Cancer
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Collaborations and top research areas from the last five years
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Patient Travel Support for Dupilumab for Itch Clinical Trial
Paller, A. (PD/PI)
12/20/24 → 12/19/25
Project: Research project
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Prot #1368-0121: Non-Interventional Study of Patients with Netherton Syndrome to Characterise Natural History of the Disease
Paller, A. (PD/PI)
United BioSource LLC, Boehringer Ingelheim International GmbH
11/7/24 → 11/7/27
Project: Research project
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Building a Spatial Transcriptomic Atlas of Ichthyosis
Paller, A. (PD/PI) & Rabbaa Khabbaz, L. (Other)
Yale University, Foundation for Ichthyosis & Related Skin Types
10/1/24 → 9/30/25
Project: Research project
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Developing consensus guidelines on management of osteoporosis in epidermolysis bullosa: a Delphi survey
Paller, A. (PD/PI)
Pediatric Dermatology Research Alliance, Inc
10/1/24 → 9/30/25
Project: Research project
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ADRN - TIME2: SAFETY AND EFFICACY OF TOPICAL BACTERIOTHERAPY FOR ATOPIC DERMATITIS USING STAPHYLOCOCCUS HOMINIS A9 [TARGETED INVESTIGATION OF MICROBIOME 2 TREAT ATOPIC DERMATITIS (TIME-2)]
Paller, A. (PD/PI)
National Jewish Health, National Institute of Allergy and Infectious Diseases
8/1/24 → 2/28/26
Project: Research project
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A Maximum-Use Trial of Ruxolitinib Cream in Children Aged 2–11 Years with Moderate to Severe Atopic Dermatitis
Stein Gold, L., Bissonnette, R., Forman, S., Zaenglein, A., Kuo, Y. T., Angel, B., Chen, X., Kallender, H. & Paller, A. S., Mar 2025, In: American Journal of Clinical Dermatology. 26, 2, p. 275-289 15 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
An international multicenter, retrospective cohort study of 203 patients with pediatric androgenetic alopecia
Lee, T. S., O'Connor, M., Castelo-Soccio, L., Eichenfield, D., Lee, D., Paller, A. S., Valdebran, M., Vroman, J., Yang, A., Lee, G. L., Craddock, M. & Sibbald, C., 2025, (Accepted/In press) In: Journal of the American Academy of Dermatology.Research output: Contribution to journal › Article › peer-review
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Artificial Intelligence-Enabled Wearable Devices and Nocturnal Scratching in Mild Atopic Dermatitis
Xu, S., Yang, A. F., Patel, S., Chun, K. S., Richards, D., Walter, J. R., Okamoto, K., Paller, A. S. & Ikoma, A., Apr 16 2025, In: JAMA dermatology. 161, 4, p. 406-410 5 p.Research output: Contribution to journal › Article › peer-review
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Assessment of Alopecia Areata Disease Severity in Pediatric Patients
Sun, D. I. & Paller, A. S., Mar 2025, In: Pediatric dermatology. 42, S1, p. 31-35 5 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
A “boring” worm? New World screwworm neuromyiasis in a patient with Darier disease
Yang, L. J., Abramovici, G., Brieva, J. & Paller, A. S., May 2025, In: JAAD Case Reports. 59, p. 50-52 3 p.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Wound closure in epidermolysis bullosa: data from the vehicle arm of the phase 3 ESSENCE Study
Murrell, D. F. (Contributor), Paller, A. S. (Creator), Bodemer, C. (Creator), Browning, J. (Creator), Nikolic, M. (Contributor), Barth, J. A. (Creator), Lagast, H. (Creator), Krusinska, E. (Creator) & Reha, A. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.c.5069759, https://springernature.figshare.com/collections/Wound_closure_in_epidermolysis_bullosa_data_from_the_vehicle_arm_of_the_phase_3_ESSENCE_Study/5069759
Dataset
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Development, Psychometric Validation and Responder Definition of Worst Itch Scale in Children with Severe Atopic Dermatitis
Paller, A. S. (Creator), Yosipovitch, G. (Creator), Weidinger, S. (Creator), DiBenedetti, D. (Creator), Whalley, D. (Creator), Gadkari, A. (Creator), Guillemin, I. (Creator), Zhang, H. (Creator), Eckert, L. (Creator), Chao, J. (Creator), Bansal, A. (Creator), Chuang, C.-C. (Creator) & Delevry, D. (Creator), Adis Journals, 2022
DOI: 10.6084/m9.figshare.20655396.v1, https://adisjournals.figshare.com/articles/media/Development_Psychometric_Validation_and_Responder_Definition_of_Worst_Itch_Scale_in_Children_with_Severe_Atopic_Dermatitis/20655396/1
Dataset
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Supplementary Material for: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, 16-Week Trial to Evaluate the Efficacy and Safety of FB-401 in Children, Adolescent and Adult Subjects (Ages 2 Years and Older) with Mild to Moderate Atopic Dermatitis
Jacobson, M. E. (Contributor), Myles, I. A. (Contributor), Paller, A. S. (Contributor), Eichenfield, L. F. (Contributor) & Simpson, E. L. (Contributor), Karger Publishers, 2023
DOI: 10.6084/m9.figshare.24099420, https://karger.figshare.com/articles/dataset/Supplementary_Material_for_A_Randomized_Double-Blind_Placebo-Controlled_Multicenter_16-Week_Trial_to_Evaluate_the_Efficacy_and_Safety_of_FB-401_in_Children_Adolescent_and_Adult_Subjects_Ages_2_Years_and_Older_with_Mild_to_Moderate_Atopic_De/24099420
Dataset
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Additional file 3: of Replicated methylation changes associated with eczema herpeticum and allergic response
Boorgula, M. P. (Contributor), Taub, M. A. (Creator), Rafaels, N. (Creator), Daya, M. (Creator), Campbell, M. (Creator), Chavan, S. (Creator), Shetty, A. (Contributor), Cheadle, C. (Creator), Barkataki, S. (Contributor), Fan, J. (Contributor), David, G. (Creator), Beaty, T. H. (Creator), Ruczinski, I. (Creator), Hanifin, J. (Creator), Schneider, L. C. (Creator), Gallo, R. L. (Creator), Paller, A. S. (Creator), Beck, L. A. (Creator), Leung, D. Y. (Creator), Mathias, R. A. (Contributor) & Barnes, K. C. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.9728480, https://springernature.figshare.com/articles/Additional_file_3_of_Replicated_methylation_changes_associated_with_eczema_herpeticum_and_allergic_response/9728480
Dataset
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Infections in Children Aged 6 Months to 5 Years Treated With Dupilumab in a Placebo-Controlled Clinical Trial of Moderate-to-Severe Atopic Dermatitis
Paller, A. S. (Contributor), Siegfried, E. C. (Creator), Cork, M. J. (Creator), Arkwright, P. D. (Contributor), Eichenfield, L. F. (Creator), Ramien, M. (Creator), Khokhar, F. A. (Creator), Chen, Z. (Creator), Zhang, A. (Creator) & Cyr, S. L. (Creator), Adis Journals, 2024
DOI: 10.6084/m9.figshare.24718977.v1, https://adisjournals.figshare.com/articles/media/Infections_in_Children_Aged_6_Months_to_5_Years_Treated_With_Dupilumab_in_a_Placebo-Controlled_Clinical_Trial_of_Moderate-to-Severe_Atopic_Dermatitis/24718977/1
Dataset