Amy Paller

  • 16191 Citations
1982 …2024
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Personal profile

Research Interests

The Paller lab studies the role of topically-applied, nanotherapy based gene therapy to treat skin disease, particularly diabetic ulcers, psoriasis, atopic dermatitis (eczema), skin cancer, and rare genetic skin problems. Her lab also focuses on unraveling the mechanism by which membrane-based glycosphingolipids modulate signaling, especially of the insulin-like growth factor-1 receptor (IGF-1R) and the epidermal growth factor receptor (EGFR)and studying the mechanism of the abnormal innervation in skin related to pain. Dr. Paller is the PI of Northwestern's Skin Disease Research Center, which includes 3 Cores dedicated to providing service to researchers of skin biology. As a pediatric dermatologist, Dr. Paller specializes in genetic (esp. ichthyoses and epidermolysis bullosa) and immune-mediated inflammatory (esp. atopic dermatitis, psoriasis and autoimmune disorders) in children. As director of pediatric dermatology clinical research, Dr. Paller has led almost 100 clinical trials. Her most recent translational research has: a) defined the immunophenotypes in early atopic dermatitis in children, paving the way for targeted therapy; b) discovered the immune dysregulation that may lead to inflamed skin in the ichthyoses, leading to a novel clinical trial with repurposed medication; and c) discovered evidence for an important role for ganglioside GM3 as an intermediate in the insulin resistance in diabetic skin and also in development of diabetic neuropathy.

Certifications and Licenses

Pediatric Dermatology

Training Experience

1981Residency, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital)
1983Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital)
1984Postdoctoral Fellowship, University of North Carolina
1984Fellowship, University of North Carolina School of Medicine

Education/Academic qualification

MD, Stanford University

… → 1978


  • Biochemistry: Lipids
  • Dermatology
  • Diabetes
  • Genetics
  • Genomic Medicine/Personalized Medicine
  • Signal Transduction
  • Skin
  • Skin Cancer

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  • 10 Similar Profiles
Atopic Dermatitis Medicine & Life Sciences
Skin Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Psoriasis Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Mutation Medicine & Life Sciences
Skin Diseases Medicine & Life Sciences
Gangliosides Medicine & Life Sciences

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Grants 2000 2024

Research Output 1982 2019

4 Citations (Scopus)

A phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis

Peppers, J., Paller, A., Maeda-Chubachi, T., Wu, S., Robbins, K., Gallagher, K. & Kraus, J. E., Jan 1 2019, In : Journal of the American Academy of Dermatology. 80, 1, p. 89-98.e3

Research output: Contribution to journalArticle

Atopic Dermatitis
Research Personnel
Body Surface Area

A retrospective cohort study to evaluate the development of comorbidities, including psychiatric comorbidities, among a pediatric psoriasis population

Paller, A., Schenfeld, J., Accortt, N. A. & Kricorian, G., May 1 2019, In : Pediatric dermatology. 36, 3, p. 290-297 8 p.

Research output: Contribution to journalArticle

Open Access
Cohort Studies
Retrospective Studies

Assessment of the Timing of Milestone Clinical Events in Patients with Epidermolysis Bullosa from North America

Feinstein, J. A., Jambal, P., Peoples, K., Lucky, A. W., Khuu, P., Tang, J. Y., Lara-Corrales, I., Pope, E., Wiss, K., Hook, K. P., Levin, L. E., Morel, K. D., Paller, A., McCuaig, C. C., Powell, J., Eichenfield, L. F., Price, H., Levy, M. L., Schachner, L. A., Browning, J. C. & 5 othersBayliss, S., Jahnke, M., Shwayder, T., Glick, S. A. & Bruckner, A. L., Feb 1 2019, In : JAMA dermatology. 155, 2, p. 196-203 8 p.

Research output: Contribution to journalArticle

Epidermolysis Bullosa Dystrophica
Epidermolysis Bullosa
North America
Epidermolysis Bullosa Simplex
Junctional Epidermolysis Bullosa

Conjunctivitis in atopic dermatitis patients with and without dupilumab therapy – international eczema council survey and opinion

Thyssen, J. P., de Bruin-Weller, M. S., Paller, A., Leshem, Y. A., Vestergaard, C., Deleuran, M., Drucker, A. M., Foelster-Holst, R., Traidl-Hoffmann, C., Eyerich, K., Taieb, A., Su, J. C., Bieber, T., Cork, M. J., Eichenfield, L. F., Guttman-Yassky, E. & Wollenberg, A., Jul 1 2019, In : Journal of the European Academy of Dermatology and Venereology. 33, 7, p. 1224-1231 8 p.

Research output: Contribution to journalArticle

Atopic Dermatitis
Referral and Consultation

Defining and measuring ‘eczema control’: an international qualitative study to explore the views of those living with and treating atopic eczema

the long-term control of eczema working group for the HOME initiative, Jun 1 2019, In : Journal of the European Academy of Dermatology and Venereology. 33, 6, p. 1124-1132 9 p.

Research output: Contribution to journalArticle

Open Access
Atopic Dermatitis
Focus Groups
Clinical Trials