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Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Drug Discovery to Ameliorate Proteostasis Failure in Tauopathies
Morimoto, R. I. (PD/PI), Morimoto, R. I. (PD/PI), Morimoto, R. I. (PD/PI), Yu, A. (Other), Yu, A. (Other) & Yu, A. (Other)
Rainwater Charitable Foundation
6/19/20 → 7/31/25
Project: Research project
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C. elegans Model for Neurodegenerative Diseases of Aging
Morimoto, R. I. (PD/PI) & Yu, A. (Other)
6/1/15 → 5/31/21
Project: Research project
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HaloTag as a substrate-based macroautophagy reporter
Xiao, Q., Cruz, G., Botham, R., Fox, S. G., Yu, A., Allen, S., Morimoto, R. I. & Kelly, J. W., Aug 6 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 32, e2322500121.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons
Capano, L. S., Sato, C., Ficulle, E., Yu, A., Horie, K., Kwon, J. S., Burbach, K. F., Barthélemy, N. R., Fox, S. G., Karch, C. M., Bateman, R. J., Houlden, H., Morimoto, R. I., Holtzman, D. M., Duff, K. E. & Yoo, A. S., Jun 2 2022, In: Cell stem cell. 29, 6, p. 918-932.e8Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
Challenging Proteostasis: Role of the Chaperone Network to Control Aggregation-Prone Proteins in Human Disease
Sinnige, T., Yu, A. & Morimoto, R. I., 2020, Advances in Experimental Medicine and Biology. Springer, p. 53-68 16 p. (Advances in Experimental Medicine and Biology; vol. 1243).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Open Access38 Scopus citations -
Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network
Yu, A., Fox, S. G., Cavallini, A., Kerridge, C., O'Neill, M. J., Wolak, J., Bose, S. & Morimoto, R. I., May 10 2019, In: Journal of Biological Chemistry. 294, 19, p. 7917-7930 14 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Key interactions for clathrin coat stability
Böcking, T., Aguet, F., Rapoport, I., Banzhaf, M., Yu, A., Zeeh, J. C. & Kirchhausen, T., Jun 10 2014, In: Structure. 22, 6, p. 819-829 11 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations