Calculated based on number of publications stored in Pure and citations from Scopus
Calculated based on number of publications stored in Pure and citations from Scopus
Calculated based on number of publications stored in Pure and citations from Scopus

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Personal profile

Research Interests

I started my scientific career at the University of Geneva in Switzerland where I obtained my Diploma degree in Biology. After obtaining scholarships and fellowships from both industry and academic entities, I joined the Department of Physiology at the University of Melbourne in Australia, where I obtained my PhD degree. I then joined the University of California San Diego (UCSD) where I worked as post-doctoral fellow in Cardiology and project scientist in Orthopaedic Surgery. In 2015 I was recruited to work as principal investigator in PM&R at Northwestern University and at the Shirley Ryan AbilityLab.

As a principal investigator in PM&R and at the Shirley Ryan AbilityLab, I aim to identify new mechanisms relating to muscle tissue and muscle stem cell dysfunction, as well as genetic and epigenetic modifications affecting muscle, nerve plasticity or therapy outcomes in patients with neurological and neuromuscular conditions.

Drug repurposing: My lab was instrumental in identifying anti-cancer 5-azacytidine as an agent that could restore myogenic potential to muscle stem cells from contractured muscle, thus suggesting that DNA methyltransferase inhibitors and other hypomethylating agents like 5-azacytidine could be repurposed to treat muscle contractures non-surgically in children with cerebral palsy.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

PhD, Biomedical Sciences, University of Melbourne

… → 2005

Research interests keywords

  • Cardiovascular Diseases
  • Cell Biology
  • Cerebral Palsy
  • Gene Regulation
  • Muscular Dystrophy
  • Stroke
  • Translational Research


Dive into the research topics where Andrea Alberto Domenighetti is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years

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