• 1065 Citations
19982018
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Personal profile

Research Interests

I started my scientific career at the University of Geneva in Switzerland where I obtained my Diploma degree in Biology. After obtaining scholarships and fellowships from both industry and academic entities, I joined the Department of Physiology at the University of Melbourne in Australia, where I obtained my PhD degree. I then joined the University of California San Diego (UCSD) where I worked as post-doctoral fellow in Cardiology and project scientist in Orthopaedic Surgery. In 2015 I was recruited to work as principal investigator in PM&R at Northwestern University and at the Shirley Ryan AbilityLab.

As a principal investigator in PM&R and at the Shirley Ryan AbilityLab, I aim to identify new mechanisms relating to muscle tissue and muscle stem cell dysfunction, as well as genetic and epigenetic modifications affecting muscle, nerve plasticity or therapy outcomes in patients with neurological and neuromuscular conditions.

Drug repurposing: My lab was instrumental in identifying anti-cancer 5-azacytidine as an agent that could restore myogenic potential to muscle stem cells from contractured muscle, thus suggesting that DNA methyltransferase inhibitors and other hypomethylating agents like 5-azacytidine could be repurposed to treat muscle contractures non-surgically in children with cerebral palsy.

Education/Academic qualification

PhD, University of Melbourne

… → 2005

Research interests

  • Cardiovascular Diseases
  • Cell Biology
  • Cerebral Palsy
  • Gene Regulation
  • Muscular Dystrophy
  • Stroke
  • Translational Research

Fingerprint Dive into the research topics where Andrea Alberto Domenighetti is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Cardiac Myocytes Medicine & Life Sciences
Cardiomegaly Medicine & Life Sciences
Angiotensin II Medicine & Life Sciences
Muscles Medicine & Life Sciences
Hypertrophy Medicine & Life Sciences
Muscle Cells Medicine & Life Sciences
Excitation Contraction Coupling Medicine & Life Sciences
Skeletal Muscle Medicine & Life Sciences

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Research Output 1998 2018

  • 1065 Citations
  • 25 Article
  • 2 Comment/debate
  • 2 Review article
5 Citations (Scopus)

Loss of myogenic potential and fusion capacity of muscle stem cells isolated from contractured muscle in children with cerebral palsy

Domenighetti, A. A., Mathewson, M. A., Pichika, R., Sibley, L. A., Zhao, L., Chambers, H. G. & Lieber, R. L., Aug 2018, In : American Journal of Physiology - Cell Physiology. 315, 2, p. C247-C257

Research output: Contribution to journalArticle

Cerebral Palsy
Muscle Cells
Stem Cells
Muscles
Skeletal Muscle Satellite Cells
7 Citations (Scopus)

Cullin E3 Ligase Activity Is Required for Myoblast Differentiation

Blondelle, J., Shapiro, P., Domenighetti, A. A. & Lange, S., Apr 7 2017, In : Journal of Molecular Biology. 429, 7, p. 1045-1066 22 p.

Research output: Contribution to journalArticle

Cullin Proteins
Ubiquitin-Protein Ligases
Myoblasts
Muscles
Homeostasis
31 Citations (Scopus)

Management of cardiac involvement associated with neuromuscular diseases: A scientific statement from the American Heart Association

Feingold, B., Mahle, W. T., Auerbach, S., Clemens, P., Domenighetti, A. A., Jefferies, J. L., Judge, D. P., Lal, A. K., Markham, L. W., Parks, W. J., Tsuda, T., Wang, P. J. & Yoo, S. J., Sep 1 2017, In : Circulation. 136, 13, p. e200-e231

Research output: Contribution to journalReview article

Neuromuscular Diseases
Heart Diseases
Heart Failure
Guidelines
Treatment Failure
25 Citations (Scopus)

Skeletal muscle intermediate filaments form a stress-transmitting and stress-signaling network

Palmisano, M. G., Bremner, S. N., Hornberger, T. A., Meyer, G. A., Domenighetti, A. A., Shah, S. B., Kiss, B., Kellermayer, M., Ryan, A. F. & Lieber, R. L., Jan 1 2015, In : Journal of cell science. 128, 2, p. 219-224 6 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Desmin
Skeletal Muscle
Muscles
Muscle Cells
12 Citations (Scopus)

Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle

Gokhin, D. S., Ochala, J., Domenighetti, A. A. & Fowler, V. M., Dec 15 2015, In : Development (Cambridge). 142, 24, p. 4351-4362 12 p.

Research output: Contribution to journalArticle

Tropomodulin
Skeletal Muscle
Muscles
Protein Isoforms
Myofibrils