Anne H Rowley

  • 7874 Citations
1986 …2019
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Personal profile

Research Interests

We recently showed that the immune transcriptome of KD coronary arteritis has features of an antiviral immune response such as activated cytotoxic T lymphocyte and type I interferon-induced gene upregulation, which can guide selection of new immunomodulatory therapies for high-risk KD patients. Our prior extensive pathologic study identified chronic arteritis in KD children with severe coronary artery disease, challenging the previously held dogma of KD as solely an acute arteritis. We are currently cloning and expressing specific oligoclonal antibodies from KD patient blood plasmablasts and using them as tools to identify antigens important in pathogenesis.

A major pediatric research priority and the long-term goal of my laboratory is the identification of the etiology and pathogenesis of Kawasaki Disease (KD), the leading cause of acquired heart disease in children in developed nations. KD can result in coronary artery aneurysm (CAA) formation with resultant myocardial infarction and/or sudden death. Clinical and epidemiologic data are consistent with an infectious cause of KD, but the etiologic agent remains unknown.We hypothesize that a "new" virus enters through the respiratory tract and infects bronchial epithelium, traveling in macrophages to targeted tissues including coronary arteries.

My clinical focus is the care of children with diverse serious infections. As clinical practice director of Pediatric Infectious Diseases, I work to make sure that our division provides optimal care for children with infections on both an outpatient and inpatient basis. My clinical research focuses on Kawasaki Disease diagnosis and treatment.

Certifications and Licenses

Pediatric Infectious Diseases
Pediatrics

Training Experience

1985Residency, Children's Hospital of Pittsburgh
1988Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine
1988Fellowship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital)

Education/Academic qualification

MD, SUNY - Syracuse

… → 1982

Research interests

  • Infectious Diseases
  • Pediatrics

Fingerprint Dive into the research topics where Anne H Rowley is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Mucocutaneous Lymph Node Syndrome Medicine & Life Sciences
Acute Disease Medicine & Life Sciences
Coronary Vessels Medicine & Life Sciences
Coronary Aneurysm Medicine & Life Sciences
Preschool Children Medicine & Life Sciences
Intravenous Immunoglobulins Medicine & Life Sciences
Immunoglobulin A Medicine & Life Sciences
Aspirin Medicine & Life Sciences

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Grants 2004 2019

Research Output 1986 2019

Coronary artery aneurysms are more severe in infants than in older children with Kawasaki disease

Cameron, S. A., Carr, M. R., Pahl, E., Demarais, N., Shulman, S. T. & Rowley, A. H., May 1 2019, In : Archives of disease in childhood. 104, 5, p. 451-455 5 p.

Research output: Contribution to journalArticle

Coronary Aneurysm
Mucocutaneous Lymph Node Syndrome
Coronary Vessels
Aneurysm
Dilatation

Improving coronary artery outcomes for children with Kawasaki disease

McCrindle, B. W. & Rowley, A. H., Mar 16 2019, In : The Lancet. 393, 10176, p. 1077-1078 2 p.

Research output: Contribution to journalComment/debate

Mucocutaneous Lymph Node Syndrome
Coronary Vessels
Mucocutaneous Lymph Node Syndrome
Intravenous Immunoglobulins
Therapeutics
Fever
Coronary Vessels
7 Citations (Scopus)

Is Kawasaki disease an infectious disorder?

Rowley, A. H., Jan 1 2018, In : International Journal of Rheumatic Diseases. 21, 1, p. 20-25 6 p.

Research output: Contribution to journalArticle

Mucocutaneous Lymph Node Syndrome
Nucleic Acids
Research
Proteins
5 Citations (Scopus)

The epidemiology and pathogenesis of Kawasaki Disease

Rowley, A. H. & Shulman, S. T., Jan 1 2018, In : Frontiers in Pediatrics. 6, 374.

Research output: Contribution to journalArticle

Mucocutaneous Lymph Node Syndrome
Epidemiology
Asymptomatic Infections
Inclusion Bodies
Immunoglobulin A