Anne H Rowley

  • 8484 Citations
1986 …2019

Research output per year

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Personal profile

Research Interests

We recently showed that the immune transcriptome of KD coronary arteritis has features of an antiviral immune response such as activated cytotoxic T lymphocyte and type I interferon-induced gene upregulation, which can guide selection of new immunomodulatory therapies for high-risk KD patients. Our prior extensive pathologic study identified chronic arteritis in KD children with severe coronary artery disease, challenging the previously held dogma of KD as solely an acute arteritis. We are currently cloning and expressing specific oligoclonal antibodies from KD patient blood plasmablasts and using them as tools to identify antigens important in pathogenesis.

A major pediatric research priority and the long-term goal of my laboratory is the identification of the etiology and pathogenesis of Kawasaki Disease (KD), the leading cause of acquired heart disease in children in developed nations. KD can result in coronary artery aneurysm (CAA) formation with resultant myocardial infarction and/or sudden death. Clinical and epidemiologic data are consistent with an infectious cause of KD, but the etiologic agent remains unknown.We hypothesize that a "new" virus enters through the respiratory tract and infects bronchial epithelium, traveling in macrophages to targeted tissues including coronary arteries.

My clinical focus is the care of children with diverse serious infections. As clinical practice director of Pediatric Infectious Diseases, I work to make sure that our division provides optimal care for children with infections on both an outpatient and inpatient basis. My clinical research focuses on Kawasaki Disease diagnosis and treatment.

Certifications and Licenses

Pediatric Infectious Diseases
Pediatrics

Training Experience

1985Residency, Children's Hospital of Pittsburgh
1988Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine
1988Fellowship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital)

Education/Academic qualification

MD, SUNY - Syracuse

… → 1982

Research interests

  • Infectious Diseases
  • Pediatrics

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Grants

Research Output

Coronary artery aneurysms are more severe in infants than in older children with Kawasaki disease

Cameron, S. A., Carr, M. R., Pahl, E., Demarais, N., Shulman, S. T. & Rowley, A. H., May 1 2019, In : Archives of disease in childhood. 104, 5, p. 451-455 5 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Improving coronary artery outcomes for children with Kawasaki disease

    McCrindle, B. W. & Rowley, A. H., Mar 16 2019, In : The Lancet. 393, 10176, p. 1077-1078 2 p.

    Research output: Contribution to journalComment/debate

    2 Scopus citations

    Microbiology of Pediatric Orbital Cellulitis and Trends in Methicillin-Resistant Staphylococcus aureus Cases

    Hsu, J., Treister, A. D., Ralay Ranaivo, H., Rowley, A. H. & Rahmani, B., Sep 1 2019, In : Clinical pediatrics. 58, 10, p. 1056-1062 7 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Is Kawasaki disease an infectious disorder?

    Rowley, A. H., Jan 2018, In : International Journal of Rheumatic Diseases. 21, 1, p. 20-25 6 p.

    Research output: Contribution to journalArticle

  • 16 Scopus citations