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Personal profile

Research Interests

Our lab is interested in understanding the molecular mechanisms underlying Glutamate Receptor (GluR) trafficking in normal and altered conditions. The majority of neuronal communication is mediated by the activation of GluRs, which triggers mechanisms able to induce changes at synaptic level that are thought to underlie higher cognitive functions. We use a multidisciplinary approach including biochemistry, cell and molecular biology and pharmacology as well as a variety of cutting-edge imaging techniques and the analysis of genetically-altered mouse lines for elucidating how GluRs are controlled during development, in response to experience or other stimuli and what is their impact on synaptic function. Similarly, we investigate how the dysregulation of these mechanisms lead to synaptic alterations and, eventually, to neurological disorders. Our current research is focused on studying the molecular mechanisms underlying synapse unsilencing and their contribution to Autism Spectrum Disorders (ASDs) and the regulation of NMDA receptors during development and Alzheimer’s disease (AD).

Education/Academic qualification

PhD, University of Zaragoza Medical School

… → 2006

Research interests

  • Alzheimer's Disease
  • Autism Spectrum Disorders
  • Cell Biology
  • Developmental Neurobiology
  • Glutamate Receptors
  • Intracellular Transport
  • Molecular Biology
  • Neurobiology

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Grants

  • Research Output

    • 1546 Citations
    • 14 Article
    • 1 Review article

    An antibody feeding approach to study glutamate receptor trafficking in dissociated primary hippocampal cultures

    Chiu, A. M., Barse, L., Hubalkova, P. & Sanz-Clemente, A., Aug 2019, In : Journal of Visualized Experiments. 2019, 150, e59982.

    Research output: Contribution to journalArticle

  • NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content

    Chiu, A. M., Wang, J., Fiske, M. P., Hubalkova, P., Barse, L., Gray, J. A. & Sanz-Clemente, A., Jul 9 2019, In : Cell reports. 28, 2, p. 332-341.e5

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    A rare variant identified within the GluN2B C-terminus in a patient with autism affects NMDA receptor surface expression and spine density

    Liu, S., Zhou, L., Yuan, H., Vieira, M., Sanz-Clemente, A., Badger, J. D., Lu, W., Traynelis, S. F. & Roche, K. W., Apr 12 2017, In : Journal of Neuroscience. 37, 15, p. 4093-4102 10 p.

    Research output: Contribution to journalArticle

  • 14 Scopus citations

    Loss of M1 receptor dependent cholinergic excitation contributes to mPFC deactivation in neuropathic pain

    Radzicki, D., Pollema-Mays, S. L., Sanz-Clemente, A. & Martina, M., Mar 1 2017, In : Journal of Neuroscience. 37, 9, p. 2292-2304 13 p.

    Research output: Contribution to journalArticle

  • 21 Scopus citations
  • 60 Scopus citations