Grants per year
Personal profile
Research Interests
Our lab is interested in understanding the molecular mechanisms underlying Glutamate Receptor (GluR) trafficking in normal and altered conditions. The majority of neuronal communication is mediated by the activation of GluRs, which triggers mechanisms able to induce changes at synaptic level that are thought to underlie higher cognitive functions. We use a multidisciplinary approach including biochemistry, cell and molecular biology and pharmacology as well as a variety of cutting-edge imaging techniques and the analysis of genetically-altered mouse lines for elucidating how GluRs are controlled during development, in response to experience or other stimuli and what is their impact on synaptic function. Similarly, we investigate how the dysregulation of these mechanisms lead to synaptic alterations and, eventually, to neurological disorders. Our current research is focused on studying the molecular mechanisms underlying synapse unsilencing and their contribution to Autism Spectrum Disorders (ASDs) and the regulation of NMDA receptors during development and Alzheimer’s disease (AD).
Education/Academic qualification
PhD, University of Zaragoza Medical School
… → 2006
Research interests
- Alzheimer's Disease
- Autism Spectrum Disorders
- Cell Biology
- Developmental Neurobiology
- Glutamate Receptors
- Intracellular Transport
- Molecular Biology
- Neurobiology
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Grants
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Northwestern University Interdepartmental Neuroscience Postbaccalaureate Research Education Program
Acosta, A., Allada, R., Apkarian, A., Awatramani, R., Beeman, M., Bevan, M. D., Bozza, T. C., Cang, J., Chetkovich, D. M., Cobia, D. J., Contractor, A., Corcos, D. M., DeVries, S. H., Dewald, J. P. A., Dhar, S., Disterhoft, J. F., Dombeck, D. A., Elliott, J. M., Feng, Y., Ferreira, A. B., Gallio, M., Garcia-Anoveros, J., George Jr, A. L., Geula, C., Gordon, K. E., Gottfried, J. A., Grafman, J. H., Hartmann, M. J. Z., Heckman, C., Hespos, S. J., Jayaraman, A., Kahnt, T., Kearney, J. A., Kessler, J., Kiskinis, E., Kohtz, J., Kording, K. P., Kozorovitskiy, Y., Krainc, D., Larson, C., Lee, S. S. M., Li, L., Losh, M. C., Maccaferri, G., MacIver, M. A., Martina, M., Mazzulli, J., McLean, D., Mesulam, M., Miller, L. E., Miller, R. J., Mussa-Ivaldi, F., Nusslock, R., Opal, P., Ozdinler, P. H., Paller, K., Parrish, T. B., Prakriya, M., Radulovic, J., Raman, I. M., Reber, P. J., Redei, E., Rogalski, E., Sanchez, J. T., Sanz-Clemente, A., Savas, J. N., Schmidt, T. M., Schwartz, G. W., Segraves, M., Shepherd, G. M. G., Siddique, T., Solla, S. A., Surmeier Jr, D. J., Swanson, G. T., Topczewski, J., Tresch, M. C., Tysseling, V. M., Vassar, R. J., Voss, J. L., Wainwright, D. A., Wang, L., Weintraub, S., Woolley, C. S. & Wright, B. A.
National Institute of General Medical Sciences
5/1/17 → 4/30/22
Project: Research project
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Differential Reorganization of Synaptic Protein Content By Typical and Atypical Antipsychotic Drugs
Brain & Behavior Research Foundation
1/15/16 → 1/14/18
Project: Research project
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Role of CK2 in NMDAR trafficking during development and in Alzheimer's disease
8/15/15 → 3/31/18
Project: Research project
Research Output
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An antibody feeding approach to study glutamate receptor trafficking in dissociated primary hippocampal cultures
Chiu, A. M., Barse, L., Hubalkova, P. & Sanz-Clemente, A., Aug 2019, In: Journal of Visualized Experiments. 2019, 150, e59982.Research output: Contribution to journal › Article › peer-review
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NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content
Chiu, A. M., Wang, J., Fiske, M. P., Hubalkova, P., Barse, L., Gray, J. A. & Sanz-Clemente, A., Jul 9 2019, In: Cell reports. 28, 2, p. 332-341.e5Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
A rare variant identified within the GluN2B C-terminus in a patient with autism affects NMDA receptor surface expression and spine density
Liu, S., Zhou, L., Yuan, H., Vieira, M., Sanz-Clemente, A., Badger, J. D., Lu, W., Traynelis, S. F. & Roche, K. W., Apr 12 2017, In: Journal of Neuroscience. 37, 15, p. 4093-4102 10 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
Loss of M1 receptor dependent cholinergic excitation contributes to mPFC deactivation in neuropathic pain
Radzicki, D., Pollema-Mays, S. L., Sanz-Clemente, A. & Martina, M., Mar 1 2017, In: Journal of Neuroscience. 37, 9, p. 2292-2304 13 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Dynamic regulation of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by posttranslational modifications
Lussier, M. P., Sanz-Clemente, A. & Roche, K. W., Nov 27 2015, In: Journal of Biological Chemistry. 290, 48, p. 28596-28603 8 p.Research output: Contribution to journal › Article › peer-review
75 Scopus citations