Antonio Sanz-Clemente

  • 1416 Citations
20052022
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Personal profile

Research Interests

Our lab is interested in understanding the molecular mechanisms underlying Glutamate Receptor (GluR) trafficking in normal and altered conditions. The majority of neuronal communication is mediated by the activation of GluRs, which triggers mechanisms able to induce changes at synaptic level that are thought to underlie higher cognitive functions. We use a multidisciplinary approach including biochemistry, cell and molecular biology and pharmacology as well as a variety of cutting-edge imaging techniques and the analysis of genetically-altered mouse lines for elucidating how GluRs are controlled during development, in response to experience or other stimuli and what is their impact on synaptic function. Similarly, we investigate how the dysregulation of these mechanisms lead to synaptic alterations and, eventually, to neurological disorders. Our current research is focused on studying the molecular mechanisms underlying synapse unsilencing and their contribution to Autism Spectrum Disorders (ASDs) and the regulation of NMDA receptors during development and Alzheimer’s disease (AD).

Education/Academic qualification

PhD, University of Zaragoza Medical School

… → 2006

Keywords

  • Alzheimer's Disease
  • Autism Spectrum Disorders
  • Cell Biology
  • Developmental Neurobiology
  • Glutamate Receptors
  • Intracellular Transport
  • Molecular Biology
  • Neurobiology

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Grants 2015 2022

pamidronate
Post Translational Protein Processing
Cognition
Antipsychotic Agents
Pharmacology
Casein Kinase II
N-Methyl-D-Aspartate Receptors
Alzheimer Disease
Phosphorylation
Nervous System Diseases

Research Output 2005 2017

  • 1416 Citations
  • 12 Article
  • 1 Review article
9 Citations (Scopus)

A rare variant identified within the GluN2B C-terminus in a patient with autism affects NMDA receptor surface expression and spine density

Liu, S., Zhou, L., Yuan, H., Vieira, M., Sanz-Clemente, A., Badger, J. D., Lu, W., Traynelis, S. F. & Roche, K. W., Apr 12 2017, In : Journal of Neuroscience. 37, 15, p. 4093-4102 10 p.

Research output: Contribution to journalArticle

Autistic Disorder
N-Methyl-D-Aspartate Receptors
Spine
Guanylate Kinases
Ionotropic Glutamate Receptors
17 Citations (Scopus)

Loss of M1 receptor dependent cholinergic excitation contributes to mPFC deactivation in neuropathic pain

Radzicki, D., Pollema-Mays, S. L., Sanz-Clemente, A. & Martina, M., Mar 1 2017, In : Journal of Neuroscience. 37, 9, p. 2292-2304 13 p.

Research output: Contribution to journalArticle

Neuralgia
Cholinergic Receptors
Prefrontal Cortex
Wounds and Injuries
Cholinergic Agents
48 Citations (Scopus)
AMPA Receptors
Glutamate Receptors
N-Methylaspartate
Post Translational Protein Processing
Lipoylation
41 Citations (Scopus)

Activated CaMKII Couples GluN2B and Casein Kinase 2 to Control Synaptic NMDA Receptors

Sanz-Clemente, A., Gray, J. A., Ogilvie, K. A., Nicoll, R. A. & Roche, K. W., Mar 11 2013, In : Cell Reports. 3, 3, p. 607-614 8 p.

Research output: Contribution to journalArticle

Casein Kinase II
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Neurotransmitter Receptor
N-Methyl-D-Aspartate Receptors
Synapses
174 Citations (Scopus)

Diversity in NMDA receptor composition: Many regulators, many consequences

Sanz-Clemente, A., Nicoll, R. A. & Roche, K. W., Feb 1 2013, In : Neuroscientist. 19, 1, p. 62-75 14 p.

Research output: Contribution to journalReview article

N-Methyl-D-Aspartate Receptors
Ionotropic Glutamate Receptors
Secretory Pathway
Synapses
Hippocampus