Arthur Prindle — Northwestern Scholars

Personal profile

Research Interests

We are interested in understanding how molecular and cellular interactions give rise to collective behaviors in microbial communities. We use synthetic biology, quantitative microscopy, and microfluidics to directly investigate the molecular mechanisms behind how cells communicate across broad spatial and temporal scales. Our goal is to apply these principles to develop new synthetic biology approaches to biomedical problems through microbiome engineering.

Training Experience

2016	Postdoctoral Fellowship, University of California, San Diego

Education/Academic qualification

PhD, University Of California-San Diego

… → 2014

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Escherichia coli Medicine & Life Sciences

Metabolic engineering Chemical Compounds

Electrophysiology Chemical Compounds

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Grants 2017 2023

3 Active

Mechanisms of Extracellular Matrix-Mediated Electrochemical Signaling

Prindle, A.

Army Research Office

3/1/19 → 3/31/22

Project: Research project

Biofilms

Extracellular Matrix

Potassium

Potassium Channels

High-Throughput Nucleotide Sequencing

Translating an ancient bioelectric language for synthetic biology

Prindle, A.

David and Lucile Packard Foundation

11/1/18 → 10/31/23

Project: Research project

Electrical signaling and multicellular organization

Prindle, A.

Burroughs Wellcome Fund

9/1/17 → 6/30/22

Project: Research project

Biofilms

Bacteria

Ion Channels

Fluorescent Dyes

Planets

Research Output 2010 2018

819 Citations
10 Article
2 Comment/debate
2 Short survey
1 Letter

2 Citations (Scopus)

Signal Percolation within a Bacterial Community

Larkin, J. W., Zhai, X., Kikuchi, K., Redford, S. E., Prindle, A., Liu, J., Greenfield, S., Walczak, A. M., Garcia-Ojalvo, J., Mugler, A. & Süel, G. M., Aug 22 2018, In : Cell Systems. 7, 2, p. 137-145.e3

Research output: Contribution to journal › Article

Phase Transition

Biofilms

Costs and Cost Analysis

Cost-Benefit Analysis

Cell Communication

36 Citations (Scopus)

Coupling between distant biofilms and emergence of nutrient time-sharing

Liu, J., Martinez-Corral, R., Prindle, A., Lee, D. Y. D., Larkin, J., Gabalda-Sagarra, M., Garcia-Ojalvo, J. & Süel, G. M., May 12 2017, In : Science. 356, 6338, p. 638-642 5 p.

Research output: Contribution to journal › Article

Biofilms

Food

Growth

Bacillus subtilis

Bacteria

2 Citations (Scopus)

SnapShot: Electrochemical Communication in Biofilms

Lee, D. Y. D., Prindle, A., Liu, J. & Süel, G. M., Jun 29 2017, In : Cell. 170, 1, p. 214-214.e1

Research output: Contribution to journal › Short survey

Electrophysiology

Biofilms

Communication

Electricity

Biological systems

52 Citations (Scopus)

Species-Independent Attraction to Biofilms through Electrical Signaling

Humphries, J., Xiong, L., Liu, J., Prindle, A., Yuan, F., Arjes, H. A., Tsimring, L. & Süel, G. M., Jan 12 2017, In : Cell. 168, 1-2, p. 200-209.e12

Research output: Contribution to journal › Article

Biofilms

Bacteria

Bacillus subtilis

Cell signaling

Potassium Channels

110 Citations (Scopus)

Synchronized cycles of bacterial lysis for in vivo delivery

Din, M. O., Danino, T., Prindle, A., Skalak, M., Selimkhanov, J., Allen, K., Julio, E., Atolia, E., Tsimring, L. S., Bhatia, S. N. & Hasty, J., Jul 20 2016, In : Nature. 536, 7614, p. 81-85 5 p.

Research output: Contribution to journal › Article

Bacteria

Population Dynamics

Lab-On-A-Chip Devices

Isogeneic Transplantation

Synthetic Biology