Grants per year
Personal profile
Research Interests
We are interested in understanding how molecular and cellular interactions give rise to collective behaviors in microbial communities. We use synthetic biology, quantitative microscopy, and microfluidics to directly investigate the molecular mechanisms behind how cells communicate across broad spatial and temporal scales. Our goal is to apply these principles to develop new synthetic biology approaches to biomedical problems through microbiome engineering.
Training Experience
| 2016 | Postdoctoral Fellowship, University of California, San Diego |
Education/Academic qualification
Bioengineering, PhD, University of California at San Diego
… → 2014
Bioengineering, PhD, University of California at San Diego
… → 2014
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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CAREER: Uncovering new rules of multicellular life using synthetic microbial communities
Prindle, A. (PD/PI) & Prindle, A. (PD/PI)
2/15/23 → 1/31/28
Project: Research project
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Main Project for Emergent metabolic coordination and cell-to-cell signaling in bacterial biofilms
Prindle, A. (PD/PI) & Prindle, A. (PD/PI)
National Institute of General Medical Sciences
8/15/22 → 5/31/27
Project: Research project
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Deciphering the role of endogenous neurotransmitters in bacterial biofilms
Prindle, A. (PD/PI) & Prindle, A. (PD/PI)
5/28/21 → 5/27/26
Project: Research project
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Deciphering the role of endogenous neurotransmitters in bacterial biofilms
Prindle, A. (PD/PI)
5/28/21 → 5/27/26
Project: Research project
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NRT-URoL: Synthesizing Biology Across Scales – A Convergent Synthetic Biology Training Program
Lucks, J. B. (PD/PI), Lucks, J. B. (PD/PI), Calkins, S. C. (Co-PD/PI), Jewett, M. C. (Co-PD/PI), Kamat, N. P. (Co-PD/PI), Kamat, N. P. (Co-PD/PI), Kamat, N. P. (Co-PD/PI), Karim, A. S. (Co-PD/PI), Karim, A. S. (Co-PD/PI), Karim, A. S. (Co-PD/PI), Tullman-Ercek, D. (Co-PD/PI), Tullman-Ercek, D. (Co-PD/PI), Tullman-Ercek, D. (Co-PD/PI), Kamat, N. P. (Co-Investigator), Karim, A. S. (Co-Investigator), Tullman-Ercek, D. (Co-Investigator), Leonard, J. N. (Other), Leonard, J. N. (Other), Leonard, J. N. (Other), Mangan, N. M. (Other), Mangan, N. M. (Other), Mangan, N. M. (Other), Prindle, A. (Other), Prindle, A. (Other), Prindle, A. (Other), Tyo, K. (Other), Tyo, K. (Other) & Tyo, K. (Other)
9/1/20 → 8/31/25
Project: Research project
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Active pH regulation facilitates Bacillus subtilis biofilm development in a minimally buffered environment
Tran, P., Lander, S. M. & Prindle, A., Mar 2024, In: mBio. 15, 3Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists
Karim, A. S., Brown, D. M., Archuleta, C. M., Grannan, S., Aristilde, L., Goyal, Y., Leonard, J. N., Mangan, N. M., Prindle, A., Rocklin, G. J., Tyo, K. J., Zoloth, L. S., Jewett, M. C., Calkins, S. C., Kamat, N. P., Tullman-Ercek, D. & Lucks, J. B., Dec 2024, In: Nature communications. 15, 1, 5425.Research output: Contribution to journal › Article › peer-review
Open Access -
Environmental purines decrease Pseudomonas aeruginosa biofilm formation by disrupting c-di-GMP metabolism
Kennelly, C., Tran, P. & Prindle, A., May 28 2024, In: Cell reports. 43, 5, 114154.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Engineered calprotectin-sensing probiotics for IBD surveillance in humans
Xia, J. Y., Hepler, C., Tran, P., Waldeck, N. J., Bass, J. & Prindle, A., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 32, e2221121120.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Erratum: Correction to: A Two-Dimensional Model of Potassium Signaling and Oscillatory Growth in a Biofilm (Bulletin of mathematical biology (2021) 83 5 (60))
Ford, N., Fisher, G., Prindle, A. & Chopp, D., Feb 18 2022, In: Bulletin of Mathematical Biology. 84, 4, p. 45 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access
Datasets
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Supplementary material from "Metabolic basis of brain-like electrical signalling in bacterial communities"
Martinez-Corral, R. (Creator), Liu, J. (Contributor), Prindle, A. (Creator), Süel, G. M. (Creator), Garcia-Ojalvo, J. (Creator) & Jintao, L. (Contributor), figshare, 2019
DOI: 10.6084/m9.figshare.c.4441778.v2, https://rs.figshare.com/collections/Supplementary_material_from_Metabolic_basis_of_brain-like_electrical_signalling_in_bacterial_communities_/4441778/2
Dataset