Asish K Ghosh

  • 2909 Citations
1986 …2022
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Personal profile

Research Interests

Major Research Interests: Molecular Basis of Organ Fibrosis: Development of Epigenetic Fibrosis Therapy. Hyperactivity of differentiated fibroblasts causes an excessive synthesis and deposition of extracellular matrix proteins in the tissues that leads to organ fibrosis, a major cause of disease-related morbidity and mortality worldwide. Fibrosis is a common end-stage pathological symptom of a wide spectrum of injury or stress related multi-organ diseases such as hypertension-induced accelerated cardiac and renal aging, myocardial infarction, liver cirrhosis, systemic sclerosis and idiopathic pulmonary fibrosis. Epigenetics plays a key role in the development of organ fibrosis. Our research interest focuses on the role of acetyltransferase p300, a major epigenetic regulator, in TGF-beta-induced profibrogenic signal transduction and organ fibrosis. We have previously demonstrated that acetyltransferase p300 is essential for profibrogenic signal-induced matrix protein collagen synthesis. Most importantly, the levels of p300 are significantly elevated in myofibroblasts derived from resident fibroblasts or vascular endothelial cells in response to TGF-beta and different fibrotic tissues. We are interested to determine i) the molecular basis of p300 elevation in fibrotic tissues; ii) the contribution of elevated level of p300 in cardiac and renal fibrogenesis; iii) epigenetics in cardiac and renal endothelial-to-mesenchymal transition (EndMT), cellular proliferation, migration and senescence; and iv) to develop novel epigenetic therapeutic approaches targeting acetyltransferase activity of p300 to control cardiac and renal fibrosis. We are testing the therapeutic efficacies of novel small molecule inhibitors of epigenetic regulator acetyltransferase p300 for prevention and reversal of cardiac and renal fibrosis using murine models. We are also investigating the role of plasminogen activator system in air pollutants-induced cardiovascular diseases.

Training Experience

1996Postdoctoral Fellowship, Chicago Medical School

Education/Academic qualification

PhD, Calcutta University, India

… → 1991

Research interests

  • Aging
  • Cardiovascular Diseases
  • Epigenetics
  • Extracellular Matrix
  • Fibrosis
  • Heart Disease
  • Hypertension
  • MicroRNA
  • Renal Diseases
  • Signal Transduction
  • TGF-beta

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  • 1 Similar Profiles
Transforming Growth Factors Medicine & Life Sciences
Fibrosis Medicine & Life Sciences
Fibroblasts Medicine & Life Sciences
Gene expression Chemical Compounds
Collagen Medicine & Life Sciences
Plasminogen Activator Inhibitor 1 Medicine & Life Sciences
Peroxisome Proliferator-Activated Receptors Medicine & Life Sciences
RNA Polymerase I Medicine & Life Sciences

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Grants 2004 2022

Plasminogen Activator Inhibitor 1
Blood Vessels
Cardiovascular System
Population
Personal Financing
Air Pollutants
Plasminogen Activators
Plasminogen Activator Inhibitor 1
Environmental Pollutants
Cardiovascular Diseases
Myofibroblasts
Fibrosis
Epigenomics
Endothelial Cells
Fibroblasts
Stem Cells
Cell- and Tissue-Based Therapy
Therapeutics
Ischemia
Extremities
Regenerative Medicine
Stem Cells
Cell- and Tissue-Based Therapy
Therapeutics
Ischemia

Research Output 1986 2019

Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis

Rai, R., Sun, T., Ramirez, V., Lux, E., Eren, M., Vaughan, D. E. & Ghosh, A. K., Apr 2019, In : Journal of Cellular and Molecular Medicine. 23, 4, p. 3026-3031 6 p.

Research output: Contribution to journalArticle

Open Access
Cardiomegaly
Fibrosis
Hypertension
Epigenomics
Myofibroblasts

PAI-1 contributes to homocysteine-induced cellular senescence

Sun, T., Ghosh, A. K., Eren, M., Miyata, T. & Vaughan, D. E., Dec 1 2019, In : Cellular Signalling. 64, 109394.

Research output: Contribution to journalArticle

Cell Aging
Plasminogen Activator Inhibitor 1
Homocysteine
Integrins
Hyperhomocysteinemia
8 Citations (Scopus)

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP

Souma, T., Thomson, B. R., Heinen, S., Carota, I. A., Yamaguchi, S., Onay, T., Liu, P., Ghosh, A. K., Li, C., Eremina, V., Hong, Y. K., Economides, A. N., Vestweber, D., Peters, K. G., Jin, J. & Quaggina, S. E., Feb 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. 1298-1303 6 p.

Research output: Contribution to journalArticle

Class 3 Receptor-Like Protein Tyrosine Phosphatases
Angiopoietin-2
Phosphoric Monoester Hydrolases
Lymphatic Endothelium
Blood Vessels

EPIGENETIC TREATMENT APPROACHES TO CARDIOVASCULAR DISEASE

Ghosh, AK. & Vaughan, DE., 2018, Epigenetics in Human Disease. Tollefsbol, T. (ed.). London: Academic Press, Elsevier, p. 607-641

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis

Rai, R., Verma, S. K., Kim, D., Ramirez, V., Lux, E., Li, C., Sahoo, S., Wilsbacher, L. D., Vaughan, D. E., Quaggin, S. E. & Ghosh, A. K., Nov 2 2017, In : Epigenetics. 12, 11, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

Fibrosis
Hypertension
Kidney
Podocytes
Mesangial Cells