Grants per year
Personal profile
Research Interests
Molecular Basis of Fibrosis: Development of Epidrug for Fibrosis Therapy. Hyperactivity of differentiated fibroblasts causes an excessive synthesis and deposition of extracellular matrix proteins in the tissues that leads to fibrosis in multiple organs, a major cause of disease-related morbidity and mortality worldwide. Fibrosis is a common end-stage pathological symptom of a wide spectrum of injury or stress related multi-organ diseases such as hypertension-induced accelerated cardiovascular disease, chronic kidney disease, liver cirrhosis, systemic sclerosis and pulmonary disease. Epigenetics plays a key role in the development of multi-organ fibrosis. Our research interest focuses on the role of acetyltransferase p300, a major epigenetic regulator, in TGF-b-induced profibrogenic signal transduction and organ fibrosis. We have previously demonstrated that acetyltransferase p300 is an essential epigenetic regulator for profibrogenic signal-induced matrix protein collagen synthesis. Most importantly, the levels of p300 are significantly elevated in myofibroblasts derived from resident fibroblasts or vascular endothelial cells in response to TGF-beta and different fibrotic tissues. We are interested to determine i) the molecular basis of p300 elevation in fibrotic tissues; ii) the contribution of elevated level of p300 in cardiac, renal and pulmonary fibrogenesis; iii) epigenetics in cardiac and renal endothelial-to-mesenchymal transition (EndMT), cellular proliferation, migration and senescence; and iv) to develop novel epigenetic therapeutic approaches targeting acetyltransferase activity of p300 to control cardiac, renal and lung fibrosis. We are testing the therapeutic efficacies of novel small molecule inhibitors of epigenetic regulator acetyltransferase p300 for prevention and reversal of stress-induced accelerated cardiac, renal and lung aging-associated pathologies using murine models. We are also testing the efficacy of a drug-like small molecule inhibitor targeting plasminogen activator inhibitor-1 in amelioration of air pollutant PM2.5-induced lung and heart disease. The research is funded by grants from American Heart Association and National Institutes of Health.
Training Experience
1996 | Postdoctoral Fellowship, Chicago Medical School |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, University of Calcutta
… → 1991
Research interests keywords
- Aging
- Cardiovascular Diseases
- Epigenetics
- Extracellular Matrix
- Fibrosis
- Heart Disease
- Hypertension
- Cytokines
- Drug Discovery
- Gene Regulation
- TGF-beta
- Molecular Genetics
- Vascular Biology
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Collaborations and top research areas from the last five years
Grants
- 13 Finished
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Plasminogen Activator System in Air Pollutants-Induced Cardiovascular Disease
7/1/18 → 6/30/21
Project: Research project
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Acetyltransferase p300 in myofibroblast differentiation and cardiac fibrosis
Ghosh, A. K. & Qin, G.
American Heart Association Midwest Affiliate
7/1/16 → 6/30/19
Project: Research project
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Cardiovascular Regenerative Medicine
Vaughan, D. E., Ardehali, H., Eren, M., Ghosh, A. K., Kume, T., Meade, T. J., Perlman, H. R., Schumacker, P. T., Stupp, S., Vaughan, D. E. & Wasserstrom, J. A.
National Heart, Lung, and Blood Institute
9/7/11 → 4/30/16
Project: Research project
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Project 2 - Vaughan
Vaughan, D. E., Eren, M. & Ghosh, A. K.
National Heart, Lung, and Blood Institute
9/7/11 → 4/30/16
Project: Research project
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Angiotensin, The Vascular Endothelium, and Fibrinolysis
Vaughan, D. E., Eren, M. & Ghosh, A. K.
National Heart, Lung, and Blood Institute
10/1/08 → 3/31/12
Project: Research project
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Cardiomyocyte PAI-1 influences the cardiac transcriptome and limits the extent of cardiac fibrosis in response to left ventricular pressure overload
Ghosh, A. K., Kalousdian, A. A., Shang, M., Lux, E., Eren, M., Keating, A., Wilsbacher, L. D. & Vaughan, D. E., Nov 27 2022, (E-pub ahead of print) In: Cellular Signalling. p. 110555Research output: Contribution to journal › Article › peer-review
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Acetyltransferase p300 is a putative epidrug target for amelioration of cellular aging-related cardiovascular disease
Ghosh, A. K., Nov 2021, In: Cells. 10, 11, 2839.Research output: Contribution to journal › Review article › peer-review
Open Access7 Scopus citations -
Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM2.5
Ghosh, A. K., Soberanes, S., Lux, E., Shang, M., Aillon, R. P., Eren, M., Budinger, G. R. S., Miyata, T. & Vaughan, D. E., Oct 15 2021, In: Environmental Pollution. 287, 117283.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
p300 in cardiac development and accelerated cardiac aging
Ghosh, A. K., 2020, In: Aging and Disease. 11, 4, p. 916-926 11 p.Research output: Contribution to journal › Review article › peer-review
20 Scopus citations -
Pharmacological activation of PPAR-γ: a potential therapy for skin fibrosis
Ghosh, A. K., Dec 30 2020, (E-pub ahead of print) In: International Journal of Dermatology.Research output: Contribution to journal › Article › peer-review
4 Scopus citations