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Asish K Ghosh

  • 3156 Citations
1986 …2019

Research output per year

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Research Interests

Major Research Interests: Molecular Basis of Organ Fibrosis: Development of Epigenetic Fibrosis Therapy. Hyperactivity of differentiated fibroblasts causes an excessive synthesis and deposition of extracellular matrix proteins in the tissues that leads to organ fibrosis, a major cause of disease-related morbidity and mortality worldwide. Fibrosis is a common end-stage pathological symptom of a wide spectrum of injury or stress related multi-organ diseases such as hypertension-induced accelerated cardiac and renal aging, myocardial infarction, liver cirrhosis, systemic sclerosis and idiopathic pulmonary fibrosis. Epigenetics plays a key role in the development of organ fibrosis. Our research interest focuses on the role of acetyltransferase p300, a major epigenetic regulator, in TGF-beta-induced profibrogenic signal transduction and organ fibrosis. We have previously demonstrated that acetyltransferase p300 is essential for profibrogenic signal-induced matrix protein collagen synthesis. Most importantly, the levels of p300 are significantly elevated in myofibroblasts derived from resident fibroblasts or vascular endothelial cells in response to TGF-beta and different fibrotic tissues. We are interested to determine i) the molecular basis of p300 elevation in fibrotic tissues; ii) the contribution of elevated level of p300 in cardiac and renal fibrogenesis; iii) epigenetics in cardiac and renal endothelial-to-mesenchymal transition (EndMT), cellular proliferation, migration and senescence; and iv) to develop novel epigenetic therapeutic approaches targeting acetyltransferase activity of p300 to control cardiac and renal fibrosis. We are testing the therapeutic efficacies of novel small molecule inhibitors of epigenetic regulator acetyltransferase p300 for prevention and reversal of cardiac and renal fibrosis using murine models. We are also investigating the role of plasminogen activator system in air pollutants-induced cardiovascular diseases.

Training Experience

1996Postdoctoral Fellowship, Chicago Medical School

Education/Academic qualification

PhD, University of Calcutta

… → 1991

Research interests

  • Aging
  • Cardiovascular Diseases
  • Epigenetics
  • Extracellular Matrix
  • Fibrosis
  • Heart Disease
  • Hypertension
  • MicroRNA
  • Renal Diseases
  • Signal Transduction
  • TGF-beta

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Grants

Spontaneous cardiac fibrosis in PAI-1-deficient mice and men: A rare mutation informs a common molecular pathophysiology

Burridge, P., Carr, J., Ghosh, A. K., Hou, L., Khan, S. S., Shah, S. J., Vaughan, D. E., Winter, D. R. & Flevaris, P. D.

National Heart, Lung, and Blood Institute

4/15/19 → 3/31/23

Project: Research project

    • PAI-1 and Vascular Senescence

    Abdelwahid, E., Eren, M., Ghosh, A. K., Khan, S. S., Shah, S. J., Vaughan, D. E. & Flevaris, P. D.

    National Heart, Lung, and Blood Institute

    8/1/18 → 7/31/22

    Project: Research project

    • Plasminogen Activator System in Air Pollutants-Induced Cardiovascular Disease

    Ghosh, A. K. & Vaughan, D. E.

    American Heart Association

    7/1/18 → 6/30/20

    Project: Research project

    • Acetyltransferase p300 in myofibroblast differentiation and cardiac fibrosis

    Ghosh, A. K. & Qin, G.

    American Heart Association Midwest Affiliate

    7/1/16 → 6/30/19

    Project: Research project

    • Cardiovascular Regenerative Medicine

    Ardehali, H., Eren, M., Ghosh, A. K., Kume, T., Macrenaris, K. W., Meade, T. J., Perlman, H. R., Schumacker, P. T., Stupp, S., Vaughan, D. E., Vaughan, D. E. & Wasserstrom, J. A.

    National Heart, Lung, and Blood Institute

    9/7/11 → 4/30/16

    Project: Research project

    • Research Output

    Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis

    Rai, R., Sun, T., Ramirez, V., Lux, E., Eren, M., Vaughan, D. E. & Ghosh, A. K., Apr 2019, In : Journal of Cellular and Molecular Medicine. 23, 4, p. 3026-3031 6 p.

    Research output: Contribution to journal › Article

    Open Access

    • PAI-1 contributes to homocysteine-induced cellular senescence

    Sun, T., Ghosh, A. K., Eren, M., Miyata, T. & Vaughan, D. E., Dec 2019, In : Cellular Signalling. 64, 109394.

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP

    Souma, T., Thomson, B. R., Heinen, S., Carota, I. A., Yamaguchi, S., Onay, T., Liu, P., Ghosh, A. K., Li, C., Eremina, V., Hong, Y. K., Economides, A. N., Vestweber, D., Peters, K. G., Jin, J. & Quaggina, S. E., Feb 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. 1298-1303 6 p.

    Research output: Contribution to journal › Article

    • 17 Scopus citations

    EPIGENETIC TREATMENT APPROACHES TO CARDIOVASCULAR DISEASE

    Ghosh, AK. & Vaughan, DE., 2018, Epigenetics in Human Disease. Tollefsbol, T. (ed.). London: Academic Press, Elsevier, p. 607-641

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

    A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis

    Rai, R., Verma, S. K., Kim, D., Ramirez, V., Lux, E., Li, C., Sahoo, S., Wilsbacher, L. D., Vaughan, D. E., Quaggin, S. E. & Ghosh, A. K., Nov 2 2017, In : Epigenetics. 12, 11, p. 1004-1013 10 p.

    Research output: Contribution to journal › Article

    • 7 Scopus citations