Grants per year
Personal profile
Research Interests
Major Research Interests: Molecular Basis of Organ Fibrosis: Development of Epigenetic Fibrosis Therapy. Hyperactivity of differentiated fibroblasts causes an excessive synthesis and deposition of extracellular matrix proteins in the tissues that leads to organ fibrosis, a major cause of disease-related morbidity and mortality worldwide. Fibrosis is a common end-stage pathological symptom of a wide spectrum of injury or stress related multi-organ diseases such as hypertension-induced accelerated cardiac and renal aging, myocardial infarction, liver cirrhosis, systemic sclerosis and idiopathic pulmonary fibrosis. Epigenetics plays a key role in the development of organ fibrosis. Our research interest focuses on the role of acetyltransferase p300, a major epigenetic regulator, in TGF-beta-induced profibrogenic signal transduction and organ fibrosis. We have previously demonstrated that acetyltransferase p300 is essential for profibrogenic signal-induced matrix protein collagen synthesis. Most importantly, the levels of p300 are significantly elevated in myofibroblasts derived from resident fibroblasts or vascular endothelial cells in response to TGF-beta and different fibrotic tissues. We are interested to determine i) the molecular basis of p300 elevation in fibrotic tissues; ii) the contribution of elevated level of p300 in cardiac and renal fibrogenesis; iii) epigenetics in cardiac and renal endothelial-to-mesenchymal transition (EndMT), cellular proliferation, migration and senescence; and iv) to develop novel epigenetic therapeutic approaches targeting acetyltransferase activity of p300 to control cardiac and renal fibrosis. We are testing the therapeutic efficacies of novel small molecule inhibitors of epigenetic regulator acetyltransferase p300 for prevention and reversal of cardiac and renal fibrosis using murine models. We are also investigating the role of plasminogen activator system in air pollutants-induced cardiovascular diseases.
Training Experience
1996 | Postdoctoral Fellowship, Chicago Medical School |
Education/Academic qualification
PhD, University of Calcutta
… → 1991
Research interests
- Aging
- Cardiovascular Diseases
- Epigenetics
- Extracellular Matrix
- Fibrosis
- Heart Disease
- Hypertension
- MicroRNA
- Renal Diseases
- Signal Transduction
- TGF-beta
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Network
Grants
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Spontaneous cardiac fibrosis in PAI-1-deficient mice and men: A rare mutation informs a common molecular pathophysiology
Burridge, P., Carr, J., Ghosh, A. K., Hou, L., Khan, S. S., Shah, S. J., Vaughan, D. E., Winter, D. R. & Flevaris, P. D.
National Heart, Lung, and Blood Institute
4/15/19 → 3/31/23
Project: Research project
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PAI-1 and Vascular Senescence
Abdelwahid, E., Eren, M., Ghosh, A. K., Khan, S. S., Shah, S. J., Vaughan, D. E. & Flevaris, P. D.
National Heart, Lung, and Blood Institute
8/1/18 → 7/31/22
Project: Research project
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Plasminogen Activator System in Air Pollutants-Induced Cardiovascular Disease
7/1/18 → 6/30/21
Project: Research project
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Acetyltransferase p300 in myofibroblast differentiation and cardiac fibrosis
Ghosh, A. K. & Qin, G.
American Heart Association Midwest Affiliate
7/1/16 → 6/30/19
Project: Research project
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Cardiovascular Regenerative Medicine
Ardehali, H., Eren, M., Ghosh, A. K., Kume, T., Meade, T. J., Perlman, H. R., Schumacker, P. T., Stupp, S., Vaughan, D. E., Vaughan, D. E. & Wasserstrom, J. A.
National Heart, Lung, and Blood Institute
9/7/11 → 4/30/16
Project: Research project
Research Output
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p300 in cardiac development and accelerated cardiac aging
Ghosh, A. K., 2020, In: Aging and Disease. 11, 4, p. 916-926 11 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Pharmacological activation of PPAR-γ: a potential therapy for skin fibrosis
Ghosh, A. K., Dec 30 2020, (E-pub ahead of print) In: International Journal of Dermatology.Research output: Contribution to journal › Article › peer-review
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Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis
Rai, R., Sun, T., Ramirez, V., Lux, E., Eren, M., Vaughan, D. E. & Ghosh, A. K., Apr 2019, In: Journal of Cellular and Molecular Medicine. 23, 4, p. 3026-3031 6 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
PAI-1 contributes to homocysteine-induced cellular senescence
Sun, T., Ghosh, A. K., Eren, M., Miyata, T. & Vaughan, D. E., Dec 2019, In: Cellular Signalling. 64, 109394.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP
Souma, T., Thomson, B. R., Heinen, S., Carota, I. A., Yamaguchi, S., Onay, T., Liu, P., Ghosh, A. K., Li, C., Eremina, V., Hong, Y. K., Economides, A. N., Vestweber, D., Peters, K. G., Jin, J. & Quaggina, S. E., Feb 6 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. 1298-1303 6 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations