Asish K Ghosh

  • 2840 Citations
1986 …2022
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Research Output 1986 2019

2019

Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis

Rai, R., Sun, T., Ramirez, V., Lux, E., Eren, M., Vaughan, D. E. & Ghosh, A. K., Apr 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 4, p. 3026-3031 6 p.

Research output: Contribution to journalArticle

Open Access
Cardiomegaly
Fibrosis
Hypertension
Epigenomics
Myofibroblasts

Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis.

Rai, R., Sun, T., Ramirez, V., Lux, E., Eren, M., Vaughan, DE. & Ghosh, AK., Feb 1 2019, In : J Cell Mol Med.. doi: 10.1111/jcmm.14162., [Epub ahead of print]

Research output: Contribution to journalArticle

2018
5 Citations (Scopus)

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP

Souma, T., Thomson, B. R., Heinen, S., Carota, I. A., Yamaguchi, S., Onay, T., Liu, P., Ghosh, A. K., Li, C., Eremina, V., Hong, Y. K., Economides, A. N., Vestweber, D., Peters, K. G., Jin, J. & Quaggina, S. E., Feb 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. 1298-1303 6 p.

Research output: Contribution to journalArticle

Class 3 Receptor-Like Protein Tyrosine Phosphatases
Angiopoietin-2
Phosphoric Monoester Hydrolases
Lymphatic Endothelium
Blood Vessels

EPIGENETIC TREATMENT APPROACHES TO CARDIOVASCULAR DISEASE

Ghosh, AK. & Vaughan, DE., 2018, Epigenetics in Human Disease. Tollefsbol, T. (ed.). London: Academic Press, Elsevier, p. 607-641

Research output: Chapter in Book/Report/Conference proceedingChapter

2017
5 Citations (Scopus)

A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis

Rai, R., Verma, S. K., Kim, D., Ramirez, V., Lux, E., Li, C., Sahoo, S., Wilsbacher, L. D., Vaughan, D. E., Quaggin, S. E. & Ghosh, A. K., Nov 2 2017, In : Epigenetics. 12, 11, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

Fibrosis
Hypertension
Kidney
Podocytes
Mesangial Cells
9 Citations (Scopus)

Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan

Rai, R., Ghosh, A. K., Eren, M., Mackie, A. R., Levine, D. C., Kim, S. Y., Cedernaes, J., Ramirez, V., Procissi, D., Smith, L. H., Woodruff, T. K., Bass, J. & Vaughan, D. E., Nov 7 2017, In : Cell Reports. 21, 6, p. 1471-1480 10 p.

Research output: Contribution to journalArticle

Restoration
Down-Regulation
Aging of materials
Cell Aging
Cardiomegaly
13 Citations (Scopus)

Epigenetics in Reactive and Reparative Cardiac Fibrogenesis: The Promise of Epigenetic Therapy

Ghosh, A. K., Rai, R., Flevaris, P. D. & Vaughan, D. E., Aug 1 2017, In : Journal of Cellular Physiology. 232, 8, p. 1941-1956 16 p.

Research output: Contribution to journalReview article

Epigenomics
Extracellular Matrix Proteins
Fibrosis
Heart Failure
Aging of materials
18 Citations (Scopus)

Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence

Vaughan, D. E., Rai, R., Khan, S. S., Eren, M. & Ghosh, A. K., Aug 1 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 8, p. 1446-1452 7 p.

Research output: Contribution to journalReview article

Plasminogen Activator Inhibitor 1
Cell Aging
Serine Proteinase Inhibitors
Plasminogen Activators
Comorbidity
12 Citations (Scopus)

Plasminogen activator inhibitor type I controls cardiomyocyte transforming growth factor-β and cardiac fibrosis

Flevaris, P., Khan, S. S., Eren, M., Schuldt, A. J. T., Shah, S. J., Lee, D. C., Gupta, S., Shapiro, A. D., Burridge, P. W., Ghosh, A. K. & Vaughan, D. E., Aug 1 2017, In : Circulation. 136, 7, p. 664-679 16 p.

Research output: Contribution to journalArticle

Plasminogen Inactivators
Plasminogen Activator Inhibitor 1
Transforming Growth Factors
Cardiac Myocytes
Fibrosis
2016
16 Citations (Scopus)

A small molecule inhibitor of PAI-1 protects against Doxorubicin-induced cellular senescence: molecular basis

Ghosh, A. K., Rai, R., Park, K. E., Eren, M., Miyata, T., Wilsbacher, L. D. & Vaughan, D. E., Oct 6 2016, In : Oncotarget. 7, 45, p. 72443-72457 15 p.

Research output: Contribution to journalArticle

Cell Aging
Plasminogen Activator Inhibitor 1
Doxorubicin
Fibroblasts
Serine Proteinase Inhibitors
64 Citations (Scopus)

MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis

Nagpal, V., Rai, R., Place, A. T., Murphy, S. B., Verma, S. K., Ghosh, A. K. & Vaughan, D. E., Jan 19 2016, In : Circulation. 133, 3, p. 291-301 11 p.

Research output: Contribution to journalArticle

Myofibroblasts
Fibrosis
Fibroblasts
MicroRNAs
RNA Sequence Analysis
4 Citations (Scopus)

Response to letter regarding article, "MiR-125b is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis"

Nagpal, V., Rai, R., Place, A. T., Murphy, S. B., Verma, S. K., Ghosh, A. K. & Vaughan, D. E., Jun 14 2016, In : Circulation. 133, 24, p. e714

Research output: Contribution to journalLetter

2014
56 Citations (Scopus)

A lymphatic defect causes ocular hypertension and glaucoma in mice

Thomson, B. R., Heinen, S., Jeansson, M., Ghosh, A. K., Fatima, A., Sung, H. K., Onay, T., Chen, H., Yamaguchi, S., Economides, A. N., Flenniken, A., Gale, N. W., Hong, Y. K., Fawzi, A., Liu, X., Kume, T. & Quaggin, S. E., Oct 1 2014, In : Journal of Clinical Investigation. 124, 10, p. 4320-4324 5 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Glaucoma
Intraocular Pressure
Angiopoietins
Drainage
4 Citations (Scopus)

FAT-free p300 is good for scar-free tissue repair

Ghosh, A. K., Jan 1 2014, In : Journal of Cellular Biochemistry. 115, 9, p. 1486-1489 4 p.

Research output: Contribution to journalArticle

Cicatrix
Repair
Tissue
Fibrosis
Collagen

Isolation and Culture of Cardiac Endothelial Cells

Ghosh, AK., Covington, JW. & Vaughan, DE., 2014, Manual of Research Techniques in Cardiovascular Medicine: Chapter 15. Ardehali, H., Bolli, R. & Losordo, DW. (eds.). Chicago: John Wiley & Sons, Ltd, p. 131-139

Research output: Chapter in Book/Report/Conference proceedingChapter

Isolation and Culture of Cardiac Fibroblasts

Ghosh, AK., Covington, JW. & Vaughan, DE., 2014, Manual of Research Techniques in Cardiovascular Medicine: Chapter 16. Ardehali, H., Bolli, R. & Losordo, DW. (eds.). Chicago: John Wiley & Sons, Ltd, p. 140-145

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Citations (Scopus)

Loss of the podocyte-expressed transcription factor Tcf21/Pod1 Results in podocyte differentiation defects and FSGS

Maezawa, Y., Onay, T., Scott, R. P., Keir, L. S., Dimke, H., Li, C., Eremina, V., Maezawa, Y., Jeansson, M., Shan, J., Binnie, M., Lewin, M., Ghosh, A., Miner, J. H., Vainio, S. J. & Quaggin, S. E., Nov 1 2014, In : Journal of the American Society of Nephrology. 25, 11, p. 2459-2470 12 p.

Research output: Contribution to journalArticle

Podocytes
Transcription Factors
Proteinuria
Knockout Mice
Basic Helix-Loop-Helix Transcription Factors
2013
13 Citations (Scopus)

Expression profiling of nuclear receptors identifies key roles of NR4A subfamily in uterine fibroids

Yin, H., Lo, J. H., Kim, J. Y., Marsh, E. E., Kim, J. J., Ghosh, A. K., Bulun, S. E. & Chakravarti, D., May 1 2013, In : Molecular Endocrinology. 27, 5, p. 726-740 15 p.

Research output: Contribution to journalArticle

Leiomyoma
Cytoplasmic and Nuclear Receptors
Leuprolide
Smooth Muscle Tumor
Myometrium
16 Citations (Scopus)

Global Gene Expression Profiling in PAI-1 Knockout Murine Heart and Kidney: Molecular Basis of Cardiac-Selective Fibrosis

Ghosh, A. K., Murphy, S. B., Kishore, R. & Vaughan, D. E., May 28 2013, In : PloS one. 8, 5, e63825.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Gene Expression Profiling
fibrosis
Gene expression
Fibrosis
73 Citations (Scopus)

Molecular basis of organ fibrosis: Potential therapeutic approaches

Ghosh, A. K., Quaggin, S. E. & Vaughan, D. E., Aug 1 2013, In : Experimental Biology and Medicine. 238, 5, p. 461-481 21 p.

Research output: Contribution to journalReview article

Tissue homeostasis
Wound Healing
Fibrosis
Peroxisome Proliferator-Activated Receptors
Acetyltransferases
50 Citations (Scopus)
Systemic Scleroderma
Transforming Growth Factors
Epigenomics
Amplification
Fibrosis
2012
16 Citations (Scopus)

Fibrosis: Is it a coactivator disease?

Ghosh, A. K. & Vaughan, D. E., Jan 1 2012, In : Frontiers in Bioscience - Elite. 4 E, 4, p. 1556-1570 15 p.

Research output: Contribution to journalArticle

Epigenomics
Fibrosis
Acetyltransferases
Genes
Extracellular Matrix Proteins
84 Citations (Scopus)

Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB

Verma, S. K., Krishnamurthy, P., Barefield, D., Singh, N., Gupta, R., Lambers, E., Thal, M., MacKie, A., Hoxha, E., Ramirez, V., Qin, G., Sadayappan, S., Ghosh, A. K. & Kishore, R., Jul 24 2012, In : Circulation. 126, 4, p. 418-429 12 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Interleukin-10
Pressure
Isoproterenol
Heart Failure
97 Citations (Scopus)

Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): Differential expression of microRNAs during EndMT

Ghosh, A. K., Nagpal, V., Covington, J. W., Michaels, M. A. & Vaughan, D. E., May 1 2012, In : Cellular Signalling. 24, 5, p. 1031-1036 6 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
MicroRNAs
Fibroblasts
Fibrosis
Endothelial Cells
243 Citations (Scopus)

PAI-1 in tissue fibrosis

Ghosh, A. K. & Vaughan, D. E., Jan 1 2012, In : Journal of Cellular Physiology. 227, 2, p. 493-507 15 p.

Research output: Contribution to journalReview article

Plasminogen Activator Inhibitor 1
Fibrinolysin
Fibrosis
Tissue
Extracellular Matrix Proteins
52 Citations (Scopus)

Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β1 signalling

Mutlu, G. M., Budinger, GR. S., Wu, M., Lam, A. P., Zirk, A., Rivera, S., Urich, D., Chiarella, S. E., Go, L. H. T., Ghosh, A. K., Selman, M., Pardo, A., Varga, J., Kamp, D. W., Chandel, N., Sznajder, J. I. & Jain, M., Jan 1 2012, In : Thorax. 67, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

Fibrosis
Lung
Wounds and Injuries
Skin
Fibroblasts
2011
51 Citations (Scopus)

Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ

Jain, M., Budinger, GR. S., Lo, A., Urich, D., Rivera, S. E., Ghosh, A. K., Gonzalez, A., Chiarella, S. E., Marks, K., Donnelly, H. K., Soberanes, S., Varga, J., Radigan, K. A., Chandel, N. & Mutlu, G. M., Jun 1 2011, In : American Journal of Respiratory and Critical Care Medicine. 183, 11, p. 1490-1498 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Adult Respiratory Distress Syndrome
Leptin
Transforming Growth Factors
Bronchoalveolar Lavage Fluid
2010
5 Citations (Scopus)
Transforming Growth Factor beta
Fibrosis
85 Citations (Scopus)

Genetic deficiency of plasminogen activator inhibitor-1 promotes cardiac fibrosis in aged mice: Involvement of constitutive transforming growth factor-β signaling and endothelial-to-mesenchymal transition

Ghosh, A. K., Bradham, W. S., Gleaves, L. A., De Taeye, B., Murphy, S. B., Covington, J. W. & Vaughan, D. E., Sep 21 2010, In : Circulation. 122, 12, p. 1200-1209 10 p.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Transforming Growth Factors
Fibrosis
Matrix Metalloproteinase 2
Plasminogen Activator Inhibitor-1 Deficiency
101 Citations (Scopus)

PPAR? Downregulation by TGF in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

Wei, J., Ghosh, A. K., Sargent, J. L., Komura, K., Wu, M., Huang, Q-Q., Jain, M., Whitfield, M. L., Feghali-Bostwick, C. & Varga, J., Nov 22 2010, In : PLoS One. 5, 11, e13778.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Systemic Scleroderma
PPAR gamma
sclerosis
Fibroblasts
2009

Curcumin prevents and reverses murine cardiac hypertrophy (Journal of Clinical Investigation (2008) 118, (879-893) DOI: 10.1172/JCI32865)

Li, H. L., Liu, C., De Couto, G., Ouzounian, M., Sun, M., Wang, A. B., Huang, Y., He, C. W., Shi, Y., Chen, X., Nghiem, M. P., Liu, Y., Chen, M., Dawood, F., Fukuoka, M., Maekawa, Y., Zhang, L., Leask, A., Ghosh, A. K., Kirshenbaum, L. A. & 1 others, Liu, P. P., Jul 1 2009, In : Journal of Clinical Investigation. 119, 7, 1 p.

Research output: Contribution to journalComment/debate

Curcumin
Cardiomegaly
86 Citations (Scopus)

Peroxisome proliferator-activated receptor-γ abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

Ghosh, A. K., Bhattacharyya, S., Wei, J., Kim, S., Barak, Y., Mori, Y. & Varga, J., Sep 1 2009, In : FASEB Journal. 23, 9, p. 2968-2977 10 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Collagen
Transforming Growth Factor beta
Fibroblasts
Histone Acetyltransferases
151 Citations (Scopus)

Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-β

Wu, M., Melichian, D. S., Chang, E., Warner-Blankenship, M., Ghosh, A. K. & Varga, J., Jan 1 2009, In : American Journal of Pathology. 174, 2, p. 519-533 15 p.

Research output: Contribution to journalArticle

rosiglitazone
Peroxisome Proliferator-Activated Receptors
Bleomycin
Transforming Growth Factors
Skin
15 Citations (Scopus)

Targeted expression of receptor-associated late transducer inhibits maladaptive hypertrophy via blocking epidermal growth factor receptor signaling

Cai, J., Yi, F. F., Yang, L., Shen, D. F., Yang, Q., Li, A., Ghosh, A. K., Bian, Z. Y., Yan, L., Tang, Q. Z., Li, H. & Yang, X. C., Mar 1 2009, In : Hypertension. 53, 3, p. 539-548 10 p.

Research output: Contribution to journalArticle

Transducers
Epidermal Growth Factor Receptor
Hypertrophy
Cardiomegaly
Isoproterenol
2008
33 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
Fibroblasts
Gene expression
Collagen
Transforming Growth Factors
103 Citations (Scopus)

Curcumin prevents and reverses murine cardiac hypertrophy

Li, H. L., Liu, C., De Couto, G., Ouzounian, M., Sun, M., Wang, A. B., Huang, Y., He, C. W., Shi, Y., Chen, X., Nghiem, M. P., Liu, Y., Chen, M., Dawood, F., Fukuoka, M., Maekawa, Y., Zhang, L., Leask, A., Ghosh, A. K., Kirshenbaum, L. A. & 1 others, Liu, P. P., Jan 1 2008, In : Journal of Clinical Investigation. 118, 3, p. 879-893 15 p.

Research output: Contribution to journalArticle

Curcumin
Cardiomegaly
Acetylation
Histones
Histone Acetyltransferases
2007
119 Citations (Scopus)

The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis

Ghosh, A. K. & Varga, J., Dec 1 2007, In : Journal of Cellular Physiology. 213, 3, p. 663-671 9 p.

Research output: Contribution to journalReview article

Transforming Growth Factors
Fibroblasts
Fibrosis
Acetyltransferases
Transcription Factors
71 Citations (Scopus)

Trichostatin A blocks TGF-β-induced collagen gene expression in skin fibroblasts: Involvement of Sp1

Ghosh, A. K., Mori, Y., Dowling, E. & Varga, J., Mar 9 2007, In : Biochemical and Biophysical Research Communications. 354, 2, p. 420-426 7 p.

Research output: Contribution to journalArticle

trichostatin A
Transforming Growth Factors
Fibroblasts
Gene expression
Skin
2006
29 Citations (Scopus)
CCAAT-Enhancer-Binding Proteins
Gene expression
Interferons
Collagen
Gene Expression
2005
65 Citations (Scopus)

Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor β

Bhattacharyya, S., Ghosh, A. K., Pannu, J., Mori, Y., Takagawa, S., Chen, G., Trojanowska, M., Gilliam, A. C. & Varga, J., Apr 1 2005, In : Arthritis and Rheumatism. 52, 4, p. 1248-1258 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Fibroblasts
Catalytic RNA
Skin
Systemic Scleroderma
40 Citations (Scopus)

Transforming growth factor β facilitates β-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner

Ray, D., Terao, Y., Nimbalkar, D., Chu, L. H., Donzelli, M., Tsutsui, T., Zou, X., Ghosh, A. K., Varga, J., Draetta, G. F. & Kiyokawa, H., Apr 1 2005, In : Molecular and cellular biology. 25, 8, p. 3338-3347 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Ubiquitination
Small Interfering RNA
Mutant Proteins
Ubiquitin
2004
158 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
Transforming Growth Factors
Fibroblasts
Skin
Myofibroblasts
43 Citations (Scopus)
Transforming Growth Factors
Tumors
Collagen
Genes
Fibroblasts
2003
7 Citations (Scopus)

Transcriptional coactivators p300/CBP and Type I collagen gene expression

Ghosh, A. K. & Varga, J., Jul 25 2003, In : Current Science. 85, 2, p. 155-161 7 p.

Research output: Contribution to journalReview article

p300-CBP Transcription Factors
Collagen Type I
Transforming Growth Factor beta
Gene Expression
Cytokines
2002
193 Citations (Scopus)

Factors involved in the regulation of type I collagen gene expression: Implication in fibrosis

Ghosh, A. K., May 1 2002, In : Experimental Biology and Medicine. 227, 5, p. 301-314 14 p.

Research output: Contribution to journalShort survey

Collagen Type I
Gene expression
Fibrosis
Gene Expression
Skin
2001
202 Citations (Scopus)
p300-CBP Transcription Factors
Transforming Growth Factors
Collagen Type I
Gene expression
Interferons
39 Citations (Scopus)

A Nucleoprotein Complex containing CCAAT/Enhancer-binding Protein β Interacts with an Insulin Response Sequence in the Insulin-like Growth Factor-binding Protein-1 Gene and Contributes to Insulin-regulated Gene Expression

Ghosh, A. K., Lacson, R., Liu, P., Cichy, S. B., Danilkovich, A., Guo, S. & Unterman, T. G., Mar 16 2001, In : Journal of Biological Chemistry. 276, 11, p. 8507-8515 9 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Insulin-Like Growth Factor Binding Protein 1
Nucleoproteins
Gene expression
Genes
80 Citations (Scopus)

Insulin suppresses transactivation by CAAT/Enhancer-binding proteins β (C/EBPβ). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPβ

Guo, S., Cichy, S. B., He, X., Yang, Q., Ragland, M., Ghosh, A. K., Johnson, P. F. & Unterman, T. G., Mar 16 2001, In : Journal of Biological Chemistry. 276, 11, p. 8516-8523 8 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
CCAAT-Enhancer-Binding Proteins
Proto-Oncogene Proteins c-akt
Transcriptional Activation
Chemical activation
2000
164 Citations (Scopus)
CREB-Binding Protein
Fibroblast Growth Factors
Transforming Growth Factors
Collagen Type I
Gene Expression
1999
16 Citations (Scopus)

Control of RNA polymerase I-directed transcription: Recent trends

Jacob, S. T. & Ghosh, A. K., Dec 1 1999, In : Journal of Cellular Biochemistry. 76, SUPPL. 32/33, p. 41-50 10 p.

Research output: Contribution to journalArticle

Upstream Stimulatory Factors
Genetic Transcription
RNA Polymerase I
Repressor Proteins
Polyomavirus Transforming Antigens