Asish K Ghosh

  • 2874 Citations
1986 …2022
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Research Output 1986 2019

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2019

Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis

Rai, R., Sun, T., Ramirez, V., Lux, E., Eren, M., Vaughan, D. E. & Ghosh, A. K., Apr 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 4, p. 3026-3031 6 p.

Research output: Contribution to journalArticle

Open Access
Cardiomegaly
Fibrosis
Hypertension
Epigenomics
Myofibroblasts

PAI-1 contributes to homocysteine-induced cellular senescence

Sun, T., Ghosh, A. K., Eren, M., Miyata, T. & Vaughan, D. E., Dec 1 2019, In : Cellular Signalling. 64, 109394.

Research output: Contribution to journalArticle

Cell Aging
Plasminogen Activator Inhibitor 1
Homocysteine
Integrins
Hyperhomocysteinemia
2018
6 Citations (Scopus)

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP

Souma, T., Thomson, B. R., Heinen, S., Carota, I. A., Yamaguchi, S., Onay, T., Liu, P., Ghosh, A. K., Li, C., Eremina, V., Hong, Y. K., Economides, A. N., Vestweber, D., Peters, K. G., Jin, J. & Quaggina, S. E., Feb 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. 1298-1303 6 p.

Research output: Contribution to journalArticle

Class 3 Receptor-Like Protein Tyrosine Phosphatases
Angiopoietin-2
Phosphoric Monoester Hydrolases
Lymphatic Endothelium
Blood Vessels
2017
5 Citations (Scopus)

A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis

Rai, R., Verma, S. K., Kim, D., Ramirez, V., Lux, E., Li, C., Sahoo, S., Wilsbacher, L. D., Vaughan, D. E., Quaggin, S. E. & Ghosh, A. K., Nov 2 2017, In : Epigenetics. 12, 11, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

Fibrosis
Hypertension
Kidney
Podocytes
Mesangial Cells
9 Citations (Scopus)

Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan

Rai, R., Ghosh, A. K., Eren, M., Mackie, A. R., Levine, D. C., Kim, S. Y., Cedernaes, J., Ramirez, V., Procissi, D., Smith, L. H., Woodruff, T. K., Bass, J. & Vaughan, D. E., Nov 7 2017, In : Cell Reports. 21, 6, p. 1471-1480 10 p.

Research output: Contribution to journalArticle

Restoration
Down-Regulation
Aging of materials
Cell Aging
Cardiomegaly
12 Citations (Scopus)

Plasminogen activator inhibitor type I controls cardiomyocyte transforming growth factor-β and cardiac fibrosis

Flevaris, P., Khan, S. S., Eren, M., Schuldt, A. J. T., Shah, S. J., Lee, D. C., Gupta, S., Shapiro, A. D., Burridge, P. W., Ghosh, A. K. & Vaughan, D. E., Aug 1 2017, In : Circulation. 136, 7, p. 664-679 16 p.

Research output: Contribution to journalArticle

Plasminogen Inactivators
Plasminogen Activator Inhibitor 1
Transforming Growth Factors
Cardiac Myocytes
Fibrosis
2016
19 Citations (Scopus)

A small molecule inhibitor of PAI-1 protects against Doxorubicin-induced cellular senescence: molecular basis

Ghosh, A. K., Rai, R., Park, K. E., Eren, M., Miyata, T., Wilsbacher, L. D. & Vaughan, D. E., Oct 6 2016, In : Oncotarget. 7, 45, p. 72443-72457 15 p.

Research output: Contribution to journalArticle

Cell Aging
Plasminogen Activator Inhibitor 1
Doxorubicin
Fibroblasts
Serine Proteinase Inhibitors
68 Citations (Scopus)

MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis

Nagpal, V., Rai, R., Place, A. T., Murphy, S. B., Verma, S. K., Ghosh, A. K. & Vaughan, D. E., Jan 19 2016, In : Circulation. 133, 3, p. 291-301 11 p.

Research output: Contribution to journalArticle

Myofibroblasts
Fibrosis
Fibroblasts
MicroRNAs
RNA Sequence Analysis
2014
58 Citations (Scopus)

A lymphatic defect causes ocular hypertension and glaucoma in mice

Thomson, B. R., Heinen, S., Jeansson, M., Ghosh, A. K., Fatima, A., Sung, H. K., Onay, T., Chen, H., Yamaguchi, S., Economides, A. N., Flenniken, A., Gale, N. W., Hong, Y. K., Fawzi, A., Liu, X., Kume, T. & Quaggin, S. E., Oct 1 2014, In : Journal of Clinical Investigation. 124, 10, p. 4320-4324 5 p.

Research output: Contribution to journalArticle

Ocular Hypertension
Glaucoma
Intraocular Pressure
Angiopoietins
Drainage
4 Citations (Scopus)

FAT-free p300 is good for scar-free tissue repair

Ghosh, A. K., Jan 1 2014, In : Journal of Cellular Biochemistry. 115, 9, p. 1486-1489 4 p.

Research output: Contribution to journalArticle

Cicatrix
Repair
Tissue
Fibrosis
Collagen
18 Citations (Scopus)

Loss of the podocyte-expressed transcription factor Tcf21/Pod1 Results in podocyte differentiation defects and FSGS

Maezawa, Y., Onay, T., Scott, R. P., Keir, L. S., Dimke, H., Li, C., Eremina, V., Maezawa, Y., Jeansson, M., Shan, J., Binnie, M., Lewin, M., Ghosh, A., Miner, J. H., Vainio, S. J. & Quaggin, S. E., Nov 1 2014, In : Journal of the American Society of Nephrology. 25, 11, p. 2459-2470 12 p.

Research output: Contribution to journalArticle

Podocytes
Transcription Factors
Proteinuria
Knockout Mice
Basic Helix-Loop-Helix Transcription Factors
2013
14 Citations (Scopus)

Expression profiling of nuclear receptors identifies key roles of NR4A subfamily in uterine fibroids

Yin, H., Lo, J. H., Kim, J. Y., Marsh, E. E., Kim, J. J., Ghosh, A. K., Bulun, S. E. & Chakravarti, D., May 1 2013, In : Molecular Endocrinology. 27, 5, p. 726-740 15 p.

Research output: Contribution to journalArticle

Leiomyoma
Cytoplasmic and Nuclear Receptors
Leuprolide
Smooth Muscle Tumor
Myometrium
16 Citations (Scopus)

Global Gene Expression Profiling in PAI-1 Knockout Murine Heart and Kidney: Molecular Basis of Cardiac-Selective Fibrosis

Ghosh, A. K., Murphy, S. B., Kishore, R. & Vaughan, D. E., May 28 2013, In : PloS one. 8, 5, e63825.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Gene Expression Profiling
fibrosis
Gene expression
Fibrosis
50 Citations (Scopus)
Systemic Scleroderma
Transforming Growth Factors
Epigenomics
Amplification
Fibrosis
2012
16 Citations (Scopus)

Fibrosis: Is it a coactivator disease?

Ghosh, A. K. & Vaughan, D. E., Jan 1 2012, In : Frontiers in Bioscience - Elite. 4 E, 4, p. 1556-1570 15 p.

Research output: Contribution to journalArticle

Epigenomics
Fibrosis
Acetyltransferases
Genes
Extracellular Matrix Proteins
88 Citations (Scopus)

Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB

Verma, S. K., Krishnamurthy, P., Barefield, D., Singh, N., Gupta, R., Lambers, E., Thal, M., MacKie, A., Hoxha, E., Ramirez, V., Qin, G., Sadayappan, S., Ghosh, A. K. & Kishore, R., Jul 24 2012, In : Circulation. 126, 4, p. 418-429 12 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Interleukin-10
Pressure
Isoproterenol
Heart Failure
99 Citations (Scopus)

Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): Differential expression of microRNAs during EndMT

Ghosh, A. K., Nagpal, V., Covington, J. W., Michaels, M. A. & Vaughan, D. E., May 1 2012, In : Cellular Signalling. 24, 5, p. 1031-1036 6 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
MicroRNAs
Fibroblasts
Fibrosis
Endothelial Cells
53 Citations (Scopus)

Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β1 signalling

Mutlu, G. M., Budinger, GR. S., Wu, M., Lam, A. P., Zirk, A., Rivera, S., Urich, D., Chiarella, S. E., Go, L. H. T., Ghosh, A. K., Selman, M., Pardo, A., Varga, J., Kamp, D. W., Chandel, N., Sznajder, J. I. & Jain, M., Jan 1 2012, In : Thorax. 67, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

Fibrosis
Lung
Wounds and Injuries
Skin
Fibroblasts
2011
52 Citations (Scopus)

Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ

Jain, M., Budinger, GR. S., Lo, A., Urich, D., Rivera, S. E., Ghosh, A. K., Gonzalez, A., Chiarella, S. E., Marks, K., Donnelly, H. K., Soberanes, S., Varga, J., Radigan, K. A., Chandel, N. & Mutlu, G. M., Jun 1 2011, In : American journal of respiratory and critical care medicine. 183, 11, p. 1490-1498 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Adult Respiratory Distress Syndrome
Leptin
Transforming Growth Factors
Bronchoalveolar Lavage Fluid
2010
86 Citations (Scopus)

Genetic deficiency of plasminogen activator inhibitor-1 promotes cardiac fibrosis in aged mice: Involvement of constitutive transforming growth factor-β signaling and endothelial-to-mesenchymal transition

Ghosh, A. K., Bradham, W. S., Gleaves, L. A., De Taeye, B., Murphy, S. B., Covington, J. W. & Vaughan, D. E., Sep 21 2010, In : Circulation. 122, 12, p. 1200-1209 10 p.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Transforming Growth Factors
Fibrosis
Matrix Metalloproteinase 2
Plasminogen Activator Inhibitor-1 Deficiency
102 Citations (Scopus)

PPAR? Downregulation by TGF in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

Wei, J., Ghosh, A. K., Sargent, J. L., Komura, K., Wu, M., Huang, Q-Q., Jain, M., Whitfield, M. L., Feghali-Bostwick, C. & Varga, J., Nov 22 2010, In : PLoS One. 5, 11, e13778.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Systemic Scleroderma
PPAR gamma
sclerosis
Fibroblasts
2009
86 Citations (Scopus)

Peroxisome proliferator-activated receptor-γ abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

Ghosh, A. K., Bhattacharyya, S., Wei, J., Kim, S., Barak, Y., Mori, Y. & Varga, J., Sep 1 2009, In : FASEB Journal. 23, 9, p. 2968-2977 10 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Collagen
Transforming Growth Factor beta
Fibroblasts
Histone Acetyltransferases
152 Citations (Scopus)

Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-β

Wu, M., Melichian, D. S., Chang, E., Warner-Blankenship, M., Ghosh, A. K. & Varga, J., Jan 1 2009, In : American Journal of Pathology. 174, 2, p. 519-533 15 p.

Research output: Contribution to journalArticle

rosiglitazone
Peroxisome Proliferator-Activated Receptors
Bleomycin
Transforming Growth Factors
Skin
15 Citations (Scopus)
Transducers
Epidermal Growth Factor Receptor
Hypertrophy
Cardiomegaly
Isoproterenol
15 Citations (Scopus)

Targeted expression of receptor-associated late transducer inhibits maladaptive hypertrophy via blocking epidermal growth factor receptor signaling

Cai, J., Yi, F. F., Yang, L., Shen, D. F., Yang, Q., Li, A., Ghosh, A. K., Bian, Z. Y., Yan, L., Tang, Q. Z., Li, H. & Yang, X. C., Mar 1 2009, In : Hypertension. 53, 3, p. 539-548 10 p.

Research output: Contribution to journalArticle

Transducers
Epidermal Growth Factor Receptor
Hypertrophy
Cardiomegaly
Isoproterenol
2008
33 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
Fibroblasts
Gene expression
Collagen
Transforming Growth Factors
103 Citations (Scopus)

Curcumin prevents and reverses murine cardiac hypertrophy

Li, H. L., Liu, C., De Couto, G., Ouzounian, M., Sun, M., Wang, A. B., Huang, Y., He, C. W., Shi, Y., Chen, X., Nghiem, M. P., Liu, Y., Chen, M., Dawood, F., Fukuoka, M., Maekawa, Y., Zhang, L., Leask, A., Ghosh, A. K., Kirshenbaum, L. A. & 1 others, Liu, P. P., Jan 1 2008, In : Journal of Clinical Investigation. 118, 3, p. 879-893 15 p.

Research output: Contribution to journalArticle

Curcumin
Cardiomegaly
Acetylation
Histones
Histone Acetyltransferases
2007
71 Citations (Scopus)

Trichostatin A blocks TGF-β-induced collagen gene expression in skin fibroblasts: Involvement of Sp1

Ghosh, A. K., Mori, Y., Dowling, E. & Varga, J., Mar 9 2007, In : Biochemical and Biophysical Research Communications. 354, 2, p. 420-426 7 p.

Research output: Contribution to journalArticle

trichostatin A
Transforming Growth Factors
Fibroblasts
Gene expression
Skin
2006
29 Citations (Scopus)
CCAAT-Enhancer-Binding Proteins
Gene expression
Interferons
Collagen
Gene Expression
2005
65 Citations (Scopus)

Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor β

Bhattacharyya, S., Ghosh, A. K., Pannu, J., Mori, Y., Takagawa, S., Chen, G., Trojanowska, M., Gilliam, A. C. & Varga, J., Apr 1 2005, In : Arthritis and rheumatism. 52, 4, p. 1248-1258 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Fibroblasts
Catalytic RNA
Skin
Systemic Scleroderma
40 Citations (Scopus)

Transforming growth factor β facilitates β-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner

Ray, D., Terao, Y., Nimbalkar, D., Chu, L. H., Donzelli, M., Tsutsui, T., Zou, X., Ghosh, A. K., Varga, J., Draetta, G. F. & Kiyokawa, H., Apr 1 2005, In : Molecular and cellular biology. 25, 8, p. 3338-3347 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Ubiquitination
Small Interfering RNA
Mutant Proteins
Ubiquitin
2004
159 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
Transforming Growth Factors
Fibroblasts
Skin
Myofibroblasts
43 Citations (Scopus)
Transforming Growth Factors
Tumors
Collagen
Genes
Fibroblasts
2001
203 Citations (Scopus)
p300-CBP Transcription Factors
Transforming Growth Factors
Collagen Type I
Gene expression
Interferons
39 Citations (Scopus)

A Nucleoprotein Complex containing CCAAT/Enhancer-binding Protein β Interacts with an Insulin Response Sequence in the Insulin-like Growth Factor-binding Protein-1 Gene and Contributes to Insulin-regulated Gene Expression

Ghosh, A. K., Lacson, R., Liu, P., Cichy, S. B., Danilkovich, A., Guo, S. & Unterman, T. G., Mar 16 2001, In : Journal of Biological Chemistry. 276, 11, p. 8507-8515 9 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Insulin-Like Growth Factor Binding Protein 1
Nucleoproteins
Gene expression
Genes
80 Citations (Scopus)

Insulin suppresses transactivation by CAAT/Enhancer-binding proteins β (C/EBPβ). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPβ

Guo, S., Cichy, S. B., He, X., Yang, Q., Ragland, M., Ghosh, A. K., Johnson, P. F. & Unterman, T. G., Mar 16 2001, In : Journal of Biological Chemistry. 276, 11, p. 8516-8523 8 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
CCAAT-Enhancer-Binding Proteins
Proto-Oncogene Proteins c-akt
Transcriptional Activation
Chemical activation
2000
166 Citations (Scopus)
CREB-Binding Protein
Fibroblast Growth Factors
Transforming Growth Factors
Collagen Type I
Gene Expression
1999
16 Citations (Scopus)

Control of RNA polymerase I-directed transcription: Recent trends

Jacob, S. T. & Ghosh, A. K., Dec 1 1999, In : Journal of Cellular Biochemistry. 76, SUPPL. 32/33, p. 41-50 10 p.

Research output: Contribution to journalArticle

Upstream Stimulatory Factors
Genetic Transcription
RNA Polymerase I
Repressor Proteins
Polyomavirus Transforming Antigens
1997
31 Citations (Scopus)

The dual role of helix - loop - helix-zipper protein USF in ribosomal RNA gene transcription in vivo

Ghosh, A. K., Datta, P. K. & Jacob, S. T., Jan 1 1997, In : Oncogene. 14, 5, p. 589-594 6 p.

Research output: Contribution to journalArticle

Ribosomal DNA
rRNA Genes
Transfection
Proteins
Complementary DNA
1996
2 Citations (Scopus)
RNA Polymerase I
Species Specificity
Ribosomal RNA
Transcription
Ribosomal DNA

Role of use a helix-loop-helk-zipper dna binding protein, in rRNA gene regulation

Ghosh, A. K., Datta, P. K. & Jacob, S. T., Dec 1 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

Fasteners
Transcription
Ribosomal DNA
rRNA Genes
Gene expression
1995
15 Citations (Scopus)
Upstream Stimulatory Factors
Core Binding Factors
RNA Polymerase I
Fasteners
DNA-Binding Proteins
1994
4 Citations (Scopus)

Effects of repetitive and non-repetitive rat rDNA enhancer elements on in vivo transcription by RNA polymerases I and II

Ghosh, A. K., Kermekchiev, M. & Jacob, S. T., Apr 20 1994, In : Gene. 141, 2, p. 271-275 5 p.

Research output: Contribution to journalArticle

RNA Polymerase I
RNA Polymerase II
Ribosomal DNA
CHO Cells
Metallothionein
44 Citations (Scopus)

Enhancer 1 binding factor, a Ku-related protein, is a positive regulator of RNA polymerase I transcription initiation

Hoff, C. M., Ghosh, A. K., Prabhakar, B. S. & Jacob, S. T., Jan 18 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 2, p. 762-766 5 p.

Research output: Contribution to journalArticle

RNA Polymerase I
Antibodies
rRNA Genes
Peptide Fragments
Proteins
1993
14 Citations (Scopus)

Characterization of the 130-bp repeat enhancer element of the rat ribosomal gene: functional interaction with transcription factor E1BF

Ghosh, A. K., Hoff, C. M. & Jacob, S. T., Mar 30 1993, In : Gene. 125, 2, p. 217-222 6 p.

Research output: Contribution to journalArticle

Ribosomal DNA
Transcription Factors
Genes
rRNA Genes
Plasmids
1992
Trisomy
X Chromosome
Chromosomes
Drosophila melanogaster
Genetic programming
1990
1 Citation (Scopus)
Drosophila melanogaster
Shock
Hot Temperature
Nuclear RNA
Uridine
1989
2 Citations (Scopus)

Autosomal dosage compensation in interspecific hybrids of drosophila: Transcriptional activity in diploid and triploid hybrids

Ghosh, A. K., Ghosh, M. & Mukherjee, A. S., Jan 1 1989, In : Current Science. 58, 16, p. 907-911 5 p.

Research output: Contribution to journalArticle

triploidy
Drosophila
diploidy
dosage
Drosophila melanogaster
1988
1 Citation (Scopus)
Genetic Transcription
Chromosomes
Drosophila melanogaster
Chromosome Aberrations
Animals
1986
1 Citation (Scopus)

Transcriptive activity of a hyperploid autosomal arm in Drosophila melanogaster.

Ghosh, A. K., Sep 1 1986, In : Indian Journal of Experimental Biology. 24, 9, p. 555-560 6 p.

Research output: Contribution to journalArticle

Genetic Transcription
Trisomy
X Chromosome
Drosophila melanogaster
Animals