• 3268 Citations
20042020

Research output per year

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Personal profile

Research Interests

One of the fundamental observations in oncology is that increasing age is the strongest statistic variable that predicts for carcinogenesis. A fact that has emerged over the last several years is that aging is a complex process that appears to be regulated, at least in part, by sirtuins, a relatively new gene family that was initially identified in S. cerevisiae and C. elegans. In this regard, it has been found that they can both increase life span and decrease spontaneous tumor development suggesting that they may regulate both processes. They appear to function as fidelity proteins and loss or decrease of function, which may occur during aging, creates a cell environment permissive for several age-related illnesses, including cancer. The significant role played by sirtuins can be explained by accumulating evidence establishing their pivotal role in regulating post-translational modifications (PTMs) in both histone and non-histone proteins involved in diverse cellular processes. Despite increasing scientific interest, there is still scarcity regarding the context-dependent functions regulated by sirtuins. By blending classic molecular/ cellular biology, biochemistry, mouse genetics and state of the art novel technologies including high throughput screens and large-scale proteomics, our ultimate research goal is to elucidate how sirtuins regulate cellular homeostasis and explore the potential implications of these findings in preclinical studies. Given the multifaceted functions of sirtuins, our research is aimed at filling current knowledge gaps in the field which will provide the basis for developing novel strategies to prevent and/or cure cancer.

Education/Academic qualification

PhD, National and Kapodistrian University of Athens

… → 2005

Research interests

  • Aging
  • Breast Cancer
  • Cancer Biology
  • Molecular Genetics
  • Nutritional and Metabolic Diseases
  • Pancreatic Cancer
  • Proteomics
  • Radiation Oncology

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Grants

  • Research Output

    • 3268 Citations
    • 32 Article
    • 6 Review article
    • 1 Chapter
    • 1 Short survey

    Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet

    Ahmed, M. A., O'Callaghan, C., Chang, E. D., Jiang, H. & Vassilopoulos, A., Jan 8 2020, In : Frontiers in Oncology. 9, 1462.

    Research output: Contribution to journalArticle

    Open Access
  • Sirtuin 2–mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses

    Kosciuczuk, E. M., Mehrotra, S., Saleiro, D., Kroczynska, B., Majchrzak-Kita, B., Lisowski, P., Driehaus, C., Rogalska, A., Turner, A., Lienhoop, T., Gius, D., Fish, E. N., Vassilopoulos, A. & Platanias, L. C., Jan 18 2019, In : Journal of Biological Chemistry. 294, 3, p. 827-837 11 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy

    Gano, L. B., Liang, L. P., Ryan, K., Michel, C. R., Gomez, J., Vassilopoulos, A., Reisdorph, N., Fritz, K. S. & Patel, M., Aug 1 2018, In : Free Radical Biology and Medicine. 123, p. 116-124 9 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Inhibition of sirtuin 6 induces neuroblastoma differentiation

    Song, H. Y., Rellinger, E. J., Park, S. H., Paul, P., Qiao, J., Vasilopoulos, A., Ozden, O., Gius, D. & Chung, D. H., Feb 2018, In : Anticancer research. 38, 2, p. 647-654 8 p.

    Research output: Contribution to journalArticle

  • 8 Scopus citations

    Mammalian Sirtuins, Cellular Energy Regulation, and Metabolism, and Carcinogenesis

    Vassilopoulos, A., Wang, R. H. & Gius, D., Apr 25 2018, Introductory Review on Sirtuins in Biology, Aging, and Disease. Elsevier, p. 141-154 14 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter