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Personal profile

Research Interests

One of the fundamental observations in oncology is that increasing age is the strongest statistic variable that predicts for carcinogenesis. A fact that has emerged over the last several years is that aging is a complex process that appears to be regulated, at least in part, by sirtuins, a relatively new gene family that was initially identified in S. cerevisiae and C. elegans. In this regard, it has been found that they can both increase life span and decrease spontaneous tumor development suggesting that they may regulate both processes. They appear to function as fidelity proteins and loss or decrease of function, which may occur during aging, creates a cell environment permissive for several age-related illnesses, including cancer. The significant role played by sirtuins can be explained by accumulating evidence establishing their pivotal role in regulating post-translational modifications (PTMs) in both histone and non-histone proteins involved in diverse cellular processes. Despite increasing scientific interest, there is still scarcity regarding the context-dependent functions regulated by sirtuins. By blending classic molecular/ cellular biology, biochemistry, mouse genetics and state of the art novel technologies including high throughput screens and large-scale proteomics, our ultimate research goal is to elucidate how sirtuins regulate cellular homeostasis and explore the potential implications of these findings in preclinical studies. Given the multifaceted functions of sirtuins, our research is aimed at filling current knowledge gaps in the field which will provide the basis for developing novel strategies to prevent and/or cure cancer.

Education/Academic qualification

PhD, University of Athens

… → 2005

Research interests

  • Aging
  • Breast Cancer
  • Cancer Biology
  • Molecular Genetics
  • Nutritional and Metabolic Diseases
  • Pancreatic Cancer
  • Proteomics
  • Radiation Oncology

Fingerprint Dive into the research topics where Athanasios Vasilopoulos is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Sirtuins Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Acetylation Medicine & Life Sciences
Carcinogenesis Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
Sirtuin 2 Medicine & Life Sciences
Cyclin-Dependent Kinase 9 Medicine & Life Sciences
Proteins Medicine & Life Sciences

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Grants 2014 2021

Triple Negative Breast Neoplasms
Neoplasms
Breast Neoplasms
Therapeutics
Mutation
Ionizing Radiation
Carcinogenesis
Neoplasms
Acetylation
Therapeutics
Acetylation
Carcinogenesis
Breast
Neoplasms

Research Output 2004 2019

  • 2951 Citations
  • 31 Article
  • 6 Review article
  • 1 Short survey
1 Citation (Scopus)

Sirtuin 2–mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses

Kosciuczuk, E. M., Mehrotra, S., Nora Vaz Saleiro, D., Kroczynska, B., Majchrzak-Kita, B., Lisowski, P., Driehaus, C., Rogalska, A., Turner, A., Lienhoop, T., Gius, D. R., Fish, E. N., Vasilopoulos, A. & Platanias, L. C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 3, p. 827-837 11 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 9
Interferon Type I
Sirtuin 2
Interferons
Transcription
3 Citations (Scopus)

Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy

Gano, L. B., Liang, L. P., Ryan, K., Michel, C. R., Gomez, J., Vasilopoulos, A., Reisdorph, N., Fritz, K. S. & Patel, M., Aug 1 2018, In : Free Radical Biology and Medicine. 123, p. 116-124 9 p.

Research output: Contribution to journalArticle

Acetylation
Temporal Lobe Epilepsy
Kainic Acid
Rats
Epilepsy
6 Citations (Scopus)

Inhibition of sirtuin 6 induces neuroblastoma differentiation

Song, H. Y., Rellinger, E. J., Park, S. H., Paul, P., Qiao, J., Vasilopoulos, A., Ozden, O., Gius, D. R. & Chung, D. H., Feb 1 2018, In : Anticancer research. 38, 2, p. 647-654 8 p.

Research output: Contribution to journalArticle

Sirtuins
Neuroblastoma
Niacinamide
G1 Phase Cell Cycle Checkpoints
Genomic Instability

NQO1 regulates mitotic progression and response to mitotic stress through modulating SIRT2 activity

Kang, H. J., Song, H. Y., Ahmed, M. A., Guo, Y., Zhang, M., Chen, C., Cristofanilli, M., Horiuchi, D. & Vasilopoulos, A., Oct 1 2018, In : Free Radical Biology and Medicine. 126, p. 358-371 14 p.

Research output: Contribution to journalArticle

Mitosis
NAD
Proteins
Poisons
Cell death
26 Citations (Scopus)

Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

Yang, X., Park, S. H., Chang, H. C., Shapiro, J. S., Vasilopoulos, A., Sawicki, K. T., Chen, C., Shang, M., Burridge, P., Epting, C. L., Wilsbacher, L. D., Jenkitkasemwong, S., Knutson, M., Gius, D. R. & Ardehali, H., Apr 3 2017, In : Journal of Clinical Investigation. 127, 4, p. 1505-1516 12 p.

Research output: Contribution to journalArticle

Sirtuin 2
Homeostasis
Transcription Factors
Iron
Lysine