Grants per year
Personal profile
Research Interests
The focus of my laboratory research is to elucidate the mechanisms of therapeutic resistance in brain tumor. We are particularly interested in investigating the role of cellular plasticity in promoting the cancer stem cell niche and disease recurrence.
Training Experience
| 2009 | Postdoctoral Fellowship, Mayo Medical School |
Education/Academic qualification
PhD, Mayo Medical School
… → 2007
Keywords
- Bioengineering
- Brain Cancer / Nervous System Cancer
- Cancer Biology
- Cancer Genetics
- Cell Biology
- Cell Imaging
- Chemotherapy
- Gene Therapy
- Stem Cells
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- 6 Similar Profiles
Glioma
Medicine & Life Sciences
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Medicine & Life Sciences
Neural Stem Cells
Medicine & Life Sciences
Neoplasms
Medicine & Life Sciences
Oncolytic Virotherapy
Medicine & Life Sciences
Brain Neoplasms
Medicine & Life Sciences
Adenoviridae
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Stem Cells
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2015 2023
SPORE for Translational Approaches to Brain Cancer
Ahmed, A. U., Balyasnikova, I. V., Bartom, E. T., Brat, D. J., Chandler, J. P., Cheng, S., Horbinski, C. M., Hu, B., James, C. D., Kumthekar, P. U., Leikin, R. G., Lesniak, M. S., Liu, B. P., Lukas, R. V., Mirkin, C. A., Platanias, L. C., Sachdev, S., Scholtens, D. M., Stegh, A. H., Stupp, R. & Wainwright, D. A.
8/17/18 → 7/31/23
Project: Research project
Brain Neoplasms
Glioblastoma
Therapeutics
Neoplasms
Survival
Cellular plasticity and equilibrium in GBM progression
Ahmed, A. U., Horbinski, C. M., James, C. D. & Shilatifard, A.
National Institute of Neurological Disorders and Stroke
4/1/17 → 1/31/22
Project: Research project
Neoplastic Stem Cells
Recurrence
Heterografts
Disease Progression
Neoplasms
Stem Cell Niche
Glioma
Glioblastoma
Stem Cells
Drug Therapy
Therapeutic Targeting of Malignant Glioma Stem Cells
Ahmed, A. U., Lesniak, M. S. & Yu, D.
11/1/15 → 7/31/22
Project: Research project
Glioma
Stem Cells
Therapeutics
Brain Neoplasms
Genetic Therapy
THE ROLE OF LNX1 IN GLIOMA STEM CELL EXPANSION
Neurosurgery Research and Education Foundation
4/25/18 → 10/25/18
Project: Research project
Glioma
Stem Cells
Glioblastoma
Neoplasms
Neuroglia
Research Output 2001 2019
Activation of dopamine receptor 2 prompts transcriptomic and metabolic plasticity in glioblastoma
Caragher, S. P., Shireman, J. M., Huang, M., Miska, J., Atashi, F., Baisiwala, S., Park, C. H., Saathoff, M. R., Warnke, L., Xiao, T., Lesniak, M. S., David James, C., Meltzer, H. Y., Tryba, A. K. & Ahmed, A. U., Mar 13 2019, In : Journal of Neuroscience. 39, 11, p. 1982-1993 12 p.Research output: Contribution to journal › Article
Dopamine Receptors
Glioblastoma
Dopamine
Neurotransmitter Agents
Tumor Microenvironment
Glioblastoma Recurrence and the Role of O 6 -Methylguanine-DNA Methyltransferase Promoter Methylation
Storey, K., Leder, K., Hawkins-Daarud, A., Swanson, K., Ahmed, A. U., Rockne, R. C. & Foo, J., Feb 1 2019, In : JCO clinical cancer informatics. 3, p. 1-12 12 p.Research output: Contribution to journal › Article
temozolomide
O(6)-Methylguanine-DNA Methyltransferase
Methyltransferases
Glioblastoma
Methylation
HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma
Miska, J., Lee Chang, C., Rashidi, A., Muroski, M. E., Chang, A. L., Lopez-Rosas, A., Zhang, P., Panek, W. K., Cordero, A., Han, Y., Ahmed, A. U., Chandel, N. & Lesniak, M. S., Apr 2 2019, In : Cell reports. 27, 1, p. 226-237.e4Research output: Contribution to journal › Article
Open Access
Hypoxia-Inducible Factor 1
Oxidative Phosphorylation
Glioblastoma
Immunosuppression
Switches
Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma
Hasan, T., Caragher, S. P., Shireman, J. M., Park, C. H., Atashi, F., Baisiwala, S., Lee, G., Guo, D., Wang, J. Y., Dey, M., Wu, M., Lesniak, M. S., Horbinski, C. M., James, C. D. & Ahmed, A. U., Apr 1 2019, In : Cell Death and Disease. 10, 4, 292.Research output: Contribution to journal › Article
Open Access
Glioblastoma
Interleukin-8
Glioma
Atlases
temozolomide
2
Citations
(Scopus)
A Dendritic Cell-Targeted Adenoviral Vector Facilitates Adaptive Immune Response Against Human Glioma Antigen (CMV-IE) and Prolongs Survival in a Human Glioma Tumor Model
Kim, J. W., Kane, J. R., Panek, W. K., Young, J. S., Rashidi, A., Yu, D., Kanojia, D., Hasan, T., Miska, J., Gómez-Lim, M. A., Ulasov, I., Balyasnikova, I. V., Ahmed, A. U., Wainwright, D. A. & Lesniak, M. S., Oct 14 2018, In : Neurotherapeutics. 15, 4, p. 1127-1138 12 p.Research output: Contribution to journal › Article
Adaptive Immunity
Glioma
Dendritic Cells
Antigens
Survival