Grants per year
Personal profile
Research Interests
The focus of my laboratory research is to elucidate the mechanisms of therapeutic resistance in brain tumor. We are particularly interested in investigating the role of cellular plasticity in promoting the cancer stem cell niche and disease recurrence.
Training Experience
| 2009 | Postdoctoral Fellowship, Mayo Medical School |
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Mayo Medical School
… → 2007
Research interests
- Bioengineering
- Brain Cancer / Nervous System Cancer
- Cancer Biology
- Cancer Genetics
- Cell Biology
- Cell Imaging
- Chemotherapy
- Gene Therapy
- Stem Cells
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Role of purine metabolism in chemoresistance
Ahmed, A. U., Ben-Sahra, I. & Horbinski, C. M.
National Institute of Neurological Disorders and Stroke
9/1/19 → 6/30/24
Project: Research project
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SPORE for Translational Approaches to Brain Cancer
Lesniak, M. S., Chandler, J. P., Hu, B., Kumthekar, P. U., Leikin, R. G., Liu, B. P., Sachdev, S., Ahmed, A. U., Balyasnikova, I. V., Bartom, E. T., Brat, D. J., Cheng, S., Horbinski, C. M., James, C. D., Lukas, R. V., Platanias, L. C., Scholtens, D. M., Stegh, A. H., Stupp, R. & Wainwright, D. A.
8/17/18 → 7/31/23
Project: Research project
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Cellular plasticity and equilibrium in GBM progression
Ahmed, A. U., Horbinski, C. M., James, C. D. & Shilatifard, A.
National Institute of Neurological Disorders and Stroke
4/1/17 → 1/31/22
Project: Research project
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De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma
Shireman, J. M., Atashi, F., Lee, G., Ali, E. S., Saathoff, M. R., Park, C. H., Savchuk, S., Baisiwala, S., Miska, J., Lesniak, M. S., James, C. D., Stupp, R., Kumthekar, P., Horbinski, C. M., Ben-Sahra, I. & Ahmed, A. U., Apr 1 2021, In: Brain. 144, 4, p. 1230-1246 17 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Molecular Classification of Gliomas is Associated with Seizure Control: A Retrospective Analysis
Easwaran, T. P., Lancki, N., Henriquez, M., Vortmeyer, A. O., Barbaro, N. M., Scholtens, D. M., Ahmed, A. U. & Dey, M., Jun 2021, In: Neuromolecular medicine. 23, 2, p. 315-326 12 p.Research output: Contribution to journal › Article › peer-review
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Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial
Fares, J., Ahmed, A. U., Ulasov, I., Sonabend Worthalter, A. M., Miska, J. M., Lee Chang, C., Balyasnikova, I. V., Chandler, J. P., Portnow, J., Tate, M. C., Kumthekar, P. U., Lukas, R. V., Grimm, S. A., Adams, A. K., Hébert, C. D., Strong, T. V., Amidei, C., Arrieta, V. A., Zannikou, M., Horbinski, C. M. & 7 others, , Aug 2021, In: The Lancet Oncology. 22, 8, p. 1103-1114 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
BET inhibition increases βIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine
Kanojia, D., Panek, W. K., Cordero, A., Fares, J., Xiao, A., Savchuk, S., Kumar, K., Xiao, T., Pituch, K. C., Miska, J., Zhang, P., Kam, K. L., Horbinski, C., Balyasnikova, I. V., Ahmed, A. U. & Lesniak, M. S., Aug 2020, In: Science translational medicine. 12, 558, eaax2879.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
LNX1 modulates Notch1 signaling to promote expansion of the glioma stem cell population during temozolomide therapy in glioblastoma
Baisiwala, S., Hall, R. R., Saathoff, M. R., Shireman, J. M., Park, C., Budhiraja, S., Goel, C., Warnke, L., Hardiman, C., Wang, J. Y., McCortney, K., Horbinski, C. M. & Ahmed, A. U., Dec 2020, In: Cancers. 12, 12, p. 1-19 19 p., 3505.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations