Grants per year
Personal profile
Research Interests
The focus of my laboratory research is to elucidate the mechanisms of therapeutic resistance in brain tumor. We are particularly interested in investigating the role of cellular plasticity in promoting the cancer stem cell niche and disease recurrence.
Training Experience
2009 | Postdoctoral Fellowship, Mayo Medical School |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Mayo Medical School
… → 2007
Research interests keywords
- Bioengineering
- Brain Cancer / Nervous System Cancer
- Cancer Biology
- Cancer Genetics
- Cell Biology
- Cell Imaging
- Chemotherapy
- Gene Therapy
- Stem Cells
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Collaborations and top research areas from the last five years
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Project 4
Ahmed, A. U. (Co-Investigator), Ahmed, A. U. (Co-Investigator), Ganger, D. R. (Co-Investigator), Ganger, D. R. (Co-Investigator), Kumthekar, P. U. (Co-Investigator), Kumthekar, P. U. (Co-Investigator), Miska, J. M. (Co-Investigator), Miska, J. M. (Co-Investigator), Stupp, R. (Co-Investigator) & Stupp, R. (Co-Investigator)
8/1/23 → 7/31/28
Project: Research project
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The hypoxic niche in glioblastoma is maintained by myeloid produced creatine
Miska, J. M. (PD/PI), Miska, J. M. (PD/PI), Ahmed, A. U. (Co-Investigator), Ahmed, A. U. (Co-Investigator), Brat, D. J. (Co-Investigator), Brat, D. J. (Co-Investigator), Lee Chang, C. (Co-Investigator) & Lee Chang, C. (Co-Investigator)
4/1/23 → 3/31/28
Project: Research project
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Cellular Plasticity and equilibrium in GBM Progression
Ahmed, A. U. (PD/PI), Ahmed, A. U. (PD/PI), Ben-Sahra, I. (Co-Investigator), Ben-Sahra, I. (Co-Investigator), James, C. D. (Co-Investigator), James, C. D. (Co-Investigator), Miska, J. M. (Co-Investigator), Miska, J. M. (Co-Investigator), Zhang, H. (Other) & Zhang, H. (Other)
National Institute of Neurological Disorders and Stroke
7/15/22 → 5/31/27
Project: Research project
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Role of purine metabolism in chemoresistance
Ahmed, A. U. (PD/PI), Ahmed, A. U. (PD/PI), Ahmed, A. U. (PD/PI), Ben-Sahra, I. (Co-PD/PI), Ben-Sahra, I. (Co-PD/PI), Ben-Sahra, I. (Co-PD/PI), Horbinski, C. M. (Co-Investigator), Horbinski, C. M. (Co-Investigator) & Horbinski, C. M. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
9/1/19 → 6/30/25
Project: Research project
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Elucidating the Role of R-loops as Modulators of Glioblastoma Aggression
Ahmed, A. U. (PD/PI)
American Brain Tumor Association
6/1/22 → 8/31/22
Project: Research project
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A covalent creatine kinase inhibitor ablates glioblastoma migration and sensitizes tumors to oxidative stress
Katz, J. L., Geng, Y., Billingham, L. K., Sadagopan, N. S., DeLay, S. L., Subbiah, J., Chia, T. Y., McManus, G., Wei, C., Wang, H., Lin, H., Silvers, C., Boland, L. K., Wang, S., Wan, H., Hou, D., Vázquez-Cervantes, G. I., Arjmandi, T., Shaikh, Z. H. & Zhang, P. & 5 others, , Dec 2024, In: Scientific reports. 14, 1, 21959.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
ARF4-mediated retrograde trafficking as a driver of chemoresistance in glioblastoma
Budhiraja, S., McManus, G., Baisiwala, S., Perrault, E. N., Cho, S., Saathoff, M., Chen, L., Park, C. H., Kazi, H. A., Dmello, C., Lin, P., James, C. D., Sonabend, A. M., Heiland, D. H. & Ahmed, A. U., Aug 1 2024, In: Neuro-oncology. 26, 8, p. 1421-1437 17 p.Research output: Contribution to journal › Article › peer-review
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B cell–based therapy produces antibodies that inhibit glioblastoma growth
Wang, S., Castro, B. A., Katz, J. L., Arrieta, V., Najem, H., Vazquez-Cervantes, G. I., Wan, H., Olson, I. E., Hou, D., Dapash, M., Billingham, L. K., Chia, T. Y., Wei, C., Rashidi, A., Platanias, L. C., McCortney, K., Horbinski, C. M., Stupp, R., Zhang, P. & Ahmed, A. U. & 8 others, , Oct 15 2024, In: Journal of Clinical Investigation. 134, 20, e177384.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Genomic analysis of human brain metastases treated with stereotactic radiosurgery reveals unique signature based on treatment failure
Shireman, J. M., White, Q., Ni, Z., Mohanty, C., Cai, Y., Zhao, L., Agrawal, N., Gonugunta, N., Wang, X., Mccarthy, L., Kasulabada, V., Pattnaik, A., Ahmed, A. U., Miller, J., Kulwin, C., Cohen-Gadol, A., Payner, T., Lin, C. T., Savage, J. J. & Lane, B. & 7 others, , Apr 19 2024, In: iScience. 27, 4, 109601.Research output: Contribution to journal › Article › peer-review
Open Access -
Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth
Rashidi, A., Billingham, L. K., Zolp, A., Chia, T. Y., Silvers, C., Katz, J. L., Park, C. H., Delay, S., Boland, L., Geng, Y., Markwell, S. M., Dmello, C., Arrieta, V. A., Zilinger, K., Jacob, I. M., Lopez-Rosas, A., Hou, D., Castro, B., Steffens, A. M. & McCortney, K. & 14 others, , Jan 2 2024, In: Cell Metabolism. 36, 1, p. 62-77.e8Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations
Datasets
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Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters
Kim, J. W. (Creator), Auffinger, B. (Creator), Spencer, D. A. (Creator), Miska, J. (Creator), Chang, A. L. (Creator), Kane, J. R. (Creator), Young, J. S. (Creator), Kanojia, D. (Creator), Qiao, J. (Creator), Mann, J. F. (Creator), Zhang, L. (Contributor), Wu, M. (Contributor), Ahmed, A. U. (Contributor), Aboody, K. S. (Creator), Strong, T. V. (Creator), Hébert, C. D. (Creator) & Lesniak, M. S. (Creator), figshare, 2016
DOI: 10.6084/m9.figshare.c.3624035, https://figshare.com/collections/Single_dose_GLP_toxicity_and_biodistribution_study_of_a_conditionally_replicative_adenovirus_vector_CRAd-S-pk7_administered_by_intracerebral_injection_to_Syrian_hamsters/3624035
Dataset