• 3984 Citations
20032020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research Interests

Local immunity in the airway; airway epithelial cell biology; mast cell biology; the pathogenesis of chronic rhinosinusitis. A long-recognized property of airway epithelial cells is their function as a complex physical barrier that defends against exposure to potentially harmful inhaled substances and microbial pathogens. It is now clear that airway epithelial cells also regulate both innate and adaptive immunity through production of functional molecules and via physical interactions with immune cells. Our laboratory is focused on the role of epithelial cytokines including BAFF, TSLP and IL-1 family cytokines in the initiation and activation of airway inflammation. Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the sinuses and upper airways that affects over 20 million Americans. Current medications have variable efficacy and over 250,000 surgical procedures are performed annually in the United States on patients who failed maximal medical therapy. Our laboratory investigates the pathogenesis of CRS. We are currently focused on the role of epithelial cells and inflammatory cells including B cells, T cells, macrophages, eosinophils, mast cells and innate lymphoid cells in patients with CRS.

Education/Academic qualification

PhD, Kochi Medical School

… → 2004

Research interests

  • Allergies
  • Asthma
  • Cytokines
  • Gene Regulation
  • Immunology
  • Inflammation
  • Respiratory Diseases
  • Signal Transduction

Fingerprint Dive into the research topics where Atsushi Kato is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 12 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants

  • Research Output

    Activation of the 15-lipoxygenase pathway in aspirin-exacerbated respiratory disease

    Stevens, W. W., Staudacher, A. G., Hulse, K. E., Carter, R. G., Winter, D. R., Kato, A., Suh, L., Norton, J. E., Huang, J. H., Peters, A. T., Grammer, L. C., Price, C. P. E., Conley, D. B., Smith, S. S., Tan, B. K., Welch, K. C., Kern, R. C. & Schleimer, R. P., Jan 1 2020, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

    Research output: Contribution to journalArticle

    Open Access
  • Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps

    Ogasawara, N., Poposki, J. A., Klingler, A. I., Tan, B. K., Hulse, K. E., Stevens, W. W., Peters, A. T., Grammer, L. C., Welch, K. C., Smith, S. S., Conley, D. B., Raviv, J. R., Soroosh, P., Takano, K. I., Himi, T., Kern, R. C., Schleimer, R. P. & Kato, A., Jan 1 2020, In : Mucosal Immunology. 13, 1, p. 86-95 10 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    TNF induces production of type 2 cytokines in human group 2 innate lymphoid cells

    Ogasawara, N., Poposki, J. A., Klingler, A. I., Tan, B. K., Hulse, K. E., Stevens, W. W., Peters, A. T., Grammer, L. C., Welch, K. C., Smith, S. S., Conley, D. B., Takano, K. I., Himi, T., Kern, R. C., Schleimer, R. P. & Kato, A., Jan 2020, In : Journal of Allergy and Clinical Immunology. 145, 1, p. 437-440.e8

    Research output: Contribution to journalArticle

    2 Scopus citations

    Use of endotypes, phenotypes, and inflammatory markers to guide treatment decisions in chronic rhinosinusitis

    Staudacher, A. G., Peters, A. T., Kato, A. & Stevens, W. W., Apr 2020, In : Annals of Allergy, Asthma and Immunology. 124, 4, p. 318-325 8 p.

    Research output: Contribution to journalReview article

  • 1 Scopus citations
  • 23 Scopus citations