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Personal profile

Research Interests

Local immunity in the airway; airway epithelial cell biology; mast cell biology; the pathogenesis of chronic rhinosinusitis. A long-recognized property of airway epithelial cells is their function as a complex physical barrier that defends against exposure to potentially harmful inhaled substances and microbial pathogens. It is now clear that airway epithelial cells also regulate both innate and adaptive immunity through production of functional molecules and via physical interactions with immune cells. Our laboratory is focused on the role of epithelial cytokines including BAFF, TSLP and IL-1 family cytokines in the initiation and activation of airway inflammation. Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the sinuses and upper airways that affects over 20 million Americans. Current medications have variable efficacy and over 250,000 surgical procedures are performed annually in the United States on patients who failed maximal medical therapy. Our laboratory investigates the pathogenesis of CRS. We are currently focused on the role of epithelial cells and inflammatory cells including B cells, T cells, macrophages, eosinophils, mast cells and innate lymphoid cells in patients with CRS.

Education/Academic qualification

PhD, Kochi Medical School

… → 2004

Research interests

  • Allergies
  • Asthma
  • Cytokines
  • Gene Regulation
  • Immunology
  • Inflammation
  • Respiratory Diseases
  • Signal Transduction

Fingerprint Dive into the research topics where Atsushi Kato is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 13 Similar Profiles
Nasal Polyps Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Cytokines Medicine & Life Sciences
Inflammation Medicine & Life Sciences
Sinusitis Medicine & Life Sciences
B-Lymphocytes Medicine & Life Sciences
Rhinitis Medicine & Life Sciences
Mast Cells Medicine & Life Sciences

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Grants 2009 2024

Natural History
Phenotype
Comorbidity
Longitudinal Studies
Bronchiectasis
Natural History
Phenotype
Comorbidity
Longitudinal Studies
Bronchiectasis

Research Output 2003 2020

Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps

Ogasawara, N., Poposki, J. A., Klingler, A. I., Tan, B. K., Hulse, K. E., Stevens, W. W., Peters, A. T., Grammer, L. C., Welch, K. C., Smith, S. S., Conley, D. B., Raviv, J. R., Soroosh, P., Takano, K. I., Himi, T., Kern, R. C., Schleimer, R. P. & Kato, A., Jan 1 2020, In : Mucosal Immunology. 13, 1, p. 86-95 10 p.

Research output: Contribution to journalArticle

Nasal Polyps
Inflammation
Cytokines
RANK Ligand
Coculture Techniques
1 Citation (Scopus)

TNF induces production of type 2 cytokines in human group 2 innate lymphoid cells

Ogasawara, N., Poposki, J. A., Klingler, A. I., Tan, B. K., Hulse, K. E., Stevens, W. W., Peters, A. T., Grammer, L. C., Welch, K. C., Smith, S. S., Conley, D. B., Takano, K. I., Himi, T., Kern, R. C., Schleimer, R. P. & Kato, A., Jan 2020, In : Journal of Allergy and Clinical Immunology. 145, 1, p. 437-440.e8

Research output: Contribution to journalArticle

Lymphocytes
Cytokines
5 Citations (Scopus)
Inflammation
Suppuration
Smell
Galectin 2
Eosinophil Cationic Protein
4 Citations (Scopus)

Group 2 Innate Lymphoid Cells in Airway Diseases

Kato, A., Jul 1 2019, In : CHEST. 156, 1, p. 141-149 9 p.

Research output: Contribution to journalReview article

Lymphocytes
Cytokines
Interleukin-7
Interleukin-13
Interleukin-5

Increased thrombin-activatable fibrinolysis inhibitor levels in patients with chronic rhinosinusitis with nasal polyps

Imoto, Y., Kato, A., Takabayashi, T., Stevens, W., Norton, J. E., Suh, L. A., Carter, R. G., Weibman, A. R., Hulse, K. E., Harris, K. E., Peters, A. T., Grammer, L. C., Tan, B. K., Welch, K., Shintani-Smith, S., Conley, D. B., Kern, R. C., Fujieda, S. & Schleimer, R. P., Dec 2019, In : Journal of Allergy and Clinical Immunology. 144, 6, p. 1566-1574.e6

Research output: Contribution to journalArticle

Carboxypeptidase B2
Nasal Polyps
Thrombin
Nasal Lavage Fluid
Chronic Disease