Grants per year
Personal profile
Research Interests
Local immunity in the airway; airway epithelial cell biology; mast cell biology; the pathogenesis of chronic rhinosinusitis. A long-recognized property of airway epithelial cells is their function as a complex physical barrier that defends against exposure to potentially harmful inhaled substances and microbial pathogens. It is now clear that airway epithelial cells also regulate both innate and adaptive immunity through production of functional molecules and via physical interactions with immune cells. Our laboratory is focused on the role of epithelial cytokines including BAFF, TSLP and IL-1 family cytokines in the initiation and activation of airway inflammation. Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the sinuses and upper airways that affects over 20 million Americans. Current medications have variable efficacy and over 250,000 surgical procedures are performed annually in the United States on patients who failed maximal medical therapy. Our laboratory investigates the pathogenesis of CRS. We are currently focused on the role of epithelial cells and inflammatory cells including B cells, T cells, macrophages, eosinophils, mast cells and innate lymphoid cells in patients with CRS.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Medical Science, Kochi Medical School
… → 2004
Research interests keywords
- Allergies
- Asthma
- Cytokines
- Gene Regulation
- Immunology
- Inflammation
- Respiratory Diseases
- Signal Transduction
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Collaborations and top research areas from the last five years
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Identification of targets and functions of TSLP in chronic rhinosinusitis with nasal polyps
Kato, A. (PD/PI) & Kato, A. (PD/PI)
AstraZeneca Pharmaceuticals LP
9/8/23 → 9/7/25
Project: Research project
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Project 2: Molecular endotypes and manifestations of chronic rhinosinusitis
Hulse, K. E. (Co-Investigator), Hulse, K. E. (Co-Investigator), Hulse, K. E. (Co-Investigator), Kern, R. C. (Co-Investigator), Kern, R. C. (Co-Investigator), Kern, R. C. (Co-Investigator), Peters, A. T. (Co-Investigator), Peters, A. T. (Co-Investigator), Peters, A. T. (Co-Investigator), Kato, A. (Other), Kato, A. (Other) & Kato, A. (Other)
National Institute of Allergy and Infectious Diseases
8/15/19 → 7/31/25
Project: Research project
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Core B: Clinical, Laboratory and Data Management Core
Kato, A. (Co-Investigator), Kato, A. (Co-Investigator), Kato, A. (Co-Investigator), Smith, S. S. (Co-Investigator), Smith, S. S. (Co-Investigator), Smith, S. S. (Co-Investigator), Tan, B.K.-H. (Co-Investigator), Tan, B.K.-H. (Co-Investigator), Tan, B.K.-H. (Co-Investigator), Kern, R. C. (Subproject PI), Kern, R. C. (Subproject PI) & Kern, R. C. (Subproject PI)
National Institute of Allergy and Infectious Diseases
8/15/19 → 7/31/25
Project: Research project
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Project 1: Mechanisms of barrier dysfunction and tissue hyperplasia in CRS
Kato, A. (PD/PI), Schleimer, R. P. (PD/PI), Schleimer, R. P. (PD/PI), Schleimer, R. P. (PD/PI), Berdnikovs, S. (Co-Investigator), Berdnikovs, S. (Co-Investigator), Berdnikovs, S. (Co-Investigator), Hulse, K. E. (Co-Investigator), Hulse, K. E. (Co-Investigator), Hulse, K. E. (Co-Investigator), Kern, R. C. (Co-Investigator), Kern, R. C. (Co-Investigator), Kern, R. C. (Co-Investigator), Peters, A. T. (Co-Investigator), Peters, A. T. (Co-Investigator), Peters, A. T. (Co-Investigator), Tan, B.K.-H. (Co-Investigator), Tan, B.K.-H. (Co-Investigator) & Tan, B.K.-H. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
8/15/19 → 7/31/25
Project: Research project
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Chronic Rhinosinusitis Integrative Studies Program 2 (CRISP2)
Kato, A. (PD/PI), Schleimer, R. P. (PD/PI), Schleimer, R. P. (PD/PI), Schleimer, R. P. (PD/PI), Schleimer, R. P. (Co-Investigator), Lindholm, P. F. (Other), Lindholm, P. F. (Other), Lindholm, P. F. (Other), Rademaker, A. W. (Other), Rademaker, A. W. (Other), Rademaker, A. W. (Other), Stevens, W. (Other), Stevens, W. (Other), Stevens, W. (Other), Welch, K. C. (Other), Welch, K. C. (Other) & Welch, K. C. (Other)
National Institute of Allergy and Infectious Diseases
8/15/19 → 7/31/25
Project: Research project
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Analysis of human neutrophils from nasal polyps by single-cell RNA sequencing reveals roles of neutrophils in chronic rhinosinusitis
Iwasaki, N., Poposki, J. A., Kidoguchi, M., Oka, A., Klingler, A. I., Stevens, W. W., Suh, L. A., Bai, J., Peters, A. T., Grammer, L. C., Welch, K. C., Smith, S. S., Conley, D. B., Bochner, B. S., Schleimer, R. P., Kern, R. C., Tan, B. K. & Kato, A., Mar 2025, In: Journal of Allergy and Clinical Immunology. 155, 3, p. 843-855 13 p.Research output: Contribution to journal › Article › peer-review
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Tezepelumab inhibits highly functional truncated thymic stromal lymphopoietin in chronic rhinosinusitis
Oka, A., Klingler, A. I., Kidoguchi, M., Poposki, J. A., Suh, L. A., Bai, J., Stevens, W. W., Peters, A. T., Grammer, L. C., Welch, K. C., Smith, S. S., Conley, D. B., Schleimer, R. P., Kern, R. C., Tan, B. K., Fujieda, S., Okano, M. & Kato, A., 2025, (Accepted/In press) In: Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Article › peer-review
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Associations Between Chronic Rhinosinusitis and the Development of Non–Cystic Fibrosis Bronchiectasis
Kim, S. L., Schwartz, B. S., Vu, T. H., Conley, D. B., Grammer, L. C., Guo, A., Kato, A., Kern, R. C., Prickett, M. H., Schleimer, R. P., Smith, S., Stevens, W. W., Suh, L., Tan, B. K., Welch, K. C. & Peters, A. T., Nov 2024, In: Journal of Allergy and Clinical Immunology: In Practice. 12, 11, p. 3116-3122.e2Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Endotypic heterogeneity and pathogenesis in chronic rhinosinusitis
Bai, J., Tan, B. K. & Kato, A., Feb 1 2024, In: Current Opinion in Allergy and Clinical Immunology. 24, 1, p. 1-8 8 p.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
IL-13 and IL-13–induced periostin levels are specifically decreased in patients following endoscopic sinus surgery for chronic rhinosinusitis
Harmon, R., Schneider, A. L., Bai, J., Racette, S. D., Reddy, A. T., Huang, J. H., Lehmann, D. S., Price, C. P. E., Rodeghiero, S., Agarwal, A., Eide, J. G., Dong, S., Conley, D. B., Welch, K. C., Kern, R. C., Shintani-Smith, S., Peters, A. T., Kato, A., Stevens, W. W. & Muhammad, L. N. & 2 others, , May 2024, In: Journal of Allergy and Clinical Immunology. 153, 5, p. 1292-1305 14 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations
Datasets
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Additional file 10 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
Soliai, M. M. (Creator), Kato, A. (Creator), Helling, B. A. (Creator), Stanhope, C. T. (Creator), Norton, J. E. (Creator), Naughton, K. A. (Creator), Klinger, A. I. (Creator), Thompson, E. E. (Creator), Clay, S. M. (Creator), Kim, S. (Creator), Celedón, J. C. (Creator), Gern, J. E. (Creator), Jackson, D. J. (Creator), Altman, M. C. (Creator), Kern, R. C. (Creator), Tan, B. K. (Creator), Schleimer, R. P. (Creator), Nicolae, D. L. (Creator), Pinto, J. M. (Creator) & Ober, C. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16780853, https://springernature.figshare.com/articles/dataset/Additional_file_10_of_Multi-omics_colocalization_with_genome-wide_association_studies_reveals_a_context-specific_genetic_mechanism_at_a_childhood_onset_asthma_risk_locus/16780853
Dataset
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Additional file 4 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
Soliai, M. M. (Creator), Kato, A. (Creator), Helling, B. A. (Creator), Stanhope, C. T. (Creator), Norton, J. E. (Creator), Naughton, K. A. (Creator), Klinger, A. I. (Creator), Thompson, E. E. (Creator), Clay, S. M. (Creator), Kim, S. (Creator), Celedón, J. C. (Creator), Gern, J. E. (Creator), Jackson, D. J. (Creator), Altman, M. C. (Creator), Kern, R. C. (Creator), Tan, B. K. (Creator), Schleimer, R. P. (Creator), Nicolae, D. L. (Creator), Pinto, J. M. (Creator) & Ober, C. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16780880, https://springernature.figshare.com/articles/dataset/Additional_file_4_of_Multi-omics_colocalization_with_genome-wide_association_studies_reveals_a_context-specific_genetic_mechanism_at_a_childhood_onset_asthma_risk_locus/16780880
Dataset
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Additional file 13 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
Soliai, M. M. (Creator), Kato, A. (Creator), Helling, B. A. (Creator), Stanhope, C. T. (Creator), Norton, J. E. (Creator), Naughton, K. A. (Creator), Klinger, A. I. (Creator), Thompson, E. E. (Creator), Clay, S. M. (Creator), Kim, S. (Creator), Celedón, J. C. (Creator), Gern, J. E. (Creator), Jackson, D. J. (Creator), Altman, M. C. (Creator), Kern, R. C. (Creator), Tan, B. K. (Creator), Schleimer, R. P. (Creator), Nicolae, D. L. (Creator), Pinto, J. M. (Creator) & Ober, C. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16780865, https://springernature.figshare.com/articles/dataset/Additional_file_13_of_Multi-omics_colocalization_with_genome-wide_association_studies_reveals_a_context-specific_genetic_mechanism_at_a_childhood_onset_asthma_risk_locus/16780865
Dataset
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Additional file 3 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
Soliai, M. M. (Creator), Kato, A. (Creator), Helling, B. A. (Creator), Stanhope, C. T. (Creator), Norton, J. E. (Creator), Naughton, K. A. (Creator), Klinger, A. I. (Creator), Thompson, E. E. (Creator), Clay, S. M. (Creator), Kim, S. (Creator), Celedón, J. C. (Creator), Gern, J. E. (Creator), Jackson, D. J. (Creator), Altman, M. C. (Creator), Kern, R. C. (Creator), Tan, B. K. (Creator), Schleimer, R. P. (Creator), Nicolae, D. L. (Creator), Pinto, J. M. (Creator) & Ober, C. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16780877, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Multi-omics_colocalization_with_genome-wide_association_studies_reveals_a_context-specific_genetic_mechanism_at_a_childhood_onset_asthma_risk_locus/16780877
Dataset
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Additional file 12 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
Soliai, M. M. (Creator), Kato, A. (Creator), Helling, B. A. (Creator), Stanhope, C. T. (Creator), Norton, J. E. (Creator), Naughton, K. A. (Creator), Klinger, A. I. (Creator), Thompson, E. E. (Creator), Clay, S. M. (Creator), Kim, S. (Creator), Celedón, J. C. (Creator), Gern, J. E. (Creator), Jackson, D. J. (Creator), Altman, M. C. (Creator), Kern, R. C. (Creator), Tan, B. K. (Creator), Schleimer, R. P. (Creator), Nicolae, D. L. (Creator), Pinto, J. M. (Creator) & Ober, C. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16780862, https://springernature.figshare.com/articles/dataset/Additional_file_12_of_Multi-omics_colocalization_with_genome-wide_association_studies_reveals_a_context-specific_genetic_mechanism_at_a_childhood_onset_asthma_risk_locus/16780862
Dataset