• 3397 Citations
20032023
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

Local immunity in the airway; airway epithelial cell biology; mast cell biology; the pathogenesis of chronic rhinosinusitis. A long-recognized property of airway epithelial cells is their function as a complex physical barrier that defends against exposure to potentially harmful inhaled substances and microbial pathogens. It is now clear that airway epithelial cells also regulate both innate and adaptive immunity through production of functional molecules and via physical interactions with immune cells. Our laboratory is focused on the role of epithelial cytokines including BAFF, TSLP and IL-1 family cytokines in the initiation and activation of airway inflammation. Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the sinuses and upper airways that affects over 20 million Americans. Current medications have variable efficacy and over 250,000 surgical procedures are performed annually in the United States on patients who failed maximal medical therapy. Our laboratory investigates the pathogenesis of CRS. We are currently focused on the role of epithelial cells and inflammatory cells including B cells, T cells, macrophages, eosinophils, mast cells and innate lymphoid cells in patients with CRS.

Education/Academic qualification

PhD, Kochi Medical School

… → 2004

Keywords

  • Allergies
  • Asthma
  • Cytokines
  • Gene Regulation
  • Immunology
  • Inflammation
  • Respiratory Diseases
  • Signal Transduction

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 17 Similar Profiles
Nasal Polyps Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Inflammation Medicine & Life Sciences
Cytokines Medicine & Life Sciences
Sinusitis Medicine & Life Sciences
B-Lymphocytes Medicine & Life Sciences
Rhinitis Medicine & Life Sciences
Mast Cells Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2009 2023

Research Output 2003 2019

Inflammation
Suppuration
Smell
Galectin 2
Eosinophil Cationic Protein

Group 2 Innate Lymphoid Cells in Airway Diseases

Kato, A., Jul 1 2019, In : CHEST. 156, 1, p. 141-149 9 p.

Research output: Contribution to journalReview article

Lymphocytes
Cytokines
Interleukin-7
Interleukin-13
Interleukin-5
4 Citations (Scopus)
Nasal Polyps
Inflammation
thymic stromal lymphopoietin
Interleukin-33
9 Citations (Scopus)

IL-10, TGF-β and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cells

Ogasawara, N., Poposki, J. A., Klingler, A. I., Tan, B. K-H., Weibman, A. R., Hulse, K. E., Stevens, W., Peters, A. T., Grammer III, L. C., Schleimer, R. P., Welch, K. C., Smith, S. S., Conley Jr, D. B., Raviv, J. R., Soroosh, P., Akbari, O., Himi, T., Kern, R. C. & Kato, A., Mar 1 2018, In : Journal of Allergy and Clinical Immunology. 141, 3, p. 1147-1151.e8

Research output: Contribution to journalArticle

Transforming Growth Factor beta
Interleukin-10
Glucocorticoids
Lymphocytes
Cytokines
2 Citations (Scopus)

Short-chain fatty acids induce tissue plasminogen activator in airway epithelial cells via GPR41&43

Imoto, Y., Kato, A., Takabayashi, T., Sakashita, M., Norton, J. E., Suh, L. A., Carter, R. G., Weibman, A. R., Hulse, K. E., Stevens, W., Harris, K. E., Peters, A. T., Grammer III, L. C., Tan, B. K-H., Welch, K. C., Conley Jr, D. B., Kern, R. C., Fujieda, S. & Schleimer, R. P., May 1 2018, In : Clinical and Experimental Allergy. 48, 5, p. 544-554 11 p.

Research output: Contribution to journalArticle

Volatile Fatty Acids
Tissue Plasminogen Activator
Epithelial Cells
Nasal Polyps
Gene Silencing