Grants per year
Personal profile
Research Interests
Local immunity in the airway; airway epithelial cell biology; mast cell biology; the pathogenesis of chronic rhinosinusitis. A long-recognized property of airway epithelial cells is their function as a complex physical barrier that defends against exposure to potentially harmful inhaled substances and microbial pathogens. It is now clear that airway epithelial cells also regulate both innate and adaptive immunity through production of functional molecules and via physical interactions with immune cells. Our laboratory is focused on the role of epithelial cytokines including BAFF, TSLP and IL-1 family cytokines in the initiation and activation of airway inflammation. Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the sinuses and upper airways that affects over 20 million Americans. Current medications have variable efficacy and over 250,000 surgical procedures are performed annually in the United States on patients who failed maximal medical therapy. Our laboratory investigates the pathogenesis of CRS. We are currently focused on the role of epithelial cells and inflammatory cells including B cells, T cells, macrophages, eosinophils, mast cells and innate lymphoid cells in patients with CRS.
Education/Academic qualification
PhD, Medical Science, Kochi Medical School
… → 2004
Research interests keywords
- Allergies
- Asthma
- Cytokines
- Gene Regulation
- Immunology
- Inflammation
- Respiratory Diseases
- Signal Transduction
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Collaborations and top research areas from the last five years
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Identification of mechanisms and biomarkers for the major inflammatory endotypes of chronic rhinosinusitis
Regeneron Pharmaceuticals, Inc.
4/27/22 → 3/1/24
Project: Research project
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Project 2: Molecular endotypes and manifestations of chronic rhinosinusitis
Hulse, K. E., Kern, R. C., Peters, A. T. & Kato, A.
National Institute of Allergy and Infectious Diseases
8/15/19 → 7/31/24
Project: Research project
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Core B: Clinical, Laboratory and Data Management Core
Kato, A., Smith, S. S., Tan, B. K. & Kern, R. C.
National Institute of Allergy and Infectious Diseases
8/15/19 → 7/31/24
Project: Research project
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5-laser 30-parameter FACSymphony-S6 SORP Cell Sorter from BD Biosciences
Perlman, H. R., Abecassis, M. M., Bharat, A., Budinger, G. S., D'Aquila, R. T., Hope, T. J., Kato, A., Le Poole, I. C., Lesniak, M. S., Luo, X., Misharin, A., Schleimer, R. P., Singer, B., Swaminathan, S., Sznajder, J. I., Tetreault, M., Thorp, E. B. & Wunderink, R. G.
Office of the Director, National Institutes of Health
8/8/19 → 8/7/20
Project: Research project
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Core B Clinical Laboratory & Data Mngt Core
Schleimer, R. P., Kato, A. & Kern, R. C.
National Institute of Allergy and Infectious Diseases
8/1/16 → 7/31/19
Project: Research project
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Epigenetic responses to rhinovirus exposure in airway epithelial cells are correlated with key transcriptional pathways in chronic rhinosinusitis
Soliai, M. M., Kato, A., Naughton, K. A., Norton, J. E., Klinger, A. I., Kern, R. C., Tan, B. K-H., Nicolae, D. L., Schleimer, R. P., Ober, C. & Pinto, J. M., 2023, (Accepted/In press) In: Allergy: European Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Article › peer-review
Open Access -
Evidence that oncostatin M synergizes with IL-4 signaling to induce TSLP expression in chronic rhinosinusitis with nasal polyps
Wang, B. F., Cao, P. P., Norton, J. E., Poposki, J. A., Klingler, A. I., Suh, L. A., Carter, R., Huang, J. H., Bai, J., Stevens, W. W., Tan, B. K., Peters, A. T., Grammer, L. C., Conley, D. B., Welch, K. C., Liu, Z., Kern, R. C., Kato, A. & Schleimer, R. P., May 2023, In: Journal of Allergy and Clinical Immunology. 151, 5, p. 1379-1390.e11Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Genetics and epigenetics of chronic rhinosinusitis
Lal, D., Brar, T., Ramkumar, S. P., Li, J., Kato, A. & Zhang, L., Apr 2023, In: Journal of Allergy and Clinical Immunology. 151, 4, p. 848-868 21 p.Research output: Contribution to journal › Review article › peer-review
4 Scopus citations -
Persistent discharge or edema after endoscopic sinus surgery in patients with chronic rhinosinusitis is associated with a type 1 or 3 endotype
Stein, E., Schneider, A. L., Harmon, R., Racette, S. D., Reddy, A. T., Price, C. P. E., Huang, J. H., Kato, A., Shintani-Smith, S., Conley, D. B., Welch, K. C., Kern, R. C. & Tan, B. K., Jan 2023, In: International Forum of Allergy and Rhinology. 13, 1, p. 15-24 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Sinus inflammation and chronic rhinosinusitis are associated with a diagnosis of new onset asthma in the following year
Schwartz, B. S., Pollak, J. S., Bandeen-Roche, K., Hirsch, A. G., Lehmann, A. E., Kern, R. C., Tan, B. K., Kato, A., Schleimer, R. P. & Peters, A. T., 2023, (Accepted/In press) In: Allergy: European Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Additional file 3 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
Soliai, M. M. (Creator), Kato, A. (Creator), Helling, B. A. (Creator), Stanhope, C. T. (Creator), Norton, J. E. (Creator), Naughton, K. A. (Creator), Klinger, A. I. (Creator), Thompson, E. E. (Creator), Clay, S. M. (Creator), Kim, S. (Creator), Celedón, J. C. (Creator), Gern, J. E. (Creator), Jackson, D. J. (Creator), Altman, M. C. (Creator), Kern, R. C. (Creator), Tan, B. K. (Creator), Schleimer, R. P. (Creator), Nicolae, D. L. (Creator), Pinto, J. M. (Creator) & Ober, C. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16780877, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Multi-omics_colocalization_with_genome-wide_association_studies_reveals_a_context-specific_genetic_mechanism_at_a_childhood_onset_asthma_risk_locus/16780877
Dataset
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Additional file 10 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
Soliai, M. M. (Creator), Kato, A. (Creator), Helling, B. A. (Creator), Stanhope, C. T. (Creator), Norton, J. E. (Creator), Naughton, K. A. (Creator), Klinger, A. I. (Creator), Thompson, E. E. (Creator), Clay, S. M. (Creator), Kim, S. (Creator), Celedón, J. C. (Creator), Gern, J. E. (Creator), Jackson, D. J. (Creator), Altman, M. C. (Creator), Kern, R. C. (Creator), Tan, B. K. (Creator), Schleimer, R. P. (Creator), Nicolae, D. L. (Creator), Pinto, J. M. (Creator) & Ober, C. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16780853, https://springernature.figshare.com/articles/dataset/Additional_file_10_of_Multi-omics_colocalization_with_genome-wide_association_studies_reveals_a_context-specific_genetic_mechanism_at_a_childhood_onset_asthma_risk_locus/16780853
Dataset
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Additional file 12 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
Soliai, M. M. (Creator), Kato, A. (Creator), Helling, B. A. (Creator), Stanhope, C. T. (Creator), Norton, J. E. (Creator), Naughton, K. A. (Creator), Klinger, A. I. (Creator), Thompson, E. E. (Creator), Clay, S. M. (Creator), Kim, S. (Creator), Celedón, J. C. (Creator), Gern, J. E. (Creator), Jackson, D. J. (Creator), Altman, M. C. (Creator), Kern, R. C. (Creator), Tan, B. K. (Creator), Schleimer, R. P. (Creator), Nicolae, D. L. (Creator), Pinto, J. M. (Creator) & Ober, C. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16780862, https://springernature.figshare.com/articles/dataset/Additional_file_12_of_Multi-omics_colocalization_with_genome-wide_association_studies_reveals_a_context-specific_genetic_mechanism_at_a_childhood_onset_asthma_risk_locus/16780862
Dataset
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Additional file 4 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
Soliai, M. M. (Creator), Kato, A. (Creator), Helling, B. A. (Creator), Stanhope, C. T. (Creator), Norton, J. E. (Creator), Naughton, K. A. (Creator), Klinger, A. I. (Creator), Thompson, E. E. (Creator), Clay, S. M. (Creator), Kim, S. (Creator), Celedón, J. C. (Creator), Gern, J. E. (Creator), Jackson, D. J. (Creator), Altman, M. C. (Creator), Kern, R. C. (Creator), Tan, B. K. (Creator), Schleimer, R. P. (Creator), Nicolae, D. L. (Creator), Pinto, J. M. (Creator) & Ober, C. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16780880, https://springernature.figshare.com/articles/dataset/Additional_file_4_of_Multi-omics_colocalization_with_genome-wide_association_studies_reveals_a_context-specific_genetic_mechanism_at_a_childhood_onset_asthma_risk_locus/16780880
Dataset
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Additional file 13 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
Soliai, M. M. (Creator), Kato, A. (Creator), Helling, B. A. (Creator), Stanhope, C. T. (Creator), Norton, J. E. (Creator), Naughton, K. A. (Creator), Klinger, A. I. (Creator), Thompson, E. E. (Creator), Clay, S. M. (Creator), Kim, S. (Creator), Celedón, J. C. (Creator), Gern, J. E. (Creator), Jackson, D. J. (Creator), Altman, M. C. (Creator), Kern, R. C. (Creator), Tan, B. K. (Creator), Schleimer, R. P. (Creator), Nicolae, D. L. (Creator), Pinto, J. M. (Creator) & Ober, C. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16780865, https://springernature.figshare.com/articles/dataset/Additional_file_13_of_Multi-omics_colocalization_with_genome-wide_association_studies_reveals_a_context-specific_genetic_mechanism_at_a_childhood_onset_asthma_risk_locus/16780865
Dataset