Bayar Thimmapaya

  • 1967 Citations
1990 …2018
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Personal profile

Research Interests

Our research focuses on cell cycle deregulation by DNA tumor virus oncogenes (Adenovirus E1A, Simian virus 40 large T, and human papilloma virus E6 and E7). In particular, we are interested to find out how binding of these viral tumor antigens to cellular proteins such as pRb, p300/CBP and other proteins affect G1/S phase transition. We use molecular genetic approaches to study these aspects. We also work on molecular mechanisms of liver cell proliferation and perturbations of these mechanisms that lead to liver cancer development. We are particularly interested in Ras induced liver cancer model and we focus on a few key proteins including Med1 (a subunit of the mediator complex) and FoxM1 which is involved in liver cancer development. Please see the link below to obtain complete list of publications: http://www.ncbi.nlm.nih.gov/sites/myncbi/1lKj3YJaj6L5G/bibliography/46771805/public/?sort=date&direction=ascending

Training Experience

1977Postdoctoral Fellowship, Yale University
1980Postdoctoral Fellowship, University of Connecticut
1980Postdoctoral Fellowship, SUNY/State University of New York, Stony Brook

Education/Academic qualification

PhD, Indian Institute of Science

… → 1975

Research interests

  • Cancer Biology
  • DNA Repair
  • DNA Replication
  • Eukaryotic Cells
  • Gene Regulation
  • Genetics
  • Molecular Biology
  • Virology

Fingerprint Dive into the research topics where Bayar Thimmapaya is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Adenoviridae Medicine & Life Sciences
Simian virus 40 Medicine & Life Sciences
Genes Medicine & Life Sciences
eIF-2 Kinase Medicine & Life Sciences
Transcriptional Activation Medicine & Life Sciences
S Phase Medicine & Life Sciences
Viruses Medicine & Life Sciences
Cell Cycle Medicine & Life Sciences

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Grants 2000 2018

Research Output 1990 2018

  • 1967 Citations
  • 53 Article
  • 1 Review article
1 Citation (Scopus)

Mouse cardiac Pde1C is a direct transcriptional target of pparα

Shete, V., Liu, N., Jia, Y., Viswakarma, N., Reddy, J. K. & Thimmapaya, B., Dec 1 2018, In : International journal of molecular sciences. 19, 12, 3704.

Research output: Contribution to journalArticle

PPAR alpha
mice
Phosphoric Diester Hydrolases
Mediator Complex
Inverted Repeat Sequences
1 Citation (Scopus)
deletion
metabolism
Cardiomyopathies
Energy Metabolism
mice
8 Citations (Scopus)

Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice

Jia, Y., Chang, H. C., Schipma, M. J., Liu, J., Shete, V., Liu, N., Sato, T., Thorp, E. B., Barger, P. M., Zhu, Y. J., Viswakarma, N., Kanwar, Y. S., Ardehali, H., Thimmapaya, B. & Reddy, J. K., Aug 2016, In : PloS one. 11, 8, e0160755.

Research output: Contribution to journalArticle

Mediator Complex Subunit 1
cardiomyopathy
Dilated Cardiomyopathy
Ablation
lethal genes
10 Citations (Scopus)

Co-activator binding protein PIMT mediates TNF-α induced insulin resistance in skeletal muscle via the transcriptional down-regulation of MEF2A and GLUT4

Kain, V., Kapadia, B., Viswakarma, N., Seshadri, S., Prajapati, B., Jena, P. K., Teja Meda, C. L., Subramanian, M., Kaimal Suraj, S., Kumar, S. T., Prakash Babu, P., Thimmapaya, B., Reddy, J. K., Parsa, K. V. L. & Misra, P., Oct 15 2015, In : Scientific reports. 5, 15197.

Research output: Contribution to journalArticle

Insulin Resistance
Carrier Proteins
Skeletal Muscle
Down-Regulation
Insulin
22 Citations (Scopus)

PPARα-deficient ob/ob obese mice become more obese and manifest severe hepatic steatosis due to decreased fatty acid oxidation

Gao, Q., Jia, Y., Yang, G., Zhang, X., Boddu, P. C., Petersen, B., Narsingam, S., Zhu, Y., Thimmapaya, B., Kanwar, Y. S. & Reddy, J. K., May 1 2015, In : American Journal of Pathology. 185, 5, p. 1396-1408 13 p., 1984.

Research output: Contribution to journalArticle

Obese Mice
Peroxisome Proliferator-Activated Receptors
Fatty Acids
Liver
Liver Neoplasms