Bayar Thimmapaya

Personal profile

Research Interests

Our research focuses on cell cycle deregulation by DNA tumor virus oncogenes (Adenovirus E1A, Simian virus 40 large T, and human papilloma virus E6 and E7). In particular, we are interested to find out how binding of these viral tumor antigens to cellular proteins such as pRb, p300/CBP and other proteins affect G1/S phase transition. We use molecular genetic approaches to study these aspects. We also work on molecular mechanisms of liver cell proliferation and perturbations of these mechanisms that lead to liver cancer development. We are particularly interested in Ras induced liver cancer model and we focus on a few key proteins including Med1 (a subunit of the mediator complex) and FoxM1 which is involved in liver cancer development. Please see the link below to obtain complete list of publications: http://www.ncbi.nlm.nih.gov/sites/myncbi/1lKj3YJaj6L5G/bibliography/46771805/public/?sort=date&direction=ascending

Training Experience

1977	Postdoctoral Fellowship, Yale University
1980	Postdoctoral Fellowship, University of Connecticut
1980	Postdoctoral Fellowship, SUNY/State University of New York, Stony Brook

Education/Academic qualification

PhD, Indian Institute of Science Bangalore

… → 1975

Research interests

Cancer Biology
DNA Repair
DNA Replication
Eukaryotic Cells
Gene Regulation
Genetics
Molecular Biology
Virology

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Grants

8 Finished

Med1 in Liver Metabolism, Regeneration and Cancer

Jia, Y., Lukas, T. J., Reddy, J. K., Thimmapaya, B. & Zhu, Y.

National Institute of Diabetes, Digestive and Kidney Diseases

7/1/16 → 12/31/18

Project: Research project

Med1 in Liver Metabolism, Regeneration and Cancer

Jia, Y., Lukas, T. J., Reddy, J. K., Thimmapaya, B. & Zhu, Y.

National Institute of Diabetes, Digestive and Kidney Diseases

7/1/13 → 6/30/16

Project: Research project

E1A Oncoprotein Induced Deregulation of Replication Origin Firing

Thimmapaya, B.

National Institute of Allergy and Infectious Diseases

2/15/11 → 1/31/14

Project: Research project

Functions of an E1A-Associated Cellular Protein

Thimmapaya, B.

National Cancer Institute

4/9/04 → 11/30/10

Project: Research project

Supplement to Functions of an E1A-Associated Cellular Protein

Thimmapaya, B.

National Cancer Institute

4/9/04 → 11/30/10

Project: Research project