Bayar Thimmapaya

  • 2014 Citations
1990 …2018

Research output per year

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Personal profile

Research Interests

Our research focuses on cell cycle deregulation by DNA tumor virus oncogenes (Adenovirus E1A, Simian virus 40 large T, and human papilloma virus E6 and E7). In particular, we are interested to find out how binding of these viral tumor antigens to cellular proteins such as pRb, p300/CBP and other proteins affect G1/S phase transition. We use molecular genetic approaches to study these aspects. We also work on molecular mechanisms of liver cell proliferation and perturbations of these mechanisms that lead to liver cancer development. We are particularly interested in Ras induced liver cancer model and we focus on a few key proteins including Med1 (a subunit of the mediator complex) and FoxM1 which is involved in liver cancer development. Please see the link below to obtain complete list of publications:

Training Experience

1977Postdoctoral Fellowship, Yale University
1980Postdoctoral Fellowship, University of Connecticut
1980Postdoctoral Fellowship, SUNY/State University of New York, Stony Brook

Education/Academic qualification

PhD, Indian Institute of Science Bangalore

… → 1975

Research interests

  • Cancer Biology
  • DNA Repair
  • DNA Replication
  • Eukaryotic Cells
  • Gene Regulation
  • Genetics
  • Molecular Biology
  • Virology

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Research Output

  • 2014 Citations
  • 53 Article
  • 1 Review article

Mouse cardiac Pde1C is a direct transcriptional target of pparα

Shete, V., Liu, N., Jia, Y., Viswakarma, N., Reddy, J. K. & Thimmapaya, B., Dec 2018, In : International journal of molecular sciences. 19, 12, 3704.

Research output: Contribution to journalArticle

  • 2 Scopus citations

    PIMT/NCOA6IP deletion in the mouse heart causes delayed cardiomyopathy attributable to perturbation in energy metabolism

    Jia, Y., Liu, N., Viswakarma, N., Sun, R., Schipma, M. J., Shang, M., Thorp, E. B., Kanwar, Y. S., Thimmapaya, B. & Reddy, J. K., May 16 2018, In : International journal of molecular sciences. 19, 5, 1485.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice

    Jia, Y., Chang, H. C., Schipma, M. J., Liu, J., Shete, V., Liu, N., Sato, T., Thorp, E. B., Barger, P. M., Zhu, Y., Viswakarma, N., Kanwar, Y. S., Ardehali, H., Thimmapaya, B. & Reddy, J. K., Aug 2016, In : PloS one. 11, 8, e0160755.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    Co-activator binding protein PIMT mediates TNF-α induced insulin resistance in skeletal muscle via the transcriptional down-regulation of MEF2A and GLUT4

    Kain, V., Kapadia, B., Viswakarma, N., Seshadri, S., Prajapati, B., Jena, P. K., Teja Meda, C. L., Subramanian, M., Kaimal Suraj, S., Kumar, S. T., Prakash Babu, P., Thimmapaya, B., Reddy, J. K., Parsa, K. V. L. & Misra, P., Oct 15 2015, In : Scientific reports. 5, 15197.

    Research output: Contribution to journalArticle

  • 12 Scopus citations

    PPARα-deficient ob/ob obese mice become more obese and manifest severe hepatic steatosis due to decreased fatty acid oxidation

    Gao, Q., Jia, Y., Yang, G., Zhang, X., Boddu, P. C., Petersen, B., Narsingam, S., Zhu, Y. J., Thimmapaya, B., Kanwar, Y. S. & Reddy, J. K., May 1 2015, In : American Journal of Pathology. 185, 5, p. 1396-1408 13 p., 1984.

    Research output: Contribution to journalArticle

  • 24 Scopus citations