Grants per year
Personal profile
Research Interests
Our research focuses on cell cycle deregulation by DNA tumor virus oncogenes (Adenovirus E1A, Simian virus 40 large T, and human papilloma virus E6 and E7). In particular, we are interested to find out how binding of these viral tumor antigens to cellular proteins such as pRb, p300/CBP and other proteins affect G1/S phase transition. We use molecular genetic approaches to study these aspects. We also work on molecular mechanisms of liver cell proliferation and perturbations of these mechanisms that lead to liver cancer development. We are particularly interested in Ras induced liver cancer model and we focus on a few key proteins including Med1 (a subunit of the mediator complex) and FoxM1 which is involved in liver cancer development. Please see the link below to obtain complete list of publications: http://www.ncbi.nlm.nih.gov/sites/myncbi/1lKj3YJaj6L5G/bibliography/46771805/public/?sort=date&direction=ascending
Training Experience
| 1977 | Postdoctoral Fellowship, Yale University |
| 1980 | Postdoctoral Fellowship, University of Connecticut |
| 1980 | Postdoctoral Fellowship, SUNY/State University of New York, Stony Brook |
Education/Academic qualification
PhD, Indian Institute of Science Bangalore
… → 1975
Research interests
- Cancer Biology
- DNA Repair
- DNA Replication
- Eukaryotic Cells
- Gene Regulation
- Genetics
- Molecular Biology
- Virology
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Grants
- 8 Finished
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Med1 in Liver Metabolism, Regeneration and Cancer
Jia, Y., Lukas, T. J., Reddy, J. K., Thimmapaya, B. & Zhu, Y.
National Institute of Diabetes and Digestive and Kidney Diseases
7/1/16 → 12/31/18
Project: Research project
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Med1 in Liver Metabolism, Regeneration and Cancer
Jia, Y., Lukas, T. J., Reddy, J. K., Thimmapaya, B. & Zhu, Y.
National Institute of Diabetes and Digestive and Kidney Diseases
7/1/13 → 6/30/16
Project: Research project
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E1A Oncoprotein Induced Deregulation of Replication Origin Firing
National Institute of Allergy and Infectious Diseases
2/15/11 → 1/31/14
Project: Research project
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Supplement to Functions of an E1A-Associated Cellular Protein
4/9/04 → 11/30/10
Project: Research project
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Research Output
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Mouse cardiac Pde1C is a direct transcriptional target of pparα
Shete, V., Liu, N., Jia, Y., Viswakarma, N., Reddy, J. K. & Thimmapaya, B., Dec 2018, In: International journal of molecular sciences. 19, 12, 3704.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
PIMT/NCOA6IP deletion in the mouse heart causes delayed cardiomyopathy attributable to perturbation in energy metabolism
Jia, Y., Liu, N., Viswakarma, N., Sun, R., Schipma, M. J., Shang, M., Thorp, E. B., Kanwar, Y. S., Thimmapaya, B. & Reddy, J. K., May 16 2018, In: International journal of molecular sciences. 19, 5, 1485.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice
Jia, Y., Chang, H. C., Schipma, M. J., Liu, J., Shete, V., Liu, N., Sato, T., Thorp, E. B., Barger, P. M., Zhu, Y. J., Viswakarma, N., Kanwar, Y. S., Ardehali, H., Thimmapaya, B. & Reddy, J. K., Aug 2016, In: PloS one. 11, 8, e0160755.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Co-activator binding protein PIMT mediates TNF-α induced insulin resistance in skeletal muscle via the transcriptional down-regulation of MEF2A and GLUT4
Kain, V., Kapadia, B., Viswakarma, N., Seshadri, S., Prajapati, B., Jena, P. K., Teja Meda, C. L., Subramanian, M., Kaimal Suraj, S., Kumar, S. T., Prakash Babu, P., Thimmapaya, B., Reddy, J. K., Parsa, K. V. L. & Misra, P., Oct 15 2015, In: Scientific reports. 5, 15197.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
PPARα-deficient ob/ob obese mice become more obese and manifest severe hepatic steatosis due to decreased fatty acid oxidation
Gao, Q., Jia, Y., Yang, G., Zhang, X., Boddu, P. C., Petersen, B., Narsingam, S., Zhu, Y. J., Thimmapaya, B., Kanwar, Y. S. & Reddy, J. K., May 1 2015, In: American Journal of Pathology. 185, 5, p. 1396-1408 13 p., 1984.Research output: Contribution to journal › Article › peer-review
28 Scopus citations