• 3886 Citations
1985 …2019

Research output per year

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Personal profile

Research Interests

I am a developmental biologist studying the molecular regulation of pancreas and liver organogenesis. I received a bachelor and Master’s degree in Biological Sciences from the National University of Mexico, and a PhD degree in Biological Sciences from the University of Uruguay. I did my postdoctoral training at the Max Planck Institute in Göttingen (Germany) in the laboratory of Peter Gruss, a well-known field leader. Subsequently, I moved to the USA and started my new independent lab at St. Jude Children's Hospital (Memphis) where I worked until 2015. Currently, I am Associate Professor of the Department of Medicine at Northwestern University Feinberg Medical School.

My laboratory uses genetically modified mouse models, in combination with conventional and cutting-edge technologies, to study how the complex architecture of the mammalian pancreas and liver is established during development, and how is disrupted and repaired after injury. We also use mouse models to sudy mechanisms that promote tumor formation and metastasis in the pancreas, processes that help re-establishing zonation in the injured liver, and mechanisms that regulate the plasticity of mature pancreatic cells.

Education/Academic qualification

PhD, University of Uruguay

… → 1991

Research interests

  • Cancer Biology
  • Cancer Genetics
  • Developmental Biology
  • Developmental Genetics
  • Developmental Origins of Disease
  • Gene Regulation
  • Pancreatic Cancer
  • Regenerative Medicine

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Grants

  • Research Output

    • 3886 Citations
    • 32 Article
    • 1 Comment/debate
    • 1 Editorial
    • 1 Review article

    Complex bile duct network formation within liver decellularized extracellular matrix hydrogels

    Lewis, P. L., Su, J., Yan, M., Meng, F., Glaser, S. S., Alpini, G. D., Green, R. M., Sosa-Pineda, B. & Shah, R. N., Dec 1 2018, In : Scientific reports. 8, 1, 12220.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer

    Drosos, Y., Escobar, D., Chiang, M. Y., Roys, K., Valentine, V., Valentine, M. B., Rehg, J. E., Sahai, V., Begley, L. A., Ye, J., Paul, L., McKinnon, P. J. & Sosa-Pineda, B., Dec 1 2017, In : Scientific reports. 7, 1, 11144.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    Lack of Prox1 downregulation disrupts the expansion and maturation of postnatal murine β-Cells

    Paul, L., Walker, E. M., Drosos, Y., Cyphert, H. A., Neale, G., Stein, R., South, J., Grosveld, G., Herrera, P. L. & Sosa-Pineda, B., Mar 2016, In : Diabetes. 65, 3, p. 687-698 12 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    Prox1-Heterozygosis Sensitizes the Pancreas to Oncogenic Kras-Induced Neoplastic Transformation

    Drosos, Y., Neale, G., Ye, J., Paul, L., Kuliyev, E., Maitra, A., Means, A. L., Washington, M. K., Rehg, J., Finkelstein, D. B. & Sosa-Pineda, B., Jan 1 2016, In : Neoplasia. 18, 3, p. 172-184 13 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction

    Shi, C., Washington, M. K., Chaturvedi, R., Drosos, Y., Revetta, F. L., Weaver, C. J., Buzhardt, E., Yull, F. E., Blackwell, T. S., Sosa-Pineda, B., Whitehead, R. H., Beauchamp, R. D., Wilson, K. T. & Means, A. L., Apr 2014, In : Laboratory Investigation. 94, 4, p. 409-421 13 p.

    Research output: Contribution to journalArticle

  • 41 Scopus citations