Grants per year
Personal profile
Research Interests
I am a developmental biologist studying the molecular regulation of pancreas and liver organogenesis. I received a bachelor and Master’s degree in Biological Sciences from the National University of Mexico, and a PhD degree in Biological Sciences from the University of Uruguay. I did my postdoctoral training at the Max Planck Institute in Göttingen (Germany) in the laboratory of Peter Gruss, a well-known field leader. Subsequently, I moved to the USA and started my new independent lab at St. Jude Children's Hospital (Memphis) where I worked until 2015. Currently, I am Associate Professor of the Department of Medicine at Northwestern University Feinberg Medical School.
My laboratory uses genetically modified mouse models, in combination with conventional and cutting-edge technologies, to study how the complex architecture of the mammalian pancreas and liver is established during development, and how is disrupted and repaired after injury. We also use mouse models to sudy mechanisms that promote tumor formation and metastasis in the pancreas, processes that help re-establishing zonation in the injured liver, and mechanisms that regulate the plasticity of mature pancreatic cells.
Education/Academic qualification
PhD, University of Uruguay
… → 1991
Research interests
- Cancer Biology
- Cancer Genetics
- Developmental Biology
- Developmental Genetics
- Developmental Origins of Disease
- Gene Regulation
- Pancreatic Cancer
- Regenerative Medicine
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Grants
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Functional analysis of Claudin-2 in pancreatic ductal cells in health and disease
National Institute of Diabetes and Digestive and Kidney Diseases
8/7/20 → 7/31/21
Project: Research project
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Development, cellular plasticity and homeostasis of the exocrine pancreas
National Institute of Diabetes and Digestive and Kidney Diseases
1/29/16 → 6/30/19
Project: Research project
Research Output
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Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts
Ma, R., Martínez-Ramírez, A. S., Borders, T. L., Gao, F. & Sosa-Pineda, B., Mar 2020, In: eLife. 9, e46206.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Complex bile duct network formation within liver decellularized extracellular matrix hydrogels
Lewis, P. L., Su, J., Yan, M., Meng, F., Glaser, S. S., Alpini, G. D., Green, R. M., Sosa-Pineda, B. & Shah, R. N., Dec 1 2018, In: Scientific reports. 8, 1, 12220.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer
Drosos, Y., Escobar, D., Chiang, M. Y., Roys, K., Valentine, V., Valentine, M. B., Rehg, J. E., Sahai, V., Begley, L. A., Ye, J., Paul, L., McKinnon, P. J. & Sosa-Pineda, B., Dec 1 2017, In: Scientific reports. 7, 1, 11144.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Lack of Prox1 downregulation disrupts the expansion and maturation of postnatal murine β-Cells
Paul, L., Walker, E. M., Drosos, Y., Cyphert, H. A., Neale, G., Stein, R., South, J., Grosveld, G., Herrera, P. L. & Sosa-Pineda, B., Mar 2016, In: Diabetes. 65, 3, p. 687-698 12 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Prox1-Heterozygosis Sensitizes the Pancreas to Oncogenic Kras-Induced Neoplastic Transformation
Drosos, Y., Neale, G., Ye, J., Paul, L., Kuliyev, E., Maitra, A., Means, A. L., Washington, M. K., Rehg, J., Finkelstein, D. B. & Sosa-Pineda, B., 2016, In: Neoplasia (United States). 18, 3, p. 172-184 13 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations