Grants per year
Personal profile
Research Interests
In the context of acute lung inflammation and injury, my laboratory focuses on DNA methylation and gene expression as features that define T lymphocyte immunoregulatory phenotype and pro-repair function. Our data show that these epigenetic phenomena can potentiate resolution of acute lung inflammation and repair of lung damage. This work is also applicable to the study of aging as well as disease states outside the lung, including autoimmune conditions, malignancy, and organ allograft rejection.
I am a physician-scientist specializing in pulmonary and critical care medicine as well as internal medicine. I received an MD from the Northwestern University Feinberg School of Medicine, where I also completed residency and chief residency in internal medicine. I then undertook fellowship training in pulmonary and critical care medicine at the Johns Hopkins University School of Medicine before returning to Northwestern as a faculty member in 2015.
My clinical focus is in critical care (ICU) medicine. I have a particular interest in acute respiratory failure, the acute respiratory distress syndrome (ARDS), mechanical ventilation, and extracorporeal life support/extracorporeal membrane oxygenation. I also specialize in physician-to-physician consultation regarding medical diagnostic challenges as well as inpatient-based general pulmonary medicine.
Certifications and Licenses
Internal Medicine | |
Critical Care Medicine | |
Pulmonary Disease |
Training Experience
2011 | Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) |
2015 | Fellowship, Johns Hopkins University School of Medicine |
Education/Academic qualification
Medicine, MD, Northwestern University
… → 2007
Research interests keywords
- Aging
- Biochemistry: Nucleic Acid
- Critical Care
- Gene Regulation
- Gene-Environment Interactions
- Immunology
- Lung Injury
- Mechanical Ventilation
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Core B: Human and Clinical phenotyping Core
Abdala-Valencia, H. (Co-Investigator), Arunachalam, A. (Co-Investigator), Braun, R. I. (Co-Investigator), Kurihara, C. (Co-Investigator), Morales-Nebreda, L. (Co-Investigator), Singer, B. (Co-Investigator), Venkata Subramani, M. (Co-Investigator) & Yan, Y. (Co-Investigator)
National Heart, Lung, and Blood Institute
9/17/24 → 7/31/29
Project: Research project
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Project 3
Braun, R. I. (Co-Investigator), Singer, B. (Co-Investigator), Venkata Subramani, M. (Co-Investigator) & Misharin, A. (Other)
National Heart, Lung, and Blood Institute
9/17/24 → 7/31/29
Project: Research project
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Machine learning to predict the development of ventilator-associated pneumonia
Luo, Y. (PD/PI), Wunderink, R. G. (PD/PI), Gao, C. A. (Other) & Singer, B. (Other)
American Thoracic Society, Inc.
7/1/24 → 7/1/25
Project: Research project
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The Neu-Lung Consortium: Neutrophilic Mechanisms of Inflammation, Injury, and Repair in Lung and Airways Diseases
Singer, B. (PD/PI)
National Institute of Allergy and Infectious Diseases
4/1/24 → 3/31/29
Project: Research project
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Machine learning to predict cure in severe pneumonia episodes
Gao, C. A. (PD/PI), Andrei, A.-C. (Other), Budinger, G. S. (Other), Luo, Y. (Other), Misharin, A. (Other), Singer, B. (Other), Starren, J. (Other), Walunas, T. L. (Other) & Wunderink, R. G. (Other)
National Heart, Lung, and Blood Institute
4/1/24 → 3/31/29
Project: Research project
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A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer
Szczepanski, A., Tsuboyama, N., Lyu, H., Wang, P., Beytullahoglu, O., Zhang, T., Singer, B. D., Yue, F., Zhao, Z. & Wang, L., Dec 2024, In: Nature communications. 15, 1, 2067.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
The NU SCRIPT Study Investigators, 2024, (Accepted/In press) In: Nature Immunology. 25, 9, p. 1607-1622 16 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation
Chaudhuri, S. M., Weinberg, S. E., Wang, D., Yalom, L. K., Montauti, E., Iyer, R., Tang, A. Y., Torres Acosta, M. A., Shen, J., Mani, N. L., Wang, S., Liu, K., Lu, W., Bui, T. M., Manzanares, L. D., Dehghani, Z., Wai, C. M., Gao, B., Wei, J. & Yue, F. & 5 others, , Mar 19 2024, In: Cell Reports Medicine. 5, 3, 101441.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitochondria regulate proliferation in adult cardiac myocytes
Waypa, G. B., Smith, K. A., Mungai, P. T., Dudley, V. J., Helmin, K. A., Singer, B. D., Peek, C. B., Bass, J., Nelson, L., Shah, S. J., Ofman, G., Wasserstrom, J. A., Muller, W. A., Misharin, A. V., Budinger, G. R. S., Abdala-Valencia, H., Chandel, N. S., Dokic, D., Bartom, E. & Zhang, S. & 5 others, , Jul 1 2024, In: Journal of Clinical Investigation. 134, 13, e165482.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial
for the I-SPY COVID Consortium, Dec 2024, In: Critical Care. 28, 1, 56.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Datasets
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Additional file 4 of Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Fang, C. (Contributor), Wang, Z. (Contributor), Han, C. (Contributor), Safgren, S. L. (Creator), Helmin, K. A. (Creator), Adelman, E. R. (Creator), Serafin, V. (Creator), Basso, G. (Creator), Eagen, K. P. (Creator), Gaspar-Maia, A. (Creator), Figueroa, M. E. (Creator), Singer, B. D. (Creator), Ratan, A. (Contributor), Ntziachristos, P. (Creator) & Zang, C. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12960917, https://springernature.figshare.com/articles/dataset/Additional_file_4_of_Cancer-specific_CTCF_binding_facilitates_oncogenic_transcriptional_dysregulation/12960917
Dataset
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Additional file 8 of Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Fang, C. (Contributor), Wang, Z. (Contributor), Han, C. (Contributor), Safgren, S. L. (Creator), Helmin, K. A. (Creator), Adelman, E. R. (Creator), Serafin, V. (Creator), Basso, G. (Creator), Eagen, K. P. (Creator), Gaspar-Maia, A. (Creator), Figueroa, M. E. (Creator), Singer, B. D. (Creator), Ratan, A. (Contributor), Ntziachristos, P. (Creator) & Zang, C. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12960929, https://springernature.figshare.com/articles/dataset/Additional_file_8_of_Cancer-specific_CTCF_binding_facilitates_oncogenic_transcriptional_dysregulation/12960929
Dataset
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Additional file 6 of Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Fang, C. (Contributor), Wang, Z. (Contributor), Han, C. (Contributor), Safgren, S. L. (Creator), Helmin, K. A. (Creator), Adelman, E. R. (Creator), Serafin, V. (Creator), Basso, G. (Creator), Eagen, K. P. (Creator), Gaspar-Maia, A. (Creator), Figueroa, M. E. (Creator), Singer, B. D. (Creator), Ratan, A. (Contributor), Ntziachristos, P. (Creator) & Zang, C. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12960923, https://springernature.figshare.com/articles/dataset/Additional_file_6_of_Cancer-specific_CTCF_binding_facilitates_oncogenic_transcriptional_dysregulation/12960923
Dataset
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Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Fang, C. (Contributor), Wang, Z. (Contributor), Han, C. (Contributor), Safgren, S. L. (Creator), Helmin, K. A. (Creator), Adelman, E. R. (Creator), Serafin, V. (Creator), Basso, G. (Creator), Eagen, K. P. (Creator), Gaspar-Maia, A. (Creator), Figueroa, M. E. (Creator), Singer, B. D. (Creator), Ratan, A. (Contributor), Ntziachristos, P. (Creator) & Zang, C. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.c.5122871.v1, https://springernature.figshare.com/collections/Cancer-specific_CTCF_binding_facilitates_oncogenic_transcriptional_dysregulation/5122871/1
Dataset
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Additional file 3 of Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Fang, C. (Contributor), Wang, Z. (Contributor), Han, C. (Contributor), Safgren, S. L. (Creator), Helmin, K. A. (Creator), Adelman, E. R. (Creator), Serafin, V. (Creator), Basso, G. (Creator), Eagen, K. P. (Creator), Gaspar-Maia, A. (Creator), Figueroa, M. E. (Creator), Singer, B. D. (Creator), Ratan, A. (Contributor), Ntziachristos, P. (Creator) & Zang, C. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12960914, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Cancer-specific_CTCF_binding_facilitates_oncogenic_transcriptional_dysregulation/12960914
Dataset