Grants per year
Personal profile
Research Interests
In the context of acute lung inflammation and injury, my laboratory focuses on DNA methylation and gene expression as features that define T lymphocyte immunoregulatory phenotype and pro-repair function. Our data show that these epigenetic phenomena can potentiate resolution of acute lung inflammation and repair of lung damage. This work is also applicable to the study of aging as well as disease states outside the lung, including autoimmune conditions, malignancy, and organ allograft rejection.
I am a physician-scientist specializing in pulmonary and critical care medicine as well as internal medicine. I received an MD from the Northwestern University Feinberg School of Medicine, where I also completed residency and chief residency in internal medicine. I then undertook fellowship training in pulmonary and critical care medicine at the Johns Hopkins University School of Medicine before returning to Northwestern as a faculty member in 2015.
My clinical focus is in critical care (ICU) medicine. I have a particular interest in acute respiratory failure, the acute respiratory distress syndrome (ARDS), mechanical ventilation, and extracorporeal life support/extracorporeal membrane oxygenation. I also specialize in physician-to-physician consultation regarding medical diagnostic challenges as well as inpatient-based general pulmonary medicine.
Certifications and Licenses
Internal Medicine | |
Critical Care Medicine | |
Pulmonary Disease |
Training Experience
2011 | Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) |
2015 | Fellowship, Johns Hopkins University School of Medicine |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, Northwestern University Feinberg School of Medicine
… → 2007
Research interests keywords
- Aging
- Biochemistry: Nucleic Acid
- Critical Care
- Gene Regulation
- Gene-Environment Interactions
- Immunology
- Lung Injury
- Mechanical Ventilation
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Project 3
Braun, R. I. (Co-Investigator), Singer, B. (Co-Investigator), Venkata Subramani, M. (Co-Investigator) & Misharin, A. (Other)
National Heart, Lung, and Blood Institute
9/17/24 → 7/31/29
Project: Research project
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Core B: Human and Clinical phenotyping Core
Abdala-Valencia, H. (Co-Investigator), Arunachalam, A. (Co-Investigator), Braun, R. I. (Co-Investigator), Kurihara, C. (Co-Investigator), Morales-Nebreda, L. (Co-Investigator), Singer, B. (Co-Investigator), Venkata Subramani, M. (Co-Investigator) & Yan, Y. (Co-Investigator)
National Heart, Lung, and Blood Institute
9/17/24 → 7/31/29
Project: Research project
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Machine learning to predict the development of ventilator-associated pneumonia
Luo, Y. (PD/PI), Wunderink, R. G. (PD/PI), Gao, C. A. (Other) & Singer, B. (Other)
American Thoracic Society, Inc.
7/1/24 → 7/1/25
Project: Research project
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Machine learning to predict cure in severe pneumonia episodes
Gao, C. A. (PD/PI), Andrei, A. (Other), Budinger, G. S. (Other), Luo, Y. (Other), Misharin, A. (Other), Singer, B. (Other), Starren, J. (Other), Walunas, T. L. (Other) & Wunderink, R. G. (Other)
National Heart, Lung, and Blood Institute
4/1/24 → 3/31/29
Project: Research project
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The Neu-Lung Consortium: Neutrophilic Mechanisms of Inflammation, Injury, and Repair in Lung and Airways Diseases
Misharin, A. (Co-PD/PI), Singer, B. (Co-PD/PI), Bharat, A. (Co-Investigator) & Muller, W. A. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
4/1/24 → 3/31/29
Project: Research project
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An Observational Cohort Study of Bronchoalveolar Lavage Fluid Galactomannan and Aspergillus Culture Positivity in Patients Requiring Mechanical Ventilation
Gao, C. A., Markov, N. S., Pickens, C., Pawlowski, A., Kang, M., Walter, J. M., Singer, B. D. & Wunderink, R. G., Mar 1 2025, In: Open Forum Infectious Diseases. 12, 3, ofaf090.Research output: Contribution to journal › Article › peer-review
Open Access -
Antibiotic de-escalation patterns and outcomes in critically ill patients with suspected pneumonia as informed by bronchoalveolar lavage results
The N. U. SCRIPT Study Investigators, 2025, (Accepted/In press) In: European Journal of Clinical Microbiology and Infectious Diseases.Research output: Contribution to journal › Article › peer-review
Open Access -
Regulatory T Cells Require TBET to Regulate Activated CD8+ T Cells During Recovery from Influenza
Mambetsariev, N., Torres Acosta, M. A., Liu, Q., Reyes Flores, C. P., Joudi, A. M., Helmin, K. A., Gurkan, J. K., Steinert, E. M., Morales-Nebreda, L. & Singer, B. D., Apr 2025, In: American journal of respiratory cell and molecular biology. 72, 4, p. 453-456 4 p.Research output: Contribution to journal › Letter › peer-review
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The Fifth Annual Symposium of the Midwest Aging Consortium
Reader, B. F., Rosas, L., Knopf, B. A., Liu, Y., Alzate-Correa, D., Bhat, A., Carey, A., Cuervo, A. M., Dayal, S., Demarco, R. S., Elliehausen, C. J., Englund, D. A., Hamilton, H. L., Johnston, M., Kang, P., Konopka, A. R., Lepola, N., Presley, C. J., Schafer, M. J. & Serrano, J. & 15 others, , Feb 1 2025, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 80, 2, glae296.Research output: Contribution to journal › Article › peer-review
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A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer
Szczepanski, A., Tsuboyama, N., Lyu, H., Wang, P., Beytullahoglu, O., Zhang, T., Singer, B. D., Yue, F., Zhao, Z. & Wang, L., Dec 2024, In: Nature communications. 15, 1, 2067.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations
Datasets
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Technology dictates algorithms: recent developments in read alignment
Alser, M. (Creator), Rotman, J. (Creator), Deshpande, D. (Creator), Taraszka, K. (Creator), Shi, H. (Creator), Baykal, P. I. (Creator), Yang, H. T. (Creator), Xue, V. (Creator), Knyazev, S. (Creator), Singer, B. D. (Creator), Balliu, B. (Creator), Koslicki, D. (Creator), Skums, P. (Creator), Zelikovsky, A. (Creator), Alkan, C. (Creator), Mutlu, O. (Creator) & Mangul, S. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5585907, https://springernature.figshare.com/collections/Technology_dictates_algorithms_recent_developments_in_read_alignment/5585907
Dataset
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Additional file 4 of Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Fang, C. (Contributor), Wang, Z. (Contributor), Han, C. (Contributor), Safgren, S. L. (Creator), Helmin, K. A. (Creator), Adelman, E. R. (Creator), Serafin, V. (Creator), Basso, G. (Creator), Eagen, K. P. (Creator), Gaspar-Maia, A. (Creator), Figueroa, M. E. (Creator), Singer, B. D. (Creator), Ratan, A. (Contributor), Ntziachristos, P. (Creator) & Zang, C. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12960917, https://springernature.figshare.com/articles/dataset/Additional_file_4_of_Cancer-specific_CTCF_binding_facilitates_oncogenic_transcriptional_dysregulation/12960917
Dataset
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CarpeDiem datasets
Gao, C. A. (Creator), Markov, N. S. (Creator), Budinger, G. S. (Creator), Wunderink, R. G. (Creator), Singer, B. D. (Creator), Misharin, A. V. (Creator) & Investigators, N. S. (Creator), ZENODO, May 10 2022
DOI: 10.5281/zenodo.6528915, https://zenodo.org/records/6528915
Dataset
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Additional file 6 of Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Fang, C. (Contributor), Wang, Z. (Contributor), Han, C. (Contributor), Safgren, S. L. (Creator), Helmin, K. A. (Creator), Adelman, E. R. (Creator), Serafin, V. (Creator), Basso, G. (Creator), Eagen, K. P. (Creator), Gaspar-Maia, A. (Creator), Figueroa, M. E. (Creator), Singer, B. D. (Creator), Ratan, A. (Contributor), Ntziachristos, P. (Creator) & Zang, C. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12960923, https://springernature.figshare.com/articles/dataset/Additional_file_6_of_Cancer-specific_CTCF_binding_facilitates_oncogenic_transcriptional_dysregulation/12960923
Dataset
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Additional file 2 of Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Fang, C. (Contributor), Wang, Z. (Contributor), Han, C. (Contributor), Safgren, S. L. (Creator), Helmin, K. A. (Creator), Adelman, E. R. (Creator), Serafin, V. (Creator), Basso, G. (Creator), Eagen, K. P. (Creator), Gaspar-Maia, A. (Creator), Figueroa, M. E. (Creator), Singer, B. D. (Creator), Ratan, A. (Contributor), Ntziachristos, P. (Creator) & Zang, C. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12960911, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Cancer-specific_CTCF_binding_facilitates_oncogenic_transcriptional_dysregulation/12960911
Dataset