Grants per year
Personal profile
Research Interests
In the context of acute lung inflammation and injury, my laboratory focuses on DNA methylation and gene expression as features that define T lymphocyte immunoregulatory phenotype and pro-repair function. Our data show that these epigenetic phenomena can potentiate resolution of acute lung inflammation and repair of lung damage. This work is also applicable to the study of aging as well as disease states outside the lung, including autoimmune conditions, malignancy, and organ allograft rejection.
I am a physician-scientist specializing in pulmonary and critical care medicine as well as internal medicine. I received an MD from the Northwestern University Feinberg School of Medicine, where I also completed residency and chief residency in internal medicine. I then undertook fellowship training in pulmonary and critical care medicine at the Johns Hopkins University School of Medicine before returning to Northwestern as a faculty member in 2015.
My clinical focus is in critical care (ICU) medicine. I have a particular interest in acute respiratory failure, the acute respiratory distress syndrome (ARDS), mechanical ventilation, and extracorporeal life support/extracorporeal membrane oxygenation. I also specialize in physician-to-physician consultation regarding medical diagnostic challenges as well as inpatient-based general pulmonary medicine.
Certifications and Licenses
Internal Medicine | |
Critical Care Medicine | |
Pulmonary Disease |
Training Experience
2011 | Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) |
2015 | Fellowship, Johns Hopkins University School of Medicine |
Education/Academic qualification
MD, Northwestern University, Feinberg School of Medicine
… → 2007
Medicine, MD, Northwestern University, Feinberg School of Medicine
… → 2007
Research interests
- Aging
- Biochemistry: Nucleic Acid
- Critical Care
- Gene Regulation
- Gene-Environment Interactions
- Immunology
- Lung Injury
- Mechanical Ventilation
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Grants
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Targeting linear ubiquitination to attenuate inflammation and promote repair after IAV infection
National Heart, Lung, and Blood Institute
9/1/20 → 6/30/24
Project: Research project
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Mechanisms of regulatory T cell-mediated recovery from severe influenza A virus infection
Singer, B., Winter, D. R. & Wunderink, R. G.
National Heart, Lung, and Blood Institute
3/1/20 → 2/28/25
Project: Research project
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Epigenetic regulation of the Klotho / Miz 1 axis in smoking-induced emphysema.
Kalhan, R., Kim, S., Liu, J., Singer, B. & Kamp, D. W.
9/1/19 → 5/31/21
Project: Research project
Research Output
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A call for rational intensive care in the era of COVID-19
Singer, B. D., Jain, M., Budinger, G. R. S. & Wunderink, R. G., Jul 2020, In: American journal of respiratory cell and molecular biology. 63, 1, p. 132-133 2 p.Research output: Contribution to journal › Letter › peer-review
Open Access8 Scopus citations -
Age-dependent differences in t-cell responses to influenza a virus
Prigge, A. D., Ma, R., Coates, B. M., Singer, B. D. & Ridge, K. M., Oct 2020, In: American journal of respiratory cell and molecular biology. 63, 4, p. 415-423 9 p.Research output: Contribution to journal › Review article › peer-review
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Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Fang, C., Wang, Z., Han, C., Safgren, S. L., Helmin, K. A., Adelman, E. R., Serafin, V., Basso, G., Eagen, K. P., Gaspar-Maia, A., Figueroa, M. E., Singer, B. D., Ratan, A., Ntziachristos, P. & Zang, C., Sep 15 2020, In: Genome biology. 21, 1, 247.Research output: Contribution to journal › Article › peer-review
Open Access -
CoRESTed development of regulatory T cells
Morales-Nebreda, L., Helmin, K. A. & Singer, B. D., Apr 1 2020, In: Journal of Clinical Investigation. 130, 4, p. 1618-1621 4 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
COVID-19 and the next influenza season
Singer, B. D., Jul 2020, In: Science Advances. 6, 31, abd0086.Research output: Contribution to journal › Editorial › peer-review
Open Access5 Scopus citations