• 945 Citations
20032022
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Personal profile

Research Interests

In the context of acute lung inflammation and injury, my laboratory focuses on DNA methylation and gene expression as features that define T lymphocyte immunoregulatory phenotype and pro-repair function. Our data show that these epigenetic phenomena can potentiate resolution of acute lung inflammation and repair of lung damage. This work is also applicable to the study of aging as well as disease states outside the lung, including autoimmune conditions, malignancy, and organ allograft rejection.

I am a physician-scientist specializing in pulmonary and critical care medicine as well as internal medicine. I received an MD from the Northwestern University Feinberg School of Medicine, where I also completed residency and chief residency in internal medicine. I then undertook fellowship training in pulmonary and critical care medicine at the Johns Hopkins University School of Medicine before returning to Northwestern as a faculty member in 2015.

My clinical focus is in critical care (ICU) medicine. I have a particular interest in acute respiratory failure, the acute respiratory distress syndrome (ARDS), mechanical ventilation, and extracorporeal life support/extracorporeal membrane oxygenation. I also specialize in physician-to-physician consultation regarding medical diagnostic challenges as well as inpatient-based general pulmonary medicine.

Certifications and Licenses

Internal Medicine
Critical Care Medicine
Pulmonary Disease

Training Experience

2011Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital)
2015Fellowship, Johns Hopkins University School of Medicine

Education/Academic qualification

MD, Northwestern University Feinberg School of Medicine

… → 2007

Keywords

  • Aging
  • Biochemistry: Nucleic Acid
  • Critical Care
  • Gene Regulation
  • Gene-Environment Interactions
  • Immunology
  • Lung Injury
  • Mechanical Ventilation

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Grants 2015 2022

Lung Injury
DNA Methylation
Computing Methodologies
Dry Ice
RNA Sequence Analysis
Acute Lung Injury
Adult Respiratory Distress Syndrome
Lung Injury
Regulatory T-Lymphocytes
DNA Methylation
Human Influenza
Lung
DNA Methylation
Organized Financing
Virus Diseases
Acute Lung Injury
Lung Injury
Regulatory T-Lymphocytes
DNA Methylation
Inflammation

Research Output 2003 2019

1 Citation (Scopus)

DNA methylation as a transcriptional regulator of the immune system

Morales-Nebreda, L., McLafferty, F. S. & Singer, B., Feb 1 2019, In : Translational Research. 204, p. 1-18 18 p.

Research output: Contribution to journalReview article

Immune system
DNA Methylation
Immune System
Epigenomics
Genes
6 Citations (Scopus)

Mitochondrial complex III is essential for suppressive function of regulatory T cells

Weinberg, S. E., Singer, B., Steinert, E. M., Martinez, C. A., Mehta, M. M., Martínez-Reyes, I., Gao, P., Helmin, K. A., Abdala-Valencia, H., Sena, L. A., Schumacker, P. T., Turka, L. A. & Chandel, N., Jan 24 2019, In : Nature. 565, 7740, p. 495-499 5 p.

Research output: Contribution to journalLetter

Electron Transport Complex III
Regulatory T-Lymphocytes
Electron Transport
T-Lymphocytes
Self Tolerance
4 Citations (Scopus)

DNA methylation regulates the neonatal CD4 T-cell response to pneumonia in mice

McGrath-Morrow, S. A., Ndeh, R., Helmin, K. A., Chen, S. Y., Anekalla, K. R., Abdala-Valencia, H., D’Alessio, F. R., Michael Collaco, J. & Singer, B., Jan 1 2018, In : Journal of Biological Chemistry. 293, 30, p. 11772-11783 12 p.

Research output: Contribution to journalArticle

T-cells
DNA Methylation
Pneumonia
T-Lymphocytes
Pediatrics
2 Citations (Scopus)
Severe Acute Respiratory Syndrome
Extracorporeal Membrane Oxygenation
Adult Respiratory Distress Syndrome
Artificial Respiration
Vital Capacity

Inflammation and transcriptional responses of peripheral blood mononuclear cells in classic ataxia telangiectasia

McGrath-Morrow, S. A., Ndeh, R., Collaco, J. M., Rothblum-Oviatt, C., Wright, J., O’Reilly, M. A., Singer, B. & Lederman, H. M., Dec 1 2018, In : PloS one. 13, 12, e0209496.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
mononuclear leukocytes
Blood Cells
Blood
Genes