• 1188 Citations
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Personal profile

Research Interests

In the context of acute lung inflammation and injury, my laboratory focuses on DNA methylation and gene expression as features that define T lymphocyte immunoregulatory phenotype and pro-repair function. Our data show that these epigenetic phenomena can potentiate resolution of acute lung inflammation and repair of lung damage. This work is also applicable to the study of aging as well as disease states outside the lung, including autoimmune conditions, malignancy, and organ allograft rejection.

I am a physician-scientist specializing in pulmonary and critical care medicine as well as internal medicine. I received an MD from the Northwestern University Feinberg School of Medicine, where I also completed residency and chief residency in internal medicine. I then undertook fellowship training in pulmonary and critical care medicine at the Johns Hopkins University School of Medicine before returning to Northwestern as a faculty member in 2015.

My clinical focus is in critical care (ICU) medicine. I have a particular interest in acute respiratory failure, the acute respiratory distress syndrome (ARDS), mechanical ventilation, and extracorporeal life support/extracorporeal membrane oxygenation. I also specialize in physician-to-physician consultation regarding medical diagnostic challenges as well as inpatient-based general pulmonary medicine.

Certifications and Licenses

Internal Medicine
Critical Care Medicine
Pulmonary Disease

Training Experience

2011Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital)
2015Fellowship, Johns Hopkins University School of Medicine

Education/Academic qualification

MD, Northwestern University Feinberg School of Medicine

… → 2007

Research interests

  • Aging
  • Biochemistry: Nucleic Acid
  • Critical Care
  • Gene Regulation
  • Gene-Environment Interactions
  • Immunology
  • Lung Injury
  • Mechanical Ventilation

Fingerprint Dive into the research topics where Benjamin Singer is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 18 Similar Profiles
Regulatory T-Lymphocytes Medicine & Life Sciences
Lung Medicine & Life Sciences
DNA Methylation Medicine & Life Sciences
Artificial Respiration Medicine & Life Sciences
Pneumonia Medicine & Life Sciences
Adult Respiratory Distress Syndrome Medicine & Life Sciences
Macrophages Medicine & Life Sciences
Lung Injury Medicine & Life Sciences

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Grants 2015 2022

Mitochondrial DNA
Chronic Obstructive Pulmonary Disease
Lung Injury
DNA Methylation
Computing Methodologies
Dry Ice
RNA Sequence Analysis
Acute Lung Injury
Adult Respiratory Distress Syndrome
Lung Injury
Regulatory T-Lymphocytes
DNA Methylation

Research Output 2003 2019

A practical guide to the measurement and analysis of DNA methylation

Singer, B. D., Oct 1 2019, In : American journal of respiratory cell and molecular biology. 61, 4, p. 417-428 12 p.

Research output: Contribution to journalReview article

DNA Methylation
Computational Biology
Computing Methodologies
1 Citation (Scopus)

Catacomb: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Piunti, A., Smith, E. R., Morgan, M. A. J., Ugarenko, M., Khaltyan, N., Helmin, K. A., Ryan, C. A., Murray, D. C., Rickels, R. A., Yilmaz, B. D., Rendleman, E. J., Savas, J. N., Singer, B. D., Bulun, S. E. & Shilatifard, A., Jan 1 2019, In : Science Advances. 5, 7, eaax2887.

Research output: Contribution to journalArticle

Open Access
deoxyribonucleic acid
COMPASS (programming language)
2 Citations (Scopus)

Detection of respiratory pathogens in clinical samples using metagenomic shotgun sequencing

Qi, C., Hountras, P., Pickens, C. O., Walter, J. M., Kruser, J. M., Singer, B., Seed, P. C., Green, S. J. & Wunderink, R. G., Jul 1 2019, In : Journal of Medical Microbiology. 68, 7, p. 996-1002 7 p.

Research output: Contribution to journalArticle

Bronchoalveolar Lavage
16 Citations (Scopus)

DNA methylation as a transcriptional regulator of the immune system

Morales-Nebreda, L., McLafferty, F. S. & Singer, B., Feb 1 2019, In : Translational Research. 204, p. 1-18 18 p.

Research output: Contribution to journalReview article

Immune system
DNA Methylation
Immune System
Direction compound
Pulmonary Vein Stenosis