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Benjamin Singer

  • 1283 Citations
20032025

Research output per year

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Personal profile

Research Interests

In the context of acute lung inflammation and injury, my laboratory focuses on DNA methylation and gene expression as features that define T lymphocyte immunoregulatory phenotype and pro-repair function. Our data show that these epigenetic phenomena can potentiate resolution of acute lung inflammation and repair of lung damage. This work is also applicable to the study of aging as well as disease states outside the lung, including autoimmune conditions, malignancy, and organ allograft rejection.

I am a physician-scientist specializing in pulmonary and critical care medicine as well as internal medicine. I received an MD from the Northwestern University Feinberg School of Medicine, where I also completed residency and chief residency in internal medicine. I then undertook fellowship training in pulmonary and critical care medicine at the Johns Hopkins University School of Medicine before returning to Northwestern as a faculty member in 2015.

My clinical focus is in critical care (ICU) medicine. I have a particular interest in acute respiratory failure, the acute respiratory distress syndrome (ARDS), mechanical ventilation, and extracorporeal life support/extracorporeal membrane oxygenation. I also specialize in physician-to-physician consultation regarding medical diagnostic challenges as well as inpatient-based general pulmonary medicine.

Certifications and Licenses

Internal Medicine
Critical Care Medicine
Pulmonary Disease

Training Experience

2011Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital)
2015Fellowship, Johns Hopkins University School of Medicine

Education/Academic qualification

MD, Northwestern University Feinberg School of Medicine

… → 2007

Research interests

  • Aging
  • Biochemistry: Nucleic Acid
  • Critical Care
  • Gene Regulation
  • Gene-Environment Interactions
  • Immunology
  • Lung Injury
  • Mechanical Ventilation

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Grants

Mechanisms of regulatory T cell-mediated recovery from severe influenza A virus infection

Singer, B., Winter, D. R. & Wunderink, R. G.

National Heart, Lung, and Blood Institute

3/1/20 → 2/28/25

Project: Research project

Epigenetic regulation of the Klotho / Miz 1 axis in smoking-induced emphysema.

Kalhan, R., Kamp, D. W., Kim, S., Liu, J. & Singer, B.

National Institute on Aging

9/1/19 → 5/31/21

Project: Research project

    • 5-laser 30-parameter FACSymphony-S6 SORP Cell Sorter from BD Biosciences

    Abecassis, M. M., Bharat, A., Budinger, G. S., D'Aquila, R. T., Hope, T. J., Kato, A., Le Poole, I. C., Lesniak, M. S., Luo, X., Misharin, A., Perlman, H. R., Schleimer, R. P., Singer, B., Swaminathan, S., Sznajder, J. I., Tetreault, M., Thorp, E. B. & Wunderink, R. G.

    Office of the Director, National Institutes of Health

    8/8/19 → 8/7/20

    Project: Research project

    • Resolution of Diffuse Inflammatory Lung Injury in Neonatal Mice

    Singer, B.

    Johns Hopkins University, National Heart, Lung, and Blood Institute

    9/1/18 → 8/31/20

    Project: Research project

    • Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center

    Abdala-Valencia, H., Amaral, L. A. N., Bartom, E. T., Budinger, G. S., Davuluri, R. V., Hauser, A. R., Horvath, C. M., Kandpal, M., Misharin, A., Ozer, E. A., Qi, C., Singer, B., Starren, J. B., Wehbe, F., Winter, D. R. & Wunderink, R. G.

    National Institute of Allergy and Infectious Diseases

    1/17/18 → 12/31/22

    Project: Research project

    • Research Output

    Erratum: Detection of respiratory pathogens in clinical samples using metagenomic shotgun sequencing (Journal of Medical Microbiology (2020) 68 (996-1002) DOI: 10.1099/jmm.0.000968)

    Qi, C., Hountras, P., Pickens, C. O., Walter, J. M., Kruser, J. M., Singer, B. D., Seed, P., Green, S. J. & Wunderink, R. G., Jan 1 2020, In : Journal of medical microbiology. 69, 1, 1 p.

    Research output: Contribution to journal › Comment/debate

    • A practical guide to the measurement and analysis of DNA methylation

    Singer, B. D., Oct 1 2019, In : American journal of respiratory cell and molecular biology. 61, 4, p. 417-428 12 p.

    Research output: Contribution to journal › Review article

    • 1 Scopus citations

    Catacomb: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

    Piunti, A., Smith, E. R., Morgan, M. A. J., Ugarenko, M., Khaltyan, N., Helmin, K. A., Ryan, C. A., Murray, D. C., Rickels, R. A., Yilmaz, B. D., Rendleman, E. J., Savas, J. N., Singer, B. D., Bulun, S. E. & Shilatifard, A., Jan 1 2019, In : Science Advances. 5, 7, eaax2887.

    Research output: Contribution to journal › Article

    Open Access
    • 2 Scopus citations

    Detection of respiratory pathogens in clinical samples using metagenomic shotgun sequencing

    Qi, C., Hountras, P., Pickens, C. O., Walter, J. M., Kruser, J. M., Singer, B. D., Seed, P., Green, S. J. & Wunderink, R. G., Jul 2019, In : Journal of medical microbiology. 68, 7, p. 996-1002 7 p.

    Research output: Contribution to journal › Article

    • 3 Scopus citations

    DNA methylation as a transcriptional regulator of the immune system

    Morales-Nebreda, L., McLafferty, F. S. & Singer, B. D., Feb 2019, In : Translational Research. 204, p. 1-18 18 p.

    Research output: Contribution to journal › Review article

    • 16 Scopus citations