Grants per year
Personal profile
Research Interests
The Perez White laboratory strives to conduct leading-edge research in the field of epidermal biology with the ultimate goal of impacting medicine and advancing our understanding of skin. To this end, we incorporate hypothesis-driven research with innovative disease models and discovery approaches. Specifically, we employ three-dimensional models of bioengineered reconstituted human epidermis and mouse models with proteomics, RNA-sequencing, or microarray analysis. We uniquely exploit our use of primary human cells to identify key signal transduction mechanisms that drive the physiological state and how these pathways may be hijacked to contribute to pathological states. The overall aim of our research direction is to define Eph receptor tyrosine kinase signal networks underlying epidermal homeostasis. As little is known about Eph receptors in skin biology, we performed a proteomics screen to generate a directory of EphA2-interacting proteins in primary human epidermal keratinocytes. So far, this rich resource has led us to appreciate an unrecognized role for EphA2 in tight junction morphogenesis. EphA2 promotes the de novo assembly and functional integrity of the epidermal tight junction barrier. The tight junction barrier is an indispensable structural network that prevents the movement of small molecules (water, solutes, ions, proteins, and pathogens, infectious agents, and allergens) into or out of an organism. Perturbations in tight junctions are relevant to several skin disorders such as cancer, atopic dermatitis, and psoriasis.
Education/Academic qualification
PhD, University of Illinois at Chicago
… → 2012
Biopharmaceutial Sciences, PhD, University of Illinois at Chicago
… → 2012
Research interests
- Cancer Biology
- Cell Biology
- Molecular Biology
- Skin
- Skin Cancer
- Tissue Engineering
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Network
Grants
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Mechanisms for Initiation of Food Allergy Early in Life
Indiana University, National Institute of Allergy and Infectious Diseases
7/1/20 → 6/30/25
Project: Research project
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Comprehensive Characterization and Contribution of the Keratinocytes-Fibroblasts Crosstalk in 3D-Scleroderma Skin Equivalent
Bhattacharyya, S., Perez White, B. E. & Varga, J.
Boehringer Ingelheim Pharmaceuticals, Inc.
3/13/20 → 3/13/23
Project: Research project
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Specific inhibition of transcription factors with Cobalt-Schiff Base Complexes
Perez White, B. E., Holmgren, R. A. & Meade, T. J.
National Institute of General Medical Sciences
7/15/17 → 4/30/21
Project: Research project
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Perez-White: Specific inhibition of transcription factors with Cobalt-Schiff Base Complexes
National Institute of General Medical Sciences
7/15/17 → 4/30/21
Project: Research project
Research Output
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Biotin identification proteomics in three-dimensional organotypic human skin cultures
Cable, C. J., Kaplan, N., Getsios, S., Thomas, P. M. & Perez White, B. E., 2020, Methods in Molecular Biology. Humana Press Inc., p. 185-197 13 p. (Methods in Molecular Biology; vol. 2109).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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FIH-1 engages novel binding partners to positively influence epithelial proliferation via p63
Kaplan, N., Dong, Y., Wang, S., Yang, W., Park, J. K., Wang, J., Fiolek, E., Perez White, B., Chandel, N. S., Peng, H. & Lavker, R. M., Jan 1 2020, In: FASEB Journal. 34, 1, p. 525-539 15 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Loss-of-function variants in C3ORF52 result in localized autosomal recessive hypotrichosis
Malki, L., Sarig, O., Cesarato, N., Mohamad, J., Canter, T., Assaf, S., Pavlovsky, M., Vodo, D., Anis, Y., Bihari, O., Malovitski, K., Gat, A., Thiele, H., White, B. E. P., Samuelov, L., Nanda, A., Paller, A. S., Betz, R. C. & Sprecher, E., Jul 1 2020, In: Genetics in Medicine. 22, 7, p. 1227-1234 8 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Progression of acute-to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses
Tsoi, L. C., Rodriguez, E., Stölzl, D., Wehkamp, U., Sun, J., Gerdes, S., Sarkar, M. K., Hübenthal, M., Zeng, C., Uppala, R., Xing, X., Thielking, F., Billi, A. C., Swindell, W. R., Shefler, A., Chen, J., Patrick, M. T., Harms, P. W., Kahlenberg, J. M., Perez White, B. E. & 3 others, , May 2020, In: Journal of Allergy and Clinical Immunology. 145, 5, p. 1406-1415 10 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
A20 and ABIN1 Suppression of a Keratinocyte Inflammatory Program with a Shared Single-Cell Expression Signature in Diverse Human Rashes
Harirchian, P., Lee, J., Hilz, S., Sedgewick, A. J., Perez White, B. E., Kesling, M. J., Mully, T., Golovato, J., Gray, M., Mauro, T. M., Purdom, E., Kim, E. A., Sbitany, H., Bhutani, T., Vaske, C. J., Benz, S. C., Cho, R. J. & Cheng, J. B., Jun 2019, In: Journal of Investigative Dermatology. 139, 6, p. 1264-1273 10 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations