Grants per year
Personal profile
Research Interests
The Perez White laboratory strives to conduct leading-edge research in the field of epidermal biology with the ultimate goal of impacting medicine and advancing our understanding of skin. To this end, we incorporate hypothesis-driven research with innovative disease models and discovery approaches. Specifically, we employ three-dimensional models of bioengineered reconstituted human epidermis and mouse models with proteomics, RNA-sequencing, or microarray analysis. We uniquely exploit our use of primary human cells to identify key signal transduction mechanisms that drive the physiological state and how these pathways may be hijacked to contribute to pathological states. The overall aim of our research direction is to define Eph receptor tyrosine kinase signal networks underlying epidermal homeostasis. As little is known about Eph receptors in skin biology, we performed a proteomics screen to generate a directory of EphA2-interacting proteins in primary human epidermal keratinocytes. So far, this rich resource has led us to appreciate an unrecognized role for EphA2 in tight junction morphogenesis. EphA2 promotes the de novo assembly and functional integrity of the epidermal tight junction barrier. The tight junction barrier is an indispensable structural network that prevents the movement of small molecules (water, solutes, ions, proteins, and pathogens, infectious agents, and allergens) into or out of an organism. Perturbations in tight junctions are relevant to several skin disorders such as cancer, atopic dermatitis, and psoriasis.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biopharmaceutial Sciences, PhD, University of Illinois at Chicago
… → 2012
Research interests keywords
- Cancer Biology
- Cell Biology
- Molecular Biology
- Skin
- Skin Cancer
- Tissue Engineering
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Core B Subproject
Green, K. J. (Co-Investigator) & Perez White, B. E. (Co-Investigator)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
8/1/24 → 6/30/29
Project: Research project
-
Potential role of skin in SARS-CoV-2 infection
Budunova, I. (PD/PI) & Perez White, B. E. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
7/21/23 → 6/30/25
Project: Research project
-
Role of healthy skin molecular phenotype in the switch to specific skin diseases
Budunova, I. (PD/PI), Budunova, I. (PD/PI), Budunova, I. (PD/PI), Perez White, B. E. (Co-Investigator), Perez White, B. E. (Co-Investigator) & Perez White, B. E. (Co-Investigator)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/23/22 → 8/31/25
Project: Research project
-
Barrier Damage and The Immune Cascade: Northwestern University CounterACT Center of Excellence (NUCCX) *Admin Core A*
Lu, K. (PD/PI), Lu, K. (PD/PI), Lavker, R. M. (Co-PD/PI), Lavker, R. M. (Co-PD/PI), Guitart, J. (Co-Investigator), Guitart, J. (Co-Investigator), Kennedy, M. (Co-Investigator), Kennedy, M. (Co-Investigator), Kim, K.-Y. A. (Co-Investigator), Kim, K.-Y. A. (Co-Investigator), Paller, A. (Co-Investigator), Paller, A. (Co-Investigator), Peng, H. (Co-Investigator), Peng, H. (Co-Investigator), Perez White, B. E. (Co-Investigator), Perez White, B. E. (Co-Investigator), Dravid, V. P. (Other), Dravid, V. P. (Other), Gianneschi, N. (Other), Gianneschi, N. (Other), Goldberg, B. B. (Other), Goldberg, B. B. (Other), Le Poole, I. C. (Other), Le Poole, I. C. (Other), Miller, S. D. (Other), Miller, S. D. (Other), Nguyen, S. (Other), Nguyen, S. (Other), Rangel, S. M. (Other), Rangel, S. M. (Other), Thaxton, C. S. (Other), Thaxton, C. S. (Other), Xu, D. (Other) & Xu, D. (Other)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/17/21 → 7/31/25
Project: Research project
-
Mechanisms for Initiation of Food Allergy Early in Life
Perez White, B. E. (PD/PI) & Perez White, B. E. (PD/PI)
Indiana University, National Institute of Allergy and Infectious Diseases
7/1/20 → 6/30/25
Project: Research project
-
Neonatal Fc Receptor Inhibition Reduces Bullous Pemphigoid Anti–Basement Membrane Zone IgG Deposition and Blistering in 3-Dimensional Human Skin Equivalents
Bao, L., Perez White, B. E., Chang, R. C., Li, J., Vanderheyden, K., Verheesen, P., Sips, M., Brinkhaus, M. & Amber, K. T., Dec 2024, In: Journal of Investigative Dermatology. 144, 12, p. 2809-2812.e2Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Receptor Tyrosine Kinase EPHA2 Drives Epidermal Differentiation through Regulation of EGFR Signaling
Perez White, B. E., Cable, C. J., Shi, B., Ventrella, R., Kaplan, N., Kobeissi, A., Higuchi, Y., Balu, A., Murphy, Z. R., Kumar, P. & Getsios, S., Aug 2024, In: Journal of Investigative Dermatology. 144, 8, p. 1798-1807.e1Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-κ activation and APOBEC3G induction
Sarkar, M. K., Uppala, R., Zeng, C., Billi, A. C., Tsoi, L. C., Kidder, A., Xing, X., White, B. E. P., Shao, S., Plazyo, O., Sirobhushanam, S., Xing, E., Jiang, Y., Gallagher, K. A., Voorhees, J. J., Michelle Kahlenberg, J. & Gudjonsson, J. E., May 1 2023, In: Journal of Clinical Investigation. 133, 9, e159393.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Nucleoli and the nucleoli–centromere association are dynamic during normal development and in cancer
Rodrigues, A., MacQuarrie, K. L., Freeman, E., Lin, A., Willis, A. B., Xu, Z., Alvarez, A. A., Ma, Y., Perez White, B. E., Foltz, D. R. & Huang, S., Apr 2023, In: Molecular biology of the cell. 34, 4, br5.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Reduced SPAG17 Expression in Systemic Sclerosis Triggers Myofibroblast Transition and Drives Fibrosis
Sapao, P., Roberson, E. D. O., Shi, B., Assassi, S., Skaug, B., Lee, F., Naba, A., Perez White, B. E., Córdova-Fletes, C., Tsou, P. S., Sawalha, A. H., Gudjonsson, J. E., Ma, F., Verma, P., Bhattacharyya, D., Carns, M., Strauss, J. F., Sicard, D., Tschumperlin, D. J. & Champer, M. I. & 3 others, , Feb 2023, In: Journal of Investigative Dermatology. 143, 2, p. 284-293 10 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations
Datasets
-
Skin rash composition after checkpoint inhibitor therapy varies by therapeutic regimen
Bhuva, D. (Contributor), Choi, J. (Contributor), Cosgrove, C. (Contributor), Hong, S. (Contributor), Jaishankar, D. (Contributor), Kosche, C. (Contributor), Le Poole, I. C. (Contributor), Li, L. (Contributor), Munir, S. (Contributor), Perez White, B. (Contributor), Ramesh, P. (Creator), Shivde, R. (Contributor) & Zhang, H. (Contributor), Mendeley Data, 2022
DOI: 10.17632/hw4j2k8xt3.1, https://data.mendeley.com/datasets/hw4j2k8xt3
Dataset