Grants per year
Personal profile
Research Interests
The Perez White laboratory strives to conduct leading-edge research in the field of epidermal biology with the ultimate goal of impacting medicine and advancing our understanding of skin. To this end, we incorporate hypothesis-driven research with innovative disease models and discovery approaches. Specifically, we employ three-dimensional models of bioengineered reconstituted human epidermis and mouse models with proteomics, RNA-sequencing, or microarray analysis. We uniquely exploit our use of primary human cells to identify key signal transduction mechanisms that drive the physiological state and how these pathways may be hijacked to contribute to pathological states. The overall aim of our research direction is to define Eph receptor tyrosine kinase signal networks underlying epidermal homeostasis. As little is known about Eph receptors in skin biology, we performed a proteomics screen to generate a directory of EphA2-interacting proteins in primary human epidermal keratinocytes. So far, this rich resource has led us to appreciate an unrecognized role for EphA2 in tight junction morphogenesis. EphA2 promotes the de novo assembly and functional integrity of the epidermal tight junction barrier. The tight junction barrier is an indispensable structural network that prevents the movement of small molecules (water, solutes, ions, proteins, and pathogens, infectious agents, and allergens) into or out of an organism. Perturbations in tight junctions are relevant to several skin disorders such as cancer, atopic dermatitis, and psoriasis.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biopharmaceutial Sciences, PhD, University of Illinois at Chicago
… → 2012
Research interests
- Cancer Biology
- Cell Biology
- Molecular Biology
- Skin
- Skin Cancer
- Tissue Engineering
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Role of healthy skin molecular phenotype in the switch to specific skin diseases
Budunova, I. & Perez White, B. E.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/23/22 → 8/31/24
Project: Research project
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Barrier Damage and The Immune Cascade: Northwestern University CounterACT Center of Excellence (NUCCX) *Admin Core A*
Lu, K., Lavker, R. M., Guitart, J., Kennedy, M., Kim, K. A., Paller, A., Peng, H., Perez White, B. E., Dravid, V. P., Gianneschi, N., Goldberg, B. B., Le Poole, I. C., Miller, S. D., Nguyen, S., Rangel, S. M., Thaxton, C. S. & Xu, D.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/17/21 → 7/31/25
Project: Research project
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Mechanisms for Initiation of Food Allergy Early in Life
Indiana University, National Institute of Allergy and Infectious Diseases
7/1/20 → 6/30/25
Project: Research project
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Comprehensive Characterization and Contribution of the Keratinocytes-Fibroblasts Crosstalk in 3D-Scleroderma Skin Equivalent
Bhattacharyya, S., Perez White, B. E. & Varga, J.
Boehringer Ingelheim Pharmaceuticals, Inc.
3/13/20 → 3/13/23
Project: Research project
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Northwestern University Skin Biology and Diseases Resource-based Center
Paller, A., Rangel, S. M., Budunova, I., Green, K. J., Lavker, R. M., Le Poole, I. C., Lu, K., Perez White, B. E. & Yemelyanov, A.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
8/20/19 → 7/31/24
Project: Research project
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Reduced SPAG17 Expression in Systemic Sclerosis Triggers Myofibroblast Transition and Drives Fibrosis
Sapao, P., Roberson, E. D. O., Shi, B., Assassi, S., Skaug, B., Lee, F., Naba, A., Perez White, B. E., Córdova-Fletes, C., Tsou, P. S., Sawalha, A. H., Gudjonsson, J. E., Ma, F., Verma, P., Bhattacharyya, D., Carns, M., Strauss, J. F., Sicard, D., Tschumperlin, D. J., Champer, M. I., & 3 others , Feb 2023, In: Journal of Investigative Dermatology. 143, 2, p. 284-293 10 p.Research output: Contribution to journal › Article › peer-review
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Cytokine responses in nonlesional psoriatic skin as clinical predictor to anti-TNF agents
Tsoi, L. C., Patrick, M. T., Shuai, S., Sarkar, M. K., Chi, S., Ruffino, B., Billi, A. C., Xing, X., Uppala, R., Zang, C., Fullmer, J., He, Z., Maverakis, E., Mehta, N. N., Perez White, B. E., Getsios, S., Helfrich, Y., Voorhees, J. J., Kahlenberg, J. M., Weidinger, S., & 1 others , Feb 2022, In: Journal of Allergy and Clinical Immunology. 149, 2, p. 640-649.e5Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Gene expression profiling of laminin α3-blocked keratinocytes reveals an immune-independent mechanism of blistering
Bao, L., Perez White, B. E., Li, J., Patel, P. M. & Amber, K. T., Apr 2022, In: Experimental Dermatology. 31, 4, p. 615-621 7 p.Research output: Contribution to journal › Article › peer-review
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Inhibition of dipeptidyl-peptidase 4 induces upregulation of the late cornified envelope cluster in keratinocytes
Bao, L., Li, J., Perez White, B. E., Patel, P. M. & Amber, K. T., Nov 2022, In: Archives of Dermatological Research. 314, 9, p. 909-915 7 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
The Desmosome-Keratin Scaffold Integrates ErbB Family and Mechanical Signaling to Polarize Epidermal Structure and Function
Green, K. J., Niessen, C. M., Rübsam, M., Perez White, B. E. & Broussard, J. A., May 24 2022, In: Frontiers in Cell and Developmental Biology. 10, 903696.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations