Bethany Elena Perez-White

  • 313 Citations
20022021
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Personal profile

Research Interests

The Perez White laboratory strives to conduct leading-edge research in the field of epidermal biology with the ultimate goal of impacting medicine and advancing our understanding of skin. To this end, we incorporate hypothesis-driven research with innovative disease models and discovery approaches. Specifically, we employ three-dimensional models of bioengineered reconstituted human epidermis and mouse models with proteomics, RNA-sequencing, or microarray analysis. We uniquely exploit our use of primary human cells to identify key signal transduction mechanisms that drive the physiological state and how these pathways may be hijacked to contribute to pathological states. The overall aim of our research direction is to define Eph receptor tyrosine kinase signal networks underlying epidermal homeostasis. As little is known about Eph receptors in skin biology, we performed a proteomics screen to generate a directory of EphA2-interacting proteins in primary human epidermal keratinocytes. So far, this rich resource has led us to appreciate an unrecognized role for EphA2 in tight junction morphogenesis. EphA2 promotes the de novo assembly and functional integrity of the epidermal tight junction barrier. The tight junction barrier is an indispensable structural network that prevents the movement of small molecules (water, solutes, ions, proteins, and pathogens, infectious agents, and allergens) into or out of an organism. Perturbations in tight junctions are relevant to several skin disorders such as cancer, atopic dermatitis, and psoriasis.

Education/Academic qualification

PhD, University of Illinois - Chicago

… → 2012

Keywords

  • Cancer Biology
  • Cell Biology
  • Molecular Biology
  • Skin
  • Skin Cancer
  • Tissue Engineering

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Breast Neoplasms Medicine & Life Sciences
Tamoxifen Medicine & Life Sciences
Keratinocytes Medicine & Life Sciences
Eph Family Receptors Medicine & Life Sciences
Protein Kinase C-alpha Medicine & Life Sciences
Atopic Dermatitis Medicine & Life Sciences
Tight Junctions Medicine & Life Sciences
Skin Medicine & Life Sciences

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Grants 2011 2021

Research Output 2002 2019

  • 313 Citations
  • 15 Article
  • 1 Comment/debate
  • 1 Letter
  • 1 Review article

A20 and ABIN1 Suppression of a Keratinocyte Inflammatory Program with a Shared Single-Cell Expression Signature in Diverse Human Rashes

Harirchian, P., Lee, J., Hilz, S., Sedgewick, A. J., Perez-White, B. E., Kesling, M. J., Mully, T., Golovato, J., Gray, M., Mauro, T. M., Purdom, E., Kim, E. A., Sbitany, H., Bhutani, T., Vaske, C. J., Benz, S. C., Cho, R. J. & Cheng, J. B., Jan 1 2019, In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Exanthema
Keratinocytes
Psoriasis
Genes
Interleukin-17
1 Citation (Scopus)

Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis

Tsoi, L. C., Rodriguez, E., Degenhardt, F., Baurecht, H., Wehkamp, U., Volks, N., Szymczak, S., Swindell, W. R., Sarkar, M. K., Raja, K., Shao, S., Patrick, M., Gao, Y., Uppala, R., Perez-White, B. E., Getsios, S., Harms, P. W., Maverakis, E., Elder, J. T., Franke, A. & 2 othersGudjonsson, J. E. & Weidinger, S., Jan 1 2019, In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Atopic Dermatitis
Psoriasis
Skin
RNA Sequence Analysis
RNA
1 Citation (Scopus)

Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council

Eyerich, K., Brown, S. J., Perez-White, B. E., Tanaka, R. J., Bissonette, R., Dhar, S., Bieber, T., Hijnen, D. J., Guttman-Yassky, E., Irvine, A., Thyssen, J. P., Vestergaard, C., Werfel, T., Wollenberg, A., Paller, A. & Reynolds, N. J., Jan 1 2019, In : Journal of Allergy and Clinical Immunology. 143, 1, p. 36-45 10 p.

Research output: Contribution to journalArticle

Eczema
Atopic Dermatitis
Therapeutics
Biological Models
Precision Medicine
6 Citations (Scopus)

Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma

North, J. P., Golovato, J., Vaske, C. J., Sanborn, J. Z., Nguyen, A., Wu, W., Goode, B., Stevers, M., McMullen, K., Perez-White, B. E., Collisson, E. A., Bloomer, M., Solomon, D. A., Benz, S. C. & Cho, R. J., Dec 1 2018, In : Nature communications. 9, 1, 1894.

Research output: Contribution to journalArticle

mutations
Microsatellite Repeats
cancer
Carcinoma
Mutation

Concurrent juxtapapillary hemorrage and optic disc edema as initial presentation of POEMS syndrome

Dong, Y., Yin, D., Perez-White, B. E., Guo, Q., Pi, Y. & Wei, S., Dec 1 2018, In : Canadian Journal of Ophthalmology. 53, 6, p. e233-e236

Research output: Contribution to journalLetter

POEMS Syndrome
Papilledema