Bethany Elena Perez-White

  • 463 Citations
20022020

Research output per year

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Personal profile

Research Interests

The Perez White laboratory strives to conduct leading-edge research in the field of epidermal biology with the ultimate goal of impacting medicine and advancing our understanding of skin. To this end, we incorporate hypothesis-driven research with innovative disease models and discovery approaches. Specifically, we employ three-dimensional models of bioengineered reconstituted human epidermis and mouse models with proteomics, RNA-sequencing, or microarray analysis. We uniquely exploit our use of primary human cells to identify key signal transduction mechanisms that drive the physiological state and how these pathways may be hijacked to contribute to pathological states. The overall aim of our research direction is to define Eph receptor tyrosine kinase signal networks underlying epidermal homeostasis. As little is known about Eph receptors in skin biology, we performed a proteomics screen to generate a directory of EphA2-interacting proteins in primary human epidermal keratinocytes. So far, this rich resource has led us to appreciate an unrecognized role for EphA2 in tight junction morphogenesis. EphA2 promotes the de novo assembly and functional integrity of the epidermal tight junction barrier. The tight junction barrier is an indispensable structural network that prevents the movement of small molecules (water, solutes, ions, proteins, and pathogens, infectious agents, and allergens) into or out of an organism. Perturbations in tight junctions are relevant to several skin disorders such as cancer, atopic dermatitis, and psoriasis.

Education/Academic qualification

PhD, University of Illinois at Chicago

… → 2012

Research interests

  • Cancer Biology
  • Cell Biology
  • Molecular Biology
  • Skin
  • Skin Cancer
  • Tissue Engineering

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Grants

Research Output

Biotin identification proteomics in three-dimensional organotypic human skin cultures

Cable, C. J., Kaplan, N., Getsios, S., Thomas, P. M. & Perez White, B. E., Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 185-197 13 p. (Methods in Molecular Biology; vol. 2109).

Research output: Chapter in Book/Report/Conference proceedingChapter

  • FIH-1 engages novel binding partners to positively influence epithelial proliferation via p63

    Kaplan, N., Dong, Y., Wang, S., Yang, W., Park, J. K., Wang, J., Fiolek, E., Perez White, B., Chandel, N. S., Peng, H. & Lavker, R. M., Jan 1 2020, In : FASEB Journal. 34, 1, p. 525-539 15 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Loss-of-function variants in C3ORF52 result in localized autosomal recessive hypotrichosis

    Malki, L., Sarig, O., Cesarato, N., Mohamad, J., Canter, T., Assaf, S., Pavlovsky, M., Vodo, D., Anis, Y., Bihari, O., Malovitski, K., Gat, A., Thiele, H., White, B. E. P., Samuelov, L., Nanda, A., Paller, A. S., Betz, R. C. & Sprecher, E., Jan 1 2020, (Accepted/In press) In : Genetics in Medicine.

    Research output: Contribution to journalArticle

  • Progression of acute-to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses

    Tsoi, L. C., Rodriguez, E., Stölzl, D., Wehkamp, U., Sun, J., Gerdes, S., Sarkar, M. K., Hübenthal, M., Zeng, C., Uppala, R., Xing, X., Thielking, F., Billi, A. C., Swindell, W. R., Shefler, A., Chen, J., Patrick, M. T., Harms, P. W., Kahlenberg, J. M., Perez White, B. E. & 3 others, Maverakis, E., Gudjonsson, J. E. & Weidinger, S., May 2020, In : Journal of Allergy and Clinical Immunology. 145, 5, p. 1406-1415 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    A20 and ABIN1 Suppression of a Keratinocyte Inflammatory Program with a Shared Single-Cell Expression Signature in Diverse Human Rashes

    Harirchian, P., Lee, J., Hilz, S., Sedgewick, A. J., Perez White, B. E., Kesling, M. J., Mully, T., Golovato, J., Gray, M., Mauro, T. M., Purdom, E., Kim, E. A., Sbitany, H., Bhutani, T., Vaske, C. J., Benz, S. C., Cho, R. J. & Cheng, J. B., Jun 2019, In : Journal of Investigative Dermatology. 139, 6, p. 1264-1273 10 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations