Grants per year
Personal profile
Research Interests
Cancer immunology and immunotherapy. The Zhang laboratory functions as an integrated translational research program with the goal of designing and developing new immunotherapies and immunologic strategies for cancer treatment. The ongoing projects are focused on dissecting the molecular mechanisms used for tumor immune evasion based on the cutting-edge technical platforms.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Cell Biology, Chinese Academy of Medical Science & Peking Union Medical College
… → 2003
MD, Medicine, West China University
… → 1999
Research interests keywords
- Cancer Biology
- Drug Discovery
- Immune Regulation
- Nanotechnology
- Translational Research
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Potentiating long-lived antitumor effector CD8+ T cells for TNBC therapy
Zhang, B. (PD/PI), Cui, W. (Co-Investigator), Gradishar, W. J. (Co-Investigator), Chandel, N. (Other) & Ji, Z. (Other)
U.S. Army Medical Research and Materiel Command
12/15/24 → 12/14/27
Project: Research project
-
Development of a novel CD73 protein degrader for melanoma immunotherapy
Zhang, B. (PD/PI) & Schiltz, G. E. (Co-Investigator)
Melanoma Research Alliance Foundation
10/4/24 → 10/3/26
Project: Research project
-
A novel pathway to overcome resistance to immunotherapy in melanoma
Nora Vaz Saleiro, D. (PD/PI), Kocherginsky, M. (Co-Investigator) & Zhang, B. (Co-Investigator)
7/1/24 → 6/30/29
Project: Research project
-
Sustaining antitumor effector CD8+ T cells for cancer therapy
Zhang, B. (PD/PI), Gradishar, W. J. (Co-Investigator), Ji, Z. (Co-Investigator) & Sosman, J. A. (Co-Investigator)
5/17/24 → 4/30/29
Project: Research project
-
Transcatheter Intra-Arterial Delivery of Oriented Anti-PD-L1 Immune checkpoint inhibitors Immobilized Nanocarriers for Local Combination Immunotherapy of Hepatocellular Carcinoma
Kim, D.-H. (PD/PI), Lewandowski, R. J. (Co-Investigator) & Zhang, B. (Co-Investigator)
4/1/24 → 3/31/29
Project: Research project
-
CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4
Chen, S., Fan, J., Xie, P., Ahn, J., Fernandez, M., Billingham, L. K., Miska, J., Wu, J. D., Wainwright, D. A., Fang, D., Sosman, J. A., Wan, Y., Zhang, Y., Chandel, N. S. & Zhang, B., Apr 15 2024, In: Journal of Clinical Investigation. 134, 8, e170071.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Comparative transcriptomic, epigenomic and immunological analyses identify drivers of disparity in high-grade serous ovarian cancer
Huang, H., Keathley, R., Kim, U., Cardenas, H., Xie, P., Wei, J., Lengyel, E., Nephew, K. P., Zhao, G., Fu, Z., Barber, E. L., Kocherginsky, M., Bae-Jump, V., Zhang, B. & Matei, D., Dec 2024, In: npj Genomic Medicine. 9, 1, 64.Research output: Contribution to journal › Article › peer-review
Open Access -
Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated blood-brain barrier opening: A novel combinatorial immunotherapy regimen for gliomas
Kim, K. S., Habashy, K., Gould, A., Zhao, J., Najem, H., Amidei, C., Saganty, R., Arrieta, V. A., Dmello, C., Chen, L., Zhang, D. Y., Castro, B., Billingham, L., Levey, D., Huber, O., Marques, M., Savitsky, D. A., Morin, B. M., Muzzio, M. & Canney, M. & 14 others, , Nov 1 2024, In: Neuro-oncology. 26, 11, p. 2044-2060 17 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Hepatocyte growth factor promotes melanoma metastasis through ubiquitin-specific peptidase 22-mediated integrins upregulation
Gao, Q., Li, N., Pan, Y., Chu, P., Zhou, Y., Jia, H., Cheng, Y., Xue, G., Song, J., Zhang, Y., Zhu, H., Sun, J., Zhang, B., Sun, Z. & Fang, D., Nov 1 2024, In: Cancer Letters. 604, 217196.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Immune Assessment Today: Optimizing and Standardizing Efforts to Monitor Immune Responses in Cancer and Beyond
Pandey, S., Cholak, M. E., Yadali, R., Sosman, J. A., Tetreault, M.-P., Fang, D., Pollack, S. M., Gnjatic, S., Obeng, R., Lyerly, H. K., Sonabend, A. M., Guevara-Patiño, J. A., Butterfield, L. H., Zhang, B., Maecker, H. T. & Le Poole, I. C., Feb 2024, In: Cancers. 16, 3, 475.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
-
Additional file 3 of Sulforaphane enhances the antitumor response of chimeric antigen receptor T cells by regulating PD-1/PD-L1 pathway
Shen, C. (Creator), Zhang, Z. (Creator), Tian, Y. (Creator), Li, F. (Creator), Zhou, L. (Creator), Jiang, W. (Creator), Yang, L. (Creator), Zhang, B. (Creator), Wang, L. (Creator) & Zhang, Y. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.17079151, https://springernature.figshare.com/articles/figure/Additional_file_3_of_Sulforaphane_enhances_the_antitumor_response_of_chimeric_antigen_receptor_T_cells_by_regulating_PD-1_PD-L1_pathway/17079151
Dataset
-
Additional file 1 of Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy
Basher, F. (Contributor), Dhar, P. (Contributor), Wang, X. (Creator), Wainwright, D. A. (Creator), Zhang, B. (Creator), Sosman, J. (Creator), Ji, Z. (Creator) & Wu, J. D. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12456779, https://springernature.figshare.com/articles/Additional_file_1_of_Antibody_targeting_tumor-derived_soluble_NKG2D_ligand_sMIC_reprograms_NK_cell_homeostatic_survival_and_function_and_enhances_melanoma_response_to_PDL1_blockade_therapy/12456779
Dataset
-
Antibody targeting tumor-derived soluble NKG2D ligand sMIC provides dual co-stimulation of CD8 T cells and enables sMIC+ tumors respond to PD1/PD-L1 blockade therapy
Zhang, J. (Creator), Larrocha, P.S.-L. (Creator), Zhang, B. (Creator), Wainwright, D. (Creator), Dhar, P. (Creator) & Wu, J. D. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4643378, https://springernature.figshare.com/collections/Antibody_targeting_tumor-derived_soluble_NKG2D_ligand_sMIC_provides_dual_co-stimulation_of_CD8_T_cells_and_enables_sMIC_tumors_respond_to_PD1_PD-L1_blockade_therapy/4643378
Dataset
-
Sulforaphane enhances the antitumor response of chimeric antigen receptor T cells by regulating PD-1/PD-L1 pathway
Shen, C. (Creator), Zhang, Z. (Creator), Tian, Y. (Creator), Li, F. (Creator), Zhou, L. (Creator), Jiang, W. (Creator), Yang, L. (Creator), Zhang, B. (Creator), Wang, L. (Creator) & Zhang, Y. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5723146, https://springernature.figshare.com/collections/Sulforaphane_enhances_the_antitumor_response_of_chimeric_antigen_receptor_T_cells_by_regulating_PD-1_PD-L1_pathway/5723146
Dataset
-
Cancer-cell-secreted CXCL11 promoted CD8+ T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC
Gao, Q. (Creator), Wang, S. (Creator), Chen, X. (Creator), Cheng, S. (Creator), Zhang, Z. (Creator), Li, F. (Creator), Huang, L. (Creator), Yang, Y. (Creator), Zhou, B. (Creator), Yue, D. (Creator), Wang, D. (Creator), Cao, L. (Creator), Maimela, N. R. (Creator), Zhang, B. (Creator), Yu, J. (Creator), Wang, L. (Creator) & Zhang, Y. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4397342, https://springernature.figshare.com/collections/Cancer-cell-secreted_CXCL11_promoted_CD8_T_cells_infiltration_through_docetaxel-induced-release_of_HMGB1_in_NSCLC/4397342
Dataset