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Personal profile

Research Interests

Cancer immunology and immunotherapy. The Zhang laboratory functions as an integrated translational research program with the goal of designing and developing new immunotherapies and immunologic strategies for cancer treatment. The ongoing projects are focused on dissecting the molecular mechanisms used for tumor immune evasion based on the cutting-edge technical platforms.

Education/Academic qualification

PhD, Chinese Academy of Medical Science & Peking Union Medical College

… → 2003

MD, West China University

… → 1999

Keywords

  • Cancer Biology
  • Drug Discovery
  • Immune Regulation
  • Nanotechnology
  • Translational Research

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2011 2023

Triple Negative Breast Neoplasms
Phosphotransferases
Neoplasms
Therapeutics
T-Lymphocytes
Immunologic Factors
Neoplasms
Tumor Microenvironment
Neoplasm Antigens
Cell- and Tissue-Based Therapy
Glioblastoma
Brain Neoplasms
Therapeutics
Neoplasms
Survival
Ubiquitin
Peptide Hydrolases
Immunotherapy
Therapeutics
Immunity

Research Output 1998 2019

Cancer-cell-secreted CXCL11 promoted CD8 + T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC

Gao, Q., Wang, S., Chen, X., Cheng, S., Zhang, Z., Li, F., Huang, L., Yang, Y., Zhou, B., Yue, D., Wang, D., Cao, L., Maimela, N. R., Zhang, B., Yu, J., Wang, L. & Zhang, Y., Feb 11 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, 42.

Research output: Contribution to journalArticle

Open Access
docetaxel
HMGB1 Protein
T-Lymphocytes
Tumor Microenvironment
Neoplasms

CD73 expression on effector T cells sustained by TGF-b facilitates tumor resistance to anti-4-1BB/CD137 therapy

Chen, S., Fan, J., al, E. & Zhang, B., Jan 11 2019, In : Nature Communications. 10, p. 150 1 p.

Research output: Contribution to journalArticle

CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy

Chen, S., Fan, J., Zhang, M., Qin, L., Dominguez, D., Long, A., Wang, G., Ma, R., Li, H., Zhang, Y., Fang, D., Sosman, J. A. & Zhang, B., Dec 1 2019, In : Nature communications. 10, 1, 150.

Research output: Contribution to journalArticle

effectors
T-cells
Tumors
therapy
tumors

Commentary: preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma by Garg et al. (2017)

Zhai, L., Ladomersky, E., Lauing, K. L., Wu, M., Scholtens, D. M., Savoor, R., Zhang, B., Wu, J. D., Horbinski, C. M., Lukas, R. V., Binder, D. C. & Wainwright, D. A., Mar 4 2019, In : OncoImmunology. 8, 3, 1548242.

Research output: Contribution to journalComment/debate

Glioblastoma
Biomarkers
Computational Biology
Gene Expression

IL-10 derived from M2 macrophage promotes cancer stemness via JAK1/STAT1/NF-κB/Notch1 pathway in non-small cell lung cancer

Yang, L., Dong, Y., Li, Y., Wang, D., Liu, S., Wang, D., Gao, Q., Ji, S., Chen, X., Lei, Q., Jiang, W., Wang, L., Zhang, B., Yu, J. J. & Zhang, Y., Jan 1 2019, In : International Journal of Cancer.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Interleukin-10
Macrophages
Neoplastic Stem Cells
Neoplasms