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Personal profile

Research Interests

Cancer immunology and immunotherapy. The Zhang laboratory functions as an integrated translational research program with the goal of designing and developing new immunotherapies and immunologic strategies for cancer treatment. The ongoing projects are focused on dissecting the molecular mechanisms used for tumor immune evasion based on the cutting-edge technical platforms.

Education/Academic qualification

PhD, Chinese Academy of Medical Science & Peking Union Medical College

… → 2003

MD, West China University

… → 1999

Research interests

  • Cancer Biology
  • Drug Discovery
  • Immune Regulation
  • Nanotechnology
  • Translational Research

Fingerprint Dive into the research topics where Bin Zhang is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Neoplasms Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Immunotherapy Medicine & Life Sciences
Immunity Medicine & Life Sciences
Interleukin-18 Medicine & Life Sciences
Tumor Microenvironment Medicine & Life Sciences
Regulatory T-Lymphocytes Medicine & Life Sciences
Non-Small Cell Lung Carcinoma Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2011 2023

Triple Negative Breast Neoplasms
Phosphotransferases
Neoplasms
Therapeutics
T-Lymphocytes
Immunologic Factors
Neoplasms
Tumor Microenvironment
Neoplasm Antigens
Cell- and Tissue-Based Therapy
Cell- and Tissue-Based Therapy
Microspheres
Natural Killer Cells
Interferon-gamma
Neoplasms
Glioblastoma
Brain Neoplasms
Therapeutics
Neoplasms
Survival
Immunity
Neoplasms
Regulatory T-Lymphocytes
Immunosuppressive Agents
Tumor Microenvironment

Research Output 1998 2020

Pembrolizumab in combination with the oncolytic virus pelareorep and chemotherapy in patients with advanced pancreatic adenocarcinoma: A phase Ib study a C

Mahalingam, D., Wilkinson, G. A., Eng, K. H., Fields, P., Raber, P., Moseley, J. L., Cheetham, K., Coffey, M., Nuovo, G., Kalinski, P., Zhang, B., Arora, S. P. & Fountzilas, C., Jan 1 2020, In : Clinical Cancer Research. 26, 1, p. 71-81 11 p.

Research output: Contribution to journalArticle

Open Access
Oncolytic Viruses
Adenocarcinoma
Drug Therapy
irinotecan
Therapeutics
1 Citation (Scopus)

A cycle involving HMGB1, IFN-γ and dendritic cells plays a putative role in anti-tumor immunity

Gao, Q., Li, F., Wang, S., Shen, Z., Cheng, S., Ping, Y., Qin, G., Chen, X., Yang, L., Cao, L., Liu, S., Zhang, B., Wang, L., Sun, Y. & Zhang, Y., Sep 2019, In : Cellular Immunology. 343, 103850.

Research output: Contribution to journalArticle

HMGB1 Protein
Dendritic Cells
Interferons
Immunity
Neoplasms

A novel strategy to block mitotic progression for targeted therapy

Chi, J. J., Li, H., Zhou, Z., Izquierdo-Ferrer, J., Xue, Y., Wavelet, C. M., Schiltz, G. E., Zhang, B., Cristofanilli, M., Lu, X., Bahar, I. & Wan, Y., Nov 2019, In : EBioMedicine. 49, p. 40-54 15 p.

Research output: Contribution to journalArticle

Open Access
Degradation
Tumors
Cells
Neoplasms
Breast Neoplasms
1 Citation (Scopus)
Open Access
Neoplasm Antibodies
Ligands
T-Lymphocytes
CD8 Antigens
Neoplasms
4 Citations (Scopus)

Cancer-cell-secreted CXCL11 promoted CD8 + T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC

Gao, Q., Wang, S., Chen, X., Cheng, S., Zhang, Z., Li, F., Huang, L., Yang, Y., Zhou, B., Yue, D., Wang, D., Cao, L., Maimela, N. R., Zhang, B., Yu, J., Wang, L. & Zhang, Y., Feb 11 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, 42.

Research output: Contribution to journalArticle

Open Access
docetaxel
HMGB1 Protein
T-Lymphocytes
Tumor Microenvironment
Neoplasms