• 3354 Citations

Research output per year

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Personal profile

Research Interests

Cancer immunology and immunotherapy. The Zhang laboratory functions as an integrated translational research program with the goal of designing and developing new immunotherapies and immunologic strategies for cancer treatment. The ongoing projects are focused on dissecting the molecular mechanisms used for tumor immune evasion based on the cutting-edge technical platforms.

Education/Academic qualification

PhD, Chinese Academy of Medical Science & Peking Union Medical College

… → 2003

MD, West China University

… → 1999

Research interests

  • Cancer Biology
  • Drug Discovery
  • Immune Regulation
  • Nanotechnology
  • Translational Research

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  • Research Output

    Development of Spherical Nucleic Acids for Prostate Cancer Immunotherapy

    Qin, L., Wang, S., Dominguez, D., Long, A., Chen, S., Fan, J., Ahn, J., Skakuj, K., Huang, Z., Lee, A., Mirkin, C. & Zhang, B., Jul 8 2020, In : Frontiers in immunology. 11, 1333.

    Research output: Contribution to journalArticle

    Open Access
  • Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies

    Zhai, L., Bell, A., Ladomersky, E., Lauing, K. L., Bollu, L., Sosman, J. A., Zhang, B., Wu, J. D., Miller, S. D., Meeks, J. J., Lukas, R. V., Wyatt, E. J., Doglio, L., Schiltz, G. E., McCusker, R. H. & Wainwright, D. A., Jun 16 2020, In : Frontiers in immunology. 11, 1185.

    Research output: Contribution to journalReview article

    Open Access
  • Interleukin-33-nuclear factor-κB-CCL2 signaling pathway promotes progression of esophageal squamous cell carcinoma by directing regulatory T cells

    Yue, Y., Lian, J., Wang, T., Luo, C., Yuan, Y., Qin, G., Zhang, B. & Zhang, Y., Mar 1 2020, In : Cancer Science. 111, 3, p. 795-806 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Scopus citations

    Metformin enhances the antitumor activity of CD8+ T Lymphocytes via the AMPK-miR-107-Eomes-PD-1 Pathway

    Zhang, Z., Li, F., Tian, Y., Cao, L., Gao, Q., Zhang, C., Zhang, K., Shen, C., Ping, Y., Maimela, N. R., Wang, L., Zhang, B. & Zhang, Y., May 1 2020, In : Journal of Immunology. 204, 9, p. 2575-2588 14 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    OX40+ plasmacytoid dendritic cells in the tumor microenvironment promote antitumor immunity

    Poropatich, K., Dominguez, D., Chan, W. C., Andrade, J., Zha, Y., Wray, B., Miska, J. M., Qin, L., Cole, L., Coates, S., Patel, U., Samant, S. & Zhang, B., Jul 1 2020, In : The Journal of clinical investigation. 130, 7, p. 3528-3542 15 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations