Grants per year
Personal profile
Research Interests
The primary goals of my research projects is to improve our understanding of the molecular mechanisms and signaling pathways of human cancer initiation, tumorigenesis, invasion, metastases and angiogenesis, and to develop novel approaches for anti-cancer therapies by targeting molecular pathways by which human tumors develop and progress. Our approaches include molecular, cellular biology, histology, tumor xenografts in cell culture and animals model systems of human brain tumors (in particular, glioblastomas).
Training Experience
| 1994 | Postdoctoral Fellowship, University of California, San Diego |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Biochemistry, Ohio State University
… → 1992
Research interests keywords
- Angiogenesis
- Brain Cancer / Nervous System Cancer
- Cell Biology
- Molecular Biology
- Neuro-Oncology
- Neurology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Targeting RNA Splicing in Glioma
National Institute of Neurological Disorders and Stroke
7/1/22 → 4/30/27
Project: Research project
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Role of Protein Methylation in Cell Mitosis and Glioblastoma
Cheng, S., Hu, B. & James, C. D.
National Institute of Neurological Disorders and Stroke
4/15/20 → 12/31/24
Project: Research project
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SPORE for Translational Approaches to Brain Cancer
Lesniak, M. S., Chandler, J. P., Hu, B., Kumthekar, P. U., Leikin, R. G., Liu, B. P., Sachdev, S., Ahmed, A. U., Balyasnikova, I. V., Bartom, E. T., Brat, D. J., Cheng, S., Horbinski, C. M., James, C. D., Lukas, R. V., Platanias, L. C., Scholtens, D. M., Stegh, A. H., Stupp, R. & Wainwright, D. A.
8/17/18 → 7/31/23
Project: Research project
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Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas
Tiek, D. M., Erdogdu, B., Razaghi, R., Jin, L., Sadowski, N., Alamillo-Ferrer, C., Hogg, J. R., Haddad, B. R., Drewry, D. H., Wells, C. I., Pickett, J. E., Song, X., Goenka, A., Hu, B., Goldlust, S. A., Zuercher, W. J., Pertea, M., Timp, W., Cheng, S. Y. & Riggins, R. B., Jun 2022, In: Science Advances. 8, 25, eabn3471.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
The Role of Non-Coding RNAs in Glioma
Goenka, A., Tiek, D. M., Song, X., Iglesia, R. P., Lu, M., Hu, B. & Cheng, S. Y., Aug 2022, In: Biomedicines. 10, 8, 2031.Research output: Contribution to journal › Review article › peer-review
Open Access6 Scopus citations -
Unconventional Protein Secretion in Brain Tumors Biology: Enlightening the Mechanisms for Tumor Survival and Progression
Iglesia, R. P., Prado, M. B., Alves, R. N., Escobar, M. I. M., Fernandes, C. F. D. L., Fortes, A. C. D. S., Souza, M. C. D. S., Boccacino, J. M., Cangiano, G., Soares, S. R., Araújo, J. P. A. D., Tiek, D. M., Goenka, A., Song, X., Keady, J. R., Hu, B., Cheng, S. Y. & Lopes, M. H., Jun 15 2022, In: Frontiers in Cell and Developmental Biology. 10, 907423.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Author Correction: miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops (Cell Research, (2013), 23, 2, (274-289), 10.1038/cr.2012.174)
Song, L., Lin, C., Gong, H., Wang, C., Liu, L., Wu, J., Tao, S., Hu, B., Cheng, S. Y., Li, M. & Li, J., Oct 2021, In: Cell Research. 31, 10, p. 1138 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells
Huang, T., Yang, Y., Song, X., Wan, X., Wu, B., Sastry, N., Horbinski, C. M., Zeng, C., Tiek, D., Goenka, A., Liu, F., Brennan, C. W., Kessler, J. A., Stupp, R., Nakano, I., Sulman, E. P., Nishikawa, R., James, C. D., Zhang, W., Xu, W., & 2 others, Mar 18 2021, In: Molecular cell. 81, 6, p. 1276-1291.e9Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations
Datasets
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Additional file 1: of Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
Wang, Y. (Contributor), Hou, Y. (Contributor), Zhang, W. (Contributor), Alvarez, A. A. (Creator), Bai, Y. (Contributor), Hu, B. (Creator), Cheng, S. (Creator), Yang, K. (Creator), Li, Y. (Contributor) & Feng, H. (Contributor), figshare, 2019
DOI: 10.6084/m9.figshare.7961468, https://springernature.figshare.com/articles/Additional_file_1_of_Lipolytic_inhibitor_G0S2_modulates_glioma_stem-like_cell_radiation_response/7961468
Dataset
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Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma
Pangeni, R. P. (Creator), Zhang, Z. (Creator), Alvarez, A. A. (Creator), Wan, X. (Contributor), Sastry, N. (Contributor), Lu, S. (Contributor), Shi, T. (Contributor), Huang, T. (Contributor), Lei, C. X. (Creator), James, C. D. (Contributor), Kessler, J. (Creator), Brennan, C. W. (Creator), Nakano, I. (Creator), Lu, X. (Contributor), Hu, B. (Creator), Zhang, W. (Creator) & Cheng, S. (Creator), Taylor & Francis, 2018
DOI: 10.6084/m9.figshare.6638873.v1, https://tandf.figshare.com/articles/Genome-wide_methylomic_and_transcriptomic_analyses_identify_subtype-specific_epigenetic_signatures_commonly_dysregulated_in_glioma_stem_cells_and_glioblastoma/6638873/1
Dataset
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Additional file 2: of Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
Wang, Y. (Contributor), Hou, Y. (Contributor), Zhang, W. (Contributor), Alvarez, A. A. (Creator), Bai, Y. (Contributor), Hu, B. (Creator), Cheng, S. (Creator), Yang, K. (Creator), Li, Y. (Contributor) & Feng, H. (Contributor), figshare, 2019
DOI: 10.6084/m9.figshare.7961480, https://springernature.figshare.com/articles/Additional_file_2_of_Lipolytic_inhibitor_G0S2_modulates_glioma_stem-like_cell_radiation_response/7961480
Dataset
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Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
Wang, Y. (Contributor), Hou, Y. (Contributor), Zhang, W. (Contributor), Alvarez, A. A. (Creator), Bai, Y. (Contributor), Hu, B. (Creator), Cheng, S. (Creator), Yang, K. (Creator), Li, Y. (Contributor) & Feng, H. (Contributor), figshare, 2019
DOI: 10.6084/m9.figshare.c.4462211.v1, https://springernature.figshare.com/collections/Lipolytic_inhibitor_G0S2_modulates_glioma_stem-like_cell_radiation_response/4462211/1 and one more link, https://springernature.figshare.com/collections/Lipolytic_inhibitor_G0S2_modulates_glioma_stem-like_cell_radiation_response/4462211 (show fewer)
Dataset
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Analysis of mRNA profiles distinguishes proneural (PN) glioma stem cells (GSC) from mesenchymal (Mes) GSCs
Kim, S. (Contributor), Nakano, I. (Contributor), Hu, B. (Contributor) & Cheng, S. (Contributor), Gene Expression Omnibus, 2015
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE67089
Dataset