Grants per year
Personal profile
Research Interests
The primary goals of my research projects is to improve our understanding of the molecular mechanisms and signaling pathways of human cancer initiation, tumorigenesis, invasion, metastases and angiogenesis, and to develop novel approaches for anti-cancer therapies by targeting molecular pathways by which human tumors develop and progress. Our approaches include molecular, cellular biology, histology, tumor xenografts in cell culture and animals model systems of human brain tumors (in particular, glioblastomas).
Training Experience
| 1994 | Postdoctoral Fellowship, University of California, San Diego |
Education/Academic qualification
PhD, Ohio State University
… → 1992
Keywords
- Angiogenesis
- Brain Cancer / Nervous System Cancer
- Cell Biology
- Molecular Biology
- Neuro-Oncology
- Neurology
Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
- 6 Similar Profiles
Glioma
Medicine & Life Sciences
Glioblastoma
Medicine & Life Sciences
Neoplasms
Medicine & Life Sciences
Angiopoietin-2
Medicine & Life Sciences
Growth
Medicine & Life Sciences
Phosphorylation
Medicine & Life Sciences
Carcinogenesis
Medicine & Life Sciences
Cell Movement
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2012 2023
SPORE for Translational Approaches to Brain Cancer
Ahmed, A. U., Balyasnikova, I. V., Bartom, E. T., Brat, D. J., Chandler, J. P., Cheng, S., Horbinski, C. M., Hu, B., James, C. D., Kumthekar, P. U., Leikin, R. G., Lesniak, M. S., Liu, B. P., Lukas, R. V., Mirkin, C. A., Platanias, L. C., Sachdev, S., Scholtens, D. M., Stegh, A. H., Stupp, R. & Wainwright, D. A.
8/17/18 → 7/31/23
Project: Research project
Brain Neoplasms
Glioblastoma
Therapeutics
Neoplasms
Survival
Autophagy Regulation of Glioblastoma Tumorigenesis and Responses to Therapy
Cheng, S., Hu, B. & James, C. D.
National Institute of Neurological Disorders and Stroke
9/30/15 → 6/30/20
Project: Research project
Autophagy
Glioblastoma
Carcinogenesis
Phosphorylation
temozolomide
Glioblastoma Phenotype Modulation Through miRNA Control of Wnt Signaling
Cheng, S., Hu, B. & James, C. D.
National Institute of Neurological Disorders and Stroke
9/1/15 → 5/31/20
Project: Research project
Glioblastoma
MicroRNAs
Glioma
Phenotype
Stem Cells
Research Output 1990 2019
Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
Wang, Y., Hou, Y., Zhang, W., Alvarez, A. A., Bai, Y., Hu, B., Cheng, S-Y., Yang, K., Li, Y. & Feng, H., Apr 5 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 147.Research output: Contribution to journal › Article
Open Access
Switch Genes
Glioma
Stem Cells
Radiation
Glioblastoma
MIR93 (microRNA -93) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy
Huang, T., Wan, X., Alvarez, A. A., James, C. D., Song, X., Yang, Y., Sastry, N., Nakano, I., Sulman, E. P., Hu, B. & Cheng, S-Y., Jun 3 2019, In : Autophagy. 15, 6, p. 1100-1111 12 p.Research output: Contribution to journal › Article
Autophagy
Glioblastoma
MicroRNAs
temozolomide
Sirolimus
Autophagy and hallmarks of cancer
Huang, T., Song, X., Yang, Y., Wan, X., Alvarez, A. A., Sastry, N., Feng, H., Hu, B. & Cheng, S-Y., Jan 1 2018, In : Critical Reviews in Oncogenesis. 23, 5-6, p. 247-267 21 p.Research output: Contribution to journal › Article
Autophagy
Neoplasms
Lysosomes
Organelles
Antineoplastic Agents
1
Citation
(Scopus)
Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma
Pangeni, R. P., Zhang, Z., Alvarez, A. A., Wan, X., Sastry, N., Lu, S., Shi, T., Huang, T., Lei, C. X., James, C. D., Kessler, J., Brennan, C. W., Nakano, I., Lu, X., Hu, B., Zhang, W. & Cheng, S-Y., Apr 3 2018, In : Epigenetics. 13, 4, p. 432-448 17 p.Research output: Contribution to journal › Article
Glioblastoma
Epigenomics
Glioma
Stem Cells
Genome
6
Citations
(Scopus)
TRIM59 promotes gliomagenesis by inhibiting tc45 dephosphorylation of STAT3
Sang, Y., Li, Y., Song, L., Alvarez, A. A., Zhang, W., Lv, D., Tang, J., Liu, F., Chang, Z., Hatakeyama, S., Hu, B., Cheng, S-Y. & Feng, H., Apr 1 2018, In : Cancer Research. 78, 7, p. 1792-1804 13 p.Research output: Contribution to journal › Article
Glioblastoma
Glioma
Non-Receptor Type 2 Protein Tyrosine Phosphatase
Carcinogenesis
Heterografts