Grants per year
Personal profile
Research Interests
The primary goals of my research projects is to improve our understanding of the molecular mechanisms and signaling pathways of human cancer initiation, tumorigenesis, invasion, metastases and angiogenesis, and to develop novel approaches for anti-cancer therapies by targeting molecular pathways by which human tumors develop and progress. Our approaches include molecular, cellular biology, histology, tumor xenografts in cell culture and animals model systems of human brain tumors (in particular, glioblastomas).
Training Experience
| 1994 | Postdoctoral Fellowship, University of California, San Diego |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Biochemistry, Ohio State University
… → 1992
Research interests keywords
- Angiogenesis
- Brain Cancer / Nervous System Cancer
- Cell Biology
- Molecular Biology
- Neuro-Oncology
- Neurology
Fingerprint
Dive into the research topics where Bo Hu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Therapeutic Targeting in EGFR-amplified Glioblastoma
Cheng, S.-Y. (PD/PI), Hu, B. (Co-Investigator) & Zhang, W. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
4/16/24 → 3/31/29
Project: Research project
-
Targeting RNA Splicing in Glioma
Cheng, S.-Y. (PD/PI), Cheng, S.-Y. (PD/PI), Hu, B. (Co-Investigator), Hu, B. (Co-Investigator), Zhang, W. (Co-Investigator) & Zhang, W. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
7/1/22 → 4/30/27
Project: Research project
-
Cysteine Depletion-induced Ferroptosis as a Therapeutic Vulnerability in Glioblastoma Temozolomide Resistance
Cheng, S.-Y. (PD/PI), Cheng, S.-Y. (PD/PI), Cheng, S.-Y. (PD/PI), Hu, B. (Co-Investigator), Hu, B. (Co-Investigator), Hu, B. (Co-Investigator), James, C. D. (Co-Investigator), James, C. D. (Co-Investigator) & James, C. D. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
6/15/22 → 4/30/25
Project: Research project
-
Role of Protein Methylation in Cell Mitosis and Glioblastoma
Cheng, S.-Y. (PD/PI), Cheng, S.-Y. (PD/PI), Cheng, S.-Y. (PD/PI), Hu, B. (Co-Investigator), Hu, B. (Co-Investigator), Hu, B. (Co-Investigator), James, C. D. (Co-Investigator), James, C. D. (Co-Investigator) & James, C. D. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
4/15/20 → 12/31/25
Project: Research project
-
SPORE for Translational Approaches to Brain Cancer
Lesniak, M. S. (PD/PI), Chandler, J. P. (Co-Investigator), Hu, B. (Co-Investigator), Kumthekar, P. U. (Co-Investigator), Leikin, R. G. (Co-Investigator), Liu, B. P. (Co-Investigator), Sachdev, S. (Co-Investigator), Ahmed, A. U. (Other), Balyasnikova, I. V. (Other), Bartom, E. T. (Other), Brat, D. J. (Other), Cheng, S.-Y. (Other), Horbinski, C. M. (Other), James, C. D. (Other), Lukas, R. V. (Other), Platanias, L. C. (Other), Scholtens, D. M. (Other), Stegh, A. H. (Other), Stupp, R. (Other) & Wainwright, D. A. (Other)
8/17/18 → 7/31/23
Project: Research project
-
Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma
Tiek, D., Song, X., Yu, X., Wu, R., Iglesia, R., Catezone, A., McCortney, K., Walshon, J., Horbinski, C., Jamshidi, P., Castellani, R., Vassar, R., Miska, J., Hu, B. & Cheng, S. Y., Feb 21 2025, In: iScience. 28, 2, 111769.Research output: Contribution to journal › Article › peer-review
Open Access -
Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis
Zeng, C., Song, X., Zhang, Z., Cai, Q., Cai, J., Horbinski, C., Hu, B., Cheng, S. Y. & Zhang, W., Dec 2023, In: Acta Neuropathologica Communications. 11, 1, 133.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Oncogenic long noncoding RNA LINC02283 enhances PDGF receptor A-mediated signaling and drives glioblastoma tumorigenesis
Goenka, A., Song, X., Tiek, D., Iglesia, R. P., Lu, M., Zeng, C., Horbinski, C., Zhang, W., Hu, B. & Cheng, S. Y., Sep 2023, In: Neuro-oncology. 25, 9, p. 1592-1604 13 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Repurposing Clemastine to Target Glioblastoma Cell Stemness
Sun, M. A., Yang, R., Liu, H., Wang, W., Song, X., Hu, B., Reynolds, N., Roso, K., Chen, L. H., Greer, P. K., Keir, S. T., McLendon, R. E., Cheng, S. Y., Bigner, D. D., Ashley, D. M., Pirozzi, C. J. & He, Y., Sep 2023, In: Cancers. 15, 18, 4619.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas
Tiek, D. M., Erdogdu, B., Razaghi, R., Jin, L., Sadowski, N., Alamillo-Ferrer, C., Hogg, J. R., Haddad, B. R., Drewry, D. H., Wells, C. I., Pickett, J. E., Song, X., Goenka, A., Hu, B., Goldlust, S. A., Zuercher, W. J., Pertea, M., Timp, W., Cheng, S. Y. & Riggins, R. B., Jun 2022, In: Science Advances. 8, 25, eabn3471.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations
Datasets
-
Analysis of mRNA profiles distinguishes proneural (PN) glioma stem cells (GSC) from mesenchymal (Mes) GSCs
Kim, S.-H. (Contributor), Nakano, I. (Contributor), Hu, B. (Contributor) & Cheng, S.-Y. (Contributor), Gene Expression Omnibus, Mar 19 2015
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE67089
Dataset
-
Additional file 1: of Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
Wang, Y. (Creator), Hou, Y. (Creator), Zhang, W. (Creator), Alvarez, A. A. (Creator), Bai, Y. (Creator), Hu, B. (Creator), Cheng, S.-Y. (Creator), Yang, K. (Creator), Li, Y. (Creator) & Feng, H. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.7961468, https://springernature.figshare.com/articles/figure/Additional_file_1_of_Lipolytic_inhibitor_G0S2_modulates_glioma_stem-like_cell_radiation_response/7961468
Dataset
-
Additional file 2: of Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
Wang, Y. (Creator), Hou, Y. (Creator), Zhang, W. (Creator), Alvarez, A. A. (Creator), Bai, Y. (Creator), Hu, B. (Creator), Cheng, S.-Y. (Creator), Yang, K. (Creator), Li, Y. (Creator) & Feng, H. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.7961480, https://springernature.figshare.com/articles/figure/Additional_file_2_of_Lipolytic_inhibitor_G0S2_modulates_glioma_stem-like_cell_radiation_response/7961480
Dataset
-
Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
Wang, Y. (Creator), Hou, Y. (Creator), Zhang, W. (Creator), Alvarez, A. A. (Creator), Bai, Y. (Creator), Hu, B. (Creator), Cheng, S.-Y. (Creator), Yang, K. (Creator), Li, Y. (Creator) & Feng, H. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4462211, https://springernature.figshare.com/collections/Lipolytic_inhibitor_G0S2_modulates_glioma_stem-like_cell_radiation_response/4462211
Dataset
-
Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in GBM and GSCs
Huang, T. (Contributor), Alvarez, A. A. (Contributor), Pangeni, R. P. (Contributor), Shi, T. (Contributor), Sastry, N. (Contributor), Lu, S. (Contributor), Kessler, J. A. (Contributor), Nakano, I. (Contributor), Lu, X. (Contributor), James, C. D. (Contributor), Hu, B. (Contributor) & Cheng, S.-Y. (Contributor), Gene Expression Omnibus, Nov 25 2016
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE90498
Dataset