Bo Hu

  • 3204 Citations
1990 …2020

Research output per year

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Research Output

2019

CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity

Sang, Y., Li, Y., Zhang, Y., Alvarez, A. A., Yu, B., Zhang, W., Hu, B., Cheng, S. Y. & Feng, H., Dec 1 2019, In : Nature communications. 10, 1, 4013.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access
Open Access

Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response

Wang, Y., Hou, Y., Zhang, W., Alvarez, A. A., Bai, Y., Hu, B., Cheng, S. Y., Yang, K., Li, Y. & Feng, H., Apr 5 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 147.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

MIR93 (microRNA -93) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy

Huang, T., Wan, X., Alvarez, A. A., James, C. D., Song, X., Yang, Y., Sastry, N., Nakano, I., Sulman, E. P., Hu, B. & Cheng, S. Y., Jun 3 2019, In : Autophagy. 15, 6, p. 1100-1111 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

SRSF3-regulated RNA alternative splicing promotes glioblastoma tumorigenicity by affecting multiple cellular processes

Song, X., Wan, X., Huang, T., Zeng, C., Sastry, N., Wu, B., David James, C., Horbinski, C., Nakano, I., Zhang, W., Hu, B. & Cheng, S. Y., Oct 15 2019, In : Cancer Research. 79, 20, p. 5288-5301 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Targeting PDGFRα-activated glioblastoma through specific inhibition of SHP-2-mediated signaling

Sang, Y., Hou, Y., Cheng, R., Zheng, L., Alvarez, A. A., Hu, B., Cheng, S. Y., Zhang, W., Li, Y. & Feng, H., Nov 4 2019, In : Neuro-oncology. 21, 11, p. 1423-1435 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

TGF-β-activated lncRNA LINC00115 is a critical regulator of glioma stem-like cell tumorigenicity

Tang, J., Yu, B., Li, Y., Zhang, W., Alvarez, A. A., Hu, B., Cheng, S. Y. & Feng, H., Dec 5 2019, In : EMBO Reports. 20, 12, e48170.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Autophagy and hallmarks of cancer

Huang, T., Song, X., Yang, Y., Wan, X., Alvarez, A. A., Sastry, N., Feng, H., Hu, B. & Cheng, S. Y., Jan 1 2018, In : Critical Reviews in Oncogenesis. 23, 5-6, p. 247-267 21 p.

Research output: Contribution to journalArticle

1 Scopus citations

Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma

Pangeni, R. P., Zhang, Z., Alvarez, A. A., Wan, X., Sastry, N., Lu, S., Shi, T., Huang, T., Lei, C. X., James, C. D., Kessler, J. A., Brennan, C. W., Nakano, I., Lu, X., Hu, B., Zhang, W. & Cheng, S. Y., Apr 3 2018, In : Epigenetics. 13, 4, p. 432-448 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

TRIM59 promotes gliomagenesis by inhibiting tc45 dephosphorylation of STAT3

Sang, Y., Li, Y., Song, L., Alvarez, A. A., Zhang, W., Lv, D., Tang, J., Liu, F., Chang, Z., Hatakeyama, S., Hu, B., Cheng, S. Y. & Feng, H., Apr 1 2018, In : Cancer Research. 78, 7, p. 1792-1804 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2017

Histone acetyltransferase KAT6A upregulates PI3K/AKT signaling through TRIM24 binding

Lv, D., Jia, F., Hou, Y., Sang, Y., Alvarez, A. A., Zhang, W., Gao, W. Q., Hu, B., Cheng, S. Y., Ge, J., Li, Y. & Feng, H., Nov 15 2017, In : Cancer Research. 77, 22, p. 6190-6201 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A

Wang, W., Zhang, H., Liu, S., Kim, C. K., Xu, Y., Hurley, L. A., Nishikawa, R., Nagane, M., Hu, B., Stegh, A. H., Cheng, S. Y. & Cheng, C., Aug 1 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. 8366-8371 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma

Huang, T., Kim, C. K., Alvarez, A. A., Pangeni, R. P., Wan, X., Song, X., Shi, T., Yang, Y., Sastry, N., Horbinski, C. M., Lu, S., Stupp, R., Kessler, J. A., Nishikawa, R., Nakano, I., Sulman, E. P., Lu, X., James, C. D., Yin, X. M., Hu, B. & 1 others, Cheng, S. Y., Dec 11 2017, In : Cancer Cell. 32, 6, p. 840-855.e8

Research output: Contribution to journalArticle

60 Scopus citations

TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma

Lv, D., Li, Y., Zhang, W., Alvarez, A. A., Song, L., Tang, J., Gao, W. Q., Hu, B., Cheng, S. Y. & Feng, H., Dec 1 2017, In : Nature communications. 8, 1, 1454.

Research output: Contribution to journalArticle

32 Scopus citations
2016

A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways

Huang, T., Alvarez, A. A., Pangeni, R. P., Horbinski, C. M., Lu, S., Kim, S. H., James, C. D., Raizer, J. J., Kessler, J. A., Brenann, C. W., Sulman, E. P., Finocchiaro, G., Tan, M., Nishikawa, R., Lu, X., Nakano, I., Hu, B. & Cheng, S. Y., Oct 4 2016, In : Nature communications. 7, 12885.

Research output: Contribution to journalArticle

33 Scopus citations

A simple, low-cost staining method for rapid-throughput analysis of tumor spheroids

Eckerdt, F., Alvarez, A., Bell, J., Arvanitis, C., Iqbal, A., Arslan, A. D., Hu, B., Cheng, S. Y., Goldman, S. & Platanias, L. C., Jan 2016, In : BioTechniques. 60, 1, p. 43-46 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial-mesenchymal transition and invasion in mice and humans

Zhang, L., Zhang, W., Li, Y., Alvarez, A., Li, Z., Wang, Y., Song, L., Lv, D., Nakano, I., Hu, B., Cheng, S. Y. & Feng, H., Oct 27 2016, In : Oncogene. 35, 43, p. 5641-5652 12 p.

Research output: Contribution to journalArticle

59 Scopus citations
2015

Gene expression profiling distinguishes proneural glioma stem cells from mesenchymal glioma stem cells

Chandran, U. R., Luthra, S., Santana-Santos, L., Mao, P., Kim, S. H., Minata, M., Li, J., Benos, P. V., DeWang, M., Hu, B., Cheng, S. Y., Nakano, I. & Sobol, R. W., Sep 1 2015, In : Genomics Data. 5, p. 333-336 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Identifying driver genomic alterations in cancers by searching minimum-weight, mutually exclusive sets

Lu, S., Lu, K., Cheng, S. Y., Hu, B., Ma, X., Nystrom, N. & Lu, X., Dec 16 2015, Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015. Schapranow, L. M., Zhou, J., Hu, X. T., Ma, B., Rajasekaran, S., Miyano, S., Yoo, I., Pierce, B., Shehu, A., Gombar, V. K., Chen, B., Pai, V. & Huan, J. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 1728-1730 3 p. 7359942. (Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets

Lu, S., Lu, K. N., Cheng, S. Y., Hu, B., Ma, X., Nystrom, N. & Lu, X., Aug 1 2015, In : PLoS computational biology. 11, 8, e1004257.

Research output: Contribution to journalArticle

10 Scopus citations

Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α

Feng, H., Li, Y., Yin, Y., Zhang, W., Hou, Y., Zhang, L., Li, Z., Xie, B., Gao, W. Q., Sarkaria, J. N., Raizer, J. J., James, C. D., Parsa, A. T., Hu, B. & Cheng, S. Y., Jan 1 2015, In : Neuro-oncology. 17, 6, p. 832-842 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis

Feng, H., Lopez, G. Y., Kim, C. K., Alvarez, A., Duncan, C. G., Nishikawa, R., Nagane, M., Su, A. J. A., Auron, P. E., Hedberg, M. L., Wang, L., Raizer, J. J., Kessler, J. A., Parsa, A. T., Gao, W. Q., Kim, S. H., Minata, M., Nakano, I., Grandis, J. R., McLendon, R. E. & 7 others, Bigner, D. D., Lin, H. K., Furnari, F. B., Cavenee, W. K., Hu, B., Yan, H. & Cheng, S. Y., Sep 2 2014, In : Journal of Clinical Investigation. 124, 9, p. 3741-3756 16 p.

Research output: Contribution to journalArticle

41 Scopus citations

EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180

Feng, H., Hu, B., Vuori, K., Sarkaria, J. N., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., May 8 2014, In : Oncogene. 33, 19, p. 2504-2512 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Rho GTPases and their activators, guanine nucleotide exchange factors (GEFs): Their roles in glioma cell invasion

Hu, B., Symons, M., Salhia, B., Fortin, S. P., Tran, N. L., Rutka, J. & Cheng, S. Y., Jan 1 2014, Signaling Pathways and Molecular Mediators in Metastasis. Springer Netherlands, p. 143-169 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2013

Bmi-1 Promotes Glioma Angiogenesis by Activating NF-κB Signaling

Jiang, L., Song, L., Wu, J., Yang, Y., Zhu, X., Hu, B., Cheng, S. Y. & Li, M., Jan 31 2013, In : PloS one. 8, 1, e55527.

Research output: Contribution to journalArticle

34 Scopus citations

Downregulation of miR-452 promotes stem-like traits and tumorigenicity of gliomas

Liu, L., Chen, K., Wu, J., Shi, L., Hu, B., Cheng, S., Li, M. & Song, L., Jul 1 2013, In : Clinical Cancer Research. 19, 13, p. 3429-3438 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype

Ying, Z., Li, Y., Wu, J., Zhu, X., Yang, Y., Tian, H., Li, W., Hu, B., Cheng, S. Y. & Li, M., Jan 15 2013, In : Cancer Research. 73, 2, p. 990-999 10 p.

Research output: Contribution to journalArticle

116 Scopus citations

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

Mao, P., Joshi, K., Li, J., Kim, S. H., Li, P., Santana-Santos, L., Luthra, S., Chandran, U. R., Benos, P. V., Smith, L., Wang, M., Hu, B., Cheng, S. Y., Sobol, R. W. & Nakano, I., May 21 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 21, p. 8644-8649 6 p.

Research output: Contribution to journalArticle

305 Scopus citations

MiR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops

Song, L., Lin, C., Gong, H., Wang, C., Liu, L., Wu, J., Tao, S., Hu, B., Cheng, S. Y., Li, M. & Li, J., Feb 1 2013, In : Cell Research. 23, 2, p. 274-289 16 p.

Research output: Contribution to journalArticle

67 Scopus citations

Noncoding RNAs in cancer and cancer stem cells

Huang, T., Alvarez, A., Hu, B. & Cheng, S. Y., 2013, In : Chinese Journal of Cancer. 32, 11, p. 582-593 12 p.

Research output: Contribution to journalReview article

75 Scopus citations

YM-155 potentiates the effect of ABT-737 in malignant humanglioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context

Jane, E. P., Premkumar, D. R., DiDomenico, J. D., Hu, B., Cheng, S. Y. & Pollack, I. F., Mar 1 2013, In : Molecular cancer therapeutics. 12, 3, p. 326-338 13 p.

Research output: Contribution to journalArticle

28 Scopus citations
2012

Dynamin 2 mediates PDGFRα-SHP-2-promoted glioblastoma growth and invasion

Feng, H., Liu, K. W., Guo, P., Zhang, P., Cheng, T., McNiven, M. A., Johnson, G. R., Hu, B. & Cheng, S. Y., May 1 2012, In : Oncogene. 31, 21, p. 2691-2702 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

Feng, H., Hu, B., Jarzynka, M. J., Li, Y., Keezer, S., Johns, T. G., Tang, C. K., Hamilton, R. L., Vuori, K., Nishikawa, R., Sarkaria, J. N., Fenton, T., Cheng, T., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 3018-3023 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets

Song, L., Liu, L., Wu, Z., Li, Y., Ying, Z., Lin, C., Wu, J., Hu, B., Cheng, S. Y., Li, M. & Li, J., Oct 1 2012, In : Journal of Clinical Investigation. 122, 10, p. 3563-3578 16 p.

Research output: Contribution to journalArticle

117 Scopus citations
2011

Activation of Rac1 by Src-dependent phosphorylation of Dock180 Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

Feng, H., Hu, B., Liu, K. W., Li, Y., Lu, X., Cheng, T., Yiin, J. J., Lu, S., Keezer, S., Fenton, T., Furnari, F. B., Hamilton, R. L., Vuori, K., Sarkaria, J. N., Nagane, M., Nishikawa, R., Cavenee, W. K. & Cheng, S. Y., Dec 1 2011, In : Journal of Clinical Investigation. 121, 12, p. 4670-4684 15 p.

Research output: Contribution to journalArticle

80 Scopus citations
28 Scopus citations

Platelet-derived growth factor receptor alpha in Glioma: A bed seed

Liu, K. W., Hu, B. & Cheng, S. Y., Sep 27 2011, In : Chinese Journal of Cancer. 30, 9, p. 590-602 13 p.

Research output: Contribution to journalReview article

25 Scopus citations

Platelet-derived growth factor signaling in human malignancies

Liu, K. W., Hu, B. & Cheng, S. Y., Sep 27 2011, In : Chinese Journal of Cancer. 30, 9, p. 581-584 4 p.

Research output: Contribution to journalEditorial

8 Scopus citations

SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans

Liu, K. W., Feng, H., Bachoo, R., Kazlauskas, A., Smith, E. M., Symes, K., Hamilton, R. L., Nagane, M., Nishikawa, R., Hu, B. & Cheng, S. Y., Mar 1 2011, In : Journal of Clinical Investigation. 121, 3, p. 905-917 13 p.

Research output: Contribution to journalArticle

53 Scopus citations
2010

ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain

Yiin, J. J., Hu, B., Schornack, P. A., Sengar, R. S., Liu, K. W., Feng, H., Lieberman, F. S., Chiou, S. H., Sarkaria, J. N., Wiener, E. C., Ma, H. I. & Cheng, S. Y., Apr 1 2010, In : Molecular cancer therapeutics. 9, 4, p. 929-941 13 p.

Research output: Contribution to journalArticle

30 Scopus citations
2009

ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway

Hu, B., Shi, B., Jarzynka, M. J., Yiin, J. J., D'Souza-Schorey, C. & Cheng, S. Y., Feb 1 2009, In : Cancer Research. 69, 3, p. 794-801 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Angiopoietin-2: Development of inhibitors for cancer therapy

Hu, B. & Cheng, S. Y., Feb 23 2009, In : Current oncology reports. 11, 2, p. 111-116 6 p.

Research output: Contribution to journalReview article

81 Scopus citations

Comparable ecological dynamics underlie early cancer invasion and species dispersal, involving self-organizing processes

Marco, D. E., Cannas, S. A., Montemurro, M. A., Hu, B. & Cheng, S. Y., Jan 7 2009, In : Journal of Theoretical Biology. 256, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity

Yiin, J. J., Hu, B., Jarzynka, M. J., Feng, H., Liu, K. W., Wu, J. Y., Ma, H. I. & Cheng, S. Y., Dec 2009, In : Neuro-oncology. 11, 6, p. 779-789 11 p.

Research output: Contribution to journalArticle

68 Scopus citations
2007

Angiopoietin-2 stimulates breast cancer metastasis through the α5β1 integrin-mediated pathway

Imanishi, Y., Hu, B., Jarzynka, M. J., Guo, P., Elishaev, E., Bar-Joseph, I. & Cheng, S. Y., May 1 2007, In : Cancer Research. 67, 9, p. 4254-4263 10 p.

Research output: Contribution to journalArticle

137 Scopus citations

ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion

Jarzynka, M. J., Hu, B., Hui, K. M., Bar-Joseph, I., Gu, W., Hirose, T., Haney, L. B., Ravichandran, K. S., Nishikawa, R. & Cheng, S. Y., Aug 1 2007, In : Cancer Research. 67, 15, p. 7203-7211 9 p.

Research output: Contribution to journalArticle

105 Scopus citations

Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway

Hu, B., Guo, P., Bar-Joseph, I., Imanishi, Y., Jarzynka, M. J., Bogler, O., Mikkelsen, T., Hirose, T., Nishikawa, R. & Cheng, S. Y., Aug 16 2007, In : Oncogene. 26, 38, p. 5577-5586 10 p.

Research output: Contribution to journalArticle

134 Scopus citations
2006

Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the αvβ1 integrin and focal adhesion kinase signaling pathway

Hu, B., Jarzynka, M. J., Guo, P., Imanishi, Y., Schlaepfer, D. D. & Cheng, S. Y., Jan 15 2006, In : Cancer Research. 66, 2, p. 775-783 9 p.

Research output: Contribution to journalArticle

129 Scopus citations

Estradiol and nicotine exposure enhances A549 bronchioloalveolar carcinoma xenograft growth in mice through the stimulation of angiogenesis

Jarzynka, M. J., Gou, P., Bar-Joseph, I., Hu, B. & Cheng, S. Y., Feb 1 2006, In : International journal of oncology. 28, 2, p. 337-344 8 p.

Research output: Contribution to journalArticle

46 Scopus citations