Bo Hu

  • 3175 Citations
1990 …2020

Research output per year

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Research Output

1990

Isolated myocytes from a normal human heart.

Hohl, C. M., Hu, B., Wimsatt, D. K., Fertel, R. H., Starling, R. C., Brierley, G. P. & Altschuld, R. A., 1990, In : Progress in clinical and biological research. 327, p. 735-742 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
1991

Phorbol esters and cyclic AMP activate AMP deaminase in adult rat cardiac myocytes

Hu, B., Altschuld, R. A. & Hohl, C. M., Nov 15 1991, In : Archives of biochemistry and biophysics. 291, 1, p. 100-106 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
1993

Adenosine stimulation of AMP deaminase activity in adult-rat cardiac myocytes

Hu, B., Altschuld, R. A. & Hohl, C. M., Jan 1 1993, In : American Journal of Physiology - Cell Physiology. 264, 1 33-1

Research output: Contribution to journalArticle

8 Scopus citations

Effects of obesity and hypertension on ventricular myocytes: Comparison of cells from adult SHHF/MCC-cp and JCR:LA-cp rats

Hohl, C. M., Hu, B., Fertel, R. H., Russell, J. C., Mccune, S. A. & Altschuld, R. A., Jan 1 1993, In : Cardiovascular Research. 27, 2, p. 238-242 5 p.

Research output: Contribution to journalArticle

31 Scopus citations

Isolation and molecular cloning of a novel bone phosphoprotein related in sequence to the cystatin family of thiol protease inhibitors

Hu, B., Coulson, L., Moyer, B. & Price, P. A., Jan 1 1995, In : Journal of Biological Chemistry. 270, 1, p. 431-436 6 p.

Research output: Contribution to journalArticle

46 Scopus citations
1996

Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family

Hu, B., Trinh, K., Figueira, W. F. & Price, P. A., Aug 27 1996, In : Journal of Biological Chemistry. 271, 32, p. 19415-19420 6 p.

Research output: Contribution to journalArticle

164 Scopus citations
1997

Effect of cell density and growth factors on matrix GLA protein expression by normal rat kidney cells

Cancela, M. L., Hu, B. & Price, P. A., May 1 1997, In : Journal of Cellular Physiology. 171, 2, p. 125-134 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
2003

Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2

Hu, B., Guo, P., Fang, Q., Tao, H. Q., Wang, D., Nagane, M., Huang, H. J. S., Gunji, Y., Nishikawa, R., Alitalo, K., Cavenee, W. K. & Cheng, S. Y., Jul 22 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 15, p. 8904-8909 6 p.

Research output: Contribution to journalArticle

120 Scopus citations

A nuclear target for interleukin-1α: Interaction with the growth suppressor necdin modulates proliferation and collagen expression

Hu, B., Wang, S., Zhang, Y., Feghali, C. A., Dingman, J. R. & Wright, T. M., Aug 19 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 17, p. 10008-10013 6 p.

Research output: Contribution to journalArticle

51 Scopus citations

Overexpression of vascular endothelial growth factor by MCF-7 breast cancer cells promotes estrogen-independent tumor growth in vivo

Guo, P., Fang, Q., Tao, H. Q., Schafer, C. A., Fenton, B. M., Ding, I., Hu, B. & Cheng, S. Y., Aug 1 2003, In : Cancer Research. 63, 15, p. 4684-4691 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment

Guo, P., Hu, B., Gu, W., Xu, L., Wang, D., Huang, H. J. S., Cavenee, W. K. & Cheng, S. Y., Apr 1 2003, In : American Journal of Pathology. 162, 4, p. 1083-1093 11 p.

Research output: Contribution to journalArticle

248 Scopus citations
2004

Identification of two novel alternatively spliced Neuropilin-1 isoforms

Cackowski, F. C., Xu, L., Hu, B. & Cheng, S. Y., Jul 1 2004, In : Genomics. 84, 1, p. 82-94 13 p.

Research output: Contribution to journalArticle

53 Scopus citations

Overexpression of VEGF121, but not VEGF165 or FGF-1, improves oxygenation in MCF-7 breast tumours

Fenton, B. M., Paoni, S. F., Liu, W., Cheng, S. Y., Hu, B. & Ding, I., Jan 26 2004, In : British Journal of Cancer. 90, 2, p. 430-435 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
2005

Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 γ 2 correlates with the invasiveness of human glioma

Quo, P., Imanishi, Y., Cackowski, F. C., Jarzynka, M. J., Tao, H. Q., Nishikawa, R., Hirose, T., Hu, B. & Cheng, S. Y., Mar 2005, In : American Journal of Pathology. 166, 3, p. 877-890 14 p.

Research output: Contribution to journalArticle

92 Scopus citations
2006

Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the αvβ1 integrin and focal adhesion kinase signaling pathway

Hu, B., Jarzynka, M. J., Guo, P., Imanishi, Y., Schlaepfer, D. D. & Cheng, S. Y., Jan 15 2006, In : Cancer Research. 66, 2, p. 775-783 9 p.

Research output: Contribution to journalArticle

128 Scopus citations

Estradiol and nicotine exposure enhances A549 bronchioloalveolar carcinoma xenograft growth in mice through the stimulation of angiogenesis

Jarzynka, M. J., Gou, P., Bar-Joseph, I., Hu, B. & Cheng, S. Y., Feb 1 2006, In : International journal of oncology. 28, 2, p. 337-344 8 p.

Research output: Contribution to journalArticle

46 Scopus citations
2007

Angiopoietin-2 stimulates breast cancer metastasis through the α5β1 integrin-mediated pathway

Imanishi, Y., Hu, B., Jarzynka, M. J., Guo, P., Elishaev, E., Bar-Joseph, I. & Cheng, S. Y., May 1 2007, In : Cancer Research. 67, 9, p. 4254-4263 10 p.

Research output: Contribution to journalArticle

137 Scopus citations

ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion

Jarzynka, M. J., Hu, B., Hui, K. M., Bar-Joseph, I., Gu, W., Hirose, T., Haney, L. B., Ravichandran, K. S., Nishikawa, R. & Cheng, S. Y., Aug 1 2007, In : Cancer Research. 67, 15, p. 7203-7211 9 p.

Research output: Contribution to journalArticle

104 Scopus citations

Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway

Hu, B., Guo, P., Bar-Joseph, I., Imanishi, Y., Jarzynka, M. J., Bogler, O., Mikkelsen, T., Hirose, T., Nishikawa, R. & Cheng, S. Y., Aug 16 2007, In : Oncogene. 26, 38, p. 5577-5586 10 p.

Research output: Contribution to journalArticle

133 Scopus citations
2009

ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway

Hu, B., Shi, B., Jarzynka, M. J., Yiin, J. J., D'Souza-Schorey, C. & Cheng, S. Y., Feb 1 2009, In : Cancer Research. 69, 3, p. 794-801 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Angiopoietin-2: Development of inhibitors for cancer therapy

Hu, B. & Cheng, S. Y., Feb 23 2009, In : Current oncology reports. 11, 2, p. 111-116 6 p.

Research output: Contribution to journalReview article

81 Scopus citations

Comparable ecological dynamics underlie early cancer invasion and species dispersal, involving self-organizing processes

Marco, D. E., Cannas, S. A., Montemurro, M. A., Hu, B. & Cheng, S. Y., Jan 7 2009, In : Journal of Theoretical Biology. 256, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity

Yiin, J. J., Hu, B., Jarzynka, M. J., Feng, H., Liu, K. W., Wu, J. Y., Ma, H. I. & Cheng, S. Y., Dec 2009, In : Neuro-oncology. 11, 6, p. 779-789 11 p.

Research output: Contribution to journalArticle

68 Scopus citations
2010

ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain

Yiin, J. J., Hu, B., Schornack, P. A., Sengar, R. S., Liu, K. W., Feng, H., Lieberman, F. S., Chiou, S. H., Sarkaria, J. N., Wiener, E. C., Ma, H. I. & Cheng, S. Y., Apr 1 2010, In : Molecular cancer therapeutics. 9, 4, p. 929-941 13 p.

Research output: Contribution to journalArticle

30 Scopus citations
2011

Activation of Rac1 by Src-dependent phosphorylation of Dock180 Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

Feng, H., Hu, B., Liu, K. W., Li, Y., Lu, X., Cheng, T., Yiin, J. J., Lu, S., Keezer, S., Fenton, T., Furnari, F. B., Hamilton, R. L., Vuori, K., Sarkaria, J. N., Nagane, M., Nishikawa, R., Cavenee, W. K. & Cheng, S. Y., Dec 1 2011, In : Journal of Clinical Investigation. 121, 12, p. 4670-4684 15 p.

Research output: Contribution to journalArticle

79 Scopus citations
28 Scopus citations

Platelet-derived growth factor receptor alpha in Glioma: A bed seed

Liu, K. W., Hu, B. & Cheng, S. Y., Sep 27 2011, In : Chinese Journal of Cancer. 30, 9, p. 590-602 13 p.

Research output: Contribution to journalReview article

25 Scopus citations

Platelet-derived growth factor signaling in human malignancies

Liu, K. W., Hu, B. & Cheng, S. Y., Sep 27 2011, In : Chinese Journal of Cancer. 30, 9, p. 581-584 4 p.

Research output: Contribution to journalEditorial

8 Scopus citations

SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans

Liu, K. W., Feng, H., Bachoo, R., Kazlauskas, A., Smith, E. M., Symes, K., Hamilton, R. L., Nagane, M., Nishikawa, R., Hu, B. & Cheng, S. Y., Mar 1 2011, In : Journal of Clinical Investigation. 121, 3, p. 905-917 13 p.

Research output: Contribution to journalArticle

52 Scopus citations
2012

Dynamin 2 mediates PDGFRα-SHP-2-promoted glioblastoma growth and invasion

Feng, H., Liu, K. W., Guo, P., Zhang, P., Cheng, T., McNiven, M. A., Johnson, G. R., Hu, B. & Cheng, S. Y., May 1 2012, In : Oncogene. 31, 21, p. 2691-2702 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

Feng, H., Hu, B., Jarzynka, M. J., Li, Y., Keezer, S., Johns, T. G., Tang, C. K., Hamilton, R. L., Vuori, K., Nishikawa, R., Sarkaria, J. N., Fenton, T., Cheng, T., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 3018-3023 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets

Song, L., Liu, L., Wu, Z., Li, Y., Ying, Z., Lin, C., Wu, J., Hu, B., Cheng, S. Y., Li, M. & Li, J., Oct 1 2012, In : Journal of Clinical Investigation. 122, 10, p. 3563-3578 16 p.

Research output: Contribution to journalArticle

117 Scopus citations
2013

Bmi-1 Promotes Glioma Angiogenesis by Activating NF-κB Signaling

Jiang, L., Song, L., Wu, J., Yang, Y., Zhu, X., Hu, B., Cheng, S. Y. & Li, M., Jan 31 2013, In : PloS one. 8, 1, e55527.

Research output: Contribution to journalArticle

34 Scopus citations

Downregulation of miR-452 promotes stem-like traits and tumorigenicity of gliomas

Liu, L., Chen, K., Wu, J., Shi, L., Hu, B., Cheng, S., Li, M. & Song, L., Jul 1 2013, In : Clinical Cancer Research. 19, 13, p. 3429-3438 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype

Ying, Z., Li, Y., Wu, J., Zhu, X., Yang, Y., Tian, H., Li, W., Hu, B., Cheng, S. Y. & Li, M., Jan 15 2013, In : Cancer Research. 73, 2, p. 990-999 10 p.

Research output: Contribution to journalArticle

116 Scopus citations

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

Mao, P., Joshi, K., Li, J., Kim, S. H., Li, P., Santana-Santos, L., Luthra, S., Chandran, U. R., Benos, P. V., Smith, L., Wang, M., Hu, B., Cheng, S. Y., Sobol, R. W. & Nakano, I., May 21 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 21, p. 8644-8649 6 p.

Research output: Contribution to journalArticle

300 Scopus citations

MiR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops

Song, L., Lin, C., Gong, H., Wang, C., Liu, L., Wu, J., Tao, S., Hu, B., Cheng, S. Y., Li, M. & Li, J., Feb 1 2013, In : Cell Research. 23, 2, p. 274-289 16 p.

Research output: Contribution to journalArticle

64 Scopus citations

Noncoding RNAs in cancer and cancer stem cells

Huang, T., Alvarez, A., Hu, B. & Cheng, S. Y., Nov 15 2013, In : Chinese Journal of Cancer. 32, 11, p. 582-593 12 p.

Research output: Contribution to journalReview article

74 Scopus citations

YM-155 potentiates the effect of ABT-737 in malignant humanglioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context

Jane, E. P., Premkumar, D. R., DiDomenico, J. D., Hu, B., Cheng, S. Y. & Pollack, I. F., Mar 1 2013, In : Molecular cancer therapeutics. 12, 3, p. 326-338 13 p.

Research output: Contribution to journalArticle

28 Scopus citations
2014

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis

Feng, H., Lopez, G. Y., Kim, C. K., Alvarez, A., Duncan, C. G., Nishikawa, R., Nagane, M., Su, A. J. A., Auron, P. E., Hedberg, M. L., Wang, L., Raizer, J. J., Kessler, J. A., Parsa, A. T., Gao, W. Q., Kim, S. H., Minata, M., Nakano, I., Grandis, J. R., McLendon, R. E. & 7 others, Bigner, D. D., Lin, H. K., Furnari, F. B., Cavenee, W. K., Hu, B., Yan, H. & Cheng, S. Y., Sep 2 2014, In : Journal of Clinical Investigation. 124, 9, p. 3741-3756 16 p.

Research output: Contribution to journalArticle

41 Scopus citations

EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180

Feng, H., Hu, B., Vuori, K., Sarkaria, J. N., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., May 8 2014, In : Oncogene. 33, 19, p. 2504-2512 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Rho GTPases and their activators, guanine nucleotide exchange factors (GEFs): Their roles in glioma cell invasion

Hu, B., Symons, M., Salhia, B., Fortin, S. P., Tran, N. L., Rutka, J. & Cheng, S. Y., Jan 1 2014, Signaling Pathways and Molecular Mediators in Metastasis. Springer Netherlands, p. 143-169 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2015

Gene expression profiling distinguishes proneural glioma stem cells from mesenchymal glioma stem cells

Chandran, U. R., Luthra, S., Santana-Santos, L., Mao, P., Kim, S. H., Minata, M., Li, J., Benos, P. V., DeWang, M., Hu, B., Cheng, S. Y., Nakano, I. & Sobol, R. W., Sep 1 2015, In : Genomics Data. 5, p. 333-336 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Identifying driver genomic alterations in cancers by searching minimum-weight, mutually exclusive sets

Lu, S., Lu, K., Cheng, S. Y., Hu, B., Ma, X., Nystrom, N. & Lu, X., Dec 16 2015, Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015. Schapranow, L. M., Zhou, J., Hu, X. T., Ma, B., Rajasekaran, S., Miyano, S., Yoo, I., Pierce, B., Shehu, A., Gombar, V. K., Chen, B., Pai, V. & Huan, J. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 1728-1730 3 p. 7359942. (Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets

Lu, S., Lu, K. N., Cheng, S. Y., Hu, B., Ma, X., Nystrom, N. & Lu, X., Aug 1 2015, In : PLoS computational biology. 11, 8, e1004257.

Research output: Contribution to journalArticle

10 Scopus citations

Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α

Feng, H., Li, Y., Yin, Y., Zhang, W., Hou, Y., Zhang, L., Li, Z., Xie, B., Gao, W. Q., Sarkaria, J. N., Raizer, J. J., James, C. D., Parsa, A. T., Hu, B. & Cheng, S. Y., Jan 1 2015, In : Neuro-oncology. 17, 6, p. 832-842 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways

Huang, T., Alvarez, A. A., Pangeni, R. P., Horbinski, C. M., Lu, S., Kim, S. H., James, C. D., Raizer, J. J., Kessler, J. A., Brenann, C. W., Sulman, E. P., Finocchiaro, G., Tan, M., Nishikawa, R., Lu, X., Nakano, I., Hu, B. & Cheng, S. Y., Oct 4 2016, In : Nature communications. 7, 12885.

Research output: Contribution to journalArticle

32 Scopus citations

A simple, low-cost staining method for rapid-throughput analysis of tumor spheroids

Eckerdt, F., Alvarez, A., Bell, J., Arvanitis, C., Iqbal, A., Arslan, A. D., Hu, B., Cheng, S. Y., Goldman, S. & Platanias, L. C., Jan 2016, In : BioTechniques. 60, 1, p. 43-46 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial-mesenchymal transition and invasion in mice and humans

Zhang, L., Zhang, W., Li, Y., Alvarez, A., Li, Z., Wang, Y., Song, L., Lv, D., Nakano, I., Hu, B., Cheng, S. Y. & Feng, H., Oct 27 2016, In : Oncogene. 35, 43, p. 5641-5652 12 p.

Research output: Contribution to journalArticle

59 Scopus citations