Bo Hu

  • 3183 Citations
1990 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Article

Activation of Rac1 by Src-dependent phosphorylation of Dock180 Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

Feng, H., Hu, B., Liu, K. W., Li, Y., Lu, X., Cheng, T., Yiin, J. J., Lu, S., Keezer, S., Fenton, T., Furnari, F. B., Hamilton, R. L., Vuori, K., Sarkaria, J. N., Nagane, M., Nishikawa, R., Cavenee, W. K. & Cheng, S. Y., Dec 1 2011, In : Journal of Clinical Investigation. 121, 12, p. 4670-4684 15 p.

Research output: Contribution to journalArticle

79 Scopus citations

Adenosine stimulation of AMP deaminase activity in adult-rat cardiac myocytes

Hu, B., Altschuld, R. A. & Hohl, C. M., Jan 1 1993, In : American Journal of Physiology - Cell Physiology. 264, 1 33-1

Research output: Contribution to journalArticle

8 Scopus citations

ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway

Hu, B., Shi, B., Jarzynka, M. J., Yiin, J. J., D'Souza-Schorey, C. & Cheng, S. Y., Feb 1 2009, In : Cancer Research. 69, 3, p. 794-801 8 p.

Research output: Contribution to journalArticle

72 Scopus citations
28 Scopus citations

Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the αvβ1 integrin and focal adhesion kinase signaling pathway

Hu, B., Jarzynka, M. J., Guo, P., Imanishi, Y., Schlaepfer, D. D. & Cheng, S. Y., Jan 15 2006, In : Cancer Research. 66, 2, p. 775-783 9 p.

Research output: Contribution to journalArticle

128 Scopus citations

Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2

Hu, B., Guo, P., Fang, Q., Tao, H. Q., Wang, D., Nagane, M., Huang, H. J. S., Gunji, Y., Nishikawa, R., Alitalo, K., Cavenee, W. K. & Cheng, S. Y., Jul 22 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 15, p. 8904-8909 6 p.

Research output: Contribution to journalArticle

120 Scopus citations

Angiopoietin-2 stimulates breast cancer metastasis through the α5β1 integrin-mediated pathway

Imanishi, Y., Hu, B., Jarzynka, M. J., Guo, P., Elishaev, E., Bar-Joseph, I. & Cheng, S. Y., May 1 2007, In : Cancer Research. 67, 9, p. 4254-4263 10 p.

Research output: Contribution to journalArticle

137 Scopus citations

A nuclear target for interleukin-1α: Interaction with the growth suppressor necdin modulates proliferation and collagen expression

Hu, B., Wang, S., Zhang, Y., Feghali, C. A., Dingman, J. R. & Wright, T. M., Aug 19 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 17, p. 10008-10013 6 p.

Research output: Contribution to journalArticle

51 Scopus citations

A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways

Huang, T., Alvarez, A. A., Pangeni, R. P., Horbinski, C. M., Lu, S., Kim, S. H., James, C. D., Raizer, J. J., Kessler, J. A., Brenann, C. W., Sulman, E. P., Finocchiaro, G., Tan, M., Nishikawa, R., Lu, X., Nakano, I., Hu, B. & Cheng, S. Y., Oct 4 2016, In : Nature communications. 7, 12885.

Research output: Contribution to journalArticle

33 Scopus citations

A simple, low-cost staining method for rapid-throughput analysis of tumor spheroids

Eckerdt, F., Alvarez, A., Bell, J., Arvanitis, C., Iqbal, A., Arslan, A. D., Hu, B., Cheng, S. Y., Goldman, S. & Platanias, L. C., Jan 2016, In : BioTechniques. 60, 1, p. 43-46 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Autophagy and hallmarks of cancer

Huang, T., Song, X., Yang, Y., Wan, X., Alvarez, A. A., Sastry, N., Feng, H., Hu, B. & Cheng, S. Y., Jan 1 2018, In : Critical Reviews in Oncogenesis. 23, 5-6, p. 247-267 21 p.

Research output: Contribution to journalArticle

1 Scopus citations

Bmi-1 Promotes Glioma Angiogenesis by Activating NF-κB Signaling

Jiang, L., Song, L., Wu, J., Yang, Y., Zhu, X., Hu, B., Cheng, S. Y. & Li, M., Jan 31 2013, In : PloS one. 8, 1, e55527.

Research output: Contribution to journalArticle

34 Scopus citations

CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity

Sang, Y., Li, Y., Zhang, Y., Alvarez, A. A., Yu, B., Zhang, W., Hu, B., Cheng, S. Y. & Feng, H., Dec 1 2019, In : Nature communications. 10, 1, 4013.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Comparable ecological dynamics underlie early cancer invasion and species dispersal, involving self-organizing processes

Marco, D. E., Cannas, S. A., Montemurro, M. A., Hu, B. & Cheng, S. Y., Jan 7 2009, In : Journal of Theoretical Biology. 256, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Downregulation of miR-452 promotes stem-like traits and tumorigenicity of gliomas

Liu, L., Chen, K., Wu, J., Shi, L., Hu, B., Cheng, S., Li, M. & Song, L., Jul 1 2013, In : Clinical Cancer Research. 19, 13, p. 3429-3438 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Dynamin 2 mediates PDGFRα-SHP-2-promoted glioblastoma growth and invasion

Feng, H., Liu, K. W., Guo, P., Zhang, P., Cheng, T., McNiven, M. A., Johnson, G. R., Hu, B. & Cheng, S. Y., May 1 2012, In : Oncogene. 31, 21, p. 2691-2702 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Effect of cell density and growth factors on matrix GLA protein expression by normal rat kidney cells

Cancela, M. L., Hu, B. & Price, P. A., May 1 1997, In : Journal of Cellular Physiology. 171, 2, p. 125-134 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Effects of obesity and hypertension on ventricular myocytes: Comparison of cells from adult SHHF/MCC-cp and JCR:LA-cp rats

Hohl, C. M., Hu, B., Fertel, R. H., Russell, J. C., Mccune, S. A. & Altschuld, R. A., Jan 1 1993, In : Cardiovascular Research. 27, 2, p. 238-242 5 p.

Research output: Contribution to journalArticle

31 Scopus citations

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis

Feng, H., Lopez, G. Y., Kim, C. K., Alvarez, A., Duncan, C. G., Nishikawa, R., Nagane, M., Su, A. J. A., Auron, P. E., Hedberg, M. L., Wang, L., Raizer, J. J., Kessler, J. A., Parsa, A. T., Gao, W. Q., Kim, S. H., Minata, M., Nakano, I., Grandis, J. R., McLendon, R. E. & 7 others, Bigner, D. D., Lin, H. K., Furnari, F. B., Cavenee, W. K., Hu, B., Yan, H. & Cheng, S. Y., Sep 2 2014, In : Journal of Clinical Investigation. 124, 9, p. 3741-3756 16 p.

Research output: Contribution to journalArticle

41 Scopus citations

EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180

Feng, H., Hu, B., Vuori, K., Sarkaria, J. N., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., May 8 2014, In : Oncogene. 33, 19, p. 2504-2512 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion

Jarzynka, M. J., Hu, B., Hui, K. M., Bar-Joseph, I., Gu, W., Hirose, T., Haney, L. B., Ravichandran, K. S., Nishikawa, R. & Cheng, S. Y., Aug 1 2007, In : Cancer Research. 67, 15, p. 7203-7211 9 p.

Research output: Contribution to journalArticle

104 Scopus citations

Estradiol and nicotine exposure enhances A549 bronchioloalveolar carcinoma xenograft growth in mice through the stimulation of angiogenesis

Jarzynka, M. J., Gou, P., Bar-Joseph, I., Hu, B. & Cheng, S. Y., Feb 1 2006, In : International journal of oncology. 28, 2, p. 337-344 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Gene expression profiling distinguishes proneural glioma stem cells from mesenchymal glioma stem cells

Chandran, U. R., Luthra, S., Santana-Santos, L., Mao, P., Kim, S. H., Minata, M., Li, J., Benos, P. V., DeWang, M., Hu, B., Cheng, S. Y., Nakano, I. & Sobol, R. W., Sep 1 2015, In : Genomics Data. 5, p. 333-336 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma

Pangeni, R. P., Zhang, Z., Alvarez, A. A., Wan, X., Sastry, N., Lu, S., Shi, T., Huang, T., Lei, C. X., James, C. D., Kessler, J. A., Brennan, C. W., Nakano, I., Lu, X., Hu, B., Zhang, W. & Cheng, S. Y., Apr 3 2018, In : Epigenetics. 13, 4, p. 432-448 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

Histone acetyltransferase KAT6A upregulates PI3K/AKT signaling through TRIM24 binding

Lv, D., Jia, F., Hou, Y., Sang, Y., Alvarez, A. A., Zhang, W., Gao, W. Q., Hu, B., Cheng, S. Y., Ge, J., Li, Y. & Feng, H., Nov 15 2017, In : Cancer Research. 77, 22, p. 6190-6201 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Identification of two novel alternatively spliced Neuropilin-1 isoforms

Cackowski, F. C., Xu, L., Hu, B. & Cheng, S. Y., Jul 1 2004, In : Genomics. 84, 1, p. 82-94 13 p.

Research output: Contribution to journalArticle

53 Scopus citations

Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets

Lu, S., Lu, K. N., Cheng, S. Y., Hu, B., Ma, X., Nystrom, N. & Lu, X., Aug 1 2015, In : PLoS computational biology. 11, 8, e1004257.

Research output: Contribution to journalArticle

10 Scopus citations

Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A

Wang, W., Zhang, H., Liu, S., Kim, C. K., Xu, Y., Hurley, L. A., Nishikawa, R., Nagane, M., Hu, B., Stegh, A. H., Cheng, S. Y. & Cheng, C., Aug 1 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. 8366-8371 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Isolated myocytes from a normal human heart.

Hohl, C. M., Hu, B., Wimsatt, D. K., Fertel, R. H., Starling, R. C., Brierley, G. P. & Altschuld, R. A., 1990, In : Progress in clinical and biological research. 327, p. 735-742 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Isolation and molecular cloning of a novel bone phosphoprotein related in sequence to the cystatin family of thiol protease inhibitors

Hu, B., Coulson, L., Moyer, B. & Price, P. A., Jan 1 1995, In : Journal of Biological Chemistry. 270, 1, p. 431-436 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family

Hu, B., Trinh, K., Figueira, W. F. & Price, P. A., Aug 27 1996, In : Journal of Biological Chemistry. 271, 32, p. 19415-19420 6 p.

Research output: Contribution to journalArticle

164 Scopus citations

Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response

Wang, Y., Hou, Y., Zhang, W., Alvarez, A. A., Bai, Y., Hu, B., Cheng, S. Y., Yang, K., Li, Y. & Feng, H., Apr 5 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 147.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype

Ying, Z., Li, Y., Wu, J., Zhu, X., Yang, Y., Tian, H., Li, W., Hu, B., Cheng, S. Y. & Li, M., Jan 15 2013, In : Cancer Research. 73, 2, p. 990-999 10 p.

Research output: Contribution to journalArticle

116 Scopus citations

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

Mao, P., Joshi, K., Li, J., Kim, S. H., Li, P., Santana-Santos, L., Luthra, S., Chandran, U. R., Benos, P. V., Smith, L., Wang, M., Hu, B., Cheng, S. Y., Sobol, R. W. & Nakano, I., May 21 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 21, p. 8644-8649 6 p.

Research output: Contribution to journalArticle

303 Scopus citations

MiR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops

Song, L., Lin, C., Gong, H., Wang, C., Liu, L., Wu, J., Tao, S., Hu, B., Cheng, S. Y., Li, M. & Li, J., Feb 1 2013, In : Cell Research. 23, 2, p. 274-289 16 p.

Research output: Contribution to journalArticle

65 Scopus citations

MIR93 (microRNA -93) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy

Huang, T., Wan, X., Alvarez, A. A., James, C. D., Song, X., Yang, Y., Sastry, N., Nakano, I., Sulman, E. P., Hu, B. & Cheng, S. Y., Jun 3 2019, In : Autophagy. 15, 6, p. 1100-1111 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma

Huang, T., Kim, C. K., Alvarez, A. A., Pangeni, R. P., Wan, X., Song, X., Shi, T., Yang, Y., Sastry, N., Horbinski, C. M., Lu, S., Stupp, R., Kessler, J. A., Nishikawa, R., Nakano, I., Sulman, E. P., Lu, X., James, C. D., Yin, X. M., Hu, B. & 1 others, Cheng, S. Y., Dec 11 2017, In : Cancer Cell. 32, 6, p. 840-855.e8

Research output: Contribution to journalArticle

58 Scopus citations

Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway

Hu, B., Guo, P., Bar-Joseph, I., Imanishi, Y., Jarzynka, M. J., Bogler, O., Mikkelsen, T., Hirose, T., Nishikawa, R. & Cheng, S. Y., Aug 16 2007, In : Oncogene. 26, 38, p. 5577-5586 10 p.

Research output: Contribution to journalArticle

133 Scopus citations

Overexpression of vascular endothelial growth factor by MCF-7 breast cancer cells promotes estrogen-independent tumor growth in vivo

Guo, P., Fang, Q., Tao, H. Q., Schafer, C. A., Fenton, B. M., Ding, I., Hu, B. & Cheng, S. Y., Aug 1 2003, In : Cancer Research. 63, 15, p. 4684-4691 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Overexpression of VEGF121, but not VEGF165 or FGF-1, improves oxygenation in MCF-7 breast tumours

Fenton, B. M., Paoni, S. F., Liu, W., Cheng, S. Y., Hu, B. & Ding, I., Jan 26 2004, In : British Journal of Cancer. 90, 2, p. 430-435 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Phorbol esters and cyclic AMP activate AMP deaminase in adult rat cardiac myocytes

Hu, B., Altschuld, R. A. & Hohl, C. M., Nov 15 1991, In : Archives of biochemistry and biophysics. 291, 1, p. 100-106 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

Feng, H., Hu, B., Jarzynka, M. J., Li, Y., Keezer, S., Johns, T. G., Tang, C. K., Hamilton, R. L., Vuori, K., Nishikawa, R., Sarkaria, J. N., Fenton, T., Cheng, T., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 3018-3023 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment

Guo, P., Hu, B., Gu, W., Xu, L., Wang, D., Huang, H. J. S., Cavenee, W. K. & Cheng, S. Y., Apr 1 2003, In : American Journal of Pathology. 162, 4, p. 1083-1093 11 p.

Research output: Contribution to journalArticle

249 Scopus citations

Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α

Feng, H., Li, Y., Yin, Y., Zhang, W., Hou, Y., Zhang, L., Li, Z., Xie, B., Gao, W. Q., Sarkaria, J. N., Raizer, J. J., James, C. D., Parsa, A. T., Hu, B. & Cheng, S. Y., Jan 1 2015, In : Neuro-oncology. 17, 6, p. 832-842 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans

Liu, K. W., Feng, H., Bachoo, R., Kazlauskas, A., Smith, E. M., Symes, K., Hamilton, R. L., Nagane, M., Nishikawa, R., Hu, B. & Cheng, S. Y., Mar 1 2011, In : Journal of Clinical Investigation. 121, 3, p. 905-917 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial-mesenchymal transition and invasion in mice and humans

Zhang, L., Zhang, W., Li, Y., Alvarez, A., Li, Z., Wang, Y., Song, L., Lv, D., Nakano, I., Hu, B., Cheng, S. Y. & Feng, H., Oct 27 2016, In : Oncogene. 35, 43, p. 5641-5652 12 p.

Research output: Contribution to journalArticle

59 Scopus citations

Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity

Yiin, J. J., Hu, B., Jarzynka, M. J., Feng, H., Liu, K. W., Wu, J. Y., Ma, H. I. & Cheng, S. Y., Dec 2009, In : Neuro-oncology. 11, 6, p. 779-789 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

SRSF3-regulated RNA alternative splicing promotes glioblastoma tumorigenicity by affecting multiple cellular processes

Song, X., Wan, X., Huang, T., Zeng, C., Sastry, N., Wu, B., David James, C., Horbinski, C., Nakano, I., Zhang, W., Hu, B. & Cheng, S. Y., Oct 15 2019, In : Cancer Research. 79, 20, p. 5288-5301 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Targeting PDGFRα-activated glioblastoma through specific inhibition of SHP-2-mediated signaling

Sang, Y., Hou, Y., Cheng, R., Zheng, L., Alvarez, A. A., Hu, B., Cheng, S. Y., Zhang, W., Li, Y. & Feng, H., Nov 4 2019, In : Neuro-oncology. 21, 11, p. 1423-1435 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

TGF-β-activated lncRNA LINC00115 is a critical regulator of glioma stem-like cell tumorigenicity

Tang, J., Yu, B., Li, Y., Zhang, W., Alvarez, A. A., Hu, B., Cheng, S. Y. & Feng, H., Dec 5 2019, In : EMBO Reports. 20, 12, e48170.

Research output: Contribution to journalArticle

3 Scopus citations